Document d8BKV9e1xQ6548vxdj7Xnwq5

AR 236 - 3246 428 5102D46a7yO8:nlSuGbashvraogneiSeuTdoxyiciintyRts PS TRADE SECRET RAG 324-6 Dupon6554 Study Title 'H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats Volume 4 of4 Laboratory Project ID: DuPont-6554 "TEST GUIDELINES: U.S. EPA Health Effects Test Guidelines 'OPPTS 870.3100 (1998) --_ AUTHOR: Don A. Delker, Ph.D STUDY COMPLETED ON: April 22, 2002 PERFORMING LABORATORY: E.L du Pont de Nemours and Company EHalskkteolnlRLoaabdo,raP.t0o.ryBfooxr 50Health and Environmental Sciences Newark, Delaware 19714-0050 WORKR!equestNumer (IN) SERVICE CODE None (ER) StooNov: CLINICAL PATHOLOGY --_ -_ wmgewoniom _ Gompany Sasitized. Dosa nok contain TSCAGBI 9H02-4D6a7y8O:raSlubGcahvraogneicStTuoxdiyciintyRats --~ DuPont6554 APPENDIX L INDIVIDUAL ANIMAL BIOCHEMICAL MEASUREMENTS IN MALE AND FEMALE RATS -- -- wm `Company Sanitized. Does not contain TSCA CBI 9H-02-4D6a7y8;OraSluGbavcaghe ronicStTuoxdiyciintyRats --_ Individual Animal Data In Male Rats At The 10-Day Time Point DuPont6554 Group Animal Beta-Oxidation Rate Number __(nmoV/min/mg protein) 1 664488332287 6976 664488333368 690s 648340 66 in 664488331196 8512 664488332205 7630 648335 134 v 664488331187 8632 664488333313 8715 648337 57 vii 660488332232 4632 --~ 664488332394 5a36 648339 60 xX 664488322911 114012 664488332264 29066 64833) 149 eee Company Sanitized. Doss not contain TSCA CBI 9$02.4Da6y7OrSuGbaevlaugoencStTuoxdiyciintyRats ~~ IRnadtisviAdtuTalheAn9i0m-aDlaDyaTtiamIen PMoailnet Dupont6554 Animal Beta-Oxidation Rate Group Number _(umol/min/mg protein) 1 6s1i55220457 19023 ssiiss330i7s 1904d sass 93 m 66155237042 273s ssiiss22979 17087 645303 84 v 64ci5s2a8s8 110017 6s4i8s30l5 110200 sisi 7 vi 645300 17 --~ Gsias2i59 81242 sis jr x iis522167 211777 Gsiiss2a4lss 214537 patin 157 --_ Company Senitized. Doss not contaun T5:A Cal 9H02-4D6a7y8:OraSluGbcahvraogneisStTuordiyciintyRats --~ Individual Animal Data In Male Rats At The 1-Month Recovery Time Point DuPont6554 Group 1 x Animal ~~ Beta-Oxidation Rate Number __(amoVmin/mg protein) 648222 145 648250 139 648260 122 648264 ns 648271 163 648241 22 648261 203 648277 2s 648284. 2s 648306 27 --~ --~ -- ww Company Saritzad. Doss net contain TSCA CBI H-24678: Subchronic Toxicity D -- 0S -- S-- AI ------------ GSH. --_ Individual Animal Data In Male Rats At The 3-Month Recovery Time Point Group 1 Animal Number 648298 648228 648297 648219 648226 Beta-Oxidation Rate _(amol/min/mg protein) 125 158 149 99 192 v 648283 132 648254 159 648310 135 648265 153 648253 20.1 vio 648279 2.1 648296 202 648314 126 ~~ 648285 166 648268 17.3 x 648292 216 648272 270 648234. 161 648240 22 648287 21 --- Tw Company Sanitized. Doss not contain TSCA CBI 9H-02-4D6a7y8:OraSlubGcahvraogneicSTtousdiyciintyRats --~ Individual Ani-mal Data In Female Rats At The 10-Day Time Point DuPont6554 Group Animal Beta-Oxidation Rate Number _(nmol/min/mg protein) I 664488446536 111506 664488445519 110377 648466 137 v 664488446486 15046 664438444554 17065 6asasl ol vi 664488444670 114316 664488445429 115380 648443 150 vi 664488446474 115917 --~ 664488445659 119468 648450 1338 x 664488446547 211667 664488444588 21915 64847] 184 --- we Company Sanitized. Doss not contain TSCA GBI 910.