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" ronDAMENTAL AnD APPLIED TOXICOLOGY 4. 973-976 (1984)
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Cholestyramine-Ennanced Fecal Elimination of Carbon-14 in Rats after
Administration of Ammonium [*C]Perfluorooctanoate or
Potassium [*"C]Perfluorooctanesulfonate
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He Soncenirion. war al Sib ede by ChokEYAmine rain wes |} Feud
The anionofperlucrooctanoic acid has been
al, 1578p.Seeerbtotih rmasaniaica
Jism fod%
wfooruknedrsin(tUhbeeseefrualm, o1f98m0a)n.ufTaocxitcuirtiyngstpuldainets aansdsapleirsfandexisatsfoanniiconasciadrarpehypsrieoplaorgeidc "1 pimiepsbeerr
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in animals bave been reported (Griffith and
Long, 1980). Ia viewofthe slow elimination
pH, they would be expected to complex with
cholestyrIanmviinveo. Aliough Pasioor &f
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andthe preseonftchee compound in plant al (1983) investigated cholestyramine inmice | ve >
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workers' serum, 2 meassofenbancing elim ianmamtioonniwuams spoeurgfhltu.orIonocaidadniotaitoen, asnidncepobtoatsh.
20d ras and found 00 enhanced climinativa OOffcchaorlbeosnt-y1r4amwiinteh gaivseinnglaet 12400b0r-magf/tekrga.1s0
3 =]
+ Samy FYarmweerr
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ctsihlaelumpporsposedirublciultotsryoaoonfcduanifsnestceuirlnmlgeodntiihateteecsolairfmepinrcaootdmiuomcnetrso,.f
MWg orl dose of ammonium ["Clper. Tf Jere fClhuorloSoTc@ynmCiantee, atdhmeiniusstuearledapptloicaetnihonancoef 33] FSeoingtaeon:
Ba ramins vs per spp perfluorooctanwaessaulsoloffoinntearetste. ~ Slimination of xenobiotics is with repeated =f feoncear.
dos a may part re ws 2 oi iiJs ahnumaannibangosntoexlcohwaenrgechorleessi.tnerwohlicbhloobdslebveeelrs,, U7ter%eAd i0nthffeeeeededffforfecotrosfesvecnehroallesdtayyrsoaomninndeteheardrmmaitneeisdo:f =f [2 tuen
iGdee chiEorrdegcoonte f(eKcaelpoenxcer)etiinonaosfh(eCophnesetr s{guliy inirmavviennoouuss ddoosseeooffasmmuoer t 3 H5 1e0a
Thom a companion hid be see. sPRiOuSm).("Clperfluoroocunesulfonate ("Ch3q+e new
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DISCUSSION
ttihgearticonomof
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admTihniestcraartbioonn-1o4f [pCreIsePnFtOiSn orfat[MliCvIerPEaOfter
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tion in controls.
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namrn SRAvorn
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JOHNSON, GIBSON, AND OBER
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REFERENCES
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many samples (>95%).Sincethe experimen.
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Ctdoaolnstcironogn.ldirstaaitomsnwpsleefoercdcoheollnessltayerawacimntidtnheai-ntaproleeyacnsttee,std,oatnhhdee
les than 100% recoveryofcrbo
B ICopoaco noantisnoBneast(UeKsedpoL5ac+wssoposGiuoazimoganS:i,nPc.5e7 . (1e5a7n,.
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freecsuelst,saonrdcloinvcelru)swiaosn.judged 10nont-a1f4fe(cutrtinhee, ofcQhoulesetytrchameadalra, suportpossibleutlity
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Serpineienprowmootiengttemseeco.) GREITR,FE. D.40Lows, J. E. (1980) nina | ELx
ACKNOWLEDGMENTS sulfonatein humans.
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