Document EvnmwY5vgkjx27k1meYZm1Zwg
AR 226_ 06S]
PFOS
Repeat Dose - Ib
000101
CIYTICS mse 3005 gages vo wor INCORPORATED 301-921-0168 Fax: 301-977-0433
Client: {3BS3MMeETaMCRuEERNDNITsEEECrRAeL2-30DS-EEa2P2A-tR0T2MEaNTno
Date Reported: 05/02/2000 Date
Date
RCeoclelievcetde:d:
0042//1280//21090909-02/26/200(
Client ro.itt1e4n5t2ion: Study: 6 ANDREW SEACAT HONTH PFOS STUDY Species: CYNOKOLGUS
Rxooen$geas.ioGnp sex hee TSiantg CShORoEke EMRbR RWUSpE Wpohh:
2223 o08oa3oas8s8a8aRi1iid33ds8e fFHToaosesasaeeseann 111
e eecadds mWTMawWe TT E B B #8 E B Bog 3$33
A[A8dReaie
Keane Ran
8 eeBB MBoHr B884 oga88 $ii
sbetan
E 4BO. RfTe hmhE ia
Group 1
AAAA s8ogooa3s9s8eee8i1i1ded8dse fTfRooesosssiimatam 2322 AAA 85S6a35s38a81i13a50s RRRoBosaAEi 332
Ho8a!n Group 2
Geooseds808mW8swW w$ 5300o0n 0m%4 .:: eeenns 88 8 %x088RB :: a5 Ew G olen B#a3 3a
Reterence Range
22 a- o8 - 8o- 8oPage 1+
000102
INCORPORATED 301921-0188 Fax: 301.977.0433
Client: 3B3MUMIMLCEDEDINNITGCEARL220D-E2PEA-R0T2MENT
DDaattee CReoclelievcetde:d:
(STt8.e1n)PtAiU3oL7n,5:-M3N1A6N1DR8E5W133S-E3A2C2A0T
Date Reported:
Client No. 1492
Study: 6 MONTH PFOS STUDY Species:
ANoc.cession AA 00009988115323 AAA 000000999888111533356 AAA 000000999888111353857
Group 3
S3pec.
TI0055531180MM TII00085s35s322248FMM TTIo00s8ss55sa3ss6rFF M$e0an
GpSexAge 33 333 333
TUSIHU,/MLSI
00..5833 000.567206 000.ll334248 s20e7s
MCGH/ODLLEST
15185 1i51e10 727844 9157.8
MHGD/LD-DLIR
aa8 323371 253412 383%.8
0042//1280//21090909-02/26/200 05/02/2000
CYNOMOLGUS
MLGD/LD-LDIR s5i6 776286 55a230
1620.1
VMGE/DDLL 10 501 i3
31.9
AAA 000000999888111666012 TII000s58s53001762MMM 444 AAA 000000999888111666335 TTI000Ss85s5433064FFF 444 A 0033166 103351F 4
Mseoa.n Group 4
010l1.717283
22s73s
115 421188
01
o11l1a72s3
555375
11ss 16
ai3o1
033
086
81
22
35
4
1S30658 1458..43 14s.6 131s3 1i.l7s
Reference Range
l2s- 241001- 0o- o0 - 0o Page 2 +
000103
GLYTICS crc si 0, cams vo ar INCORPORATED 301-821-0168 Fax: 301-977-0433
Client: 33B%4UIMLCEDEDIRINTCGEARL220D-E2PBA-R0T2MENT
DDaattee RCeocleliavcetde:d: 0024//2108//13909090-02/26/2001
AS(fT6,E3a1)hPeAlU5oL7n,5:-"3M0"N6M1br5e5w13s3-e3a2c2a0r
Date Reported: 05/02/2000
Client No. 1492
Study: 6 MONTH PFOS STUDY Species: CYNOMOLGUS
Accession gee op Sex Age TSH, SICHOLES? HDL-DIR LDL-DIR
No.
