Journals.ASM.org Metabolism, Excretion, and Mass Balance of the HIV-1 Integrase Inhibitor Dolutegravir in Humans Stephen Castellino,a Lee Moss," David Wagner,' Julie Borland,a Ivy Songla Shuguang Chen,a Yu Lou,a Sherene S.

Pathology and Toxicology Rlker Laboratories, Inc.

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AR A56 - 0lOl ACUTE TO XIC ITY TO FISH (FATHEAD MINNOW ) TEST SUBSTANCE _________________________________________ Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC -3041. (1Octanesulfonic acid) (CAS # 2795-39-3).

AR 226 - 0916 ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-85, or as a component of FX-3104. (1Octanesulfonic acid) (CAS # 2795-39-3).

AR 226 _ 0922 ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity: ArefmeirxrteudretocaonstPaiFnOiSng, pFeCr-f9l5u,oroorocatsanaescuolmfponoanteen,twohficFhX-m3a1y06a.ls(o1-be Octanesulfonic acid) (CAS # 2795-39-3).

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AR226-2801 TRADE SECRET Study Title H-24215: Static, Acute, 96-Hour LC5o to Rainbow Trout, Oncorhynchits mykiss Laboratory Project ID: DuPont-3381 TEST GUIDELINES: U.S.

AR226-3334 TTt fri 4/t 6/" 4 ^ / : ^ a-<" t& - ^-..--.i;?.

InternCaolrrespondence dc: V.

AN ASSAY OF CELL TRANSFORMP.TIO!

ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity:A mixturecontainingperfluorcoctanesulfonatweh,ich may also be referredtoas PFOS, FC-95, or as a component ofFC-600. (1-Octanesulfoniaccid,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-p,otassium salt,CAS # 2795-39-3) Remarks: The 3M productionlotnumber was 628.

BOAAARNNDNNUUAAOFLL DMMEIEERETETIICNNTGGORS MMIINNNNEESSOOTTAA MMIINNBIIONNAGGRDAANONFDD MDAINRUECFTAOCRTSURING MANUFACTURING COMPANY COMPANY MMaayy 1122,, 11998811 RDReeiccrooerrcddtoroosf~ ottfhheeMimmniinnneuutsteoestsa ooffMinttihhneeg aannannnduuaallManmmueefeetatiicnntggurioonffgtthCheeompBBaoonaaryrdd hoeoffld CDaaeittnrtettechhrtee,oraasMddammpoiilfnneiiwsMsotitornrdana,tetisivovMeteiannooeMffsiffoniiticcanee,gss aoaoftnfd1tt:Mhh1eea5nCuCofoPrar.Mcpp.too,urrraaittMniiagooynnC12oaa,mttpa133n9MM8y1.held Center, Maplewood, Minnesota, at 1=15 P.M., May 12, 1981.

HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE cc: G.

mm-onaBESTCOPY AVAIlABLE Ji:i 1lillSON Ml OK ' : o n i . m o u vs j i : 11tn; l R E C E IV E D Daniel Baugh Institute of Anatomy Department o f Anatomy Offiee o f the Director and Chairman mC5& ..