She sign is supposed to attract the attention of the motorist, however, and to give him suitable warning, so to speak, that he is purchasing gasoline containing tetraethyl lead .

If by finding some lead in urine 3 or 4 years after a man came in contact with Tetraethyl gasoline in small quantities of 2-1/4 gallons per month, used in starting small engine and cleaning some machinery, a doctor can say that lead poisoning was contracted by absorption through the skin, it would seem that your profession would be assuming physical facts based upon the wildest imagination.

As you know, -nOv's report indicates that sterniing cannot As considered aa a of recnvrn: tetraethyl lead or its decanusositloa wyoriucts, H'h&rerHJNj it -^oulv. : -, ' r t-wt workmen denning out the sludge j?

The tests in question were repeated using gasoline colored red but containing no tetraethyl lead.

Kehoe and our management yesterday, the following policy was agreed upon in connection with distribution of the medical report from the Kettering Laboratory entitled "An Investigation of the Potential Hazards of Exposure to Lead Associated With the Handling and Use of Gasoline Containing An Antiknock Fluid in Which Tetramethyl Lead is Substituted for Tetraethyl Lead:" 1.

We are serving notice that we wish to cancel this agreement at the end of 1959* \ As you know, the Surgeon General xaade certain recommendations relative to the measurement of lead in the atmosphere in connection with the use of 4 ml of tetraethyl lead in gasoline.

Kehoe and our management yesterday, the following policy was agreed upon in connection with distribution of the medical report from the Kettering laboratory entitled "An Investigation of the Potential Hazards of Exposure to Lead Associated With the Handling and Use of Gasoline Containing An Antiknock Fluid in Which Tetramethyl Lead is Substituted for Tetraethyl Lead:" 1.

There is every likelihood, I think, that from time to time somewhat higher concentrations of tetraethyl lead will be Introduced into aviation gasoline than are permissible or will ever be permissible in automobile gasoil fs# The problem of the exhaust gases which has been investigated only with relation to the maximal concentration of 3 cos. of lead per gallon of gasoline, is not a serious one in the case of airplanes because of their field of operation# This problem is an important one In the case of automobiles find it is my opinion that there will not be any justification from an hygienic point of view for allowing the concentration to be raised in ' automobile fuels# If this should be done in the case of aviation fuels, and I believe It will be, the problem of handling such fuels will become Increasingly important.

Gasoline containing tetraethyl lead in the commercial amounts does not give rise to t he danger of lead absorption by skin contact or by inhalation.

If the oans had been used over and over for gasoline without cleaning, and.fi there were large quantities of rust in which small quantities of decomposition products of tetraethyl lead were deposited, the situation would be altered somewhat.

On the other hand, In order to provide you with the basis on which my opinion was arrived at, .1 am sending ypu under separate cover a reprint which details"certain studies w have made ori individuals who have been exposed over the longest period of time in the handling of gasoline containing tetraethyl lead, I feel both from the results of these analyses as well as from the consideration of the article which I am sending you, that you will have to consider some other cause for your patient*s complaints.

The reasons for tqy objection are as followsi (1) it will lead to oonfuslon, especially If the noise ever beoomesjw^d^^nsed, as there are many other ethyl gases besides^totraetigrl leedt (2) since the real ob ject of our Imrestigotion is to determine whether or not lead is deleterious in the combustion produote, it Beans to me that we would be wise in our investigations to refer to its ohemlo&l name "tetraethyl lead", or one of the other ones possible.

CLINICAL AFFECTS OF TETRAETHYL LEAD (TEL) POISONING.

We think it is quite feasible to make Fb203 using our accelerator 203 and to label lead tetraethyl with the Fb .

We estimate that the specific activity of the labeled lead tetraethyl will be sufficiently great to follow the lead using a conventional radiographic scanning technique as the lead is cleared from the lungs.