-2D46a7y8O:nlSuGbacvhargoeneStTuodsyicitnyRats -- Individual Animal Data In Female Rats At The 90-Day Time Point Dupont6554 Animal Beta-Oxidation Rate Group Number _(amolmin/mg protein) n 664488432913 115799 666444883344533160 211670 193 v 664483349069 648410 119452 146 664488336997 119954 vi 664488443036 1168s6 664488444114 117890 648366 180 vin 664488338810 71670 ~~ 664488444302 210892 648348 158 x 66448843736 227520 664488349027 215964 45347 218 --- wm Gompany Sanitizad. Does not contain TSCA CBI 9H0--2D46a7y5O:raSluGbcahvraogneicStTuoxdiyciintyRats --_ Individual Animal Data In Female Rats At The 1-Month Recovery Time Point DuPont655 Group I} x Animal Number 648389 648425 648434 648394 648426 648355 648378 648387 648419 648350 Beta-Oxidation Rate _(amol/min/mg protein) 202 177 142 185 182 201 28 219 197 26 --- `Company Sanilizsd. Does not contain TSCA OBI 9HL02-4D6a7y5O:ralSuGbcahvvaogneicSTotxiuciitdRyatys Individual Animal Data In Female Rats At The 3-Month Recovery Time Point DuPont6554 Group Animal Number 648356 648431 648422 648357 648405 Beta-Oxidation Rate _(amol/min/mg protein) 153 23 185 148 196 vi 648384 186 648365 152 648413 179 648385 156 vin 648349 267 648415 257 648379 21s 648386 197 ~ 648360 us X 648373 27 648358 184 648367 280 648391 27 casa 2.1 a `Company Senitizsd. Does rot contain TSCA C81 9102.4D6a7y8:OnSlubGeahrvoreicSTtuodsyicitnyRats -- Dupont655t APPENDIX M INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS --_ -- mw Gompany Senitzed. Doos not contain TSCA Cal Po plmsmme al pm i 3 : CL 8 Pod {5 |DRBRRZREZ E44 | BIGRASLERSR 5 P Popoo ppEmE mmE anl gnnaa a ii pam m3 mem ERIN RL F 40 iE i33Eiianed 3% ni5.igsapssrsEl 3 gi jaan ka pn C|]H memegp1]3 ma eene |0 B31i8g;Bii3m3pEnRaIaEaisEsY 3s8n fciggghipRsirImGsEauaEgYn {0 Bis ipsppsassl 2% pl: Poo diosa si i diosa TIER{0 Hi pismaaanmem Bip masEnEnEG fg DEESog puna f 28 ti lsmmsmessr| 7 ipemaseassl 4 ~~ 3i 5 Eg is : i i i iis Ad Iannis 33] i Po oi ai Loe i { e fr oa ggreade an - F ig i giEiRnEE ERpiEmERREm EANERe81 lp ERIE SE 3 IRNERIEANE BY or ae Diplo ppm Lo ind SHINEE J | iG E Li nnnnn #0 piifjaEmEmE #0 Mis Maman ~ EH piEE] gEREE BY i ~ og E Po] REY nm i 2 Plime th {1 iTgizeesseszmsasl || Jizmigzsssmeas! 8 [| gimme ah fasten : Bi ime al iineteeens! i 3 | pEERaRIE bH Cp ig| |zizvrmveremnpg | 3 mednERnEm ghia a gf seid) fos pM Ry a iEi EE Egiserganeeanpsi 51 3 aREREEAR AHS} Hmerg] B33 nl NEieeseest ig i | gi jeddddaadad dy 5 i3383333380 : 8 39 | iulE--isEcoEosRiaaIaaEri MtiTaiZzmaemsssEsi & 28 iE iarmeeasr | Cl lssmamscas. I{ CPo ogRigEwa Lode iq! 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E hR e' 3 CP o EgnE esssR ait snl bnpiseasmaamnns 3i Pop Benea Deeds i Hl fei] fmf] gn gt a (pF DIREIIEEEEE RO 0 DEEREEREED CNSme 1 naan Dre al nnn Po ppBiEsEEiaaid an RR SRRisAy i i of di55s3as3as 33 i di25ds3ddad) B3 SE pGainnmnnEaEgaiR samaE nee 28 FY mamessss | spnmeam ~ B 100 He i} LE FoaE aE PoadEe CihaEE ~ Hein | F HU iE s [E idE e CoE gd 0E0E1 iiI F iE ~8 ile J ; : ; !i : ; i: : ~~ g : {| E|1 B' mEEmIeHL Efmemie i= 5 pssa pee 3 Hi je a iH Hab I J gE Enns i[g8i] gii dgjisIAoRoASsAsRAeNeseAo3s1nyFgi5e4AeNAeRiAAiIRn] Poni giaueiaiad any ol gi3EREEEEEY 30Cb Fii sm e AEErepnieae S00 Figg izgssasase sp dipoizamsszaast i | i si isdssssass Ee 2 jisadssdsas i ) | SYmmm. ti mmmmanm of ~ 3d promEsE gEsms] og Poo oaE oF ~ EiigE FLEE die Bs B4 o1d3a3 ~8 itn i | ' :i ~ 3y3 o N : Lo i i Z | gbioos Phe] | 30 Pi Pina ~~ ig} ipa & 3 2 8 i gi iii B Pio g E opEPiO m eEeE aE edigH iL| d Hi PoogiTiimi ol IRE Cider aes A i = iB = Ho jan Bg i ~ 8 ple Ee ~I Po if Cam iRany g id or myLg fE Eioh ny iai![EIg LiTYE TnTrar8ey ~ g Cliblaemsa PEiid2 PHOiE mer a E pepL e a aE Pa A i 8 Bo ~ 238g 10 BpFhmEurmEwl iE pgl gulima awm aiJmzisdmieds asa HH HBoMgEe a gBfEalEEbEEeEErAet i Emse es Pi TEE i I 5I } .i ;i i: 9H02-4D6a7y8O:raSlubGcahvraogneicSTtouxdiyciitnyRats --~ DuPont6554 APPENDIX N INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS I Company Santized. Does not contain TSCA CBI 9H0--2D46a7y8O;raSluGbachvraogneiSctuTodxyiicintRyats ~~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: O mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648216 TKeirlmliendalonSDaacyrif: ic1e22 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorveorpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTAPRHYNOGDLEA,ND,THYMUS, TPHHYARROYNIXD/LGALRANYDN,X, PEAYREA(TSH)YRWOIIDTHGOLAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNVEESSIJCOLIENST,, USRTIERNNAORNY, BNLAODSDEER, TESTES, EPIDIDVIIDES, PP Histopathology + KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal THYROIADLTEGRLAATNIDON:, COLLOID, minimal. No uiLcIrVoEsRcopic Abnormality Observed : --- ww Company Sanitized. Doss not contain TSCA CBI H9-02.4D6a7y8O:raSluGbcahvraogneicSTtouxdiyciintyRats --_ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group: I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648219 KTeirlmliendalonSDaacyrif: ic1e83 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrencecorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NAL"SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, `PTHHAYRRYONIKD/LGALRAYNND,K, PAEVREA(TSH)YRWOIIDTHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, P`SEENMUIRN/AKLNVEEESIJCOLIENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology : r LIVER IFNAFTLTAYMMCAHTAINOGNE,, MSEUDBIAACNUTSC/LCEFHTR,ONImCi,ld.minimal. THYROAILDTEGRLAATNIDON:, COLLOID, minimal. --~ eT ------ Company Saniuzs. Lows uot contain TSCA CBI 9H02-4D6a7y8O:raSluGbcahvraogneieStTuoxdiyciintyRats DuPont6554 Showing anIinndailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648220 KTielrlmeidnalon SDaacyr:ific92e AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJEIJCUNLOYMM,PH ANDODREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TSPHHEYAMRRIOYNNIAXDL/LVGALERASYNINDC,XL,ESP,EAYREUA(RTSIH)NYARRWOYIITDBHLGALODAPDNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIENPE,ISDOIPPDHRYAONGSIUTDSA,ETSE,, FENUR/KNEE JOINT, STERNUM, NOSE Histopathology LaverINFLAMMATION, SUBACUTE/CHRONIC, minimal. No MiKIcDrNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y OSbKEsLeErTvAeLd M USCLE, SPLEEN, AORTA, SPBRAAANLICINRV,EAARSYS,PGILCNAEANCLDUSNC,,ORDMC,OALNODSNIT,BOUMALRCAEHRC,TULMYD,MUOPDMHEENSNUEOMDN,ET,ERJITECHJYUMNLUUYSMM,,PHAIDNLOREDUEEMN,,AL BGPYLASAR(NASDT)SH,YWRIOSTICHDIAOGTLPIATCNIDCNSE,RNVEERT,VREA,CPHIESTAKU,IINT,AESROYPPRHOGASLGTAUANTSDE,,, TPHSHYEARRMYOININKDA/LLGAVLREAYSNNIDK,C,LES, SUTREIRNNAURMY, BBLOADNDEERM,ARRTOEWS,TESN,OSEEPIDIDYNIDES, FEMUR/KNES JOINT, --~ ee recat `Company Sanitizsc. Doss not contain TSCACBI 9H0--24D6a7y8O;naSubGeahvraogneiSctTuodxiyicintRyats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings sa8222 TKeirlmliendalonSaDcaryi:fic12e2 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoerpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JESJPULNEOEMN., NAIODLDEREUE,MN,ALSAPGLALINAVCNRADERSAY,S,GLSACCNIEDASCT,I,CMCNAOENLRDOVINEB,,ULARPREICTTLUUYIMWT,PAHRMYENOSGDLEEAN,NTDE,RTHIYCMULSY,MPH