Document LoKGMZa4VJKDoqLBVkkvYL1X3
AttacShtmuednitess atondLeOtttehrertoICn.foArumeatridoanteodn MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds
3. PFOSAA | Perfluorooctane sulfonylamido (ethylacetate
Acute Toxicity,
1) ANoc.utTe-O1r9a8l3T(oFxCi-c1i2ty8,~pRoattass,sBiiuomsesaalrtch1,00In%c,,sPorliodj)e,ctJaNnou.ar7y7-5,1110987A5, 3M Reference.
2)
Acute Oral No. T-2001
Toxicit--y (FC-128),
RJaatnsu,arByio6s,ca1r9c7h8,
Inc,
Project
No.
77-1274, 3M Reference.
3) RPerfiemraernycEeyNeo.IrTri-t2a0ti0o1n S(tFuCd-1y2~8)R,abJbaintusa,rByi6o,se1a9rc7h, Inc., Project No. 77-1274, 3M
# RPerfiemraernycSekNion.ITi-t2at0i0o1n(SFtC-u1d2-8y),RaJbabnitusa,ryBi6o,s1e9ar7c8h, Inc, Project No. 77-1274, 3M
3) ParnojAecctutNeo.In7h8a-la7t1i8o6n,T3oxMicRietfyerSetnucdey Noof.T-T2-3203707C(oFCC-i1n2t8h)e,RFaerb,rBuiaor/yd8y,na1m9i7c6s, Inc. Additional Acute Toxicity Studies Not Submitted (Bibliography only) 1) ANoc.utTe-2O0ra8l1 T(oFxCi-c1i2t9y,~aRpaptrso,xBiimoasteealrych4,0-In5c0.%PirnojseocltutNioon.),78M-a1r1c9h1A2,, 139M78Reference 2) RPerfiemraernycEeyNeo.IrTi-a2t0i8o1n S(tFuCd-1y2~9)R,abMbaitrsc,hB2i,os1e9a7r8ch, Inc, Project No. 78-1191, 3M
3) RPerfiemraernyceSkNion.ITi-t2at0i8o1n(SFtC-u1d2--9y),RaMbabirtcsh, B2,io1s9e7a8rch, Inc, Project No. 78-1191, 3M
4) 3LAac2bu9otr0ea4tO0orra%yl,TKRoi'xkiPecFritOLyaSbSAocrAraetieonnri3wei%st,hEITnXc-O,3H2,Pr9o10j7Cec%otCNIioPn.AA0lab8ni8dnA4oR00Ra3t6s2,,Sa3fMetyReEfvearleunacteioNno. T-
501), November 5, 1982
% H.0, L-6778, F-6873, Lot
3). L3Par2bi9omr0aa4rty0orS%yk,inKRi'IkiPetrFaOtLiaSboAonrATaetiosnrt3iweis%t,hEInITcO-.,H3,P2r9o10j7Cec%otCNIioPn.AA0al8bn8idEn4oB00R4%a2bb3Hi,yt0s3,,MSLa-Rf6eefteyrEevnacleuaNto,ionT-
501), October 15, 1982
778, F-6873, Lot
) ALacbuotreatOocruyl,arRiIkmeirtaLtaiboonrTaetosrtiweist,hInTc-.,3P2r9o0jeCcotCNion.A0l8b8iEnoB0R4a2b4bi,ts3,MSaRfeefteyrEevnacleuNaot.ion1-
"3
600177
-- ee ------------
AttacShtmuednitess atondLeOtttherertoInC.foArumeatridoantoend MCearyta1i8n, 2000 Perfluorooctane Sulfonate-Related Compounds
350219),0O4c0to%beKr'26P,FO19S8A2A in 3% EIOH, 17% IPA and 40 % Ho, L-6778, F-6873, Lot
Genotoxieity
!). BB1ai8co1tt5ee,rsitRaielnpgoRrCetevneNtroes.re,TMC4uh6te6amt3ii,coan3lsTMeIsRntesofpfeercvte-in1oc,neHaNinotda.TRTee-ss6te6i6an8rgchInsItaibtourtea,toSrtiusd,yCChoedmei:caKlo1-
50%
in
solutionofwater
and
organic
solvent),
.1. October,
FC-139 1996
(approximately
40-
2) K3In2'9VP9iFtCtOooCS,MAiAcSrRioInbiI3onlt%eorgEniaIctaOiloHn,Maul1,ta7Pgr%eonjIieccPtiAtNyaonA.ds3s41a04y%5s,o3fM3 RefCeormepnacneyN'os.CTo3m3p0o0u.n(d40T-%
November, 1982
Hy0, L678, F-6873, Lot 501),
Pharmacokinetic Studies
1) RR2e8efaeDureaertnmicaoelnNPloea.brocTru-at3ta9onr9yc1,o,uRsMiakArebcrshoLrap1b5to,irao1tn9o8rS1iteusd,yIwnict,hPFrCoj-e1c2t8Noi.n A0l9b7i9nAoBR0a6b2bi6t,s,sSnagfety
2) RS2ea8ffDeetrayeynEcDveealrNumoaa.tliTo-Pn3e9rl8scb9uo,traaMntacoorruyc,shRA1ib4ks,eorr1p9Lt8ai1boonraSttoruideys,wiItnhc.F,CP-ro1j2e9ctinNoA,lb0i9n7oR9aAbBb0i6t2s7,, 3M
