FC-17-R Submitted to: BIOSEARCH, INC.

Pathology Review of Reported Tumorigenesis in a Two Year Study ofFM-3924 in Rats November 25,1998 BY Pathology AssociatesInternational 6217 Centre Park Drive West Chester,Ohio 45069 Telephone (513)779-9600 Fax (513)779-9603 PathologyReview ofTumors ReportedinRatsGivenFM-3924 Introduction:Thisrepoprrtesenatnsindependaesnstessmeonftumorigenedsaitsa obtainedfrom a studytodeterminethechronictoxicitaynd carcinogenipcotentiaolfthe fluorochemicaFlM-3924 in ratsT.he study,entitle"dTwo Year (Diet)Toxicity/ CarcinogenicitSytudyof FluorochemicaFlM-3924 inRats,"was sponsoredby the3M Company, St.

REPORT EVALUATION OF THE MUTAGENIC ACTIVITY OF T-5869 IN THE AMES SALMONELLA/MICROSOME TEST (WITH INDEPENDENT REPEAT) NOTOX Project 115965 NOTOX Substance 38196 page 1 of 23 - T-5869 STATEMENT OF GLP COMPLIANCE NOTOX Project 115965 NOTOX B.V., Is-Hertogenbosch, The Netherlands The study described in this report was conducted in compliance with the most recent edition of: The OECD Principles of Good Laboratory Practice which are essentially in conformity with: The United States Food and Drug Administration.

ntpeAnalyticaLlabopatopieIsn,c. 3048ResearchDrive Phone: (814)231-8032 StateCollege,PA 16801 Fax: (814)231-1253 or (814)231-1580 Ana@fi(;Raelport Fluorochemical Characterizationof Surface Water Samples Decatur,Alabama (Wl979) Centre AnalyticalLaboratory Report No. 023-007B Testing Laboratory CentreAnalyticaLlaboratoryI,nc. 3048 Research Drive StateCollege,PA 16801 3M Environmental Laboratory Contact Kent R.

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BS Lr Fees 9 " ronDAMENTAL AnD APPLIED TOXICOLOGY 4. 973-976 (1984) .J .

3M ENVIRONMENTAL LABORATORY METHOD ANALFYLSUIOSROOFCPHOETMAISCSAILUCMOPMEPROFULNUODRSOIONCUTRAINNEESEUXLTFROANCATTSE UOSRIONTGHER HPLC-ELECTROSPRAY/MASS SPECTROMETRY/MASS SPECTROMETRY Method Number: ETS-8.97.0 Adoption Date: F-2B-49 Author: Lisa Clemen, Robert Wynne, GlennLangenburg Approved By: 7 /3.

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CORNINGHazleton MUTAGENICITY TEST ON o T6292 ; IN AN IN VIVO MOUSE MICRONUCLEUS ASSAY EINALREPORT AUTHOR Hemalatha Murli, Ph.D.

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Sa (4 IN] 3 etm' AR226- 1078 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 5 628 Dear Interested Party: MAR 28 2002 PRETVEoNTnIOoNr,SrUiPBcESeSToTArNCCEEESSMO Attached is a copy in PDF file format (389KB)ofthe DraftHazard Assessment Of Perfluorooctanoic Acid (PFOA) And Its Salts, prepared by the Risk Assessment Divisionof the EPA Office of Pollution Prevention and Toxics.