m Z 'O ift Pathology Associates International A Company of Science Applications International Corporation SECOND DRAFT CELL PROLIFERATION REPORT 104-WEEK DIETARY CHRONIC TOXICITY AND CARCINOGENICITY STUDY W ITH PERFLUOROOCTANE SULFONIC ACID POTASSIUM SALT (PFOS;T-6295) IN RATS COVANCE STUDY NUMBER 6329-183 PREPARED FOR: 3M TOXICOLOGY SERVICES BUILDING 220-2E-02, 3M CENTER ST.

CAS Number 1691-99-2 3M Company M SLAGjQ g/ Voluntary Use and Exposure Information Profile N-Ethylperfluorooctylsulfonamido ethanol I.

A K M G _ D g J U f- ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE_________________________ Identity: A mixture containing perfluorooctanesulfonate; may also be referred to as PFOS, FC-95, or as a component of FC-206CF or FC-206CF-X. (1-Octanesulfonicacid) (CAS # 2795-39-3).

ARX& - 03U BIODEGRADATION TEST SUBSTANCE Identity: Perfluorodecanesulfonate, ammonium salt; may also be referred to as PFDS, FC-120, or 3M Sample J2905-1. (1-Decanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10heneicosafluoro-, ammonium salt, CAS # 67906-42-7) Remarks: Test sample is a mixture of the test substance in water and butyl cellosolve (approximately 25% test substance, 37.5% butyl cellosolve and 37.5% water).

AR226-2455 Ohio River monthly average flows at Cincinnati, OH River flow data from <ftp://www.lrd-wc.usace.army.mil/Monthly_htm/> Assume: 1 ft3/sec= 0.0283m3/sec; 1 m3 = 1*10A6 cm3; 1 cm3 - 1 mL Estimated Estimated Estimated Mo-Yr Measured Long-term normal flow, of normal, flow, ft3/sec % ft3/sec normal flow. m3/sec normal Estimated flow, normal m3/mo flow, L/mo Jun-98 131,400 175 75086 2.12E+03 S.51E+09 5.51E+12 Jul-98 94,452 211 44764 1.27E+03 3.39E+09 3.39E+12 Aug-98 28,387 80 35484 1.00E+Q3 2.69E+09 2.69E+12 Sep-98 21,200 74 28649 8.11E+02 2.10E+09 2.10E+12 Oct*98 21,065 77 27357 7.74E+02 2.07E+09 2.07E+12 Nov-98 21,400 40 53500 1.51 +03 3.92E+09 3.92E+12 Dec-98 34,548 35 98709 2.79E+03 7.48E+09 7.48E+12 Jan-99 178,190 131 136023 3.85E+03 1.03E+10 1.03E+13 Feb-99 134,860 81 166494 4.71E+03 1.14E+10 1.14E+13 Mar-99 180,260 85 212071 6.00E+03 1.61E+10 1.61E+13 Apr-90 118000 66 178788 5.06E+03 1.31E+10 1.31E+13 May-99 60226 49 122910 3.481+03 9.32E+09 9.32E+12 Total 1.02E+06 1.18E+06 3.34E+04 8.74E+10 8.74E+13 C8 discharge to Ohio River in 1996, ibs 40600 RJZ0154QO EID137010 t C "t Estimated C8 C8 discharge concentration to Ohio River in Ohio River, in 1996, kg kg/L Estim ated C8 concentration in Ohio River, mg/L Estimated C8 concentration in Ohio River, ug/L 18416 2.11E-10 2.11E-Q4 0,211 RI2015401 BXD137011

AR226-3007 DuPont HLR 696-92 Study Title Subchronic Inhalation Toxicity Study with in Rats Laboratory Project ID Haskell Laboratory Report No. 696-92 Author Hanan N.

AR226-3075 snidv Title Inhalation Toxicity Screen wi rf hnrtflP> Project.1C HL-1997-00600 Author David P.

AR226-3086 DuPont H L Q -f 998-00729 Study title A cute D erm al Irritatio n /C o rro sio n Study w ith H -22481 in R ab b its FINAL REPORT H askell Laboratory P roject ID : H L O -1998-00729 P& dbm iine Laboratory Project ID : W IL-189160 O rganization for Econom ic C ooperation and Development (O EC D ), P art 404 (1992) European Econom ic Com m unity (EEC) 92/69 Annex V - M ethod B 4 (1992) 1 A uthor Tom G .

AR226-3138 DuPont-3615 TRADE SECRET Study Title H-24256: Eye Irritation Test in Rabbits Laboratory Project ID: DuPont-3615 Author: Deborah A.

Ad a.a.6 - 0768 BIODEGRADATION (BOD/COD) TEST SUBSTANCE_______________________________________________ Identity: Mixture containing perfluorooctanesulfonate which may also be referred to as PFOS, FC-95, or as a component of FC-203FC. (1Octanesulfonic acid) (CAS # 2795-39-3).

-M A 2 6 - 0770 ACTIVATED SLUDGE RESPIRATION INHIBITION TEST T E S T SUBSTANCE__________________________________________________ Identity: Mixture containing perfluorooctanesulfonate which may also be referred to as PFOS, FC-95, or as a component of FC -203FC . (1Octanesulfonic acid) (CAS # 2795-39-3).

Corporate Health Physics Corporate Occupational Medicine Corporate Product Responsibility Corporate Toxicology 3M Medical Department 3M Center, 220-2E-02 PO Box 33220 St.

ARIU'OO?

AAA6-0679 MULTI-CITY STUDY FINAL FIELD REPORT FOR COLUMBUS GEORGIA AND PORT ST.

3M REPORT: BIOACCUMUIATION STUDIES -O200- b i t March 8, 1993 UA6-0370 Ca> -p .