Document j79ExzgONQpmGOQB7vkBZxbp

000694 /Hl EM Pt-O VeE RELATIONS D EPARTM EN T March 15, 1979 PERSONAL AMD CONFIDENTIAL P. G. GILBY CD&P B-- 13265 CHAMBERS KORKS FLOOROSULFACTANT STUDY (Ref, Letter from RDR to PGG, 1/23/79) In response to our request to the plant for additional information to analyze the data statistically, we received a tab ulation of the Dispensary Visits and Disability Wage incidents in the exposed and control groups (Attachment V ) . These data were broken-down by body systems. We were also informed of the number of employees in each group who had abnormal liver function tests. We performed a "chi-square" test to test the significance of differences between the exposed and control groups. The at tached table shows only those differences that were found to be statistically significant. In the category, "Allergic, Endocrine, and Metabolic" disorders, a significantly higher incidence was found in the exposed group for both Dispensary Visits and Disability Wage incidents. Tins was attributed in the report to a higher number of diabetics i.. the exposed group. The exposed group also showed significantly higher numbers for "mental and psychoneurotic" disorders and for disorders of "skin and cellular tissues." The control group, on the other hand, had considerably more Disability Wage incidents for circulatory diseases, 25 com pared to 5. This difference, is highly significant (P< 0.001). Explanations for these differences cannot be found from the available data. It. would be helpful to find out what specific diagnosis within these general categories accounted for the differences between the two groups- T H E R E 'S A W O R LD O F TH IN GS W E A R E D O IN G SO M E T H IN G A B O U T Company Sanitized. Does not contain TSCA CM 0 0 0 6 95 Although the number of employees with abnormal liver function tests was notably higher in the exposed group (6 com pared to 1), the difference is not statistically significant {P<0.05). Nevertheless, the data do suggest that the exposed group may be at an excess risk of developing liver disease, so continued surveillance would be advisable. MEDICAL DIVISION S. Sidney Pell Manager Epidemiology Section SPrmsd Attach. ) 000696 ORGANIC FLUORINE IN BLOOD Group (sample size) ppm Organic Fluorine* 3M Data General population (106) Pu n t office worker Plant worker - general Pun t worker - long service IN f/c area NEWER PLANT OLDER PLANT Du Pont Data 0.002 to 0.13 [0.02]** 0,01 to 0.06 0,13 to 1.18 0.9 to 9,1 5.9 to 71 * Wilmington control group (25) Chambers Works group (55) (23 of 25) 0 - 0,38 *** [0.039] 64 OF 55) .0 - 0,37 **** [0.153 Conclusions - Chambers Works employees do not have elevated levels of organic FLUORINE IN THEIR BLOOD AS WAS REPORTED FOR 3m WORKERS, O The mean value for Chambers Works employees mas slightly higher THAN THE WILMINGTON CONTROL GROUP CO,15 VERSUS O.'QQAj, BUT ALL VALUES ARE CONSIDERED TO BE "NORMAL" C<1 PPM EXCEPT ONE VALUE in the Wilmington control group (10,6 ppm). * By difference between TOTAL AND INORGANIC FLUORrNE ** [Median values] *** except 2 values 10,6; 0.78 except 1 value 0,89 ppm 000697 TABLE I CONCENTRATION OF PERFLUOROOCTANOATE IN BLOOD (a) .Date Sampled I 6/16/81 1 6/16/31 I 6/17/81 I 6/23/81 GC Analysis__ Date Analyzed 6/26/81 6/26/81 6/26/81 6/26/81 fen3>ug.f/g b: 0.007 0.011 n.d, 0.096 (a) Analysis as described in Lab Method ES-567 ("Determination