AR226-1894 Reproductive Effects of C8 James Dahlgren, MD Pamela Anderson-Mahoney, PhD November 2004 Reproductive Hormones Male C8 Workers Increased PFOA Levels Lower Testosterone Prolactin Higher Estrogen Prolactin if high alcohol intake Health Study in Residents Near a Large C8 Source Methods 301 fem ales and 296 m ales with docum ented P F O A -E xp o su re >. 0.05 ug/L in drinking w ater standardized questionnaire SEER prevalence data were used for com p arison Demographics for Residential Study Participants A ge C ategory 20 - 34 35 - 4 4 45 - 54 55 - 64 65 - 80 G ender M ale Fem ale R ace/E thnicity W hite African Am erican Others Education Level L e s s th a n 9 th g r a d e 9 1 1 grade 12 lh/ V o c a t i o n a l / S o m e C o lle g e College Graduate N o. 105 104 135 154 80 284 294 558 6 9 17 59 430 65 /o 18.17 17.99 23.36 26.64 13.84 49.13 50.87 97.38 1.05 1.57 2.98 10.33 75.31 1 1.38 Demographics for Residential Study Participants a w-- t i H T i ~-i'll-- nHiMTinrin iiiiMi iii 'iWMiii[ T M "T rrfigrtB n'iii[iririT r-T '-g ^ ,;^ No. ' B ody M ass Index U nderw eight (<23) A verage (23 - 28) O verw eight (>28 ) 106 190 276 % 18.53 33.22 48.25 Sm oking Status N ever smoked S m o k e d less th a n 15 y e a rs S m o k e d m o re th an 15 y ears 252 60.58 72 17.31 92 22.12 W ork H istory Plant 1 Plant 2 N o plant w ork 54 9.42 19 3.32 500 87.26 Reproductive Cancers in Residents Near a C8 Source CANCER TYPE U terin e/C ervical Breast Prostate Number of Cancers 9 5 9 Observed R ates3 (per 100,000) 3,061 1,701 3,169 Expected R atesb (per 100,000) 96 1,579 1633 PR 33.12 1.12 1.96 C lc 1 7 .0 3 -6 4 .4 1 * 0 .4 6 -2 .7 1 0 .9 8 -3 .9 2 Uterine/Cervical Cancer in Residents Near a C8 Source Age Category 20-29 30-39 40-49 50-59 60+ # of C a n ce rs 0 2 2 3 2 N P R P-value 34 0 - 38 56.40 0.0002 64 25.02 0.0008 84 34.18 0.00001 74 31.83 0.0005 Total 9 294 Age at Menopause in Residents Near a C8 Source Age By Category 38 U .S .

AR226-2004 W* *1 * February 8, 1988 /ZJ fO!

AR226-2112 Sample Date Range Concentration Range Action Level Industrial H ygiene 1/1/84 12/31/84 100% Sample Dt Sample# Duration Type Employee Name BTO: 08 TEFLON LOC: 701 FINE POWDER DRYER-EAST SIDE#2 1/8/84 46247 390 Z 1/13/84 46248 380 Z 3/11/84 46249 360 z 4/10/84 46250 395 z 5/7/84 46251 380 z 6/3/84 46252 380 z 7/2/84 46253 360 z 7/30/04 46254 360 z 8/24/84 46255 330 z 9/23/84 46256 420 z 10/21/84 46257 360 z 12/17/84 46258 370 z Pers Chemical C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 C-8/FC-143 Cone Unit Percent 82 MPB 146429%** 0.19 MPB 339% 0,31 MPB 55.4% OZI MPB 379% 0.47 MPB 839% 0.29 MPB 51.8% 0 .0 3 MPB 5.4% 0.26 MPB 509% QJ53 MPB 94.6% 0.62 MPB 110.7%** 056 MPB 64.3% 0.39 MPB 69.6% BTO: 08 TEFLON LOC : 702 FINE POWDER DRYER CONTROL ROOM (ALSO SEE TTF031 1/23/84 3656$ 345 z C-8/FC-143 1/27/84 36587 420 z C-8/FC-143 2/20/84 36568 360 z C-8/FC-143 3/17/84 36569 360 z C-8/FC-143 6/12/84 36570 385 z C-8/FC-143 7/8/84 36571 340 z C-8/PC-143 8/4/84 36572 420 z C-8/FC-143 10/2/84 36573 360 z ' C-8/FC-143 11/2484 36574 350 z C-8/FC-143 12/23/84 36575 340 z C-8/FC-143 0.62 MPB 0.51 MPB 038 MPB 0.37 MPB 0.S3 MPB 0.15 MPB 0.38 MPB 0.77 MPB 0.26 MPB 0.23 MPB <1 110.7%** 91.1% 679% 66.1% 94.6% 26.8% 67,9% 137.5%** 46.4% 41.1% BTO!

C harles J Zarzecki 02/24/2003 02:43 PM To: Catherine A Barton/AE/DuPont co: Subject: Slid e s Cathie, Here they are.

Katherine E.

TSCA Document Processing Center Attn: Section 8(e)/FYI M2.Z6 - 373V August 10,2006 Page 4 of 10 Attachment 1 July 19, 2006 "Note for settling parties" from the Science Panel (1 page) Note for settling parties We have prepared some outline protocols for several interlinked research components addressing the potential health effects of exposure to C8 around the Washington Works plant.

GRAIN SIZE DISTRIBUTION 100 95 90 85 80 75 70 . 65 60 m>- 55 O' 50 z 45 HI UCLJ 40 35 30 25 20 15 10 5 U S.

P # te 7 I UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 F V Z -O S o l- /3 7/ M arch 20, 2001 FYI-00-00137B a 9 6 - ,0 3 OFFICE OF PREVENTION.

