2 OPPORTUNITIES FOR IMPROVEMENTS: 1.

From: Sent: To: Subject: Cagen, Stuart SZ SCC Wednesday, January 24,2001 3:18 PM Clegg, Patsy M SCC-CHSE-PC; Tsai, Shan SP SHLOIL-SPS FW: Benzene Follow Up Flag: Due By: Flag Status: file in china study Follow up Monday, July 02, 2001 5:00 PM Flagged -----Original Message----- From: Beatty, Patrick (PWBE) [SMTP:PWBE@chevron.com] Sent: Wednesday, January 24, 2001 2:33 PM To: 'arschna'; 'Cagen, Stuart SZ SCC' Subject: RE: Benzene I have spoken to Otto and emphasized to him that his exposure experts need to coordinate with Tom Armstrong to ensure that we have a consistent approach that will not invite criticisms when the studies are reported in the literature.

To: David Hunt (E-mail)<dghunt@dow.com> From: Lorraine Twerdok <Twerdokl@api.org> Cc: Patrick Beatty (E-mail) <PWBE@chevrontexaco.com>; Stuart Cagen (E-mail) <szcagen@shellus.com>; Tom Armstrong (E-mail) <twarmst@erenj.com>; Andrew Jaques (E-mail) <andrewjaques@americanchemistry.com> Bcc: Received Date: 2002-05-1 0 19:43: 17 GMT Subject: (API) Benzene study Hi DavidNice to meet you at the VCCEP meeting on Wednesday.

To: Richard Irons (E-mail) <richard.irons@uchsc.edu>; Otto Wong (E-mail) <OttoWong@aol.com>; Robert Schnatter Ph.

To: BHRC Communications Committee (E-mail) <benzconsort-cc@api.org>; BHRC Oversight Committee (E-mail) <benzconsort-oc@api.org>; BHRC Technical Committee (E-mail) <benzconsort- tc@api.org>; Bill Frick <Frick@api.org>; Shannon Stewart (E-mail)<sstewart@apcoassoc.com> From: Matt Todd <ToddM@api.org> Cc: Bcc: Received Date: 2003-02-2619:12:02 GMT Subject: API Executive Briefing Document - Draft 2/26/03 Benzene Health Research Consortium Committee Members: Attached is the fifth revision of the API Executive Committee Briefing Document for the March 18th meeting.

To: BHRC Communications Committee (E-mail) <benzconsort-cc@api.org>; BHRC Oversight Committee (E-mail) <benzconsort-oc@api.org>; BHRC Technical Committee (E-mail) <benzconsort- tc@api.org> From: Matt Todd <ToddM@api.org> Cc: Bcc: Received Date: 2003-05-02 20:36:20 GMT Subject: Shanghai Health Study Update: May 2, 2003 To Benzene Health Research Consortium Members: Please click on the following link, then click on "SHS Update" on the left hand navigation bar to view this week's update. http://www.shanghai healthstudy. org Announcements: * A Oversight Committee conference call is scheduled for Thursday, May 8, at 2:00 EDT to discuss the annual meeting.

To: BHRC Oversight Committee (E-mail) <benzconsort-oc@listserve.api.org>; BHRC Technical Committee (E-mail) <benzconsort-tc@listserve.api.org>; BHRC Communications Committee (E-mail) <benzconsort-cc@ listserve. api. org> From: Matt Todd <ToddM@api.org> Cc: Bcc: Received Date: 2004-02-20 17:35:49 GMT Subject: Shanghai Health Study Update: February 20, 2004 Shanghai Health Study Update Announcements: * The progress report from Otto Wong for the Case Control Study is now posted on the "Technical" page along with a SHS Project Team Organizational Chart. * A meeting with Ed Murphy, API's upper-management replacement for Bill Frick, has been scheduled for February 27th at 9:30 AM EST.

To: BHRC Oversight Committee (E-mail) <benzconsort-oc@listserve.api.org>; BHRC Technical Committee (E-mail) <benzconsort-tc@listserve.api.org>; BHRC Communications Committee (E-mail) <benzconsort-cc@ listserve. api. org> From: Matt Todd <ToddM@api.org> Cc: Bcc: Received Date: 2004-04-3015:15:06 GMT Subject: Shanghai Health Study Update: April 30, 2004 Shanghai Health Study Update Announcements: * The final 4Q2003 financials are posted on the Financials page. * The Oversight Committee met in Houston on April, 21-22.

To: BHRC Oversight Committee (E-mail) <benzconsort-oc@listserve.api.org>; BHRC Technical Committee (E-mail) <benzconsort-tc@listserve.api.org>; BHRC Communications Committee (E-mail) <benzconsort-cc@ listserve. api. org> From: Matt Todd <ToddM@api.org> Cc: Bcc: Received Date: 2004-10-2914:36:26 GMT Subject: FW: Economist article on China's health care system BHRC Committee Members: The attached document is an article about the Chinese healthcare system that Lynn Russo has requested I forward on to you.

