A Pharmacokinetic Study of Potassium Perfluorohexanesulfonate in the Cynomolgus Monkey Southern Research Institute Study ID: 9921.5 April 22, 2003 Final Report on A Pharmacokinetic Study of Potassium Perfluorohexanesulfonate in the Cynomolgus Monkey To: 3M Corporation P.O.

BACK TO MAIN 3M FLUOROCHEMICAL SUBMISSION TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE October 1987 C lick on S tudy Title to V iew R eport October 29, 1987 " Two-Year Toxicity/Carcinogenicity Study of Fluorochemical FC-143 [PFOA] in Rats," Review letter from Greg Sykes (Haskell Laboratory for Toxicology and Industrial Medicine) to Charles Reinhardt, October 29, 1987.

R ep ort T itle Evaluation of the Northwest Bioanalytical Method V alidation Reports fo r PFOS and Related Analytes in Human Serum or Plasma in Meeting the Requirements o f the - _________EDA BioanalyticaLMethod Validation QAI Report No. 405-503 Data R equirem ent Full Validation o f Bioanalytical Method Author Nancy Benson Philippe Ourisson Quality Associates, Inc. 9017 Red Branch Road, Suite 102 Columbia, MD 21045 Sponsor 3M Environmental Laboratories 935 Bush Avenue Bldg 2-3E-09 St Paul, MN 55106 R eport Date December 31,2001 Report Number QAI 405-503 Number o f Pages 26 TABLE OF CONTENTS QAI Report No. 405-503 I.

0 //5A R M - I BIOACCUMULATION TEST SUBSTANCE Identity: [2-(N-Ethylperfluorooctanesulfonamido) ethyl acrylate: may also be referred to as B1228, D-1, EtFOSEA, or FX-13. (2-Propenoic acid, 2[ethyl[heptadecafluorooctyl)sulfonyl]amino]ethyl ester, CAS # 423-825) Remarks: Material is an amber solid.

flRUG'OHSO PHOTODEGRADATION TEST SUBSTANCE Identity: Perfluorooctanoic acid, ammonium salt; may also be referred to as PFOA ammonium salt, Ammonium perfluorooctanoate, PFO, FC116, FC-126, FC-169, or FC-143.

BIODEGRADATION (BOD/COD) TEST SUBSTANCE Identity: Perfluorooctanoic acid, ammonium salt; may also be referred to as PFOA ammonium salt, Ammonium perfluorooctanoate, FC116, FC-126, FC-169, or FC-143.

A R X & - 0 5 (0 ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE Identity: Perfluorooctanoic acid, ammonium salt; may also be referred to as PFOA ammonium salt, Ammonium perfluorooctanoate, FC116, FC-126, FC-169, or FC-143.

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AR226-2252 Mark H.

AR226-2494 IQY- mm 1T123 08/31/01 11:01 0 :06/13 NO:150 nwrniicorr eHOfUMOV JwFant jBwse-II'SI'iiks w^%mai3-s2i?

AR226-2528 TOXICOLOGY LIMITS - TLV - AEL - CEGA - CEGw uf/n3 100 10 0,3 - fife 5,6 0.56 0.0015 1.0 CALCULATED DOSE - AEL - CE6 100 ug/day 0 ug/day RJZO10003 / EID079258

AR226-2562 Meeting Notes - September 25,2001 Washington Works Groundwater Model A meeting was held on September 25, 2001, at EPA headquarters in Philadelphia to discuss the groundwater model developed for the Washington Works Plant in Parkersburg, WV.

AR226-2564 Andrews Hartten 11/01/2001 03:59PMl To: weniworth.willlam @ epam ail.epa.gov cc: Subject: Update on Things Sill, A couple of things I wanted to update you on.

