COVANCE> Sponsors: APME Ad-Hoc APFO Toxicology Working Group PROTOCOL Study Tite: 26-Week Capsule Toxicity Study with Ammonium Perfluorooctanoate (APFO) in Cynomolgus Monkeys Date: September 23, 1998 Performing Laboratory: Covance Laboratories Inc. 3301 Kinsman Boulevard Madison, Wisconsin 53704-2595 Laboratory Study Identification: Proposal No. w6806a Covance 6329-231 T- (%%9 02518 : -_-- Covance 6325231 Pag6e2.r Study 26-Week Capsule Toxicity Cynomolgus Monkeys Study with Ammonium Perfluorooctanoate (APFO) in Purpose To assess the effectofthe test material on critical enzyme levels, hormones, and other selected biochemical parameters `monkeys for at least 26 weeks when administered daily by capsule to.

AR226-0499 ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity: P26e,rfolrucFrXo-o1c0t0a1n.oic(Oaccitda;nomiacyacailds,opbeentraedfeecrarfeldutooroa-s, PCFAOSA,#3F3C5-- 67-1) Rt'esmpaurriktsy:was3nMotpsruofdfuicciteinotnlylocthanruamcbteerriz2e6d9,.thTohueghtesctursraemnptlienifsormFaCt-i2o6n. iannddicCastepseriftilsuoaromihxotmuoreloogfu8e6.c5o-mp1o0u0n%dst.est substance and 0 - 3.5% Ce, Cr, METHOD: TMyepteh:od:Static Nacouttneoted.

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} AR286 -- 0708 MICROBICS MICROTOX TOXICITY TEST TEST SUBSTANCE Identity: A mixture containing referred to as PFOS, perfluorooctanesulfonate, which may also FC-95, or as a component of FC-201F-X.

ARQ26- 0722 ACUTE TOXICITY TO FISH (RAINBOW TROUT) IESTSUBSTANCE Identity: A mixturecontainingperfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-203. (1Octanesulfonic acid) (CAS # 2795-39-3).

AR Q26 - 0760 ACUTE TOXICITY TO FISH (FATHEAD MINNOW) IESTSUBSTANCE Identity: Mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95,oras a component of FC-203CF-X or FC-203CF. (1-Octanesulfonic acid) (CAS # 2795-39-3).

AR 226 _ 0890 BIODEGRADATION (BOD/COD) IEsTsuesTANCE Identity: MriefxetrurreedctoontaasinPiFnOgSp,erFfCl-u9o5r,ooocrtaansesaulcfoomnpaotneewnhticohf FmCa-y30a1l7so. b(e1- Octanesulfonic acid) (CAS # 2795-39-3).

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AR226TM1732 A SURVEY OF SELECTED FLUOROCHEMICALS IN THE DECATUR ALABAMA AREA ~ 2002 SAMPLING Bo Revised Report 11/3/03 a2 es Preparedfor: 3M St.