of Perfluorooctacioic Acid in Blood, Gas Chromatographic Method", S, Stafford, 4/3/81), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration standard. (b) Although the analysis is specifically for perfluorooctanoate (acid or salts), concentrations are given in ppm fluorine for comparison with the results of total organic fluorine analyses, (ppm F 0.688 x ppm perf luorooc carioic acid) Estimated uncertainty is + 10% relative standard deviation. The lower limit for quantitation is 0.007 pgF/g. The detection limit is n, 0.004 NgF/g, but concentrations in that range cannot be -well quantitated and are reported as < 0.007. Mane detected (n.d.) is reported for samples with [Cg] < 0.004 ppm. which cannot be distinguished from reagent background, ^ Company Sanitized. Dosa no! contain T SC A CBI 000698 TABLE X CONCENTRATION pF PERFLUOROOCTANOATE IN BLOOD (a) / .Sample Date Sample 7/14/81 7/14/81 7/15/81 7/22/81 7/22/81 7/22/81 7/22/81 7/22/81 7/22/81 7/22/81 7/22/81 7/23/81 7/23/81 !3 7/23/81 7/23/8.' 7/23/8: 7/24/8 7/24/8 GC A n a l y s i s ________ ______ Date Analyzed [Ck I, o r F/g b . 7/28/81 & 7/29/81 7/28/81 7/28/81 7/28/81 7/29/81 7/29/31 7/29/81 7/28/81 . 7/28 & 7/29/81 7/29/81 7/29/31 7/29/81 7/29/81 7/29/81 7/29/31 7/30/81 7/30/81 7/30/81 0.014 0.25 -- 0.11 -0.015 0.033 n.d. 0,010 0.12 -- 0.015 0.062 < 0.007 0.016 0.14 -- ' 0.007 0.15 ,,-- 0.032 0.084 0.027 6/23/8 7/28/81 o,ioic)._- (a) Analysis as described in Lab Method ES-567 ("Determination of Perfluorooctanoic Acid in Blood, Gas Chromatographic Method", S. Stafford, 4/3/81), using the packed column GC Analysis with perfluoro-n-octanoic acid as calibration standard. i (b) Although the analysis is specifically for perfluorooctanoate (acid or salts), concentrations are given in ppm fluorine for comparison with the results of total organic fluorine analyses, (ppm F = 0.688 x ppm perfluorooctanoic acid) Estimated uncertainty is + 10% relative standard deviation. The lower limit for quantitation is 0.007 pgF/g. The detection limit is s, 0.004 -jgF/g, but concentrations in that range cannot be well quantitated and are reported as < 0.007, None detected (n.d.) is reported for samples with [Cg] < 0.004 ppra, which cannot be distinguished from reagent background. (c) Previously analyzed sample, re-analyzed for comparison with repeat sample 81-3189; result of the initial analysis on 81-2779 was 0.096, reported 7/13/81. Company Sanitized. Does not contain T SCA CBI 000699 Ai{ ANALYTICAL RESULTS AS MICROGRAMS FLUPRINE/GRAM BLOOD Group A Group B Group C Group D* Groao E Group F . : - ---- 0.032 ,015 .033 ... .014 .062 .077 7 .140 .025 ..084 ,'.150 :'r;. . n o .039 ~ .027 .250 .150 0,059 0.013 (0.013) 0.020 N .D .** .016 ( -015$ N.D,** N.D.** ( .007) <.007*** ... ( 007) <.007*** ( .011) .010 { .016) ' .. ( .096V - ( ,120) . ..-/i . .*-,.V " *'- - -. " ~- ----- .. * Range 0,014-.25 -- "0--,016 0.007-.12 0-- .020. Mean' 0.0805 0,0590 0.0097, 0.0356 0,0088 Samples Employees ' ..IS 1 ...; ' ; 3 ' '/; 8 1 ' 3 . 4 5 -j5 Overall: Range 0-.25 Mean 0,049 Samples 33 Employees' 29_ 0 1 ' 1 , Pre-work and post-work. specimens were, taken from 4 employees in Group D (Pre }. Time lapse between samples was 2-5 weeks. (Post) . -7. .**. None detected. Zero concentration used in computing means. * * .