Document 6bZRGM2Eow2oEnDpK20Gzd7no

C : e 3M Specialy Materials 1M7sCantenromo o F sr-0500- 1378 bef May15, 2000 ARNL-0203 -- Lepr ee 3M cuir BFYII-SeeA-cRo1A378A Director Chemical Control Division OUfnfiitceedofStPaotlelsuEtnivoinrPornemveennttailonPraontdecTtoixoincAsgency 4R0o1oMm 4S0tr3eeEta,stSoTuotwhewers(tMail Code 7405) Washington, D.C. 20460 ou Ors ai. ic fi~ = R oe? ( . Con;aaimm nye, RE: Supplemental Information on Perfluorooctane Sulfonates CG CBr Dear Charlie: 3daMteids Menacylo4s,in2g00a0d.ditTihoenasluipnpfloermmeanttiaolnionnfopremraftliuoonrocoocntsainstessoufltfhoneatfeoslltoowsinugp:plement our submittal 1. Fionturrodpuacgteisoonfs teoxctheeuteinvveirsounmmmeanrtiaelsstchiaetncweeraereaisn.clHudoewdevinert,heoMurayco4v,er20l0et0tesrutbomiytotualofas Minaaydve4rtaelnstoliyndfiaiclaetdedtothiantclwuedewotuhledm pasropvairdteocfotphieesatatsacpahrmteonftsthteo tchoevecrovleetrtelre.teWr,eand do'so now. 2. `AAcsiudmPmoatarsysienutmitSlaeldt"(2P6F-OWSe)eiknCCaypnsoumloelTgouxiscMitoynkSetyusd,y wCiutrhrePnetrfSluumormoaorctyanaessouflfMoaniyc4, 2L0a0rr0y."ZoIbteils oaturaurnedceenrtstmaenedtiinnggthbaetttwheiesnsu3mMmaarndy EwPaAs,habnudt-wdeelisvueprpeldy taonoytohuerbycoDpry. to complete the filing. 3. TMhaeyc4o.veWrepaigneadtvoerttheenrtelsyubfmaiiltetdaltoofpcroonvfiiddeenbtoitahlaisnafnoirtmiazteidoannpdrecovnifoiudselnytisaulbmciotptye,daonnd Terry O'Brien asked that we resubmit this information to the Document Processing Center. Please do not hesitate to contact me at 651-733-6374 should you have any questions. w Very truly yours, Asta3ro. 2Hggpren William A. Weppner, Ph.D &DirReecgtuolraotforEynvAifroanrmental, Health, Safety S3pMeciCaelnttyerM,atBelrdigal2s36M-a1rBk-e1t0s St. Paul, MN 55144-1000 JAINRERS RECIIJT Ei em P2g)2!8 oZ = e BF BS / 85000000003 AperRfolbuuosrotoScutamnmeasrulyf,onFaitnealaRreepionrctl,udaenddfPorroetaocchoolfotnhtehfeoplhlyoswiicnagl-pcahreammiectaelrsp:roperties of PARAMETER DATEOFREPORT Melting Point/MeltingPointRange ~~ 2/24/99 n`-VOacptoarnPorle/sWsautreerPartition Coefficient 52//51/19/900 ASoilru-bWilaitteyrinPaprutriteiwonatCeoerfficient Solubility Measurements on FC-95 35/31/99/090 2/6/81 RESULTS 2400C 3No3t1cxa1lc0u'laPb@le2;0thCree phases 0S(<720xm1g09) . 108mg Tinhdeirdeacttamepraessuernetmeednitn,tnhoetsbtyudayct"uSaolluabnialliytsyisM.eaThseurreefmoreea,tsthoendaFtCa-9i5s ,n"otwareslidaebltee.rmined by PPsoleleruafbslieuloinrtoyotcdehaetthmaaitocantlhwseaiMtnaetrrhcoehtEh1ne,rv2it0rh0oa0nnmspeuubnrmteiSt(otiuar,lcteforse,EsDPhiAwspaeetiretsrii;toifnei,dlFt"eaSrtueeldfasoennadawtEaeftdfeerc;tsu"nfiinlctleurdeeddsea wuastienrg)G. LThPesSetadnadtaardwse.reFodrevtehlisopreeda,sohno,wRevoebru,stinSsuumpmpaorriteosf,oFtihnearlsRteupdoiretssa,nodrnportotporcoodluscfeodr. this specific data are not being provided. 