DuPont Engineering July 22,2002 AR226-2609 OuPont Engineering BurloyMill PlKt.Blds.27 Lincastrr Pjk6 & Rtg. 141 Wilffiingtmi, DE 1S805 Mr.

AR226-2('>- 695 AR226-2695 Biodegradability ofTelomer-Based Polymeric Products 1.

FER_ 120k -- 1SES6 A rSomes.

AR226-2960 DU FONT USE ONLY Du Font HLR 457-91 Study Title STATIC, ACUTE, 48- AND 64-HOUR EC50 O^II^JUr10 Paphnia aagna Data Requirement Organisation tor Economic Co-Operation and DevelopfBent (OECD) GuiHeifne for' festTng ChemicaTsY 2'02' Author Kevin N.

AR226-3114 TRADE SECRET Study Title H-23773 and H-23775: Skin Irritation Test in Rabbits Laboratory Project ID: DuPont-2121 AUTHOR: Carol Finlay, B.A.

AR226-3134 CONFIDENTIAL SPONSOR ElfAtochemS.A.

AR226-3210 TRADE SECRET Study Title H-23925: Biopersistence Screening 10-Dose Oral Gavage Study in Rats Supplement No. 1 Laboratory Project ID: DuPont-2921 AUTHOR: Carol Finlay, B.A.

AR226-3360 ATMOSPHERIC LIFETIMES AND DEGRAD MECHANISMS OF FLUOROTELOMER ALCOHOLS C^F^C^CR^Ofi Valerie Bossoutrot*, Tanya Kelly^ Isabelle Magneron*, Wahid Howard Sidebottom#, Klaus Wirtz and Georges Le Br * Laboratoire de Combustion et Systemes Reactifs, CNRS Orle # Chemistry Department, University College, Dublin (IRL Centro de Estudios Ambientales del Mediterraneo, Valencia SETAC Prague 18-22 April 2004 .ontext: 1 A .i -^Sis^ Long chain perfluorinated carboxylic acids (PFCAs, Cj^C(0)OH observed in fish and mammals PFCAs : not generally used directly in consumer or industrial materials - presumably degradation products of precursor chemicals : potentially FTOHs Fluorotelomer alcohols (FTOHs, C^F^CH^CH^OH): -Uses: intermediates in manufacture of diverse products - Production: 5x106 kg yr1 (80% polymeric applications) (20% non polymeric ) - Observed in the atmosphere (up to 135 pg m"3) - Atmospheric sources : degradation o^ polymer and non polymeric that incorporate FTOHs (?)

r )93 Developmental changes in the expressionof genes in,,,olved in cholesterolbiosynthesisand lipidtransportin human and ratfetalan'd neonatal livers iviarcS.

SUMMARY OF THE EFFECTS OF PFC's ON MITOCHONDRIAL IN VITRO BIOENERGETICS The attacheddiagram describesthe metabolic relationshipfor the various PFC's thatwere selectedforinclusionin thisstudy.

CENTRAL ANALYTICAL LABORATORY Report No. ---@219 -----------Date--- --May-- 16,- 1978 ------ Subject: F C-143 Analysis of IRDC 137-090 Samples Requestor: Dept.

7ri@@ RETRCOEECXEEI3lCtvVrIr-F--yDD@ Enhanced Elimination of 14 FC-143- C in Rats with Cholestyramine OLOG 3m TOXICOLOGVY-- and Treatment March 5, 1980 Conducted at: D-iring: Conducted by: Report by: Reviewed by: Riker Laboratories, Subsidiary of 3M St.

CAS Number 335-67-1,3825-26-1,335-95-5 3M Company 6/8/2000 Voluntary Use and Exposure Information Profile PerfluorooctanoicAcid and Salts 1.

ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfbnatweh,ich may alsobe referredtoas PFOS, FC-95, or as a component of FC-201.

ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95, or as a component ofFC-602. (1Octanesulfoniaccid)(CAS # 2795-39-3).