Document RaXw0ka0NKmLVo9VjBgXrEK7

AR22%6-0013 vou. 1 : . SdMMeNcrie,dieeHneesnptarPTmhnyotsor S5pOMP oCsansessi1in33g32220250. FYI. 0500-137 Sao 3M (Grrrrereyrs) Attachments to April 21, 2000 letter to C. Auer from W. Weppner (Teratology Studics in Rats and Rabbits) 1. Rat Teratology Study T-3351 Final Report Dec 19, 1983, Hazelton Laboratories America Project #154-160. 2. December 7, 1983 Letter to Mr. William C. McCormick, III from E. Marshall Johnson, Ph.D., reviewing draftofabove. 3. Oral Teratology Study of FC-95 in Rats, Riker Laboratory, Experiment # (068TRO008, December, 1980. 4. PNho.vDe.,mbreevrie12w,in1g98t2h,e Laebtotveer.to Franklin D. Griffith, Ph.D. from E. Marshall Johnson, 5. Oral (Stomach Tube) Developmental Toxicity Study of PFOS in Rabbits, Study #418-012, January 11, 1999, Argus Laboratories. -- 000529 . 3IMneMdduiMscteirdniieac,laHHleyDaglietephnaePr,hmyTesoinxctisc:ology P3OM BCeonxte3r22Bu0ilding 20.26.02 St Paul MN $5133.3220 S278 0 -- Oral Developmental Toxicity (Teratology) in Rats and Rabbits aAtnRiokraelr tLearbaotroaltoogryisetsu(dRyiiknerraPthsawrimtahcepuottiacsasliuPmatpheorlfolguyor/ooTcotxainceosluolfgoynaLtaebowraastocroyn)ducted Dose levels (oral) Maternal toxicity given to (reduced the pregnant weight gain) rat dams occurred were 0, 1, at the high 5, and 10 mg/kg dose of 10 mg/kg on days 6 through 1S of No skeletal and gestation. soft tissue Evidence of fetal toxicity teratogenic changes were was not found at found at any dose any dose level level with one ceoxncteprtoilonb.ut tAhecihnacnigdeenicnetihne hliegnhs odfostehegeryoeupwwaassfosiugnndifiincaanltlldyohsieghgerr.oupTshiisnccluhdainnggetwheas reported as compound a developmental was teratogenic. eye An oaubtnsoirdmeaclointsyulatnadntthaendsutmermaatrolyogoyf the report expert, Dr. states E. the eMyaersshpaelcliJmoehnnssionnqfuersotmioJne.ffeHresocnoMnecdliucdaeld College, visited that the eye/lens 3M and reviewed changes were, in the rat fact, pup lseetctetri)o.ninAg raertpiefaatctsstaundyd wnaots ccoomndpuocutnedd artelHaatezdletteornatLoalbogoyraatbonroiremsalAimteireisc(ase(eseeencbleolsoewd) `which revealed no effects on the lens. (Isnutshpeesnudbesdeiqnuecnotmstouild)ywmaesntaidomnineidsatbeorveed,opnogteasstsaituimonpaelrdfalyuosr6o-o1c5tabnyesourlaflongaatveage to mrgo/ukpgs/odfay25(HparzelgentaonntLSabporraagtuoer-ieDsawAlmeeyriCcaD).ratSseavterdeosmeasteorfna0l(tcoonxtircoilt)y,o1c,cu5,rraenddin10the `mwge/igkhgt agnaidn,10temrgmi/nkagl dboosdeygwreouipgsh,t amsienvuisdgernacveiddbuytesriignneifwieciagnhttreadnudctfiooonds cionnmseuamnptbioodny `caommopnagrendumteorcoountsrdolamdsamasn,dadcetautalh lionstsewsoidnabmosdyinwtehiegh1t0 omng/ckogmmdoesnecegrmoeunptporfiotrrteoatment 3ge5s(tSa.tDi.onaalndday3420.73Me(aSn.D.b)o,dryeswpeeictgihvtelgya,inass (cdoamypsa0r-e2d0)toat1525an+d2410(Sm.gD./) kignwetrhee c1o0n4tr+ol (grSo.uDp..) anMdea2n64fo+o9d0co(Sn.sDu.m),ptriesopnecvtailvueelsy,(daasycso0m-p2a0r)ead toa4n2d1 1+02m8g/fkorgtwheerceon3t6r3ol+gr6o0up. (M8e.aD.n)taenrdmi2n4a1l bo6d0y(w$e.iD.g)h,trmeispneucstigvrealvyi,dasutceorimnpeawreeidghtto 3at215 +an2d3 1(0S.mDg./)kign twhaesco2n9t3ro+l28 rgorouugph.haCilricnoiacta,lasniogrnesxiian.suGravsitvrionigntdeastmisnailncalnuddekdidhnuenychliensgi,onlsowweerrebonodtyewdeiinghtth,e ahliogphe-cia, dose dams. iTnrceraetamseendt-rreesloartpetdiofnestaalnedfffeecttasl dtheaatthw,erdeecartetarsiebdutefedtatlo bmoatdeyrwneailgthotx,icdietlyaiynecdlusdkeedl:etal | 000530 :. 3IMneMdduiMscetirdnieia,cHaHeyaDgleitephnaerP,ihmTyoesxincitscology aPStOMPBCaoelnx.te3Mr3N2B2u0$i5l1d3i3ng.32202.026.02 627% 110 Toshseisfiecaetfifoenc,tsclocecfuprarleadtep,rsiumabrciultyanicnotuhse ehdigehm-adoasnedgcrroyuppt.orTchheismmat(eurnndaelscaennddfeedtatlesticles) NOAELS for this study were both | mg/kg/day. ALanboorraatlordieevse.lopImnetnhtisalsttuodxyi,cidtoys(etgerraotuoplsoogf) 2s2tupdryeignnarnabtbniteswwzaesalcaonnddwuhcitteedraatbAbirtgsuwsere dosed PFOS, on days 7 through 20ofgestation with either 0, 0.1, 1.0, 2.5, or 3.75 mg/kg/day Maternal toxic `with a minimal effects effect included: at the 1.0 mg1)/kdegcdroesaes;ed2)bdoedcyrewaesiegdhtfoaotdthceohnisguhmepsttitohnreaet dose the levels ahtitghheeshtitgwheostdotsweso;d3o)sefsr.equent scant feces at the highest dose, and 4) increased abortions tFheetahligtohxeisctetfwfoecdtossiesn.cluNdoedtreeradtuocgeednifcetealvewnetisgwhetraenodbasnerivnecdreiansethien sdteuldya.yed ossification at Based on maternal this and study, PFOS fetal NOELs awraes0.n1otmgte/rkagt/odgaenyiacnudnd1e.r0 mcgon/dkigt/idoanys,ofrteshpeecstitvuedlyy.and the Ttehruast,ogtehneicweeifgfhecttsoftinheratesvainddenrcaebbiintdsicwahteesntdhoatsepderaftluloevreolosctwahniecshulafroenantoet dmoaetsernnoatllcyause tsoexcitci.onTinhge alretnisfaccthaanngdewoabssenrovtefdoiunndraut ppounpsreipnetahtesRtuidkieersPahtaarnmaicneduetpiecnadlensttuldaybowraatsoray. 2 000531