2 [ENVIROFATNEMANED TNRATNSAPOLRT sTohiilsasdescotripotnipornessteundtisesi.nfDoergmraatdiaotnioanndsttuedsitesreisnucltlsudferhoymdraobliyostiics,, aphnodtobliyostiisc,daengdradation and `biodegradation. Much ofthis work is in progress with final reports scheduled for the June to August, 2000 timeframe. As these studies progress, there are certain key findingsthatcan be presented as preliminary results: d1.egTrhaedraetihoans fbreoema hnyodrionldyisciast,iopnhotthoaltyspiesr,flourorboioocdteagnreasdualtfioonnatmeecuhnadneirsgmose.s any . `2.deItnecatleldBaysdraoldyesgirsadaantdiopnhoptroolydsuicstsitnudainesy,cpoencrlfulsuiovreoeoxcpterainmeesnutl.fTohnihasatsperoeltimbieneanry finding calls into question the assumptionofexpected degradationofother fluorochemicals to perfluoroctanesulfonate. 3. In the studies focused on hydrolysisoffluorochemical polymers that form the : structure of the specific industrial and consumer products, it has been determined that these materials are relatively stable in the environment. For example, the following half-lives are estimated for various polymers: POLYMER Acrylate and ester HALF-LIFE 1-5 years . . Polyethylene glycol based Urethane 3-50 years >500 years F`owhrihcyhdirsolnyostiesxpteocotcecdurt,o pooclcuyrmeirns2mmuusnticbiepaslubojrecitneddusttoriaanl alaqnudefoiulls environment, `w4i.plrRlopplearhtioiitevseotlfhoyetzpnhoeostucolalfryobsnioasxt,yeltsahitenectsuhtrarrutectnthtuerdyeasat.raTeshmuegusgceehssttlsreusacsthbuyirpoeoastchhceausvmieuslmtahutacitvhtehdieinsfefeecmroaeltaoetgriicaalls species. Additional discussion of these results and ongoing studies will be preseated in subsequent submissions and reports. [ECOTOXICITYELEMENTS `This section presents information and test results from a seriesofecotoxicity studies on perfluorooctanesulfonates.Theinformation is preseated as Robust Summaries, Final Report and Protocolforeach ecotoxicity element. `The studies performed during 1999 and inearly2000 were carried out using GLP Standards.Incontrast, ecotoxicity studies performed during the period 1974 to 1998 were conducted using protocols and analytical methodologies available at the time of the study. In addition, in these older tests, the sulfonated perfluorochemical products were variable `tmhiexpteurrefsluaonrdocchoenmtiacianledanmdorreesuilmtpsurairteieesx.pSreevsesreadlatse"stgsrewaetreerhtahamnp"ertehde mbeyatshuereindsosloulbuibliiltiytyo.f `Therefore, the data preseated in these historical reports may not be reliable. ENVIRONMENTALMONITORING: PMARU T OL NET -- E-CIST TUY DY fTlhueormouclhtei-mciictaylsstiandtyhweaesnvdiersoingmneendtt,ouopbttaakien pinrteolifmoiondasraynddatpareasbeonucte diinsdpreirnsikoinngof wtahattermitgohutndreesruslttafnrdotmhtehipsotteynpteioalfsdoiusrpceerssioofn.huTmhaenmaulntdi-eintvyirsotnumdeynptaailreexdpaoscuitryes : . chuasvtionmgemrasnaulfeascwtiutrhinacgiotrytchoamtmdeorecsianlotu.seInoiftifalluloysrioxcchietmiiecsa,l(tphrroedeupctas biaasreredbsoeni)ng