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BACK TO MAIN i May 3,2001 . .

BACK TO MAIN June 25,2001 Overview of the 3M Company Study "An Epidemiologic Analysis of Episodes of Care of 3M Decatur Chemical and Film Plant Employees, 1993-1998" The analysis of administrative databases, including health insurance claims data, have been infrequently reported in occupational epidemiologic research studies.

BACK TO MAIN BIODEGRADATION TEST SUBSTANCE Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or C8F17SO3-K+. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: PFOS is a white powder.

ACUTE TOXICITY TO FISH (Rainbow Trout) TEST SUBSTANCE Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: The test substance is a white powder.

3M Medical Department Study: T-6316.5 3M Medical Department Study: T-6316.5 Analytical Study: FACT-TOX-013 LRN-U2095 Analytical Report: FACT TOX-013 LRN-U2095 Study Title Analytical Study 2(N-Ethylperfluorooctanesu1fonamido)-ethanol in Two Generation Rat Reproduction Amended Analytical Laboratory Report Determination of the Presence and Concentration of PFOS, M556, PFOSAA, and PFOSA in the Liver and PFOS, M556, PFOSAA, PFOSA, and EtFOSE-OH in the Sera of Crl:CD@BR VAF/PIUS@Rats Exposed to EtFOSE-OH Data Requirement Not Applicable Author 3M Environmental Laboratory Study Completion Date MAayt s3ig1n,in2g001 Performing Laboratories Sera Analyses Liver Analyses 3M Environmental Laboratory Building2-3E-09, 935 Bush Avenue St.

0 3M Corporate Toxicology 8 Id Rcgulrtoy Servlm 3 M Center, Building 0220-02-E-02 St.Paul.

Final Report 28-Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats Fraunhofer ITEM - Study No.: 01G 00 0 02 Original ... of 2 Test Facility: Fraunhofer Institute of Toxicology and Experimental Medicine [Fraunhofer ITEM] Nikolai-Fuchs-Str. 1 30625 Hannover Germany Director: Prof.

Fraunhofer ITEM Fi nal R ep ort 0 1 G 0 0 0 0 2 [Appendices A-D ] 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Daw ley Rats P ag e 1 of 5 6 _____________________________________________________________________________________________________________ Appendix A: T es t S a m pl e R e-a na l y s is [p e r f o r m e d b y 3 M ] Fraunhofer ITEM Fi nal R ep ort 0 1 G 0 0 0 0 2 [Appendices A-D ] 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Daw ley Rats P ag e 2 of 5 6 _____________________________________________________________________________________________________________ Appendix A1: 1st T e s t S a m p l e R e -a n a l y s i s In te rn a l C o rre s p o n d e n c e 3M TO : J o h n B u te n h o ff N ovem ber 14,2000 FRO M : Fred L.

-- CHARLAEBSORARTIORVIEERS Sponsor: 3M St.

Toxicological Summary PFOS Dictary Chronic Plot Reproductive Study: Mallard TestSubstance: Perforoocincsul(fPoFnOaSe) Structure: est Remarks: potion salt CASH 2795.39 1-Octanesulfonic acid, 1,1,2.2,3,3,4,4,5,5,6,6,7,7.8,88-heptadecafluoroTShoereestdsebssiaamnbcieesnacownhdiittiopnosw,daenrd(pBuMttLyowtas#2d17e)t.rTmihneesdamtopl6ew8a6s.9% by LC/MS, "H-aN ndeMlemRent,al analysis techniques.

`Toxicological Summary PFOS Dietary Chronic Definitive Reproductive Study: Northern Bobwhite Test Substance: Perfluorooctanesulf(oPnFaOtSe) Structure: d1e-cOacftlaunoersou,lfpoontiacssaicuidm,sa1l,t1,2C,2A,3S,3N,o4..4,257,955,-63.69,-73,.7.8.8,8-hepta- Test Remarks: TFCh-e95t.est Tsuhbestsaanmcpeleiswaaswhsioterepdouwnddeerr(a3mMbiLeontt #c2o1n7d)i,tiaolnssoaknndopwunriatsy awnaaslysdiestetremcihnnieqduetso. be 869% by LC/MS, 'H-NMR, and elemental METHODS Method: ASTM Standard E1062-86, OECD 206, and FIFRA Subdivision E., Section 714 `Type: Dietary Reproduction ear: 2001in-life phase, 2002-2003 analytical phase, Final report in 2003 Species: Northen bobwhite quail (Colinus virginianus) Experimental Design: Adult northern bobwhite quail were exposed to PFOS at nominal `wceoenkcse.ntrEaatciohnstroefat0m,en1t0,gr5o0u,pocron1t5a0inpepdm16inpatihresodfiqetuaolv,eronaeppeariirodpeorfpaenp.proIxniamdadtietlyio2n41, dotuhreirngpathies toefst.quaTihlewepreensmathianttawienreed upseerdtrfoeratbmleonotdacnodllwecetrieonusdeudrifnogrtbhleotoedstcowlelreectinoont ubsyeWdeteokas3s,estsheretprreoadtumcetnitonl.evDeluewatosorveedrucseidgntsoo2f0tpoxpimc.ityTnhoeted15i0n72t0hep1p5m0 dpopsme wtraesattmheennt stiegrnmsinoaftetdoxiactitWy.eekAll5. emTahieni5n0gpapdumltdoqusaeilwawserteerombisneartveeddatdaiWleyefkor7,siaglnssoodfuteoxtiociotvyerotr abnormal behavior.

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