c SaKaitfheVriisenePEr.esRideeent, PhD. : off FN Coen 3SaMfetEymiOpreornamteinotnsal Heath and ne Haze. 3SHE O5SEP-2 0:38 ne S79C000PBBaauxlsh3MA0Nv1e$ne5,13B3u.il3d1ing 4225.26 )ST a 258765 August 26,2005 Teh-otos-037 RDoocoumme6n4t28Processing Center (Mail Code 7407M) NO TSCA CBI OAtftfeincteioofnP:olTlSutCiAon8P(r)evCeonotridoinnaatnodrToxics US.

~ of ores 1,230 Ease O4KO1V9 pH1: 13 ARRRG _ 3551 AR 224 `By Hand Delivery ODeSoEecmeuChommonteeOnefofitvoce (enCOon)gletTncoyoss Ensue 1201 en en Constitution Avenue, NW feAttn: Ms.

JEFFERSON MEDICAL COLLEGE of THO,MAS JEFFERSON UNIVERSITY DanielBaugh Institute Departmentof 4nafomy Officeof the Directorand Chairman December 7. 1983 Philadelphia1,9107 (215)928-7820 Mr.

Corporate Health-Physics CorporateOccupationalMedicine CorporateProduct Responsibility Corporate Toxicology 3M Medical Department 3M Center,220-2E-02 PO Box 33220 St.Paul,MN 55133-3220 651733 1110 Working Memorandum on Data QualityAssessment(oftheMean and Range of PFOS (ppb)LevelsinCurrent and HistoricaHluman Populations) ThisreportdocumentsBattellee'vsaluatioonfthestatistiqcuaallitaynd defensibiliotfy 12 datasourcesof serum perfluomoctanesulfona(tPeFOS) levelsfound innonoccupationahluman populations.These datawere summarized inthe3M whitepaper, "PerfluorooctanSeulfonate:CurrentSummary ofHuman Sera,Healthand Toxicology Data" providedtotheEPA inJanuary,1999.The purposeof thisinitiaclollectioonf human non-occupationaslerum samplesby the3M Medical Department was to determinethepresenceor absenceofPFOS inhuman blood from currentand historical samples. 3M requesteda reviewofthesedata by Battellteo determinewhat additional inferencescouldbe obtainedby analysesofthesedata.Battellsetatisticiafneslthatonly thepooled serum from the 18 U.S.blood banks was judged defensiblefora statistical analysis.Of thesedata,thegeometricmean PFOS blood levelwas 28.2ppb (95% confidenceinterva2l3.9-33.3).Regionaldifferencecsouldnotbe explainedwithout additionadlata and analyses.

CorporatOeccupationMaeldicine 3M CenterB,uildin2g20-3W-05 St.PaulM,N 55144-1000 IV571374230Telephone 651 7339066Fax 4.

WATER SOLUBILITY TEST SUBSTANCE Identity:Perfluorooctanoiaccid,ammonium salt;may also be referredto as PFOA ammonium salt,Ammonium perfluorooctanoateF,C116, FC-1 26, FC-1 69, or FC-1 43.

ACUTE TOXICITY TO FISH (MUMMICHOG) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may also be referredto as PFOS, FC-95, or as a component of FC-203. (1Octanesulfonicacid)(CAS # 2795-39-3).

TOXICITY TO AQUATIC PLANTS TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may also be referredtoas PFOS, FC-95, or as a component of FC-203CE. (1Octanesulfonicacid)(CAS # 2795-39-3).

ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95, or as a component of FX-60 1. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICITY TO AQUATIC INVERTEBRATES (DAPHNIA MAGNA) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95, or as a component of FC-602. (1Octanesulfonicacid)(CAS # 2795-39-3).

ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE Identity:MixturecontainingPeffluorooctanesulfonatmea;y alsobe referred toas PFOS, FC-95, oras a component ofFC-3072. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ARRRG _ 31404 --~ 8 9 i - 000075 | J lmD || | || i ARBKAG - 3404 METHOD VALIDATION REPORT TITLE: DATE: MAemtmhoondiVuamliPdeartfilounofroorocthteanQouaatneti(tAaPtFiOo)n,of (MPeFasOuAr,e0d.0a5s ttohe10Peprgf/lmuLo.roCoocntcaennotartaetiAonnioRnange), in Human Serum by Turbo Ton Spray LC/MS/MS ' 12 July 2002 REPORT: 02120VDJA_DUDOC Far owe] AUTHORS: David J.

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