TPSHHEAYWRRIYONNIAXDL/LVGAELRSAYINNDC,XL,ESP,EAYREUA(RTSIH)NYARRWOYIITDHBLGALODAPDNTEDIRSC,, NTETERRSVATEC,EHSE,AS,KIENPE,ISDOIPPHDRAVOGWSUITSDA,ETSE,, FENUR/KNEE JOINT, STERNUM, NOSE --~ Histopathology : LaverINFLAMMATION, SUBACUTS/CHRONIC, minimal. KIDNEYNESPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. No M"iTcHrYoRsOcIoDpiGcLANADbnormality Observed -_-- `Company Sanitized.Does notcontain TSCA CBI 9H0--2D4a67y8O;rSaulbGcahvraogneiSctTuodxiyciintRyats --_~ DuPont6554 Showing anIinndailviddautaal fAonrimailndiLviisdtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ret Microscopic & Macroscopic Findings 548225 KTeirlmliendalonSaDcayrif: ic92e AEnxipmoaslureisGrsoiugpned: o9f0fdafyr.om necropsy Gross Pathology : No MaLIcVrEoRs,coKpIiDcNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE:LETAL MUSCLE, SPLEEN, AIOLRETUMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUND,UODMEENSUEEN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, TPSHHEAYWRRIYONNIAXDL/LGVALERASYNINDC,XL,ES`,PEAYRUEA(RTSIH)NYARRWOYIITDHBLGAOLDAPDNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIZNPE,ISDOIPPDHRVAONGSIUTDSA,ETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology + ' LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal KIDNENYESPHROPATHY, CHRONIC PROGRESSIVE, minimal. PANCREARTSROP:HY, minimal. THYROAILDTEGRLAATNIDON:, COLLOTD, miniral. PROSTAITNEFLA:MMATION, SUBACUTE/CHRONIC, minimal 648225 Continued on the next page ... -- - CompanySanitized. Dossnotcontain TSCACal 9H0--2D4a67y8O;rSaulbGcahvraogneiStTuodxiyciintRyats ~~ DuPont6554 | iii Coin iro revs san Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals | Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males | Animal Ret Microscopic & Macroscopic Findings Histopathology / No MCiLOUcRNrDGo,Ss,coSpTHOiEMAcARCTAH,b,noSrDKmUEOaLDlEEiTNtAUyLM,OMUbSJsCeELrJEvU,eNdYS,P:LEIELNE,UM,AORCTEAC,UM,BRACIONL,ON,SPINAL RLEYCMTPUHM,NODMEE,SETNHTYEMRUISC, LAYDMRPEHNANOLDEG,LANSDASL,IVSACRYIATGLIACNDNSE,RVEM,ANDISULAR VPPEHISATRIUYCIILTNEAKSR/,YLARGUYLRNAIXNN,DA,RY'EPYBAELR(ASA)DTDHEWYRIR,TOHITDEOSGPTLTEAISNC,DSN,EERPVITEDR,IADCVHSMEKIAID,NE,SE,SSEOPPNHEIAMNGUAURLS/,KNEE JOINT, STERNUM, BONE MARROW, NOSE -- --_~ CompanySanitized. Dossnotcontain TSCACBI 9H0--2D4a67y8O;raSlubGeahvvaogreiSctTuodxiyciintRyats --_ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648226 TKeirlmliendalonSDaacyrif: ic1e83 EAnxipmoaslureisGrsoiugpned: 3offMonftrhomrneeccorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PINCAECLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNNDX,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMWUIRN/AKLNVEEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, --~ Histopathology + LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYRO`IADLTGELRAANTIDON:, COLLOID, minimal --~ --- `CompanySanitized. DossnotcontTSaCAiCnBI H9-02.4D6a7y8O:raSluGbachvraogneiSctTuodxiyciintRyats --~ DuPont6554 Showing anIinmdailviddautaal AfnoirmailndLiivsidtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648228 TKeirlmliendalonSaDcaryi:fic1e83 AEnxipmoaslureisGrsoiugpned: 3offMonftrhomrneeccorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLES, SPLEEN, AIOLRETUMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULIYTMAPRHYNGOLDEA,ND,THYMUS, TPHHYARROYNIND/LGALRAYNND,X, `PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNEVEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, --_ Histopathology + L1veRINFLAOGATION, SUBACUTE/CHRONIC, minimal THYRO`IADLTGELRAANTIDON, COLLOTD, minimal. - Ww Company Sanitized. Does not contain TSCA CBI 19.02.4D6a7y8O;nSlubGcohvraogneicStTuoxdiyciintyRats -- DuPont.6554 Showing anIinndailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : I - 0 m/ka/day Treatment: 0 mg/kg/day I Aninal Ret sus233 Microscopic & Macroscopic Findings TKeirlmliendalonSDaacyri:fic1e22 AEnxipnoaslureisGrsoiugpned: o1ffMonftrhomrneeccorveorpysy Sex: Males Gross Pathology Yo MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE:LETAL MUSCLE, SPLEEN, ANIOOLDREETU,AM,, SABPRLAANIICVNRA,ERAYSS,GPLIANCNEADCLSU,NC,OR`DMC,AONLDOSINTB,OUMLARACERHC,TLUYMMD,PUOHDMENEONSDUEEMN,,FERTJHEIYJCMUUNLSG,MH,G ATPDHHRYAERRYIONAIKLD/LGGALLRAAYNNNDDK,S,, PEASYRCEAI(TASTH)IYCRWOIINEDTRHVGELO,APNTDIPSCI,TNUETIRRTVAAECR,HYEAGS,KLIANNE,DS,OPPHRAOGSUTSA,TE, SFEENNUIRN/AXLONVEERSIJCOLIENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPADIDMIDES, -- Histopathology : LiveRINFLAMMATION, Koes SUBACUTE/CHRONIC, minimal. NHEYSDHRROONPSAPTHHRYO,STSC,HROUNNIILCATPERROAGLR,ESSmIiVnEi,nalm.inimal. Yo MiTcHrEoRsOcToDpiGcLANADbnormality Observed ~~ TE CompanySanitized.Dossnotconta Tcca 1902.4D6a7y5O:raSluGbalvraogneicSTtoxyiciitnyRts Duponts54 -- Showing anIinndailvidduaatla afnoirmailndLiivisdtuianlg animals Dose Growp : I - 0 mg/kg/day Treatment: 0 mo/kg/day T Sex: Males Animal Ref Hicroscopic & Macroscopic Findings pre ETKoxirplnolisenudarleonGSrDaoacuyrpif:ic5e290 day Aninal is sioned off from necropsy Gross pathology No MaLAIOcVRrEToRAs,,copKSiRIcADTNNEA,YmSo,SrPmTLaUNlNAiGLtS,yCORHODEb,AsReTrS,vTOeMdSAKCEHL,ETADLUODMEUNSGCNLE,, JESCEULNEOSM,, NATODLDEREGE,KI,ALSAPGLALNIACVNRADERSAY,S,GLSACCNEIDCASUTN,I,CMANCEONRLDVOIENB,,ULAPRREICTTLUUYIMMT,APRHYMENGOSDLEEAN,NTDE,RTHIICNGLSi,mp STPHEHANYRIRYNOIAIVLDK/VGLLEAASRNIYDCN,LEE,SP,EAYREUA(RTSIH)NYARWROIYITDHBGLLAOADPNDTDEISRC,, NETTRERVSAETC,EHSE,NS,KIENPS,ISOOIPROHOVASHGTIUADST,EES,. FEMUR KE JOINT, STERNUM, NOSE Histopathology tavaINFLAMMATION, xoNEYS : SUSACUTE/CHRONIC, minimal PANCRENAESPHR1OPATHY, CHRONIC PROGRESSIVE, minimal. AITNRFOLPAEMYM,ATImOiNn,inaSlU.BACUTE/CHRONIC, minimal THROTADLTEGRLAATNIDON, COLLOTD, EYE(S) WITH OPTIC NERVE | severe. srosTAATTRSOP+HY, RETINAL, minial. 648238 Continsed onTtNhFeLAnReAxTtIOpNa,geS.U.B.ACUTE/CHRONIC, minimal --_ -_--kmm-- mm Company Sanit. DossnotcontT8aCAicani 9H0L2D4a67y8:OraSlubGcahvraogneicStTuodnyciintyRats --_ Dupont 6554 Showing anIinndailvidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : T = 0 ma/kg/day Treatment: 0 mg/ka/day I Sex: Males Aninal Ref Microscopic & Macroscopic Findings sus238 Continued from previous page Histopathology : Yo MiLUcNrGoSs,copHiEAcRTA,bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edSP LEEN, AORTA, BRAIN, SPINAL CROERCDT,UM,STMOEMASCEHN,TERDIUCODELNYUMMP,H JNOEDJEU,NUMS,ALIILVEAURMY,GLCAENCDOSM,, CMOALNODNI,BULAR LPYIMTPUHITNAORDYE,GLATNHDY,MUSP,ARAATDRHEYNRAOLIDGLGALNADNSD,S, STCRIANCTKIECR,NEREVSEO,PHAGUS, TPEHSATREYSN,X/LSAPRIYDNIXD,VNISDKEISN,, SPEEMMUIRN/AKLNVEEESIJCOLIEWSI,, USRTIENRAWRMY, BLBAODNDEER, ARROW, NOSE --_ --_ I -- `Company Sanitizsd. Does not containTSCACai 9H0--24D6a7y8O:raSluGbachvraogneiScTuodxyiciintRyats --_ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648245 TKeirlmliendalonSbaacyrif: ic9e2 EAnxipmoaslureisGrsoiugpned: 