AR 236 - 3246 428 5102D46a7yO8:nlSuGbashvraogneiSeuTdoxyiciintyRts PS TRADE SECRET RAG 324-6 Dupon6554 Study Title 'H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Volume 4 of4 Laboratory Project ID: DuPont-6554 "TEST GUIDELINES: U.S.

In addition, historical control data is available from 13 chronic toxicity/oncogenicity studies conducted at DuPont Haskell Laboratory from 1984-87.

In addition, historical control data is available from 13 chronic toxicity/oncogenicity studies conducted at DuPont Haskell Laboratory from 1984-87.

DuPont Specialty Chemicals E.

P-1 ENVIRONMENT CANADA AND HEALTH CANADA CONSULTATIONS ON THE PROPOSED ACTION PLAN FOR PERFLUOROCARBOXYLIC ACIDS AND PRECURSORS REPORT OF CONSULTATION MEETING Ottawa, Ontario, Canada February 6 and 7,2006 P-2 Table of Contents INTRODUCTION............................................................................................................... 2 WELCOME/OBJECTIVES..............................................................................................3 PART 1 THE SCIENTIFIC CONTEXT................................................................... 4 PFCAs and Precursors: Simplified Terminology/Sources and Fate...............................4 Environmental Fate of Fluorotelomer Based Substances...............................................5 External Review and Science Update............................................................................. 8 PART 2 THE REGULATORY CONTEXT.............................................................. 8 Assessment and Management of Substances.................................................................. 9 PART 3 PROPOSALS ON PFCAs AND PRECURSORS...................................... 9 Overview o f Proposed Action Plan................................................................................. 9 Proposed Action Plan: New Substances....................................................................... 11 FEEDBACK ON PROPOSED ACTIONS FOR NEW SUBSTANCES.............12 Process for preparing a Regulatory Impact Analysis Statement.................................... 13 Proposed Action Plan: Existing Substances...................................................................14 FEEDBACK ON PROPOSED ACTIONS FOR EXISTING SUBSTANCES .. 14 Proposed Action Plan: Research and International Cooperation..................................16 CLOSING COMMENTS AND NEXT STEPS............................................................. 18 APPENDIX A: Consultation Agenda APPENDIX B: List of Participants Environment Canada Health Canada - PFCAs and Precursors: Action Plan Consultations - Report page 1 P-3 INTRODUCTION In 2004, the New Substances Program of Environment Canada and Health Canada assessed four new substances which are considered sources of perfluorinated carboxylic acids (PFCAs).

C8 was later determined not to be teratogenic by 3H and DuPont's Haskell Labs.

This research is funded by the CB Class Action Settlement Agreement (Circuit Court of Wood County, WV, USA) bctwcen DuPont and plaintiffs, which resulted from releases into drinking water of the chemical perfluorooceanoic acid (PFOA, or C8) .

DuPont has an external Epidemiology Review Board which will review this protocol, and - DuPont will provide technical be submitted for review and oversight approval for by the the durationofthe University of study.

AR226-2534 UNITED STATES NVIK0M-1ENTM.

THE USE OF PTFE IN THE CLOTHING AND FOOTWEAR INDUSTRY IS HARMFUL TO THE ENVIRONMENT AND HEALTH - AND THANKS TO EXISTING ALTERNATIVES, NOT ESSENTIAL A scientific opinion on the European Green Deal target "Transforming the EU's economy for a sustainable future: A zero pollution ambition for a toxic-free environment", with a focus on the PFAS group of substances under the EU Chemical Strategy for Sustainability, the EU Sustainable Product Initiative as well as the climate goals of the Paris Agreement.

DEPARTMENT OF THE NAVY naval research laboratory 4565 OVERLOOK AVE SW WASHINGTON DC 20375-5320 in s i p l y n c r t n to 3905 Ser 6180/0060 From: Commanding Officer, Naval Research Laboratory To: Commander, Naval Air Systems Command (Code 4.3.T Sinwell) Subj: ^ P R O V E D AFFF N TM E DEVELOPMENT 0 F AN ENVIRONMENTALLY Enel: (1) Two copies of subject report 1.

P-1 Taft/ Taft Stettinius & Hollister LLP 425 Walnut Street, Suite 1800/Cincinnati, OH 45202-3957 /Tel: 513.381.2838 /Fax: 513.381.0205 / www.taftlaw.com Cincinnati / Cleveland / Columbus / Dayton / Indianapolis / Northern Kentucky / Phoenix / Beijing R o ber t A.

It contains FYI submissions by 3M and DuPont, as well as administrative files.

Environmental Protection Agency EPA East, Mail Code 7405M 1200 Pennsylvania Avenue, NW Washington, DC 20460 From : Bob Buck, DuPont Subject : TRP Study Reports : Submission to AR-226 On behalf of the Telomer Research Program (TRP), the following study reports for work conducted by the TRP are submitted to the EPA for inclusion in Administrative Record 226.

Does no.een.aInTSCACB UJJSB1 DUPONT GLOBAL APFO COVSUIVPTI ON AND EM SSI ON Company Sanitized.