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AR226-2673 63 PROJECT SRCNAME AIR SAMPLING 2003 AMS1-E1 AIR SAMPLING 2003 AMS1-E10 AIR SAMPLING 2003 AMS1-E11 AIR SAMPLING 2003 AMS1-E2 AIR SAMPLING 2003 AMS1-E4 AIR SAMPLING 2003 AMS1-E5 AIR SAMPLING 2003 AMS1-E7 AIR SAMPLING 2003 AMS1-E8 AIR SAMPLING 2003 AMS1-E9 AIR SAMPLING 2003 AMS2-E1 AIR SAMPLING 2003 AMS2-E11 AIR SAMPLING 2003 AMS2-E2 AIR SAMPLING 2003 AMS2-E4 AIR SAMPLING 2003 AMS2-E5 AIR SAMPLING 2003 AMS2-E7 AIR SAMPLING 2003 AMS2-E8 AIR SAMPLING 2003 AMS2-E9 AIR SAMPLING 2003 AMS3-E1 AIR SAMPLING 2003 AMS3-E10 AIR SAMPLING 2003 AMS3-E11 AIR SAMPLING 2003 AMS3-E2 AIR SAMPLING 2003 AMS3-E4 AIR SAMPLING 2003 AMS3-E5 AIR SAMPLING 2003 AMS3-E8 AIR SAMPLING 2003 AMS3-E9 AIR SAMPLING 2003 AMS4-E1 AIR SAMPLING 2003 AMS4-E10 AIR SAMPLING 2003 AMS4-E11 AIR SAMPLING 2003 AMS4-E2 AIR SAMPLING 2003 AMS4-E4 AIR SAMPLING 2003 AMS4-E7 AIR SAMPLING 2003 AMS4-E8 AIR SAMPLING 2003 AMS4-E9 AIR SAMPLING 2003 AMS5-E1 AIR SAMPLING 2003 AMS5-E10 AIR SAMPLING 2003 AMS5-E11 AIR SAMPLING 2003 AMS5-E2 AIR SAMPLING 2003 AMS5-E4 AIR SAMPLING 2003 AMS5-E5 AIR SAMPLING 2003 AMS5-E7 AIR SAMPLING 2003 AMS5-E8 AIR SAMPLING 2003 AMS5-E9 AIR SAMPLING 2003 AMS6-E1 AIR SAMPLING 2003 AMS6-E10 AIR SAMPLING 2003 AMS6-E11 THEME DATESMPL SMPLT SAMPLE NUMBER Ambient Air 11/6/2003 FS WWK-A-AMS1-E1 Ambient Air 1/15/2004 FS WWK-A-AMS1-E10 Ambient Air 1/16/2004 FS WWK-A-AMS1-E11 Ambient Air 11/12/2003 FS WWK-A-AMS1-E2 Ambient Air 11/24/2003 FS WWK-A-AMS1-E4 Ambient Air 11/30/2003 FS WWK-A-AMS 1-E5 Ambient Air 12/11/2003 FS WWK-A-AMS1-E7 Ambient Air 12/12/2003 FS WWK-A-AMS 1-E8 Ambient Air 12/19/2003 FS WWK-A-AMS1-E9 Ambient Air 11/6/2003 FS WWK-A-AMS2-E1 Ambient Air 1/16/2004 FS WWK-A-AMS2-E11 Ambient Air 11/12/2003 FS WWK-A-AMS2-E2 Ambient Air 11/24/2003 FS WWK-A-AMS2-E4 Ambient Air 11/30/2003 FS WWK-A-AMS2-E5 Ambient Air 12/11/2003 FS WWK-A-AMS2-E7 Ambient Air 12/12/2003 FS WWK-A-AMS2-E8 Ambient Air 12/19/2003 FS WWK-A-AMS2-E9 Ambient Air 11/6/2003 FS WWK-A-AMS3-E1 Ambient Air 1/15/2004 FS WWK-A-AMS3-E10 Ambient Air 1/16/2004 FS WWK-A-AMS3-E11 Ambient Air 11/12/2003 FS WWK-A-AMS3-E2 Ambient Air 11/24/2003 FS WWK-A-AMS3-E4 Ambient Air 11/30/2003 FS WWK-A-AMS3-E5 Ambient Air 12/12/2003 FS WWK-A-AMS3-E8 Ambient Air 12/19/2003 FS WWK-A-AMS3-E9 Ambient Air 11/6/2003 FS WWK-A-AMS4-E1 Ambient Air 1/15/2004 FS WWK-A-AMS4-E10 Ambient Air 1/16/2004 FS WWK-A-AMS4-E11 Ambient Air 11/12/2003 FS WWK-A-AMS4-E2 Ambient Air 11/24/2003 FS WWK-A-AMS4-E4 Ambient Air 12/11/2003 FS WWK-A-AMS4-E7 Ambient Air 12/12/2003 FS WWK-A-AMS4-E8 Ambient Air 12/19/2003 FS WWK-A-AMS4-E9 Ambient Air 11/6/2003 FS WWK-A-AMS5-E1 Ambient Air 1/15/2004 FS WWK-A-AMS5-E10 Ambient Air 1/16/2004 FS WWK-A-AMS5-E11 Ambient Air 11/12/2003 FS WWK-A-AMS5-E2 Ambient Air 11/24/2003 FS WWK-A-AMS5-E4 Ambient Air 11/30/2003 FS WWK-A-AMS5-E5 Ambient Air 12/11/2003 FS WWK-A-AMS5-E7 Ambient Air 12/12/2003 FS