Document XRmER93aOYzM03rwBVooXgMpG
5 PTRSONAL AND CONFIDENTIAL
:
.:
AL2267~1619
cc: J. M. Cordrey
TDT..oLAA... FESorcsdhtmreaernnk pl Thistleton
G. L. Kennedy - Haskell Lab. T. P. Pastoor - Haskell Lab.
July 29, 1982
TO:
rows
R. J. ZIPFEL
a. 6. LoscHIavo Gobet.
RETENTION OF AMMONIUM PERFLUOROOCTANOATE (C-8;
Using data from the FLAIR* program and from air sampling records, it is estimated
blood (see attachment). points. Also,
that 40% of inhaled C-8 vapor is retained in the This estimate is rough since it is based on only the rate of C-8 absorption varies by .
four data individual.
Air C-8 levels are also variable.
Data on males only were used due to potential sex differences in
C-8 absorption and elimination as observed Powder/Dispersion employees only were used
in to
rat studies. eliminate the
Data on Fine variable of
particle contained
size. .In areas where in polymer particles,
a
significant portion of blood retention should
airborne C-8 be less than
is 40%
of inhaled C-8. This reduced blood C-8 retention is due to the particle size distribution. Large particles (i.e., particles >
airborne 5 microns
in diameter) the alveolar
will not likely reach the lung region where inhaled gases and
alveolar region. It is in vapors are absorbed into the
blood. Probably for this significantly lower blood
reason, TEFLON C-8 levels than
FEP Operators have Fine Powder/Dispersion
Operators.
According htoaleG.d CL.-8Keancnceudmyu,latHeasskeilnl boLdaybortaitsosruyes Tobxeisciodleosgibslto,od.not
more than 20% of in Rat studies indicate
that
10
to
20%
of
inhaled
C-8
is
pooled
or
accumulated by other body tissues.
+FLAIR - Fluoropolymers Laboratory Analysis Information Retrieval.
0885KH-1
000k:1
EIDO79294
2
-2-
.
The remaining 40% of inhaled C-8 has 3 potential fates:
oo IItt iiss eixnhhaalleedd bbuatck nootut.absorbed into the body. .
o It is eliminated by the kidneys or intestines.
accuratelyThethefolflaotewinogf aidndhiatlieodnaCl-:8:information is needed to determine more
o
More MMoorree
blood bblloooodd
C-8 CC--88
data ddaattaa
on oonn
mnaelwesmalweho TlEeFfLtONTEFeLmOpNlo.yees. new female TEFLON employees.
o o
Data on amount of C-8 excreted over a 24-hour period pfaorltliocwlieng-siezxeposduirset.ribution of airborne polymer particles
o ctPooenrtfdaoeirtnmeirnmaginHeaC-s8kw.ehlelreLaabndorahtoowrymucshtudCy-8usiisngstorraeddiolinabetlhleedbodCy-8
o iDamtmaedioanteCl-y8 acfotnetrentexpionsuerxeh.aled air during exposure.
Attachment
.
J6L/nsw 0885H-2
2 g
: EID079295
3
000212
"*.
CALCULATIONS AND DATA
J
Blood C-8 accumulation rates in four male Fine Powder/Dispersion
Operators with less than 550 days of service are as follows:
0.0093 ppm C-8 in .blood/workday
:
:
00..00008403
ppm
ppm
C-8
C-8
in
in
bblloooodd//wwoorrkkddaayy
0.0022 ppm C-8 in blood/workday
X = 0.0060
OPepresroantaolrsaidrurisnagmpltehe rseasmueltsperiinodmolaerse: per billion (mpb) C-8 on these
.
<0.03, 0.09, 0.12, 0.12, 0.15, 0.24, 0.24,
:
0.66, 0.69, 0.73, 0.75, and 1.39
X= 0.46 mpb or 8.2 ug./m3 _
a Averaagre emanle a hhaosurd 5,5E0Ra 0ITE gt m. or f Tbrlg oaonde inworhk.is(1boy and inhales - 10 m3 of
At a C-8 concentration of 0.46 mpb (8.1 ug./n3), an average male would
.
inhale 81 ug. of C-8 during an 8-hour shift.
If all C-8 inhaled was retained in the blood, an average male
accumulate C-8 in blood at a rate of:
581.5ugX. 10C-a8/fwo:rkBdla;ood X 10 6
=
0.0147
ppm
C-8 in blood
Workday
would
However, the average daily C-8 accumulation rat we observe in new
employees is only 0.0060
a
Therefore, of the total
c-8 inhaled, about {5:008% X 100 = 40%) 40% is retained in blood.
{1)Radiological Health Handbook, U.S. Department of Health,
ducation, and Welfare;
(pp. 215 and 216).
Revised Edition, January, 1970,
3
J6L /nsw
0885K-3
~
:
000213
g
EID079296