90 day off from necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYNIXD/LGALRANYDN,X, PAEYREA(TSH)YRWOIIDTHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSREMMUIRN/AKLNVEEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDVMIDES, --_ Histopathology LiverINFLAMMATION, SUBACUTE/CHRONIC, minimal. THYRO`IADLTGELRAANTIDON, COLLOID, mild. No MiKIcDrNoEsYcSo,picLUNAGbSn,ormHaEAlRiTt,y OSbKsEeLrEvTeAdL MUSCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUND,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ILNEOUDME,, SGLAALNIDVSA,RYSGCLIAANTDISC, NMERAVNED,IBUPLITAURITLAYRMPYHGLNAONDDE,, TPHAYRMAUTSH,YRAODIRDENGLAALNDS, 648246 Continued on the next page .... --~ --- Company Sanitized. Doss not contain TSCA CBI 9H0--2D4a67y8O;raSluGbachvraogneicSTtouxyiicintRyats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648246 Continued from previous page Kistopathology : No miTcRArCoHsEcAo,picESOAPbHnAoGrUmSa,litPyHAORbYNsKe/rLvAeRdYN:X, BUYRBI(NSA)RYWIBTLHADDOEPRT,ICTENSETREVSE,, SSKPIIND,IDYPMRIODSETSA,TE,FESMEURM/IKNNAELEVEJSOIICNLTE,S, STERNUM, BONE MARROW, NOSE ~~ --~ EE -- `Company Sanitzed. Does not ortain TSCA cay 9H0L-24D6a7y8O;raSlubGcahvraogneiStTuodxiyciintRyats -- DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Growp : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648247 TKeirlmliendalonSDaacyrif: ic9e2 AEnxipmoaslureisGrsoiugpned: o90ffdafyrom necropsy Gross Pathology No MaLcIrVEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJIECJUNLUYMM,PH NAODDREE,NALSALGLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYINKD/LGALRAYNNDX,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEEMMUIRN/AKLNEVEESIJCOLTENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYHIDES, -- Histopathology : LaverINFLAMMATION, SUBACUTE/CHRONIC, minimal KIDNEYNESPH+ROPATHY, CHRONIC PROGRESSIVE, minimal. PROSTAITNEFLA:MMATION, SUBACUTE/CHRONIC, mild. No MiLUcNrGoSs,copHiEAcRTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL `CCOOLRODN,, ST`ROEMCATCUHM,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODTEL,EUMS,ALIPVAANRCRYEAGSL,ANDCSE,CUM, MNEARNVDEI,BULPAIRTULIYTMAPRHY GNLOADEN,D, TTHYHMYURSO,IDADGLRAENNDA,L GPLAARNADTSH,YRSOCIDIATGLIACNDS, 648247 Continued on the next page ... --~ mie: Company Sanitized.Doesnotvontain Tscacay H9L02.4D6a7y8O:raSlubGeahvvaogneicStTuodxiyciintyRats Dupont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Aninal Ref Microscopic & Macroscopic Findings sa207 Continued from previous page Histopathology : Ho MiTcRArCoHsEcRo,picBSAObPHnAoGrUmSa,litByHAORbYsNeKr/vLeAdRY:R, EBYLEA(DSD)ER,UITTHESTOEPST,ICENPEIRDVIED,YNISDKEISN,, BONE MARKO, NOSE FSEEMMUIRN/AKLNVEESSIJCOLIENST,, USTREIRNNAURMY, -- -- Te rte `CompanySaniizec. Dossnotcontain TSCACBI H9-02-4D6a7y8O:rSaulbGcahvraogneicSTtouxdiyciintyRats --_ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Rot Microscopic & Macroscopic Findings 648250 TKeirlmliendalonSDaacyrif: ic1e22 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,X, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNVEEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, SPYDIDYMIDES, --_ Histopathology LIVER:FATTY CHANGE, MEDIAN CLEFT, minimal. xroNEYISNFLAMMATION, SUBACUTE/CHRONIC, minimal. THYRONIEDPHGRLOAPNADTH:Y, CHRONIC PROGRESSIVE, minimal. ALTERATION, COLLOID, mild. - ws `CompanySanitzed.Doss notcontain TSCACBI 