A & 6 - lA'Jg OTHER HALOGENATED POPs OF CONCERN THE FIRST ENVIRONMETAL SURVEY OF PERFLUOROOCTANE SULFONATE (PFOS) AND RELATED COMPOUNDS IN JAPAN Sachi Taniyasu1, Kurunthachalam Kannan2, Yuich Horii1and Nobuvoshi Yamashita1 'National Institute of Advanced Industrial Science and Technology (AIST), 16-1, Onogawa, Tsukuba, Ibaraki 305-8569 JAPAN "National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan, USA 2003APR 21) PM 2=23 Introduction Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds (e.g.

AR226-1307-5 Summary * APFO reproductive effects, 8/23/2002 Created By:Nancy S Selzer on 10/07/2002 at 01:47 PM Document Category: Mammalian Toxicology Testing Sub Category : PFOA Consortium Products Additional Authors: Nancy S Selzer/AE/DuPont Li APFO Reproductive effects summary.d 0 .Edit History: Editor Nancy S Selzer/AE/DuPont Edit Date 10/07/2002 01:48:54 PM *Onlypast five adits are shown 000050 PTDB00OB30 EID613678 DuPont Summary - August 23,2002 Oral (Gavagc) Two-Generation (One Litter Per Generation) Reproduction Study of Ammonium Perfluorooctanoate (APFO) in Rats 3M study conducted at Argus (Argus Study #T-6889.6) The multigeneration reproduction study with APFO has been reviewed and DuPont's position on the study is reported below, in addition to some comments on potential endocrine effects of APFO.

SOIL ADSORPTION - REVISED TEST SUBSTANCE____________________________________________ Id en tity: Perfluorooctanesulfonate; m ay also be referred to as P FO S or F C -95. (1 O ctanesulfonic acid, 1,1 ,2 ,2 ,3 ,3 ,4 ,4 ,5,5 ,6 ,6 ,7 ,7 ,8 ,8 ,8 -h e p ta d e c a flu o ro -, potassium salt, C A S # 2 7 9 5 -3 9 -3 ) R em arks: The test substance is a w hite powder.

3.M Press Box - 3M Phasing Out Some o f its Specialty Materials http://www. 3m.com/profile/pressbox/fluorochem.html *ff 3M News AR&3.& _ 661/-!

STUDY TITLE Extraction of Potassium Perfluorooctanesulfonate from Red Blood Cells and Serum for Analysis Using HPLC-Electrospray/Mass Spectrometry DATA REQUIREMENTS Analytical Method Requirements STUDY DIRECTOR Sean Gallagher ANALYTICAL REPORT DATE June 2, 2003 PERFORMING LABORATORY / TESTING FACILITY Exygen Research 3058 Research Drive State College, PA 16801 Phone: 814-272-1039 STUDY SPONSOR 3M Environmental Technology and Safety Services Building 2-3E-09 POBox 33331 St.

D u P o n t-15302 Study Title Ammonium Perfluorooctanoate: Age Effect on the PFOA Plasma Concentration in Post-Weaning Rats Following Oral Gavage Test Guidelines: None applicable AUTHOR: Paul M.

AR226-2207 Debbie J Mulrooney 11/02/2001 09:43 AM To: Robert F Pinchot/DEV/AE/DuPont@DuPont cc: Subject: C8 Particle Density Rob, In addition to the particle size distribution, I need a particle density in order to start doing a sensitivity analysis.

AR226-2295 ^ Paul J Bossert 01/28/2003 05:05 PM To: cc: S u b je c t Gerald L Kennedy/AE/DuPont@ DuPont, Robert W Rickard/AE/DuPont@ DuPont Catherine A Barton/AE/DuPont@ DuPont, David M Rurak/AE/DuPont@ DuPont, John R Bowm an/AE/DuPont@ DuPont, M.

TRADE SECRET Study Title H-24018: Biopersistence Screening 10-Dose Oral Gavage Study in Rats Laboratory Project ID: DuPont-2927 AR226-3157 DuPont-2927 A u t h o r : Carol Finlay, B.A.

AR226-3174 trade secret FINAL REPORT Study Title H-24616; In Vitro M am m alian Chromosome A berration Test in Chinese H am ster O vary (CHO) Cells Authors Ramadevi Gudi, Ph.D.

AR226-3185 DuPont-4739 TRADE SECRET Study Title with OneH9-G0-2-eD4n6ae1yra6Gt:ioSanvuabRgceehprSrootnudidcuycTtiionoxnRicEaittvsyaluations Volume 2 of 5 Laboratory Project ID: DuPont-4739 Te st G u id e l in e s: OUP.SP.TESPA87H0.e3a1l0th0E(1ff9e9c8ts) Test Guidelines Author: Don A.

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3Afl A&2S16- $S7Z 3M ENVIRONMENTAL LABORATORY PROJECT NO.E05-0442 Analytical Report Definitive Study: Quantitative Screening of Commercial Lots of Human Serum Obtained in 2004 for Endogenous Fluorochemicals Using Solid Phase Extraction and Liquid Chromatography/Tandem Mass Spectrometry Laboratory Request Num ber EQ5-0442 Testing Laboratory 3M Environmental Health and Safety Operations 3M Environmental Laboratory' _________________ _ _ _____________________________________________ ;_________ _ 3M Environmental Laboratory Project Lead Mark E.