AR226-2805 MEMORANDUM To: From: Date: Subject: Gerald Kennedy Michael DeLorme 19 June 2002 APFO Aerosol Generation and Particle Size Introduction Inhalation toxicology studies with APFO in rats conducted by Haskell in 1980 demonstrated biological correlations between the airborne concentration of APFO and toxicological responses in exposed rats.

AR226-3184 DuPont-4739 TRADE SECRET Study Title H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 1 of 5 Laboratory Project ED: DuPont-4739 TEST GUIDELINES: U.S.

AR 226 _ O743 ACUTE TOXICITY TO FISH (MUMMICHOG) TEST SUBS" ANCE Identity: A mixturecontainingperfluorooctanesulfonate; may also be referred to as PFOS, FC-95, oras a component of FC-203C a1,n1d,2L,-25,434,03.,4,(41,-5O,c5t,a6n6e,s7u,l7f,o8,n8i,c8a-chiedp,tadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: sample is The 3M production lot number FC-203C and is referred to by the was not noted.

AR RAE -- 331] 493 H2r_ 3300 | .

FINAL REPORT PROTOCOL 418-013 ORAL (GAVAGE) PHARMACOKINETIC STUDY OF PFOS IN RATS SPONSOR'S STUDY NUMBER: T-6295.12 FINAL REPORT DATE: 24 JUNE 1999 PROTOCOL 418-013 ORAL (GAVAGE) PHARMACOKINETIC STUDY OF PFOS IN RATS SPONSOR'S STUDY NUMBER: T-6295.12 TABLE OF CONTENTS SUBJECT 1.

4W# FUNDAh4E?

Fluoroche Samples.

FinalReport Unscheduled DNA SynthesisinRat LiverPrimary CellCultures With PFOS PREPARED FOR: 3M CorporateToxicology COVANCE STUDY NUMBER: 20784-0-447 C 0 V A- -C'-E-.'@-' THEDENU UNSCHEDULED FINAL REPORT DNA SYNTHESIS IN RAT LIVER PRDAARY CELL CULTURES WITH PFOS AUTHOR Maria A.

IN VITRO MICROBIOLOGICAL MUTAGENICITY ASSAYS OF 3M COMPANY COMPOUNDS T-2247 CoC AND T-2248 CoC Final Report 5 September 1978 By.: Vincent F.

lAbOMtDry ComposiRteport AnalyticaRleportsofData for FluorochemicalAnalysisinHuman Sera LIEMS No. 1623 TestingLaboratory 3M EnvironmentaTlechnology& SafetyServices 3M EnvironmentalLaboratory FluorineAnalyticaClhemistryTeam (FACT) 2-3E-09 935 Bush Avenue, St.PauL MN 55106 Laboratory Cont"t KrisHansen,Ph.D.

Experiment No.: Conducted At: Dates Conducted: Conducted By: Acute Ocular Irritation Test with T-3608 in Albino Rabbits 0984ES0367 Pathology and Toxicology Riker Laboratories, Inc.

InternCaolrrespondence dc: M.

'"-'@'HAZLEMON WASHINGTON 9200 LEESBURG PI6 KE VIENNA, VA.22 1 82 1 99 ANALYSIS OF T-5878 IN A CELL PROLIFERATION ASSAY IN RAT LIVER CELLS L FINAL REPORT AUTHOR Maria A.

ACUTE TOXICITY TO AQUATIC INVERTEBRATES (E.G.

CAS Number 423-82-5 3M Company VoluntaryUse and Exposure InformationProfile N-ethylperfluorooetylsulfonamido ethyl acrylate 1.