SHS Annual Meeting Cost Estimate ASSUMPTIONS Pis traveling from China, travel costs to US location for all participants Oversight Mike Johnston Patsy Clegg Patrick Beatty Don Burnett Brian Doll Communications Camille Costello Lynn Russo Technical Chris Roythorne Stu Cagen Michael Bird Shan Tsai travel time hotel/meals ERP Juhana Idanpaan-Heikkila Zongliang Xu Zhengliu Liang (translator) Ellen Clayton Paul Lombardo PI US Rob Schnatter Otto Wong Rich Irons Tom Armstrong Yimei Zhou travel 4,000.00 4,000.00 4,000.00 500.00 1,100.00 4,000.00 4,000.00 4,000.00 4,000.00 time 3,000.00 1,000.00 1,000.00 5,000.00 4,375.00 hotel/meals 800.00 800.00 800.00 800.00 800.00 800.00 800.00 800.00 800.00 PI-CHINA Fu Hua Youxin Liang 4,000.00 4,000.00 800.00 800.00 SRP Others (J) I Dick Albertini 800.00 2,000.00 800.00 Gary Elliston m Harvey Checkoway 500.00 2,000.00 800.00 Geoff Granville r r John Cherrie 1,800.00 7,000.00 800.00 s:I Helmut Greim 700.00 2,000.00 800.00 APCO () Robert Herrick 2,400.00 2,000.00 800.00 Laurie Labuda 750.00 3,000.00 800.00 () r Richard Larson 400.00 2,000.00 800.00 C Guilan Li 4,000.00 2,000.00 800.00 API ;a Mark Minden 0.00 0.00 800.00 Lorraine Twerdok 750.00 5,000.00 800.00 G) I Jerry Rice 1,200.00 3,500.00 800.00 Matt Todd 750.00 5,000.00 800.00 0c..n Howard Rockette 700.00 2,000.00 800.00 Bruce Jarnot 750.00 5,000.00 800.00 -.....J 0 (J) I'V SHS Annual Meeting Cost Estimate ASSUMPTIONS Subtotals Pis traveling from China, travel costs to US location for all participants 12,500.00 24,500.00 8,000.00 Madeleine Sellouk ATTENDEE TOTALS MEETING ROOMS/FOOD IFINAL TOTAL 130,725.00 5000 135,725.001 750.00 41,350.00 32,375.00 12,000.00 (J) I m r r sI : () () r C ;a G) oI c..n o-.....J (J) c..>

To: BHRC Oversight Committee (E-mail) <benzconsort-oc@listserve.api.org>; BHRC Technical Committee (E-mail) <benzconsort-tc@listserve.api.org>; BHRC Communications Committee (E-mail) <benzconsort-cc@ listserve. api. org> From: Matt Todd <ToddM@api.org> Cc: Bcc: Received Date: 2005-02-01 20:43: 19 GMT Subject: Shanghai Health Study Update: February 1, 2005 Shanghai Health Study Update Announcements: * The Munich Benzene Symposium papers are posted on the homepage of the website. * The Technical Committee hosted a conference call with Dr.

Benzene Task Force API Meeting, Washington DC 2005 Projects 23 February 2005 CONCAWE epidemiology meta-analysis project (Jan Urbanus) o Total API contributions ... o $1 OOK to Phase II ($65K '05 + $35K '04) o $80K to Phase I ($40K '03 + $40K '04) Biologically-based benzene risk modeling (Tony Cox) o Renewal of the early-1990s BBRA modeling effort: Cyclophosphamide-induced perturbations to the hematopoietic system in mice Hematology risk model for benzene leukemogenesis (effects on stem cell differentiation) o Need to request that Tony Cox develop a work plan ...

To: From: Cc: Bcc: Received Date: Subject: jarnotb@api.org <jarnotb@api.org> OttoWong@aol.com <OttoWong@aol.com> Cagen, Stuart Z SCC-CF-SS <stuart.cagen@shell.com> 2005-04-0805:44:02 GMT Additional budget for 2005-2007 Dear Bruce: Our request for additional budget to complete the case-control study of AML and NHL is attached.

To: Richard Irons (E-mail) <richard.irons@uchsc.edu>; Rob Schnatter (E-mail) <a.r.schnatter@exxonmobil.com> From: Bruce Jarnot <jarnotb@api.org> Cc: benzconsort-tc@ listserve. api. org <benzconsort-tc@ listserve. api. org> Bcc: Received Date: 2005-05-17 20:37:24 GMT Subject: SHS... status of IPHS database?

Agenda - Benzene Task Force Meeting - 20 February 2006 1-3pm Research Housekeeping (antitrust, safety review, etc) -- BzTF website...