* The lower limit for quantitation isrO.0-37 `and'flower '.values : '' are reported simply as <0.007; however, the 0.007 value was v. used in calculating means.' ... . . / I I 00070Q PjLO&l D e tUT SfctoPLB PZ. M & d E M e to x * T & V i s i r S e ^ lV M T F : BteB-U N e . iw e J S n t g ''/* P o u o u m /? INC "Ai ft* > 4/l * fm CompanySanitized. Do*netcontainTSCA CBI J 000701 / t* h(M l L NAME FLUOftij&ATgJ) p r e T M E o r ni e tfe W ATE TOTM E A 5F - $ AhJM&Eg. SoPfLY PASTE U M g SAmAie , yw "\c>. 1 hM Vto m y e s Ko nh h?A 'V ip pfi1 yes yj " h ftfn - "A PM yes nfi -- y<5 Sa-tnp/e ye? ye.? . I^I/t/foe m pfri 'Y-, ...... .. "/l Pfll UMjr y & id e d y. ~ fie e .... W orker A.W ork S ie . p d f j n J i c - f Q Xposofe -fitri dc.$ JO i _ fcV< _ <>>O y. * t j *. ,.-- . . . . .. ... . ... . Tk* ftrv^l u r m . SO.repU UI&5 /oit/fie/ 4-ff/r Uibrlcr ka.d bfi-e* S u b j e c t e d tvJD rk s"f-e jOo'fsH^A./ G s fp o fo fiz . y> f et. ?r*trurt\<sr*s. *>: hpors d o c k .. "itm e. ................................................ ................ . . . . Results H . fJ .J & frm.ttg<ftMS F pgr U T E ^ &Fiu to / ShmPLES. & EFbR AFTE ftcK-oP 2 1 .................... _____ * i ? ........ . s v i . ._ . u . 2.2 3 .2 .. 3 . . o _______ 2 3 ...... _____ 3.4 __ 0.4____ ____ _ 23 ........3.3 _ . .>. . .2.7 . . ... .........J 5 . .. _ A. !....... ... .o N 1O S H _P (zOftflE~AJ PA r/5M (Crfna-...^ocmrv j -- ~th.{ po zTtsJrk .,sko.// hof &yLC-ee.<J.. .7.0 i^--J Shn// jCTe </ p?r - LOOrk- speeetTn-tf. . hi p i c C -O ^3^-r-. *d?sV/~ 3 . D. instil\^fa/yytx i~ p e r ItifS ..D-f ..V>rir>e . . . 000702 ''') PERSONAL AND CONFIDENTIAL ORGANIC FLUORIDES IN BLOOD SAMPIES NAME P.R. NO. GRANULAR OPERATORS Polymerization "1 501 3520 593 . 3097 380 3120 3417 3278 ZONE ORGANIC fluoride PPM COMMENTS - 6 6 6F 6 6 6 6" 6 0.47 8/60-6/71, 12/72 to present * 2.33- Exposure since 1968, granular polymer ization since 2/74. .0.52 Special job. Relief on granular polymerization about 1 day/^aek 2/69 to present. 3.-54 F.P. p.0. 8/62 to 3 /69. PEP polymer ization 8/69 to 7/70, polymerization 12/71 to present: 5.61 12/72 to present, others jobs since 5/55 3.91' . 9/71 to present. 6.84, -- FP, P.D. 9/65 to 12/72, polymerization9/73 to present 2.23 3/76 to present. 3720 4335 - 4278 4 4 4 2.6. 0.-69 0.72 Disp. P.O- 9/71 to 7/72, details to polymerization 5/76 to present. Detailed to polymerization 65 days, in past 5 months. Detailed to granular polymerization 8 of last 10 weeks as of 9/13/79. OPERATOR JION - Polymerization 4214 ' 6 '' 4 .'39 F.F. Dryers and Disp. P.O. 9/76 to 4/79 Polymerization 4/79 to present. . 1484 S{22;i7) 21.22 -- . Service--operator jobs 6/56 to 6/60, polymerization since 2/63. l> samples taken in June. Redacted - Privacy '-7 ^ ' 1 000703 NAME P-R. NO, (Cont-1 3352 953 KOKE ORGANIC FDUORIDE PPM 6 0.17 ' 6 (9.53) 8.25 -- 3522 1482 6 6F 1,52 ' A. 0.59 426 1508 943 6 20.81 -- > * ? ' 6F (10.56) 8.70 - y ^ w -4- 6 (15.02)13.75-- 3564 3994 6 6 1.60 3.55 1951 6 -5.90 4146 . 3485 6 6 0.38 6.91 _ 3854 6' 16.89'-- 3568 - 6 0.98 3987 6 3,81 3424 6. 3.23 , ` ti { } Previous blood -.samples taken in'June- COMMENTS 8/76 to present- 4/62 to present/ others job previous 6 years. F-P. P.O. anil Dryer 6/66 to 3/72, polymerization 2/74 to present. 3/63 to present, except monomer operator 10/77-4/79, 1960 to present, 11/75 to present, 4/62 to present. Service operator' jobs previous 4 years. 11/75 to present- 3/76 to 8/78 F.p, dryer, polymer ization 8/79 to present. ,5/65 to present, -service operator 'jobs additional 5 years. 