examined. The study may be expanded depending on further results. Tpohteenmtuilatlis-coiutrycsetsoudfyhwiulmlayineelxdpeonsvuirer.onmTehnetaciltideisswterirbeutsieolnedcatetdataosrweeplrlesaesndtautraboann T`omcuantiicoinpsalwiwtahtevrarsiuopupslileesv.elTsohfefslaumoprloecshetmoibcealobrtealienaeseds,awnhdevraerpioosussibtlyep,eisncolfude: . udrribnakninaigrw, astuerfraicnetwakaet,etrrceaotleudmdnrainnkdinsugrwfaatceerm,itcarpolwaayteerr,, stehdeiimnefnltu,enrtitvoerafnisdh, lefefalcuheantte.frAodmdiptuiobnlailcllyy,-oaw"nmeadrwkaesttebatsrkeeatt"moefnstevwoerrkasl,fsolouddgper,odauncdtsmuwnililcibpeaslalmapndlfeidl.l `Tahpepsleesifnrcolumdeg:robceeerfy,sptoorrke,s cahnidc,keifn,pohsositbdloe,gsp,rcoadtuficseh,fergogms,lomciallk,fabrrmeeards,"gmraereknebtesa.ns, . s`tTuhedyaattnadchreedprmeasteenrtisalthdeatfiarsptrorvesiudletss mforroem tdheteamilulotni-tchietydsetsuidgyn.aInndcslturduecdtuarreeofthe. rreespuolrttssofotnhtehedrquianlkiitnygwaasstuerranscaempplleasn taankdenfifelrdosmamthpelisnixgcpitrioecs.edTuhreesruessueldtsainndditchaete that drinking water Alabama; and Port in St. fLouucriec,itFielsor(iDdeac)atduird,nAoltacboanmtaai;nCdleetveecltaanbdl,e Teanessee; levels of Mobile, cTlounotraoicnheedmidceatlesc.tabOlnellyevtewlsoocfitsiueslf(oCnoaltuemdbfulsu,orGoecohregmiiac,alasndinPtehnesadcroilnak,inFlgowraitdear). The . rpeesruflltusorsohcotwantehastultfhoeialtevee.lsOanrleyionnethceitrya,nCgoeluofmb40u-s6,0Gpeoragipaer,rstrhtiolwlseiodnvoefry low detectable levelsof perfluorooctanoate. Adaelppvsleoilcioanptceildoundfoeofdr"PissFaaOfeScto.ypyfTahocitsfaorasdd.rv"aifstTorh"yleriafeefdtlvieimcseto"srdyravileenvrkeiylnocgfown1aspteraevrrathtepiaevlretbahiplapldirovoniasscohhroyubladsendotonbe o`mnisacpopnlsitcrauteidonaosftchornessehrovladtfiovre dmaentgheordsoracnodntcheerni,nfbourtmoautliyonaarvefaeirleancbetlopeodiantteb.aAsed acroemptawroiosrodneorfstohfemdarginniktiundgewoaftsearfedtaytabeftrwoemetnhtehmeuldtria-fctidtyrisntkuidnygiwnadticeartaesdtvihsaotrtyhere and the results from these two cities in the multi-city study. 5 EPANRVTIRTOWNOME-NBTIAOSLPMHOENRIETSOARMIPNGL:ING AND ANALYSIS A`offlphulioarsnocpthloeaamnsiscaeavsloslspvuoebtssetncathniacarelascethneavrsiirbzoaentemineonndteoafvtlehleoexpgpeedoobsgyur3artpoeMhipcaenrdfdilsoutuortirbsouiotdcietoaennxoepfseruftllsfu.oonOraontceehaecmnoidmcpaolotsnheeirnn t b3`giMlootbiDacelcabanitdousrap,bhieAortlieacbmroaenmcieatpatmorarinsnu.gfTpawrctoougrsrtiaunmdg.iefTaschaielrietpyri,enalpinrmdoigntrhaeersyso,trheosenurelatfsomocubuctsaheidnmieondrtethoecdovaimtcpiernheiathyveoenfsbtiehveeen TtehpeoErntveidrionnmtheent3:MSoEunrvcierso,nDmiesnptearsliWohn,itFeatPeaapnedr eEnftfietcltesd.""Sulfonated Perfluorochemicals in Twoafhpteerros,dtuuscdeytdiiiomnentnhotepseDraeanctdaitofunirss,hIAannltdahbebailrmodcaaslapreeencavieiisrswobinelmilenbngetd.ceoSslailmgenpceltdeedstoionfuMntdhaeeyrgsartnoaudnndJduwtnaheet,ei2rm,0p0as0cutrf,foiarfcaeny, ``aannadtlyosaess.seTshsisthdeatpaotweinltlibaeloufsaend