. a =) ema ARQ26 _ 120 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 or 23 22 PREVETNoTnIeONssFetscanocEESs MO MEMORANDUM 8 SUBJECT: FROM: TO: Draft PFOA Exposure Data Gaps Discussion Document =Bn. in CMhaermyicF.aDloCmointnriolk Diision =foil oi Administrative Record File AR-226: PFOS, PFAS, PFOA, Telomers, and Re~ed Chemicals Discuss"iTohne Pautrtpacohseeds dOoncluym,ednatt,edidAeuntgiufsited3a0s, a20D0r2a,ftwEaxspdoesvuerleoDpaetdabGyaEpPsADoatcutmheenrte,queFsotrof the gFuliudoerotphoeldyimsecrusMsainonufdaucrtiunrgiangcoGnrfoeurpen(cFeMcaGl)l aarnrdantgheedTbeyloFmeMrGRefosreaSrecphtePmrboegrra1m2,(2T0R0P2.) tTohihselp draft prior document to the call, was shared with Lynne Harris of FMG and with Steve Korzeniowski of TRP Record Please include file AR-226.

on : con LE, RkoCsoerer oA,sareios r TELECOPY TAF' T, STET.TINIUS & HOLLISTERALLRPR26 1800 FIRSTAR TOWER 425 WALNUT STREET CINCINNATI, OHIO 45202-3957 wo 13T380E2000 -- June 10.2002 -- 1182 PB wd Sn Ee =g Z a3n3 = 55 Chris Negley, Esq.

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spf AR &&6 -- 129] March 24, 2003 To Mary F.

AR RRC _ 1228 FINAL REPORT PROTOCOL 418-027 O`WRIATLH (TGHAEVRAEGPE)ROCDOUMCBTIINOEND/DREEVPEELAOTPEMDEDNOTSAELTTOOXXIICCIITTYYSSTCURDEYENOIFNTG7T5E99S.T7 SPONSOR'S STUDY NUMBER: T-7599 FINAL REPORT DATE: 25 MARCH 2003 PROTOCOL 418-027 - ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDYOF T 7599.7 WITH THE REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING TEST SPONSOR'S STUDY NUMBER: T-7599 SUBJECT TABLE OF CONTENTS L SUMMARY AND CONCLUSION Ll.

: 3M MEDICAL DEPARTMENT TOXICOLOGY SERVICES To: Georjean Adams 290-4-01 cc: John Butenhoff 220-2E-02 From: Marv Case 220-2E-02 Subject: FC 95 and 143 Teratology Date: 26 May 1998 John passed on to me your request for someone to review and write an analysis on the eye lens defect that was reported in the the toxicology study files on FC 95 original and FC FC 143. 95 rat teratology study.

OCTANOL/WATER PARTITION COEFFICIENT ~ TEST= SUBS STANT CE OoUBSTANCE Identity: aPserPflFuOorAooacmtamnooniciuacmids,alat,mAmmomniounmiusamltp;emrfalyuoarlosooctbaenoraetfee,rrFeCd-to p1e1n6t,aFdeCc-a1f2l6u,orFoC--,1a69m,moorniFCu-m14sa3l.t,(COcAtSa#noi3c82a5c-i2d6,-1) sRuebmjaecrtksc:ompoTuhned3iMs FpCr-o1d4u3c.tioInt'slopturniutmybwearswnaost snuoftfirceicenotrldyecdh.arTahcteerized, stuhbosutgahnccuerraenndt i0n--fo3rm.a5t%ioCns,inCd7i,caatnedsCitsipsearfmliuxotruoreanofal9o6g.u5e- c1o0m0p%outnedsts.

AR 226_ 06S] PFOS Repeat Dose - Ib 000101 CIYTICS mse 3005 gages vo wor INCORPORATED 301-921-0168 Fax: 301-977-0433 Client: {3BS3MMeETaMCRuEERNDNITsEEECrRAeL2-30DS-EEa2P2A-tR0T2MEaNTno Date Reported: 05/02/2000 Date Date RCeoclelievcetde:d: 0042//1280//21090909-02/26/200( Client ro.itt1e4n5t2ion: Study: 6 ANDREW SEACAT HONTH PFOS STUDY Species: CYNOKOLGUS Rxooen$geas.ioGnp sex hee TSiantg CShORoEke EMRbR RWUSpE Wpohh: 2223 o08oa3oas8s8a8aRi1iid33ds8e fFHToaosesasaeeseann 111 e eecadds mWTMawWe TT E B B #8 E B Bog 3$33 A[A8dReaie Keane Ran 8 eeBB MBoHr B884 oga88 $ii sbetan E 4BO.

AR 226. 0703 ACUTE TOXICITY TO FISH (FATHEAD MINNOW) IEsTsusstANCE 0 Identity: MreifxetrurreedctoontaasinPiFnOgSp,erFfCl-u8o5r,ooocrtaansesaulcfoomnpaotenewnhticohf mFCa-y20a1lsFo. be (1-Octanesulfonic acd, 1.1,2.2.3.3.4,4,5,5.6.6.7.7,8.8.8heptadecafluoro-, potassium salt, CAS # 2785.30:3) Remarks: The 3M production lot number was 1.

AR 226 - 0797 ACUTE TOXICITY TO FISH (FATHEAD MINNOW) EST SUBSTANCE Identity: Mixture containing Perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-206A. (1Octanesulfonic acid) (CAS # 2795-39-3).

AR 226 _ 0258 ACUTE TOXICITY TO FISH (FATHEAD MINNOW) IESTSUBSTANCE Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-603EF. (1Octanesulfonic acid) (CAS # 2795-39-3).

NOTE TO FILE .

AR226 - 0TH yrmse Contain NO CBI EH _12R 00_ 3773 December 4, 2000 Pp HR oo bq S55 Document Processing Center (7407) (Attn: Section 8(e) Coordinator) Office of Toxic Substances US EPA 401 M Street, SW.

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