April27,2000 One GenerationReRroduction Study ofPFOS Mevalonic Acid/CholesteroClhallengeand NOEL InvestiL-atiionnRats Draft Study Outline Study ObjectivesT:hisstudywillserveasa follow-upstudytoCombined Oral(gavage FertilitDye,velol2mentaland Perinatal/PostnaRteaplroductionToxicityStudy of PFOS in Rats(ArgusProtocol418-008,3M studynumber T-6295.9).The objectiveosf thestudy areasfollows: 1) todeterminewhetherornotco-administratiofnmevalonicacidor cholesteroclan preventor antagonizetheadversematemal and fetaleffects(reducedmatemal body weightgain,increasedpercentstillbordne,creasedbirthweightand decreasedpup survivalo)bservedinthepreviousstudy;and 2) torefmetheno observedeffectlevel(NOEL).

PHOTODEGRADATION (AQUEOUS) TEST SUBSTANCE Identity:N-ethylperfluorooctasnuelfonamidoethanolm;ay alsobe referredto as N-ETFOSE Alcoholor FM-3422. (1-OctanesulfonamideN,-ethyl1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-N-(2-hydroxyethyl)-, CAS # 1691-99-2) Remarks: Materialisan off-whitwea,xy solidT.he testsubstanceused was 14C labeled(220dpm/pg).

ACUTE TOXICITY TO AQUATIC INVERTABRATES (DAPHNIA MAGNA) TEST SUBSTANCE Identity:Perfluorooctanesulfonylamido(ethyi)acmeatyaatles;obe referretdo as PFOSAA, FC-128 or as themajor component of FC-127,FC-129, FC-109, or FC-109-X.

TOXICITY TO AQUATIC PLANTS (E.G.

TOXICITY TO AQUATIC PLANTS TEST SUBSTANCE Identity:Mixturecontainingperfluorooctanesulfonatweh,ich may also be referredto as PFOS, FC-95, or as a component of FC-203CF-X or FC-203CF. (1-Octanesulfoniaccid)(CAS # 2795-39-3).

ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95, oras a component ofFC-3017. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may also be referredtoas PFOS, FC-95, or as a component ofFX-3103. (1Octanesulfonicacid)(CAS # 2795-39-3).

CentreAnalyticaLlaboratoriEsI,nc. 3048 ResearchDrive Phone: (814)231-8032 StateCollege,PA 16801 Fax:(814)231-1253 or(814)231-1580 AnalyficRaelport Fluorochemicat Characterizationof SurfaceWater Samples Port St.Lucie,Fl(W2363) Centre AnalyticalLaboratory Report No. 023-014F TestingLaboratory CentreAnalyticaLlaboratoryI,nc. 3048 Research Drive StateCollege,PA 16801 3M Environmental Laboratory Contact Kent R.

3 71 .

T6ft/ Taft Stettinius & Hollister LLP 425 Walnut Street, Suite 1800/ Cincinnati, OH 45202-3957 /Tel : 513 .381 .2838 / Fax 513 .381 .0205 /www .taftlaw.com Cincinnati / Cleveland / Columbus / Dayton / Indianapolis / Northern Kentucky / Phoenix / Beijing ROBERT A BILOTT 513.357 .9638 bilott@taftlaw .com ~~ ++Q -~0-373 ~4~a~.s- 3qoa, July 14, 2009 TSCA Confidential Business Information Center (7407M) EPA East - Room 6428, Attn : Section 8(e) & FYI U .S .

- AR R26~ 3756 Dyno Nobel Americas 3 (.

ee C3C5oo1rrppMooerrdaatitealTPorDoiedcpuncaotrgmRyeesnptonsibility SHS 1St. 7Pa3ul, 1M1N055133-3220 ARRE-0970 2 aM CSeLrUuEm 1F1l(u1o9r8o9c)heempiicdaelmitorleongdiscoifnvoeustt-iogfa-ticoonusn.ty residents in CLUE I (1974) and "This project is joint collaboration between 3M and Johns Hopkins University School of Public Health researchers.

AttacShtmuednitess atondLeOtttehrertoICn.foArumeatridoanteodn MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds 3.

Oral Rassintipnrdeegsnansttamtsatoefr29990 i ---- Conducted at: -- E Study Director: cssonscors : SRSiaNefsep,tyaSaEyvesahmluueaartsiiioenonnLaaboorratory Febeuary 1, 1581 co mare 13, 4 E.

CHEMGUARD: r,,,, Banited] Docs sf M8a11n77s..f44i77el33d..,9096T60e46xafsa.xUSA 76063 on hemmouard com A9Si00Oo1 N CondTie.