SIERRA BIOM EDICAL A CHARLES RIVER CO M PAN Y PATHOLOGY PEER REVIEW REPORT 26-WEEK CAPSULE TOXICITY STUDY WITH AMMONIUM PERFLUOROOCTANOATE (APFO) IN CYNOMOLGUS MONKEYS Covance Study Number 6329-231 OBJECTIVE A microscopic peer review of the all tissues from ail high-dose animals, selected control animals, and the two animals that had an unscheduled sacrifice (105721 and 105724) was performed.

AR226-2080 ROGER, HERE IS THE IN FORMATION ON THE C-8 SAMPLING DONE IN FINE POWDER SINCE JANUARY 199A.

* AR226-2097 Sample Date Range Concentration Range Action Level Industrial Hygiene m1/1 12/31/97 100% ' Sample Dt Sample# Duration Type Employe* Name STO: 07 TECHNICAL LOG: 2S2 BLDG.3 -GENERAL 6/2S/07 6890 390 A Pern Chemical C-8/FC-143 BTO: 08 LOG: 0 TEFLON BLDG. 162ROOF-GENERAL 7/9/97 7137 362 A 7/9/97 7138 362 A 7/21/97 7130 370 A 7/21/97 7219 371 A 7/21/97 7225 368 A 7/22/97 7 1 370 A 7/22/97 7220 374 A 7/22/97 7226 375 A 7/22/97 7232 384 A 7/23/97 7141 396 A 7/23/97 7221 400 A 7/23/97 7227 7123197 7233 374 A 391 A 7/24/97 7142 362 A 7/24/97 7222 7124197 7228 7124/97 7234 361 A 338 A 366 A 7/2397 7223 354 A 7/2397 7229 351 A 7/2397 7235 351 A 7/29/97 7230 376 A 8/397 7224 378 A 8/397 7231 371 A 8/5/97 7236 370 A C-8/FC-143 C-8/FC-143 C-6/FC-143 08/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C45/FC-143 C-8/FC-143 C-8/FC-143 C-8/F-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-B/FC-143 08/FC-143 C-8/FC-143 GSA-0-143 C-8/FC-143 C-8/FC-143 C-B/FC-143 C-8/FC-143 C-8/FC-143 BTO : 08 TEFLON LOC: 048 B-162 OUTSIDE SMOKING AREA - 2ND LEVEL 7/9/97 7143 382 A C-8/FC-143 Tuesday, May23,20001:16:50 PM Cone Unit Percent 0.08 MPB 89% 0.1 MPB 0.13 MPB 0.15 MPB 0.113 MPB 0.26 MPB 0.07 MPB 0.17 MPB 121 MPB 019 MPB 0.11 MPB 0.16 MPB 1.08 MPB 0.51 MPB 0.14 MPB 0.39 MPB 213 MPB 096 MPB 034 MPB 0.69 MPB 2 9 MPB 217 MPB 007 MPB 019 MPB 0.3 MPB 17/9% 23.2% 268% 202% 46.4% 125% 30.4% 2161%" 339% 19.6% 28.6% 192.9%" 91.1% 25/0% 69.6% 380.4% " 171.4% " 60.7% 1232% " 517.9% " 387.5% " 125% 33.9% 53.6% 043 MPB 768% Page 1 of 12 AJPQ00462 E ID 072868 SampleDt Sample# Duration Type Employee Name 7/10197 7144 7/11/97 7145 7/21/97 7146 7/22/97 7147 7/23/97 7148 7/24/97 7149 7/25/97 7150 8/4/97 7151 8/7/97 7152 387 A 370 A 366 A 377 A 390 A 352 A 351 A 354 A 367 A Per Chemical C-6/FC-143 C-8/FC443 ' C-8/FC-143 C-8/FC-143 C-8/PC-143 C-8/FC-143 C-6/FC-143 C-8/FC-143 C-fl/FC-143 BTO : 08 TEFLON PISLOC 100 - MONOMER OPERATOR CONTROL ROOM (08PA/P8/PC) 7/21/97 7207 372 A C-8/FC-143 7/22/97 7208 351 A C-S/FC-143 7/23/97 7209 398 A C-8/FC-143 7/24/97 7210 7/25/97 7211 352 A 355 A C-8/FC-143 C-8/FC-143 7/28/97 7212 3375 A C-8/FC-143 8/4/97 7213 356 A C-8/FC-143 8/5/97 7214 376 A C-8/FC-143 8/7/97 7215 367 A C3/FC-143 8/8/97 7216 307 A C-8/FC-143 8/12/97 7217 458 A C-a/FC-143 8/13/07 7218 335 A C-8/FC-143 BTO: 06 TEFLON LOG: 113 P/S - SHIFT MECHANIC (58MD) 3/13/97 25282 390 P 6/25/97 25793 370 P 10/21/97 26712 360 P 55MD C-8/FC-143 58MD C-8/FC-143 58MD C3/PC-143 BTO: OS TEFLON LQC: 708 P/S - FINE POWDER PACKOUT (08PJ) 6/24/97 25792 360 P 10/6/97 26426 390 P HEADLEY, ANNE MARIE 08PJ C-8/FC-143 08PJ C-8/FC-143 BTO: 06 TEFLON LOG: 710 FP&D AUTOCLAVE CONTROL ROOM 7/9/97 8862 363 A 7/10/97 8863 388 A Tuesday.

