Document d2kq0qnR6MNQ9noLdomzNRkb

Benzene Task Force API Meeting, Washington DC 2005 Projects 23 February 2005 CONCAWE epidemiology meta-analysis project (Jan Urbanus) o Total API contributions ... o $1 OOK to Phase II ($65K '05 + $35K '04) o $80K to Phase I ($40K '03 + $40K '04) Biologically-based benzene risk modeling (Tony Cox) o Renewal of the early-1990s BBRA modeling effort: Cyclophosphamide-induced perturbations to the hematopoietic system in mice Hematology risk model for benzene leukemogenesis (effects on stem cell differentiation) o Need to request that Tony Cox develop a work plan ... Updated literature review (post-1998) Biological validation of the BBRA model in mice Could Shanghai Health Study human data be used to validate a human benzene BBRA model? Co-exposure modulation of benzene leukemogensis o Project fully funded 4Q04; reprogrammed H&PS $$ Benzene regulatory response o $80K total ($50K from 2004 funding of co-exposure project) o Childhood leukemia review (peer-review manuscript) o Child-to-adult sensitivity to benzene (peer-review manuscript) $65K $50K $501{ $30K 2005 Approved BzTF Budget S195K SH ELL-MCCLU RG-057328