August 21: 2000 Document Processing Center (`7407) Office of Pollution, Prevention and Toxics U.S.

36-6~ 9 p. 1 ti, C.

Katherine E .

Cee Bative report Hedin T0225 Be f seamed +o SRPT T0245 -35 Xenochemical Receptor trans-Activation by Perfluorooctane-based Chemicals T-29s" 35 AR226- 1723 oF or T-6375.357 E36 9 en. 3 piE-BY T-1563:) Contributing Scientists at Boston University: Jonathan Shipley Megon Walker DaJ.vWaixmdan dated12/08/2000 between 3M Medical Department, Corporate Toxicology 3M Center 220-2E-02 Aun: Andrew M.

1 3M Speckally Materials 3M Center '( St.

Toxicological Summary PFOS Dietary Acute Mallard Study Test Substance: Perfluorooctancsulfonate (PFOS) Structure; p1o-tOacstsanieusmuslaflot,niCcASa#cid2,7951-,3192.23.33.44.5.5,6,67,7,88$-heptadecafluoro-, Remarks: sTthoeretdesutndseurbstaamnbcieenits caonwdhiittieonpsoawndderpu(ri3tMy wloats#2o1r7i)g.inalTlyhedestaemrpmlienewdatso tbeechn9i0q.ue4s9.% bIny aLCsu/bMsSe,que'nHt-aHnMaRly,sis"oFf-tNhMeRtesatndsubcslteamnecen,talpuraitnyalywsaess determined to be 86.9%.

E err1~ESEARCH AR226-1864 OccupatIonal andEnvironmental Health Analysts of perftuorooctenotCAcId (PFOA) In Human Serum Samples \ E~cygenReport No.

AR226-2234 Steven L Grise 12/12/2001 03:26:26 PM To: cc: Subject: Debbie J Mulrooney/AE/DuPont@DuPont Bernard J Reilly/AE/DuPont@DuPont, Robert P PinchoVDEV/AE/DuPont@DuPont Re: C.O.

AR226-2260 Chris E Shoop 02/20/2002 05:20 PM To: cc: Subject: Robert F Pinchot/DEV/AE/DuPont@DuPont.

AR226-2556 June 23, 2000 Dr.

AR226-2812 TRADE SECRET Study Title Perfluorooctanoic Acid: Relationship Between Repeated Inhalation Exposures and Plasma PFOA Concentration in the Rat AUTHOR: Paul M.

I 3M Environmental Laboratory FinalReport-AnalyticaSltudy Single-DoseDermal Absorption/ToxicitSytudy ofT-6067,T-6068 and T-6069 in Rabbits In-VivoStudy ReferenceNumber: HWI#6329-152 Study Number: AMDT-01 1095.1 TestSubstance:L-13492 (T-6067,T-6068 and T-6069) Name and Address ofSponsor: 3M SCD Division 367 Grove Street St.Paul,MN 55106 Name and Address ofTestingFacility: 3M EnvironmentalTechnology & Services 935 Bush Avenue -St.Paul,MN 55106 Method Numbers AMDT-M-1-0, AMDT-M-2-0, AMDT-M-4-0, AMDT-M-5-0, AMDT-M-8-0, AMDT-M-14-0, and Revisions: Thermal Extractionof Fluorideby Means of a Modified Dohrmann DX2000 OrganicHalideAnalyzer-Liver FluorideMeasurement by Means of an Orion EA940 Expandable Ion Analyzer Extractionof Fluorocheniicalfsrom Rabbit Liver Analysisof RabbitLiverExtractforFluorochemicalsUsing ElectrosprayMass Spectrometry AnalysisofFluorideUsing theSkalarSegmented Flow Analyzer with Ion SelectiveElectrode Thermal Extractionof Fluorideby Means of a Modified Dohnnann DX2000 Organic HalideAnalyzer-Serum InitiatioDnate: See attachedprotocol Author:James D.

AR 226-0084 TOXICITY TO AQUATIC PLANTS (E.G., ALGAE) FE-2 TEST SUBSTANCE Identity: PFeCr-f9l5u.oro(o1c-tOacnteasnuelsfuolnfaotnei;c macaiyd,a1l,s1o,2b,e2.r3e,f3e,r4r,e4d,5t,o5,a6s,6P,F7,O7,S8,o8r,8heptadecafluoro-, potassium salt, CAS # 2795.35-3) 3ReMmlaort knsu:mbTehre21te7s.t sSuabmsptlaencweaiss astwohrietdeupnodwedrera.mbiSeanmtpcloendwiatsiontsakperniofrrtoom etelsetminegn.taPluraintayldyesteesrmteicnhendiqtuoesb.e 90.49% by LC/MS, 'H-HMR, *F-NMR and METHOD Method: OECD 201, Test: Static acute OPPTS 850.5400, ASTM 1218-S0E GLP: Yes SYpeeacriecso:mplSeetleedn:asSttruudmyccaopmrpilceotmeudtu19m99.

AttacShtmuednitess taondLeOtttehrertoICn.foArumeartidoanteodn MCearyta1i8n, 2000 AR226 O13 Perfluorooctane Sulfonate-Related Compounds Pertwee AcuteToxicity 1) FAimnearlicRaep,oIrntc,.

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