RECYCLED N> AR226-2614 AR226-2614 DUPONT TELOMER MANUFACTURING SITES: ENVIRONMENTAL ASSESSMENT OF PFOA LEVELS IN AIR AND WATER Date: September 2003 Project No.: 508501 18983843.00003 CORPORATE REMEDIATION GROUP An Alliance between DuPont and URS Diamond Barley Mill Plaza, Building 27 Wilmington, Delaware 19805 DuPont Telomer Manufacturing Sites: Environmental Assessment of PFOA Levels in Air and Water______ Table of Contents TABLE OF CONTENTS Executive Summary..............................................................................................................iv 1.0 Introduction.....................................................................................................................1 1.1 Chambers W orks....................................................................... ........................ 1 1.2 Washington W orks............................................................................................ 2 2.0 Data Analysis and Analytical Reporting...................................................................... 3 3.0 Air Dispersion Modeling.............................................................................................. 4 3.1 Chambers Works - ISC3 Modeling Methodology and Results........................ 4 3.1.1 Emission Source Information................................................................. 4 3.1.2 Modeling Methodology......................................................................... 4 3.1.3 Modeling Results.................................................................................... 4 3.2 Washington Works - Screen3 Modeling Methodology and Results................. 6 3.2.1 Data and Modeling Procedures..............................................................6 3.2.2 Modeling Results.....................................................................................8 4.0 Chambers Works Groundwater Sampling.................................................................... 9 4.1 Background........................................................................................................... 9 4.2 Regional Geology................................................................................................. 9 4.3 Site Geology.......................................................................................................... 9 4.4 Site Hydrogeology...............................................................................................10 4.5 Sample Location Selection..................................................................................11 4.6 Sampling Activities and Results......................................................................... 11 4.7 Summary o f Results............................................................................................ 12 5.0 Chambers Works Surface Water Sampling................................................................ 14 5.1 Site Effluent Sample Results.............................................................................. 14 5.2 Chambers Works and Upstream Surface Water Intake Results....................... 14 5.3 Delaware River Surface Water Sampling..........................................................15 5.3.1 Delaware River - Discussion o f Results..............................................16 5.4 Salem Canal......................................................................................................... 17 5.5 Summary o f Results............................................................................................ 17 6.0 Conclusions...................................................................................................................18 7.0 References.....................................................................................................................19 EnvIronmentalAssessmentdoc Oct. 1, 03 Wilmington, DE DuPont Telomer Manufacturing Sites: Environmental Assessment of PFOA Levels In Air and Water______ Table of Contents Table 1 Table 2 Table 3 Table 4 Table 5 Table 6 Table 7 Table 8 Table 9 Table 10 Table 11 Table 12 Table 13 Table 14 TABLES CATT Established Screening Levels.......................................................... vi Summary o f Air Dispersion Modeling Results.......................................... vi Summary o f Groundwater Sampling Results-Chambers W orks...............vi Summary o f Surface Water Sampling Results-Chambers W orks............ vi Chambers Works Stack Parameters and Emission Rates.............................5 Chambers Works Building Heights.............................................................. 5 Chambers Works Site Air Dispersion Modeling Results.............................6 Chambers Works Telomers Operations Air Dispersion Modeling Results6 Washington Works GEP Stack Heights........................................................ 7 Chambers Work Groundwater Analytical Results..................................... 12 Chambers Works Outfall DSN001 Results.................................................14 Chambers Works Surface Water Intake Results........................................ 15 Chambers Works Delaware River Sampling, June 9, 2003.......................... .......................................................................................

AR226-2709 31 American Chemical Society (ACS) Summary of DuPont Presentations AR226-2709 Annual Meeting, August 2004 Extraction of Perfluorooctanoic Acid from Polytetrafluoroethylene Polymers and Determination by LC/MS/MS Barbara S.

AR226-2859 Company Sanitized.

AR226-3112 S ABIO TIC DEG RADATIO N: H YDRO LYSIS A S A FUN C TIO N O F pH (PR ELIM INA RY TEST) Sponsor DuPont Specialty Chemicals Jackson Laboratory Chambers Works Deepwater NJ 08023 USA Research Laboratory Huntingdon Life Sciences Ltd Eye Suffolk IP23 7PX ENGLAND Draft: 23 December 1998 Final: 2 February 1999 aswpssif SanHteed.

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AR226-3350 Biotransformation of the 14C-labeled Fluorotelomer 8-2 Telomer B Alcohol* Wang N.1.

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Ad Sa 6 - N-Et FOSE alcohol Pharmacokinetic - / 0 0 0 3 oz Biotrreformation of '^C-N-Btbyl FOSE in Rats Aitar Administration in Feed for One Week .. 7 January 28, 1983 Conducted At: During: Conducted By: Report By: Reviewed By: Rlker Laboratories, Inc. 3M Center St.

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