Il
UIU/ML MG/DL MG/DL MG/DL
AAA 000000933858111666753 1II00053353a4i33i3FM7 a44RR% A 0038170 IoasiM
o00:.e62s05 1213473 5:53 108
53Eo81] bta1
3%
&
Me8an
Tds73110h $5.5 smasa
roup 4 WKS2 RECOVERY
VLDL
MG/DL
2805 ? auish
Reference Range
32%- 41%01- o8 - So- 8o-
RagR e 3 of 3SN 25} 000104
Andrew M. Seacat, Ph.D. 3M Medical Dept. 3M Center, Building 220-2E-02 St. Paul, MN 55133-3220 Phone: (612) 575.3161 FAX: (612)733-1773 e-mail: amseacat] @mmm.com 3/6/2000 Peter J. Thomford, Ph.D. Study Director, Toxicology Covance Laboratories Inc 3301 Kinsman Blvd. Madison WI 53704 Phone: 608-241-7202 Fax: 608-242-2736 (PReF:O2S6;-wTe-e6k29c5a)psiunlCeytnooximcoiltygustsuMdoynwkietyhs.perCfolvuaornocoectSatnuedsyulNfuomnbiecra:ci6d3p2o9t-a2s2s3i,um salt Peter, t3hMe draetqeusesotfssipencfiofrimcathioornmfornoemdtehteersmtiundaytrieocnosrcdosnodfuc6t3e2d9-b2y23AnfiorLyttheicmseItnhcoodrspoursateedda,nd Gdaeittehremrisnbautrigo,n MfoDr.T3,SpTe4ci,fifcraelelTy3,,wfereneeTed4 maonrdeTSiHnf.orAmnateixopnloannatthieonmeotfhtohdeszeorfo values for fToSrHTSisHreiqnuetshteemd.etWhhoadtusiesdt,heanldimsithoouflddettehectzieorno(vLaOlDue)sabnedrleipmliatcoefd qwuiatnhtit<aLtiOoDn (oLrO<Q) sLaOmQp.leFsur(rtehfeerrmeonrcee,, awpepennedeidxt6o uonfdDerrasfttanidnttehreimhRiegphoTrt3 vfarloumesCroevpaonrctee)d,fofrorthwehdiacyh t3h7e T3 svaalmupelsewiesraelshoigrheqiunesatleldd.oAsenigrLoyutpisc.sTishbeediantgectohpaitetdheontetshtsiswreerqeuepsetrifnoorrmdeedrotno eeaxpcehdite the transfer of information. Sincerely. Andrew M. Seacat Ph.D. Study Monitor
cc: Dr. Saroj Das Ani Lyties 2G0ai0tGhierrasbrudrgSt,reMeatr,ySluainted 22000877 TFaeclseipmhiolneeNNoo..: 330011--997271--00413638
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000105
LYTICS conc csv ster cums woes INCORPORATED 301-921-0168 800-237-2815
05 Apes 2000 [Boee--ee--a--EaNman0.20.0 oo its Deas px. sence,
REF: Fax dated es 3/20/00
oEBEwenaEnta, tlooE brrSniinengdbtootyye ToupraOlaitntgeenoetui"ooneSpitahftaa,otnmZepeIirdAniDgmaStTheeSiTnHSaNaneaatnniaal-lyhsvuiamsLatonweaed,tYATAnonoint SoEToerenocrnbciitaootnnaneafrlo"ervraminaattlFiitonohrenidnyTgo:nhepheeelarvyteeatisooofmroneltvhtSeehaotssteeTaoesvsntate)systmaLrneaing"eennrotcoeen,no2cTnatonnoHo5otounrb8g,eeveea2inneznddey Rr a a roc TALsiemeaiAnidariechTaretoedTrRoentocLhyaouv,syaptreihnme.athNees aTinesgeeonearatlLThErav,epquEia tee JloowDTTTOoSEH
sincerely.
2
2,
"SSaro)aR. Das, M.S., Ph.D.
cer pEetEerA3s.E rThogmtoA rdR , m5i. alafame
000106
GIYTICS sums sas gapeson ose INCORPORATED 301-921-0168 800-237-2815
RESULT REPORTING POLICY
Linear regression accepted.
curve
correlation
coefficient
of
0.99
or
greater
Results observed over the on appropriate dilution.
highest
calibrator
concentration
repeated
Lowest limit concentration.
of quantitation Values below this
is the lowest calibrator concentration are computer
generated based In some assays
on the standard curve. These values are reported. the exact calibration range is kit lot number
specific.
A zero value indicates same as or close to or
t>haztertohestcaonudnatrsd bcoouunndtsf.or
the
sample/s
were
000107
CAYTICS cociussio sez curs wos INCORPORATED 301-921-0168 800-237-2815
ANALYTE: Noniiuman Primate Thyroid Stimulating Hormone (TSH)
PROCEDURE: DToounbolueseAnPtriobcoeddyureRIA ---- HSuimmaan ATlSdHriscthandTaacr.d c(aRte.f wrodest WHO standard 68/38) RSalbobmiata-laonrtiichhumTaacn. cat. #T4eci TSH (polyclonal) RA adiolabsied Hsee, me. Views, ma CGeAbLeInBdReAnTtIOuNpoRAnNGtEh:e i0n.t4egetoity50omfIwt/hael.iod(iLnoawteedndhosremnosniet.i)vity is pRCeorsmeupcLuyTtse:r Gmeznue/raalted values reported below low end sensitivity of the CffOfMeiMoEiNuTi:te OovreoralnlowTSEiflevtehliss in`tesNt.EP oafrfeersextsriegmmeiltyiclsomwt s`oCliitniciss
000108
INCORPORATED 301-921-0168 800-237-2815 ANALYTE: Free T4 PROCEDURE: Coat-A-Count RIA REAGENT SOURCE: Diagnostic Products Corporation, CA. CALIBRATION RANGE: 0.1 to 10 ng/dl (kit lot # specific) RESULTS: nCgo/mdpluter generated values reported below the standard.
000109
ANI :
a}
GLYTICS svonssso mocmon worn INCORPORATED 301-921-0168 800-237-2815
ANALYTE: Total Ta PROCEDURE: RIA Coated Tube Assay REAGENT SOURCE: DEC, CA.
CALIBRATION RANGE: 1 to 24 ug/dl
RESULTS: uCogm/pdulter generated values reported below 1 ug/dl.
000110
INCORPORATED 301-921-0168 800-237-2815
ANALYTE: Free T3
PROCEDURE: Coat-A-Count RIA
REAGENT SOURCE: DEC, CA.
CALIBRATION RANGE: 0.5 - 42 pg/ml (kit lot # specific)
RESULTS: pg/ml
computer standard
gcuernveeratceadlivbarlauteosr
rcoenpcoerntterdatbieolno.w
the
lowest
000111
INCORPORATED 301-921-0168 800-237-2815
ANALYTE: Total T3 PROCEDURE: RCoaadtieodimTmuubneoaAssssaayy (RIA) REAGENT SOURCE: Diagnostic Products Corporation (DEC), CA. CALIBRATION RANGE: 20 to 600 ng/dl RESULTS: ng/dl
Computer generated values reported below 20 ng/dl
000112