ytoefefveacltusautseitnhgeeecaotvoixriocnomleognitcaall ptersetsereascueltosf.fluorochemicals T`MhiechBiigoasnphSetarteemUonniivteorsriitnyg.pTrhoigsrpalmanwaissbdeeisniggvnieedwiendcaosnsaunltiatetriaotniwveitphroDcre.ssJotohnasGseeisssygloofbal distribution offluorochemicals. As results are obtained from the global environment, the pfolcaunsisontoacdodnitcieonntarlatseamopnltihnogseanadreaansawlyhseerseifnltuhoorsoechsepmeciicfailcsloacraetidoentse.cted in samples and Icnoivteiarlilnyg, sdiafmfpelreesnotfstpiescsieusesanadndlobclaotoiodnsp.laAsrmeaasaorfefboeciunsgicnocllluecdteeNdofrrtohmAamrecrhiivcead(sGpreecaitmens Lialanbckaletusrdoeassnl;adkmceuotsarssoetualtls,mawaanrldliesnyheeel,llosfciaaslthmi;oonmnsa,)r,ciatnthfeeismahar,tmaimncadlrbesgr;iooawnn,ndatnorotduhtEe;urrcsoopperecmi.oersSa.pneTtchsii,essesatagomlbepeslisantnugddpileadn is in progress and as datais obtained and reports generated, additional submissions will be made to EPA. - : Included in this section are the following documents: 1 oLfCPMerSflMuSorAinnaaltyedsiCsoomfpExoturnadctssinreEpnovritreodnimne:n"tParlelSiammipnlaersy"RbeypoPr.tJoAnnaelsysis and K. Kannan - 4/7/99 2. FinalLaboratory 3M Reports on Analysisof Fluorochemicals in Wild Bird Livers - 428/99 3. Screening of PROS levels in Eagle and Albatross -S/8/98 26-Week Capsule Toxicity Study (PFOS) iwnitChynPeormfollugoruosocMtoannkeseuylsfonic Acid Potassium Salt Current Summary asofMay 4, 2000 "roTehppeepmnutcreodpdnocaselenoytrfeaxttphioiossnssutfruoedrtyopuwprostpaotssoseiisduemonfptiiefsrykftoahrseoseeoascrsltimaeensntetcsaluinlndficmoaneladltyiecmea(alPsmFouOnrSia)tbaolrneidnbigooolcofogriercxeaplloartseeesdpipoosnpsurelefasrtpiooonmnsse.to SGSeerxo)su,p0bs.oy1f5cma(aiplxeepaenrvdisfxeg)am,saotlrreicC0iy7no5tumb(oasltxigopune,srTmswoenxok)memaypls/erksegac/endiadvytepwddooatfaieslmsyaidluoemsspeiesnrofalfvco0hroo(soficxttpaeen0rcs,seu)0l.f,o10n5aa.tn0ed3f(0ofr.o7u2r56per mGgr/okuhgpo/,ud"anTydhdiasonrsdeeprodergtrvcooeuvpresrswseitrbhoefeif2eolf6lfiwlecteotweysek.Tdsfhooefrrodeonwseeayrgee.aroaoArsfeeepcraocrevasetsreaytarieonnpioomraftlwdsoiislnitdnhegetaol0o.tb0hs3eemrgfva/edkidgne/gpduarfayrtdoiomosn5eo2f SCoeoeemkpoossuotmnforderncetofvheoerfdyt.irnEecflafutedmece:t1no)t2cc;)suelrvioenwrgeerlibnltohsdeys0ow.ef7i5tgmwhgot/mikanglm/eadslaweyshdaioncshdedfgieremdoaouleprsww;heir3)cehsiaarcenribfecilciereldviievendertewaxoetbirsegehmetawdnitdhin I"n`aohredpefaaetsomicanellgelssuel;arr6u)hmlyopPweFerOtrreSodlpeehsvytaerlnasdddiuovrlai(cnEgu2o)tlrlaeattiemioeannitvn;an5mei)amlalllsso.;we4rN)eodlstoirwgiearoiidfnocgtaobnfrtscyeoomrrpuioemu(cnhTdo3l-)ervseatlelarutoeelsdiiennffbceooctrtshrmewalelaretesiotno