WWK-A-AMS5-E8 Ambient Air 12/19/2003 FS WWK-A-AMS5-E9 Ambient Air 11/6/2003 FS WWK-A-AMS6-E1 Ambient Air 1/15/2004 FS WWK-A-AMS6-E10 Ambient Air 1/16/2004 FS WWK-A-AMS6-E11 TOP 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C8 results Envista 111104.xls W W K - air AR226-2673 M FILTERED CASNO ANALYTE RsItPost RsItVal UNITS Hit LAB_ANALYTE QUAL_EPA QUALJNHOUSE REVIEW 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0T 335671 PFOA 0.0003 0.0003 MG/M3 1 PFOA 0 T 335671 PFOA <0.00012 0.00006 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA 0.00007 0.00007 MG/M3 1 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA OT 335671 PFOA 0.0009 0.0009 MG/M3 1 PFOA 0T 335671 PFOA 0.0002 0.0002 MG/M3 1 PFOA 0T 335671 PFOA 0.0007 0.0007 MG/M3 1 PFOA OT 335671 PFOA 0.0003 0.0003 MG/M3 1 PFOA OT 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA 0.00011 0.00011 MG/M3 1 PFOA 0 T 335671 PFOA 0.00008 0.00008 MG/M3 1 PFOA 0T 335671 PFOA 0.0004 0.0004 MG/M3 1 PFOA 0 T 335671 PFOA <0.0002 0.0001 MG/M3 0 PFOA 0T 335671 PFOA 0.0009 0.0009 MG/M3 1 PFOA 0T 335671 PFOA 0.0002 0.0002 MG/M3 1 PFOA 0T 335671 PFOA 0.0007 0.0007 MG/M3 1 PFOA OT 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA 0.00011 0.00011 MG/M3 1 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA OT 335671 PFOA <0.00012 0.00006 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA OT 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA OT 335671 PFOA 0.0003 0.0003 MG/M3 1 PFOA 0T 335671 PFOA 0.0003 0.0003 MG/M3 1 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA OT 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA 0 T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA Page 1 METHODNO PREPMTHD PREPREP DRY LAB NUMBER EXM21703 NS NS W L0001277-2 EXM21703 NS NS w L0001667-2 EXM21703 NS NS w L0001668-2 EXM21703 NS NS w L0001308-2 EXM21703 NS NS w L0001359-2 EXM21703 NS NS w L0001400-2 EXM21703 NS NS w L0001444-2 EXM21703 NS NS w L0001448-2 EXM21703 NS NS w L0001508-2 EXM21703 NS NS w L0001277-3 EXM21703 NS NS w L0001668-3 EXM21703 NS NS w L0001308-3 EXM21703 NS NS w L0001359-3 EXM21703 NS NS w L0001400-3 EXM21703 NS NS w L0001444-3 EXM21703 NS NS w L0001448-3 EXM21703 NS NS w L0001508-3 EXM21703 NS NS w L0001277-4 EXM21703 NS NS w L0001667-3 EXM21703 NS NS w L0001668-4 EXM21703 NS NS w L0001308-4 EXM21703 NS NS w L0001359-4 EXM21703 NS NS w L0001400-4 EXM21703 NS NS w L0001448-4 EXM21703 NS NS w L0001508-4 EXM21703 NS NS w L0001277-5 EXM21703 NS NS w L0001667-4 EXM21703 NS NS w L0001668-5 EXM21703 NS NS w L0001308-5 EXM21703 NS NS w L0001359-5 EXM21703 NS NS w L0001444-4 EXM21703 NS NS w L0001448-5 EXM21703 NS NS w L0001508-5 EXM21703 NS NS w L0001277-6 EXM21703 NS NS w L0001667-5 EXM21703 NS NS w L0001668-6 EXM21703 NS NS w L0001308-6 EXM21703 NS NS w L0001359-6 EXM21703 NS NS w L0001400-5 EXM21703 NS NS w L0001444-5 EXM21703 NS NS w L0001448-6 EXM21703 NS NS w L0001508-6 EXM21703 NS NS w L0001277-7 