Document MGNj3m44rQeXvOMYYXrkgRbYL

FOR D PONT USE ONLY AR226-2891 Copies Co E. I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial nedicine Eikton Road, Newark, Delaware 19711 HASKELL LABORATORY REPORT NO. 70-81 Jackson Laboratory EYE IRRITATION TEST IN RABBITS Procedure: One-tenth milliliter of undiluted test material was placed into the right conjunctival sac of each of 2 male albino rabbits. After 20 seconds, 1 treated eye was washed with tap water for 1 minute. The treated eye of the other rabbit was not washed. Observations of the cornea, iris and conjunctive were made with an ophthalmoscope at 1 and 4 hours, and at 1, 2 and 3 days; Fluor-i-strip stain and a slit-lamp biomicroscope were used at examinations after the day of treatment. noiconiairiTSCA CBS 1 Results: Dose Treatment Cornea Ocular Effects_________________ Iris Conjunctiva 0.1 ml Not Washed undiluted test material A small area of slight cloudiness 1 hr-2 days. None Redness: Mild 1 hr1 day. Swelling: MiId 1~4 hrs. Discharge .'Moderate 1-4 hrs and severe 1-2 days. Hemastixi positive 1 hr-2 days. 0.1 ml Hashed undiluted test material A small area of slight cloudiness 1-4 hrs. Slight c lo u d in e ss was seen with the biomicroscope 1-3 days. None Redness : 1 hr-1 day. Swelling:Slight 1-4 hrs. Discharge:None. Summary; ~ L ^ B | ^ W [ U ^ K j | D r o d u c e d a small area of transient slight corneal c l o u a i n e s ^ a n d S l d c n n j u n c t i v i t i s with no iritic effects after treatment in both the washed and unwashed rabbit eyes. There was copious discharge in the unwashed rabbit eye. The unwashed rabbit eye was normal within ? days and the washed eye was normal within 7 days after treatment. This material produced mild ocular effects with severe discharge. In the event of eye contact, flush copiously with water. Synonym; CAS Registry Number: Composition: 2- - Company Sanitized. Does not contain T SC A CBI Report by: Technician Approved by: ' jL Gerald L. Kennsoy Chief, Acute Investigations Section JEH:jrg Study Director: 0. L. Dashlell .Date Issici: February 1?, 1981 Report No 70-B1 - 3- TSC A CBl Sanitized. Does n0icontai