iinnccereaetaryseteioinnsamenrauekmrePasgFetOorSefiatn1e8tdahwneidt09h.0075i.m0ng3/thkoerg0/0.d.10a35yadnmods0ge.g1r/5oukmpowggvaes/r/2nok6dtwdlgeaioenskieysea.grddruoSaruepirysn,ugtmrhPeesFdpOeocsStiivnvagellpuyee.rTsiihnoecdarenadsed pEoPonsmtfhloeevreal0sn.0wa3iv,te0hr.ia1ng5e3,o6afdn2ad1y0s5.op7fp5mmrgec/aokvge/fr2dy6,aweywidetoehrskoesuotgfcroodruorpssei,lnagrd.eoLsnpietvcotesireverPluFym.OCPShFollOeeSvse.tlesarSovelevrraualmgueePdsF2O5Sr,ebt8a0udananendtdo41pr5e- S0pn7pi5amraemlngetw/ekalgis/mcdioannayftdiioornsmeeBdgarlaoufptfshe,eorefeasr2pl7ei5ecasttinmveedlays1,u2Tr8hdabaelydeseocclvrieenairsctaelhnrfertsopstotanlssiesx.eTrmuohmnetchhsloleoofsrteewrcooloveefortbrysterailvtesndheierng0uh.mi1g5ha-dnodse GShheospreaerstvtoercdoeillnucaohroiupsresrrteoadxyioaslroyemeactpornsosleiisrftueemrnattPwiRoinOt,Shapscroionobcesrneotrdrveanteiitonannrsodgdmreoetrasi,tktwyhasastnuod1it0e0sopbwpismte.hrtThvheeencdbxiohocilpsotgisiotcnuadltyh.raetsHpeonasles Cegcfefcneuecprtaastlhilaoyvnlaeelnsoetxtphboeesneusnriexobpespseumrlvi(endgOfilrsnoaemtvnyeraaleg,eJosaOefrmEeurMdmicScsoeanpcl.e,mnt1r9oa9t9ni)o.nisToohtfefroae3fpMoprrrceoh,iseinmmnoaintc-geaolclycowunpoaertkieo0rntsalwoliypthepxmp,os0edd BeD oriluSoeh nrsnaw,vieHtrehapaga toehowalonerddkeaTn vroesxreiarcgouelmsogecyroDunacmtePan"tF,rOaJtSeicmoounnsacre(yn3t2M1r,,a*1ti9Poe9nr9f)ltuhhoaartvoaeorcatmaaannreegSiu0nloftofwnsoaaotfere:dtCyeurorsfroef1nmt0Sa0ugnm1im0tauwrdiyetohf Tespectotheiret clinicallymeasurablebiological response 0peluorooctanesulfonate exposure, cholesterollowering. o y . 7 DCCoorproerraete!vpoenPotnii.ne Sn Corporate Toricology SPCWhoEi,ETdotvangm025.02 3M May 15,2000 Document Processing Center (Mail Code 7407) Information Management Division OOfnfitcoeoSfPaotleluEtniovnsPornevmeenntiaonPraondecTiooxnicasgency 401 M Street, SW Room 699 East Tower Washington, D. C. 20460 Attn: FYI Dear Sir/Madam: "This submission is being made per the phone conversation between Terry O'Brien (EPA) and Dan Hakes (3M) on May 10, 2000. Terry requested a non-confidential version ofa specific toxicological study. 1 would like to confirm that portionsofthe "Exploratory 28Day Oral Toxicity Study with (various fluorochemicals) By Daily Gavage in the Rat Followed by a 14/28-Day Recovery Period", plus the associated laboratory report submitted to Dr. Charles Auer on May 4, 2000 is considered TSCA Confidential Business Information. Attached for your review is a new copy ofthe above mentioned study to be included with the submittal on perfluorooctane sulfonates made by 3M to Dr. Charles Auer dated May 4,2000. Attached to this letter is a complete non-confidential report with the TSCA Confidential Business Information redacted. In a separate envelope is the same report `with the TSCA CBI included and highlighted. Very truly yours, Flu 2.cater MJoahnnagLe. rB,uCtoernphoofrfa,tePhT.oDx.i,coCl.oLgHy, D.A.B.T. Corporate Toxicology 3M Medical Department Building 220-2E-02 3M Center St. Paul, MN 55144 651-733-1962