2 70% PREPCTEIVC3E: WIECT29 Mili: 01 AR226-1542 STATUS REPORT COMBINED REPEATED DOSE TOXICITY STUDYWITH REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENINGTEST WITH T-7601 ADMINISTERED BY ORAL GAVAGE IN WISTAR RATS November 4,2003 8:25AM NOTNOOXTOSXubPsrtoajneccte31815377167818 Page 1017 .

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ACUTE TOXICITY TO FISH AR226-053Y TEST SUBSTANCE Identity: Paelrsfoluboeroroecfteyrlrseudlftoonaaste,Flduoirdoeaclykylldiammemtohynliaummmodneiriuvmatsiavlte;. m[a1-y Decaminium, N-decyl-N,N-dimethyl-, salt with 11,2.2,33,4,4.5,5,6,6,7,7,8,8,8-heptadecafluoro-1octanesulfonic acid (1:1), CAS # 251099-16-) Remarks: The 14394 referred 3M production lot number was Lot to by the test laboratory as P3025. 1.

ARR26 _ 0662 N-EtFOSA Acute Toxicity - | 000466 acute oma. sostetty screen ond Netciu) cman rs I CXELEDTobCsa Htires srEiesn i ae ei ys oo 1 00 i LEnRThEbes E fhhem mm s T7A79 000467 sumary Jo acute rad tosicity screen vith -306705C vas condeuted from ApELd 8, 1961 to Apri) 22, 1981 using male and famale albino race ranging in boty eight from 325-299 grams.

: AR 286 _ 0685 BIODEGRADATION (BOD/COD) TEST SUBSTANCE Identity: ArefmeirxrteudretocaonstPaiFnOiSng,pFeCr-f9lu5o,rooorcatsanaescuolmfopnoanteen;tmoafyFaCl-s1o85bFe. (1Octanesulfonic acid) (CAS # 2795-39-3) Remarks: FC-185F, cc The 3M 817-19.

AR 226 - O7#7 BIODEGRADATION (BOD/COD) TEST SUBSTANCE Identity: ArefmeirxrteudretocaonstaPiFnOiSng,pFeCr-f9i5u,oroorocatsanaescuolmfponoanteen,twhoficFhC-m2a0y3CaEl.so b(1eOctanesulfonic acid) (CAS # 2795-39-3). 2R0e3mCaEr.ksC:urreTnhtein3fMorpmraotdiuocntiinodnic[aottensuimt bisera wmiaxstu5r1e9.ofT1h.e8t4e%stPsFaOmSpl,e30is%FCeStodhiyulmenocetygliyscuollfabtuet,yl2.et1h%erp,o6ly0o.x2y3e%thwyalteenre,m2o.n5o6oc%tSyulplhteonnylfoeatmheerr,, 03..112%% sodium lauryl sulfate, and 0.05% tolyltriazole. crTehhfaelreafccottltlehorewiizbneigdodsceougnmrcamedanatrbriyaltiaitpyoponlfsioetfshietmopfualrumioitrxiotecushr.eemDwiaicttahal icmnoacmyopmnopolnteetanectlcoyufrtahteelytest sample.

AR 226 -- 0842 MICROBICS MICROTOX TOXICITY TEST TEST SUBSTANCE Identity: ArefmeirxrteudretocaosntPaiFnOiSng, pFeCr-f9i5u,oroorocatsanaescuolmfponoanteen,twohficFhC-m60a2y. al(s1o- be Octanesulfonic acid) (CAS # 2795-39-3). 6R0e2m.arCkusr:rent Tihnfeor3mMatipornodiuncdtiicoantelsotitniusmabemrixwtuarse 501.

AR 226 --OL52 DEHYDROGENASE ACTIVITY (TTC TEST) TEST SUBSTANCE Identity: ArefmeirxrteudretocaonstPaiFnOiSng, pFeCr-f9l5u,oroorocatsanaescuolmfponoanteen,twhoficFhC-mBa0y3EaFl.so (b1e- Octanesulfonic acid) (CAS # 2795-39-3).

AR 226 _ 0292 ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity: A mixture containing perfiuorooctanesulfonate, which may also be . referred to as PFOS, FC-95, or as a component of FC-3017. (1Octanesulfonic acid) (CAS # 2795-39-3).

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TEFLON FINE POWDER/DISPERSTON OPERATORS : C-8 BLOOD SAMPLE RESULTS AR224- 1630 C-8 SFaimrpstle 26.0 24.0 11.0 9.4 8.2 7.0 6.9 5.6 4b in Blood SSeacmoplned 20.0 25.0 8.2 7.9 6.5 7.7 5.9 42 4.9 (ppm) Change -6.0 +1.0 -2.8 1.5 -1.7 +0.7 -1.0 "1.4 40.5 Days SBaemtpwleeesn 363 364 391 364 363 364 337 33 365 % PCehrangYeear -23 + -24 -16 -21 +10 -16 -27 +13 4.3 5.6 +1.3 401 +27 3.9 3.6 -0.3 364 -8 3.6 2.7 -0.9 362 -25 3.5 2.1 -L.4 363 -40 2.9 2.8 -0.1 357 -3 2.8 2.8 0.0 365 0 2.6 2.4 -0.2 391 -7 2.5 1.8 -0.7 336 -28 2.5 2.5 0.0 349 0 2.1 1.6 -0.5 288 -30 1.6 1.5 -0.1 384 -6 1.5 1.2 -0.3 366 -20 1.3 1.1 -0.2 362 -15 3 JWR:1dr/10/19/83 5 ~ EID079746 = 000226 .

BACK TO MAIN STABILITY IN THE ATMOSPHERE (PHOTOLYSIS) TEST SUBSTANCE Identity: Perfluorooctanesulfonyl fluoride.

SOIL ADSORPTION (METHOD DEVELOPMENT / PILOT STUDIES) TEST SUBSTANCE Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: Sample was radiolabeled (isotope and labeling position not specified).