COVANCE> Sponsors: APME Ad-Hoc APFO Toxicology Working Group PROTOCOL Study Tite: 26-Week Capsule Toxicity Study with Ammonium Perfluorooctanoate (APFO) in Cynomolgus Monkeys Date: September 23, 1998 Performing Laboratory: Covance Laboratories Inc. 3301 Kinsman Boulevard Madison, Wisconsin 53704-2595 Laboratory Study Identification: Proposal No. w6806a Covance 6329-231 T- (%%9 02518 : -_-- Covance 6325231 Pag6e2.r Study 26-Week Capsule Toxicity Cynomolgus Monkeys Study with Ammonium Perfluorooctanoate (APFO) in Purpose To assess the effectofthe test material on critical enzyme levels, hormones, and other selected biochemical parameters `monkeys for at least 26 weeks when administered daily by capsule to.

AR 826 _0705" MICROBIAL INHIBITION (DEHYDROGENASE ACTIVITY) TEST SUBSTANCE Identity: Mr(ie1fx-etOrucrrteeadncetoosnutalasfionPniFinOcgSapc,eirdF,fCl-1u9,o15r,,o2o.oc2rt,a3an,se3s.ad4,ic4fo.om5np,a5ot,ne6e.wn6h.ti7c,oh7f.mF88Ca,-y82-0a1lsFo. be heptadecafluoro-, potassium salt, CAS # 2795-39-3) Rsaemmpalreksis: FC-T2h01eF3.

\: DuPont DCFuOoramntamyran Sirgen mans Aezze- 662 October 3. 1994 DFirr.stJaBcrkanAd. sMaCcoPrphoerrastoino,n Group Leader 7201 Adams Street `Willowbrook, IL 60521 Dear Dr.

AR226-2466 "Roger J.

AR226-2543 RCRA FACILITY INVESTIGATION PLAN DuPont Washington Works Washington, West Virginia September 24,1997 MRS Project No. 7179 Prepared by DuPont Corporate Remediation Group & DuPont Environmental Remediatfon Services Barley Mill Plaza 27 P.O.

AR226 _ 2800 ' `DuPontCompanyConfidentialInformation -For DuPontUseOn[ ly -- ( | | I | | || | | | | | 1 ||{ (--AE-- ROBIC-- BIODEG-- RADATI-- ON STUDY OF AMMONIUM!

AR226-2955 Du Pont HLO 235-91 BU PORT USE OSLY Study Title Static Acute Toxicity ofi4------f to the Freshwater Alga, Seleaastrua capricornutua Authors Timothy J.

3M MEDICAL DEPARTMENT, CORPORATE TOXICOLOGY ProtocoflorStudyNo.T-6316.17T,-6295.21T,-7132.3S;T-41 FecesMethod Develot)menMtetabolismStudyforPerfluorooetanesulfonate Derivatives.

08/13/99 T-6316.15;ST-30 3M MEEDICAL DEPARTMEENT, CORPORATE N-ETFOSE Bile TOXICOLOGY ProtocolforStudy No.

MICROBICS MICROTOXO TEST SUBSTANCE TOXICITY TEST Identity:Mixturecontainingperfluorooctanesulfonatweh,ich may also be referredto as PFOS, FC-95, or as a component ofFC-203CF-X or FC-203CF. (1-Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICITY TO AQUATIC INVERTEBRATES (ACARTIA TONSA) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95, or as a component of FC-603EF. (1Octanesulfoniaccid)(CAS # 2795-39-3).

BIODEGRADATION (BOD/COD) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95, or as a component ofFC-603F. (1Octanesulfoniaccid)(CAS # 2795-39-3).

C O R N IN G Hazleton MUTAGENICITY TEST ON T - 6294 IN AN IN VIVO MOUSE MICRONUCLEUS ASSAY.^. &* FINAL REPORT AUTHOR Hemalatha Murli, Ph.D.

HAZLETON WASHINGTON 9 2 0 0 LEESBURG PIKE VIENNA.

BACK TO MAIN BIOCONCENTRATION (n-OCTANOL/WATER PARTITION COEFFICIENT) TEST SUBSTANCE_________________________________________ Identity: N-methylperfluorooctane sulfonamidoethanol; may also be referred to as N-MeFOSE Alcohol, FC-790, FM-3925 or T-5874. (1-Octanesulfonamide, N-methyl1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-N-(2hydroxyethyl)-, CAS # 24448-09-7) Remarks: Material is a cream-colored solid of uncharacterized purity Batch 2334.