3/79 to present. 4/77 to -present, PEP service operator 2/75 to .4/77 F.P. dryer 10/75 to 4/77, polymer ization 8/78 to present. r.P. dryer and P.O. 2/75-5/76, some granular polymerization. F.P./disp. polymerization 4/79 to present. - ' Service operator jobs 9/72-11/77. Polymerization 11/77 to present. .8/76 to present 9- I -r 4 5 R edacted-Privacy >1 ' ii- *r 7 \ ! i 000704 SAME Service Operator P.R. I.'O. - 3- 2QKE ORGANIC FLUORIDE PPM .3613 4 4390 4 4153 * 4 1591 4F 4300 4111 4 4 4452 4216 4331 1498 4 4 4 4. 3490 a 4266 4 4 4299 4202 4 4 4.97 1.98 4.84 2.24 1.03 2,92 0.50 ll04 1.80 2-97 3.89 2.30 1.78 '1.81 COMMENTS F.P. dryer and P.O. 6/66 to 12/69, Polymerization 10/77 to 10/78. F.P. Dryer since. 11/78. F.P. Dryer and Disp. P.O, 9/76 to prese-.nt. Service Operatorjobs 5/57 to present. 12/78 to present F'.P. Dryer, detailed to polymerization. 3/7.9 to present all 3 jobs. F.P. padfcput. F.P. Dryer 12 years, pr;P. P.O 8 years, other 3 years. 12/72 to present F.P. Dryer and p.o; . 1/79 to present Disp.- and -Polymerisation.' F.P. paetout. F.P. P.O. 11/76 to present, . Details to polymerization. 370 432 932 . 858 1447 625 864 7 7 - 7 6E 7 7 7- 0.35 0.39 P.Off 0.54 0.17 0.37 0.52 <* ' \ -> % Redacted - Privacy 000705 NAME F5P QPEBST03S Polymerization Dispersion RESEARCH Research Chemists P.R. NO. -- 4~ ZONE ORGANIC FLUORIDE 'PPM - . COMMENTS rt/ - k h / 1743 \.\i 6 (1.36) 0.99 707 ` 6F . 1.72 3223 -6 2.71 1920 1510 1572 6 6 6 . 0.91 2.10 4.64 1578 1761 1928 1619 1744 . 6 3.70 l&> 6 (3.61) 1.93 6 1.95 6 1.47 6 4.96 1426 889 6. 6 4 *5.2 4.14 1976 to present. Additional exposure in homopolymers 1976 to present. Additional exposure in homopolymers Disp. 1964-1971; polymerization 1976 to present. 1976 to present. 1976 to present. Disp. 10/60-11/63; polymerization 1976.to present. 1976 to present. Additional exposure to homopolymers 1976 to present. 1976 to present. 1976 to present. 1976 to present. Additional exposure in homopolyroers. ' 10/77 to present. Additional exposure in homopolymers. 12/76 to present. Additional exposure in horaopblymers. 4329 4 1.31 6/78 to present.- 0.43 0.45 ( ) Prviens blood samples taken in .June R e d a c te d -P riv a c y 000706 name P.R. HO- Seriworks Laboratorians r m -- -% 870 3793 -5- ZONE ORGANIC FLUORIDE 'PPM - 6 0.44 6 1.50 3904 6F 911 6 560 .6/' 3133 6 3690.- ' 6F 11, 0.24 0.70 0.26 0.30 0-24 1592 ; 6 (0.72) 0.59 - 't o k o m s r cFBaarcas w e i h ; W a S I FIES POWDER/DZSP. gobragRSZsaam exposure 939 7 * * -- *. - . , 3044 ' 7 ......- 1633 * 7 FOREMAN VUJNTEER W/S 6.66 '**1'5-29 5,64 X *S'A 0.69 'ctu COMMENTS 5/70 to present8/77 to present. Finishing operator 9/6B to' U / 6 9 , service operator 5/72 to 12/72, homopoly service operator- 12/72 to 7/74, 8/75 to 11/7; 4/77 to present. 2/75 to present. 4/77 to present. 7/69 to 10/72, 5/79 to present.' 8/77 to present- Service operator 2/75 to 9/75. 10/72 to present. Teflon exposure 9/59-4/62, service operator 3/63-2/6 Polymerization. 1/62 to 10/78 Monomer operator 11'months. Exposure: 5/6.2 to 5/77. M o n o m e r ' O p e r a t o r 28 months. ' Exposure 9/62 to 11/77. Monomer operator 22:months. Various jobs with C-8 10/5ff to 3/63.. .Monomer, operator 3/63 to 2/69. Foreman 2/69 to present-. - { ) Previous blood samples taken in June. OFDoughty:mps 10/10/79 Redacted- Privacy o- I t-s S' f-S V, s / 3 000707