EXM21703 NS NS w L0001667-6 EXM21703 NS NS w L0001668-7 C8 results Envista 111104.xls ^asBSssBSKi W W K -air RSLTMOD RESULT UNIT MDL PQL Expr1029 LOCATION ID DUPNO < 0.00014 MG/M3 0.00014 11767997 11767997 1 < 0.00014 MG/M3 0.00014 11768173 11768173 1 < 0.00014 MG/M3 0.00014 11768193 11768193 1 < 0.00014 MG/M3 0.00014 11768041 11768041 1 < 0.00014 MG/M3 0.00014 11768085 11768085 1 < 0.00014 MG/M3 0.00014 11768073 11768073 1 0.0003 MG/M3 0.00014 11768107 11768107 1 < 0.00012 MG/M3 0.00012 11768123 11768123 1 < 0.00014 MG/M3 0.00014 11768135 11768135 1 0.00007 MG/M3 0.00014 11767999 11767999 1 < 0.00014 MG/M3 0.00014 11768195 11768195 1 0.0009 MG/M3 0.00014 11768043 11768043 1 0.0002 MG/M3 0.00014 11768087 11768087 1 0.0007 MG/M3 0.00014 11768075 11768075 1 0.0003 MG/M3 0.00014 11768109 11768109 1 < 0.00014 MG/M3 0.00014 11768125 11768125 1 0.00011 MG/M3 0.00014 11768137 11768137 1 0.00008 MG/M3 0.00014 11768001 11768001 1 0.0004 MG/M3 0.00014 11768175 11768175 1 < 0.0002 MG/M3 0.0002 11768197 11768197 1 0.0009 MG/M3 0.00014 11768045 11768045 1 0.0002 MG/M3 0.00014 11768089 11768089 1 0.0007 MG/M3 0.00014 11768077 11768077 1 < 0.00014 MG/M3 0.00014 11768127 11768127 1 0.00011 MG/M3 0.00014 11768139 11768139 1 < 0.00014 MG/M3 0.00014 11768003 11768003 1 < 0.00014 MG/M3 0.00014 11768177 11768177 1 < 0.00014 MG/M3 0.00014 11768199 11768199 1 < 0.00014 MG/M3 0.00014 11768047 11768047 1 < 0.00014 MG/M3 0.00014 11768091 11768091 1 < 0.00012 MG/M3 0.00012 11768111 11768111 1 < 0.00014 MG/M3 0.00014 11768129 11768129 1 < 0.00014 MG/M3 0.00014 11768141 11768141 1 < 0.00014 MG/M3 0.00014 11768005 11768005 1 0.0003 MG/M3 0.00014 11768179 11768179 1 0.0003 MG/M3 0.00014 11768201 11768201 1 < 0.00014 MG/M3 0.00014 11768049 11768049 1 < 0.00014 MG/M3 0.00014 11768093 11768093 1 < 0.00014 MG/M3 0.00014 11768079 11768079 1 < 0.00014 MG/M3 0.00014 11768113 11768113 1 < 0.00014 MG/M3 0.00014 11768131 11768131 1 < 0.00014 MG/M3 0.00014 11768143 11768143 1 < 0.00014 MG/M3 0.00014 11768007 11768007 1 < 0.00014 MG/M3 0.00014 11768183 11768183 1 < 0.00014 MG/M3 0.00014 11768203 11768203 1 Page 2 W W K - air PROJECT SRCNAME THEME DATESMPL SMPLT SAMPLE NUMBER TOP BOTTOM FILTERED CASNO ANALYTE RsitPost RsitVal UNITS Hit LAB ANALYTE QUAL EPA QUAL INHOUSE REVIEW AIR SAMPLING 2003 AMS6-E2 Ambient Air 11/12/2003 FS WWK-A-AMS6-E2 0 0T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA AIR SAMPLING 2003 AMS6-E5 Ambient Air 11/30/2003 FS WWK-A-AMS6-E5 0 0T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA AIR SAMPLING 2003 AMS6-E7 Ambient Air 12/11/2003 FS WWK-A-AMS6-E7 0 0T 335671 PFOA <0.00012 0.00006 MG/M3 0 PFOA AIR SAMPLING 2003 AMS6-E9 Ambient Air 12/19/2003 FS WWK-A-AMS6-E9 0 0T 335671 PFOA <0.00014 0.00007 MG/M3 0 PFOA AIR SAMPLING 2003 AMSFBLK-E1 Ambient Air 11/6/2003 FB WWK-A-AMSFBLK-E1 0 0T 335671 PFOA <100 50 NG/ML 0 PFOA AIR SAMPLING 2003 AMSFBLK-E10 Ambient Air 1/15/2004 FB WWK-A-AM