AR226-1523 FINAL REPORT RECEIVED OPPT NClC 03 SEP 30 PM1:OO PROTOCOL 418-028 ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDY OF T-7706 WITH THE REPRODUCTION/DEVELOPMENTALTOXICITY SCREENING TEST SPONSOR'S STUDY NUMBER: T-7706.1 FINAL REPORT DATE: 3 1 JULY 2003 PROTOCOL 418-028 - ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDY OF T-7706 WITH THE REPRODUCTIONLDEVELOPMENTAL TOXICITY SCREENINGTEST SPONSOR'S STUDY NUMBER: T-7706.1 TABLE OF CONTENTS SUBJECT 1.

Toxicological Summary PFOS Dietary Chronic Definitive Reproductive Study: Mallard Test Substance: Perfluorooctanesulfonate (PFOS) Structure: 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro, potassium salt.

Hollyhouse Inc.

- ADIETARYLCS0STUDYWIrToHTsHENORTHERN BOBWHITE WILDLIFE INMTELRANABTRIEOQNUAELSLTTDN,o.PRO0J2E7C23T NO 454.103 S5r U0S.

AR226-1880 Overview of APFO/Telomer Active DuPont/DuPont-Sponsored Projects Presented to US EPA Robert W.

AR226-2112 Test Results Sample Date Range Concentration Range Action Level - n < - ' g----CT'g In =;-TC d W3-;i u s t r i eJ :;ry;nTip;'-ra-j<j,,-jt ; ';=t.S-CT,-.-'----- -:----- -:-- JHygie ; -,- : - ne - - ----' 1/1/84 12/31/84 100% Sample Dt Sample Duration Type Employee Name BTO: 08 LOG; 701 TEFLON FINE POWDER DRYER--EAST SIDE (K 11QB4 46247 3SO Z 1/13HB4 46248 380 Z 3/11/84 46240 3SO Z 4/10/84 46250 398 Z 5f7/84 48251 390 Z 6084 46252 7/284 46233 380 Z 360 2 7/30/B4 46254 360 2 8C484 4625S 330 Z 9H23(B4 46256 420 Z 10(21/84 46257 3GO Z 12/17/S4 46258 370 Z Pers Chemical C-8/FC-143 C-6/FC-143 Cfl/FC-143 C</FC-143 <>a/FC-143 C-8/PC-143 C-WG-143 C-8ffC-143 08/FC.143 (>8/FC-143 C4/FC-143 08/PC-143 Cone Unit Percent 82 MPB 0.19 MP8 0.31 MPB 0.21 MPB 0.47 MPB 0.29 MPB <0.08 MPB 03B MPB OJ53 MPB 0.02 MPB 036 MPB 039 MPB 146425%* 33.6% 55.4% 375% 83S% 51.8% 5.4% 50j0% 94.6% 110.7%** 43% 69,6% BTO: 06 TEFLON U3C; 702 FINE POWDER DRYER CONTROL ROOM (ALSO SEE TTF031 1/23(84 36566 345 Z C-8/FC-143 1/27/S4 36567 420 Z C.8/FC-143 2/20(84 36568 3/17/84 36668 360 Z 360 Z 0-8^0.143 C-fl/FC-143 6/12<B4 36670 385 Z C-e/PC-143 7/8184 36571 340 Z C-8/PC-143 8/4(84 36572 420 Z Ofi/FC-143 10/2/B4 36573 360 Z C^/PC-143 11/24(84 36574 390 Z C-e/FC-143 1203(84 3S5?

SITE SCREENING LEVEL ASSESSMENTS FOR PFOA AND THE RELEVANCE OF SOIL SAMPLING Date: OctobertO, 2003 Project No,; 18983753.00034 ^ CORPORATE REMEDIATION GROUP An Alliance between DuPont and URS Diamond Barley Mill Plaza, Building 27 Wilmington, Delaware 19805 EXP001453 SHe Screera'ng Level Assessments for PFOA and the Relevance of Soa Sampling Table of Contents TABLE OF CONTENTS Executive Summary. 1.0 Introduction ..... 2.0 Data Presentation................................................................................................ 2.1 Development of a Generalized PFOA Screening Level Site Conceptual Model...............,................................................................................................3 2.2 Laboratory Studies of PFOA and Field Sample Verification........................... 4 2.2.1 The Behavior of PFOA in Water......................................................... 5 2.2.2 Adsorption/Desorption of Ammonium Perfluorooctanoate to 2.2.3 2.2.4 Soil.......................................................................................................5 Little Hocking Water Association Investigation Results..................... 7 Washington Works RFI Soil Sampling Results................................... 8 3.0 Summary... .10 4.0 References. .11 Table I Table 2 Table 3 Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 TABLES Washington Works RFI Soil PFOA Results '-- Washington Works RFI Surface Soil PFOA Results Washington Works RFI ADP SWMU Soil PFOA Results FIGURES PFOA Screening Level Assessment Model Comparison of K^s for PFOA and Other Chemicals Little Hocking Water Association Well Field Soil PFOA Results Washington Works RFI Soil PFOA Results Washington Works RFI Surface Soil PFOA Results Washington Works RFI ADP SWMU Soil PFOA Results soil position paper4.doc Oct. 20, 03 Wilmington, DE EXP001454 Site Screening Level Assessments for PTOA and the Relevance of SoB Sampling _____EXCCUtlVe Summary EXECUTIVE SUMMARY DuPont's extensive implementation of both media specific assessment modeling tools and comprehensive on-site and off-site soil, surface-water, and groundwater monitoring for perfluorooctanoate1at the Washington Works site in West Virginia allowed for compilation of a generalized screening level assessment model.