3) 00Fi11n35a01l591R5e1ap,nodritnTv--i6Av0no5aSl4ytitunidcRyaalRbebSiftteusrd,eyn:3cMSeiNnEogn.lveiH-rDWoonIsmee6nD3te2ar9lmaLalboArbastoorrpyt,ioSnt/uTyoxNiec.itAyDStLud,y of
SNoMveRemfbeerren2c2e,
Nos. 1995
T-6051
(FC-129
treated
fabric-)1a3n3d
(TH-a6z0l3e4to(nFWCi.s1c9o5nssoilnu,tiIonnc).),,
R2Foi1nt-ael6re0Rne5cp4eoriNtno,.RAanHbaWbliIyt#ts6i,c33a2lM9R-e1Epn3ov8ri,troSantnmudednSytiNanolg.iTeAe-cMDhDonsToe-l1Io2ngt2yr0ad9v4eSneoruvsicPehsa,rmIancvoikeirnSettuicSdtyudy
129, November 22, 1995
.3, 3M Returns neFC
Studies in Progress 1) SCtorraptoergaicteToTxoixciocloolgoygyLaSbtourdaytoOruyt,liJnuel,y,FC1-919829 Preliminary ADME Sercen in Rats, 3M
-4-
000178
Attachments Studies
atondLeOtttehrertoICn.foArumeatridoanteodn
May 18, Certain
2000
Perfluorooctane Sulfonate-Related Compounds
Pre-1976 Studies (bibliography only)
1)
Skin and Eye Irritation Reference No. FC-128, individual eye scores
Assay April
Report, WARF Institute, 24, 1962 (plus Decembey
Project No. 2031046, 3M 29, 1966 letter containing
)
5.
a
----------------
000179
` Fe-izp
Submitted to:
BIOSEARCH. INC. tp.oe.lbeoxph85o9neph:ilade(lp2hi1a5, )penns8yl4v8an.ia441991091 Project Number - 77-1108A
33MM CCoemnptaenry, 5St5.101Paul, Minnesota
Material: Sample Received: Date of Report: Test: Object of Test:
Procedure:
3M Company - T-1983c0C
11/2/77 Study Initiated: 11/18/77 Study Completed:12/15/77 1/5/78
Acute Oral Toxicity - Rats tTohesstuubdjyectthemaatceurtiealo.ral toxicity in rats of
aSFnhodeurrm30ag0nr-ogWumipsswteaorrfeS5etmrmpaaliloneyew&dei5gihnfientmghailsbeetsatwluebdeiynn.o20rT0ahtes of the ma2ranatdteshrdoiowuasrelserdeprbdyieoprdriirvteeocdtdoosfaidnmfgio.nodistEbruaatcthinoaonntimowafaltetrwhaesfeoxwrpeeirgihneedntal and dosinginnteoedtlhee. stomach by means of a syringe
The sample was dosed as a 50% w/v suspension in water. The following dosage levels were administered:
1.25 2.50
mmll//kkgg..
150..00 mmll//kkgg..
Results: Conclusion:
pfFeoorolidloodawniddnugrwiaantdgemriwnhiaidscthr1aittbiiiomtenuntthfheoerraanttihsemawl1os4redwaeoyrbesoebarslvelerso.vwaetdion for signs of toxicity and mortalities. See Table 1. 22T1.h8e5innsolu/bkjrgeacttsofmhaaatse5r0ai%nalwac/uvwtheesnuosrpsaetlnusdiiLoe0nd50 iinonfwmaaatpleperroaoxnridma1ft.ee2ml5aylge/kg. of the original sample.
000180
DKiarrelctLo.r Gabriel, V.M.D., Ph.5
--_--
1 Ket tral Toxicity
Material IN Company TISBSEC, 5 o 508 w/e suspension in water.
SS[ an -- Si,
15 sms
o M5 Sfemls
S #0 sms
2B2S0O
seme smile
50 stele
00 smile
00 stewie
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o
5 s
2 we mus
0110000000 0000 020000001 000 00
3 sas : dom
so... 40...
o us o 50 -
soo... soo... LLL,
. o
zo us
-
The L950a15msppriateolyt2.a5 alg. of a 502 uv suspension in water
a042S8h9che,Ton1c0u1r2aIes5p0psneaksadkrgae.ndG.o1"t4meo(dr(0ro2.it1t631.5ghhaga"iaREn.g3s.r1u)3enruW5tlm:ihua0okrcasy3a"nuSittamh1rgar1slo)3su5hghwposeaurhteaatrtieh)gedhctaulhsyearTenoecrthirermstrohcreiefeohrn,2u4orhootnurr$sa3aenndd
3G5ronsinStaeisimiaonsdiccoemxstnotnreatwihoinninTo3seWtaerss"sothitnhg
anil were remarkable.
eatery
ore