Garl Mueller of the Chemnyco, Inc. regarding the 1 G, patent on the use of fluorides ^ for stabilizing tetraethyl lead.

,,was, injured; . through the use' of gasoline containing tetraethyl lead.

I am sending you, for whatever use it may be to memorandum prepared some time ago by my associa a consequence of our experience, in dealing with tetraethyl lead poisoning.

Some substances require protection against not only damage to the respiratory system but also systemic mpuy through die skm All substances should be investi gated to learn whether this double hazard is involved Some common substances which are hazardous through both the respiratory system and the skm are Amlme Carbon disulfide Cresol (cresylic acid) Dichloroethylene-1,1 Decalm (decahydronaphthalene) Diethylene oxide (dioxane-1,4) Disthylphthalate Dimethylanihne Duutrobenzene Duutrochlorobenzene Hydrogen cyanide (hydrocyanic acid) Iodoform Lead tetraethyl Mercury and its compounds Nicotine Nitrobenzene Nitroglycerine Organic phosphate insecticides Phenyl hydrazine Tetrahn (tetrahydronaphthalene) 36-21

The problem is of great interest to us from the point of view of the possible absorption of small amounts of tetraethyl lead from gasoline residues into the walls of the hose and we will naturally be very much interest ed in testing any hose of improved resistance which you may develop.

From a hygienic point of view we would favor the use of smaller volumes of gasoline than are now used, since less air, saturated with tetraethyl lead vapor will be displaced (present quantity about 9 cubic feet). 3:.nee the Manufacturing Department washes drums quite elaborately prior to repainting and refilling, I can see no 0 ictions from their end, but would suggest that after you have studied this thing, you communicate with Charlie Y/assernan and get his reaction to the introduction of this type of standpipe.

Kehoe has spent many years of research and clinical investigation both on the subject of tetraethyl lead and ethyl gasoiinej and there is no one in the country more competent to give you information which you seek than he, - I trust that you will hear from him within a very short time, With my very kindest regards, I am - . .. .

Stovall's letter to the Public Health Service was written in ignorance of the fact that the use of 4.5 c.c. of tetraethyl lead in aviation gasoline had been approved by the Service years before.

This morning I contacted the men who are working directly with tetraethyl lead with the purpose of correct ing as far as possible the gross errors in handling so that you can devote your short time here to the less evident' hazards.; In checking through our work on the chlorphenols I find that we have run some toxicities .studies on intra venous injections.

Be am Gentlemen* I am sending you herewith for such use as It may be to you at once, an Incomplete copy of a report on the status of the tetraethyl lead plants For a number of reasons that have been beyond my control, it has been Impossible to finish the text of this report, and since 1 shall be out of my office for the next ten days or so, I v&nt to put as much of this as I can into your hands promptly.

Drinker; I am sending yon herewith a rather lengthy article on the study of the Industrial and public health hazards related to gasoline containing tetraethyl lead.

Taylor a ddr ess New York Changes in the Regulations for the Sale and Distribution of Gasoline Containing Tetraethyl Lead as Approved from Time to Time up to June, 194-6 date June 11, I94.6 In accordance with your letter of May 9, we have checked the draft of your proposed regulations.

Now that tetraethyl lead is being restricted, there is an increased use of benzene to obtain the necessary antik nock ratings.

You will note Mr, Crane states it is entirely possible to draw off sludge with the gasoline during tank car or barge loading opera tions, and it is my thought that possibly some Tetraethyl Lead was carried to the Cleveland tank in this manner.

THRESHOLD LIMIT VALUE FOR TETRAETHYL LEAD (1967) (1968) 0.075 mg/m3 Downward revision?