Various small tetraethyl, lead manufacturing activities have developed in various parts of the country and with the expiration of the Ethyl patents which will occur reasonably soon, there will, of course, be no obstacle, except the economic one, to an increase In these enter prises.

Dr, Kdgsr has brought this patently the deposit is in the na of tetraethyl lead.

I don't" think they have any idea that the tetraethyl lead content in.Q-treated gasoline had anything to do with this man's illness.

Beatty Ethyl Corporation 1600 West Eight Mile Road Ferndale 20, Detroit, Michigan Dear Hal: There is little that I can say by way of constructive criticism about your draft thus far of the memorandum or statement on the significance of tetraethyl lead in the development of high octane gasoline.

Kehoe: I received your very excellent reprints concerning tetraethyl Ethyl lead and gasoline dermatitis and viish to thank you very kindly for the same.

M AXfiELL, ADOPTION, LONDON YOUR 4-0 AND 4 2 P LEASE DELIVER FOLLOWING LETTER TO APPRO PRIATE O FFIC IA L OR O FFIC IA LS SIGNED IN THE NAHE OF ETHYL GASO LINE CORPORATION QUOTE WE ARE ADVISED THAT COMMITTEE I S BEING FORMED TO IN VESTIGATE ANY HAZARDS ASSO CIATED WITH THE D ISTRIBU TIO N OF ETHYL PETRO L STOP WE ARE THE SO LE DISTRIBU TO RS TO O IL COMPANIES OF ETHYL FLU ID OF WHICH TETRAETHYL LEAD I S A PART STOP WE AND OUR PREDECESSO R HAVE BEEN ENGAGED IN T H IS BU SIN ESS FOR FI V E YEARS AND MAY BE OF SOME SERV ICE IN CONNECTION WITH T H IS INVESTIGATIO N STOP WE W ILL BE PLEASED TO FURNISH THE COMMITTEE ANY INFORMATION OR DATA AVAILABLE TO US BEARING i UPON T H IS SU BJECT STOP DR GRAHAM EDGAR WHO HAS BEEN IN CHARGE OF OUR CHEMICAL LABORATORY FOR SEVERAL YEARS AND WHO I S NOW IN LONDON W ILL BE GLAD TO RENDER ANY SERV ICE HE P O SSIBLE GAN WHICH ALSO A P P LI E S TO ANYONE ELSE IN OUR ORGANIZATION STOP ASSURING YOU OF OUR FULL COOPERATION UNQUOTE WEBB KB 0001296

In talking to Dr.Fischbein the other evening he was very positive that this man had a minor case of tetraethyl lead poisoning.

I have hoped that tetraethyl lead might find some usefulness here, but I am extremely skeptical.

The blood cannot be used In this situation since the metabolic products of tetraethyl lead in the body do not combine with the constituents of the erythrba/te Thus the urinary load concentration reveals the level of absorption but the blood does not.

With reference to the analytical results, first, I think it wise to point out that the absorption of tetraethyl lead does not elevate the lead content of the blood materially, but it does elevate the urinary lead concentration greatly and promptly.

In our somewhat scanty experience this has not given favorable clinical results, nor have we been able to demonstrate any unusual localization of lead in the tumor# I have hoped that tetraethyl load might find some usefulness here, but I am extremely skeptical.

The point is . whether or not the difference in symptoms is due merely to differences in the rate of absorption by the body or whether lead tetraethyl has a specific toxicity c its own.

In our somewhat scanty experience this has not given favorable clinical results, nor have we been able to demonstrate any unusual localization of lead in the tumor# I have hoped that tetraethyl load might find some usefulness here, but I am extremely skeptical.

Physical examination at this time disclosed no apparent illness as a result of handling tetraethyl lead.

Moreover, as I have indicated, it is never seen in tetraethyl lead poisoning, and so your statement of its ''constancy1' la not correct.