-Pt({ Jl SlQ _ /// -teosc,^ UNITED STATES EN VIRO NM EN TAL PROTECTION AGENCY WASHINGTON D.C., 20460 September 5, 2002 OFFICE 0F PREVENTION, PESTICIDES AND TOXIC SUBSTANCES Mr.

M 2.2-6. _ / / S > _______ -out SAW HM Compositor of Tootod Products, Dermal Contact AtoaorototYToxleolofly Study (PFQS, PFHS, M570) .c&s- _______ Dectmber 4,2002 - ._______ T-7068^NqukO, T-7333(dHsd) Com oonont Nm m W ATER IS Q 6 U T A N E ^ -ffO X YPR O PO X Y)-a* PROPANOL t-ilETH O X Y**PR O PA N O L tETH YL ALCOHOL 7 * J _______..................

Northwest Bioanalytical M6 - ' O y Study No.

M&M- \& i DuPoni Engineering Earley Mill Pla:a - Blrhj. 27 Lancaster Pil.e & Fits.

AR226-1384 Revised 10-24-80* IJ _W_O_RD__P_R_O_C_E_S_SI_N_G__W_O_R_K _F_O_R_M TO: EMPLOYEE RELATIONS DEPARTMENT WORD PROCESSING CENTER - N-12533 AD O D Q ' * *** Tape# /IP2.y __ /QffJj.

AR226-1403 mm INTEROFFICE MEMORANDUM - Iif03 Date: Fronts Dept: Tel No: 0 1 -Apr-1991 11:07 am VMSMail User ANDERSWP ANDERSWPISCDCVM2SCDCIL10MRGATE 3: BERGAS<?

W 8 S 6 - \Jht~] Dure:;; Enginsari-u Saris!'

COLUMBUS.

D u P o at H ask ell L ab o rato ry :u*bkHufcad -loarrauv w Tmeaoqi ma immm Meatiie 3 cm tart. .1 3<aJO tawwxaE '5714-181 /S S S June 13, 2000 Or.

< 6*) ESlABULKfLHi.

TEFLON FINE POWDER/DISPERS ION OPERATORS C-8 BLOOD SAMPLE RESULTS /(*lO C-8 in Blood (ppm) First Sample Second Sample Change 26.0 20.0 -6.0 24.0 25.0 +1.0 11.0 8.2 -2.8 9.4 7.9 -1.5 8.2 6.5 -1.7 7.0 7.7 +0.7 6.9 5.9 - 1.0 5.6 4.2 -1.4 4.4 4.9 +0.5 4.3 5.6 +1.3 3.9 3.6 -0.3 3.6 2.7 -0.9 3.5 2.1 -1.4 2.9 2.8 -0.1 2.8 2.8 0.0 CM o 2.6 2.4 2.5 1.8 -0.7 2.5 2.5 0.0 2.1 1.6 -0.5 1.6 1.5 - 0.1 1.5 1.2 -0.3 1.3 1.1 -0.2 JWR:ldr/10/19/83 Days Between Samples 363 364 391 364 363 364 337 334 365 401 364 362 363 357 365 391 336 349 288 384 366 362 000246 % Per Year Change -23 +4 -24 -16 -21 +10 -16 -27 +13 +27 -8 -25 -40 -3 0 -7 -28 0 -30 -6 -20 -15 EID079746 TEFLON FEP OPERATORS C-8 BLOOD SAMPLE RESULTS C-8 in Blood (ppm) First Sample Second Sample Change 7.5 6.6 -.9 4.5 3.7 -.8 3.1 2.8 -.3 2.1 1.5 - .6 1.8 1.1 -.7 1.8 1.6 -.2 1.6 1.4 -.2 1.25 1.20 -.05 1.20 1.00 -.2 0.95 0.79 -.16 0.86 0.75 -.11 0.75 0.72 -.03 0.52 0.44 -.08 0.51 0.42 0.41 0.48 0.39 0.46 -.03 -.03 + .05 0.38 0.36 -.02 Days Between Samples 362 380 384 364 364 392 393 171 333 391 565 364 365 337 445 363 363 % Per Year Change -12 -17 -9 -29 -39 -10 -12 -9 -18 -7 -8 -4 -15 -6 -6 +12 -5 JWR:ldr/10/19/83 V 00024V EID079747 SHORT SERVICE OPERATORS C-8 BLOOD SAMPLE RESULTS Fine Powder Last Sample PPM .02 .19 .93 4.00 Days in Job 61 212 375 603 PPM Per Year Change + .09 +.24 + .03 -.18 FEP .05 .05 .15 .23 .66 o U1 95 124 135 165 492 266 + .15 + .10 +.38 + .09 + .24 -.24 JWR:ldr 10/19/83 00248 EID079748 NEW HIRES - TEFLON Date of First Sample 07/28/81 10/01/81 10/07/81 10/13/81 Date Hired 07/27/81 08/03/81 04/20/81 04/20/81 C-8 Blood Level (ppm) <0.007 0.009 0.007 0.015 Months on Plant Before First C-8 Blood Test 0 2 5 1/2 5 3/4 AJP002380 JWR: Idr 10/19/83 000ZA9 EID079749

Precise Research.

/H U i -03r?

/dR226- ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity: Perfluorooctanesulfonylamido(ethyl)acetate; may also be referred to as PFOSAA, FC-128 or as the major component of FC-127, FC-129, FC-109, orFC-109-X.

SRPT T-629-.8, T-6889.1, T-6316.4 DT15-A M S & b -lb itf 3M M E D IC A L DEPARTMENT, CORPORATE TOXICOLOGY Title: Inter-Species Comparison of Mechanisms Fluorochemical Toxicity following Intraperitoneal dosing of perfluorooctanesulfonate (PFOS, T-6295) or ammonium perfl^iorooctanoate (APFO, T-6889) in Rats and Guinea Pigs and oral dosing of N-ethyl perfluorooctanesulfonamido ethanol (N-EtFOSE, T-6316) in Rats.