02-4D6a78yO:rSaulbGcahvraogneicSTtousdyiciintRyats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl aninals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648255 TKeirlmliendalonSaDcaryif:ic9e2 ASnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLOMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYINXD/LGALRAYNNDX,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPERAOGSUTSA,TE, SFERMMIUNRA/LKNEVEESIJCOLTENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYVNIDES, --_ Histopathology : LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. HEARTCA:RDIOMYOPATEY, minimal. No MiKIcDrNoEsYcSo,picLUNAGbSn,ormSaKlEiLtEyTALObMsUeSrCvLeEd, : SPLEEN, AORTA, BRAIN, CSEPCIUNMA,L CCOOLRODN,, SRTEOCNTAUCMH,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPAVNACRRYEAS, GSLCAINADTSI,C NMEARNVDEI,BULPAIRTULIYTMAPRHY NGOLDAEN,D, THTYHMYURSO,IDADGLRAENNDA,L GLANDS, 648255 Continued on the next page .... --~ --- ws `Company Sanitized. Does not cantain TSCA CBI 9F0--2D4a6y78O;raSlubGcehvraogneicSTtouxdiyclitnyRats DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648255 Continued from previous page Histopathology : No MiPcArRoAsTcHoYpRiOcIDAbGLnAoNrDmSa,litTRyACOHbEsRe,rveBdSOP:HAGUS, PHARYNK/LARYNE, UERYIE(NSA)RYWIBTLHADDOEPRT,ICTENSETREVSE,, ESKPIIND,IDYPMRIODSETSA,TE,PESMEUMRI/NKANLEEVEJSOIINCTL,ES, `STERNUM, BONE MARROW, NOSE --_ - = Company Santized. Dossnotcontain TSCA CBI 9H0--2D46a7y8O;raSluGlachvraogneiSctTuodxyiicintRyats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Animal Ref Microscopic & Macroscopic Findings 648256 TKeirlmliendalonSDaacyrif: ic9e2 AEnxipmoaslureisGrsoiugpned: o90ffdafyrom necropsy Gross Pathology : Sex: Males No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUVMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYOIINDK/GLLAARNYDN,K, PAEVREM(TSH)YRWOIITDHGOLAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNEVEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology + LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal KIDNEYNESPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. PANCREAATSROPHY, minimal. . PARATNHOYTROIPDRESGELNATN.DS 648256 Continued on the next page .... --_ - CompanySenitized. Dossnot contain TSCACBI H9-02-4D6a7y8:OraSlubGcahvraogneicStTuodxiyciintyRass PS DuPont655 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Wales Animal Ref Microscopic & Macroscopic Findings 648256 Continued trom previous page Histopathology No MiLOcNrGoSs,copHiEAcRTA,bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL CROERCDT,UM,STOWMEASCEHN,TERDIUCODELNYUMMP,H NJOEDJEU,NUMS,ALIIVLEAORMY, GLCAENCDOSM,, CMOALNODNI,BULAR LPYIMTPUHITNAORDYE,GLATNHDY,MUST,HYRAODIRDENAGLLANGDL,ANDTSR,ACHSECAI,ATIECSOPNHEARGVEU,S, `PSHEAMRIYNNAXL/LVAERSYINCXL,ES,'EYUER(SI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRVOMSITDAETSE,, FEMUR/KNGE JOINT, STERNUM, BONE MARROW, NOSE -- CompanySanitized. Doss notcontainTSCA CBI 9H0--2D46s7y8O;rSaulbGcahvraogneiSctTourdiyciintRyats DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648257 TKeirlmliendalonSDaacyrif: ic12e2 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANTCNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEYN,TERJIECJUNLUYMM,PH NAODDREE,NA'LSAGLLIAVNADRSY, GL`ASCNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,X, PAEVREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMUIRN/AKLNVEEESIJCOLIENST,, USTREIRNNAUREY, BNLAODSDEER, TESTES, EPIDIDVIIDES, --_ Histopathology LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYFSATT: Y CHANGE, MEDIAN CLEFT, minimal. THYROINDEPHGRLOAPNADTHY, CHRONIC PROGRESSIVE, minimal. ALTERATION, COLLOID, moderate. -- TTT = CompanySanitized.DoesnotcontainTSCACBI H9-02-4D6s7y8;OraSluGbcahvraogneicSTtouxdiyciintyRats DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : T - 0 mg/kg/day Treatment: O mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648260 KTeirlmliendalonSaDcaryif: ic1e22 EAnxipmoaslureisGrsoigunped: o1ffMonftrhomrneeccorveorpysy Gross Pathology LIVERHE:RNIA, INVOLVING DIAPHRAGH. No MaKIcDrNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y SOKbEsLeErTvAeLd M: USCLE, SPLESN, AORTA, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJIECJUNLUYMM,PHINLOEDUEM,, GSLAALNIDVSA,RYSCGILAANTDISC,NEMRAVNED,IBUPLIATRUITLAYRMYPHGLNAONDDE,, TTHHYYNRUOSI,D AGLDARNEDN,AL EPYAER(AST)HYWRIOTIHD GOLPATNIDCS,NERTVREA,CHESAK,IN,ESOPPRHOASGTUAST,E, PSHEAMRIYNNKA/LLAVREYSNIXC,LES, -- USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYNIDES, FEMUR/XNEE JOINT, Histopathology LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal KIDNEYASTT:Y CHANGE, CENTRILOBULAR, minimal THYRONIEDPHGRLOAPNADTH:Y, CHRONIC PROGRESSIVE, minimal. `ALTERATION, COLLOID, minimal --- `Company Saniized.Dossnotcontain TSCA CBI H9-2046-78O:DnaaSuGbyaehvraogneicSTotxiiucintdRyayts -- DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ret Microscopic & Macroscopic Findings 648260 TKeirlmliendalonSaDcaryi:fic12e2 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoerpysy Gross pathology + No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GL`ASCNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYOIINDX/GLLAARNYDN,K, PAEYREA(TSH)YRWOIITDHGOLAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFERMMIUNRA/LKNEVEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, --_ Histopathology LIVER:TNFLAMMATION, SUBACUTE/CHRONIC, minimal. No MiKIcDrNoEsYcSo,picTHAYbRnOoIrDmGaLlAiNtDy Observed : --_ `Company Saniized. Doesnotcontain TSCACal H90--2D4a6y78O:raSluGbchraonivSctTuoadxiycigintRyaets -- DuPont6554 Showing anIinrdailvidduaatal AfnoirmailndiLviisdtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648271 TKeirlmliendalonSaDcaryif: ic1e22 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoerpysy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUIYTMAPRHY NOGDLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNNDX,, PEAVREA(TSH)YRWOIITDHGOLAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFERMMIUNRA/LKNEVEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology : LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal. No MiKcIDrNoEsYcSo,picTHAYbRnOoIrDmGaLlAiNtDy Observed --_ TTT ------TT-- `Company Senitized.Does notcontain TSCA CBI H-24678: Subchronic Toxicity 90-DayOralGavageStudyinRats --_ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings sa8278 TKeirlmliendalonSaDcaryi:fic1e22 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrencecorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDRSE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTAPRHYNGOLDEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,K, PAEVREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEENMUIRN/AKLNVEEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPXDIDVNIDES, --_ Histopathology : LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYFSATT: Y CHANGE, MEDIAN CLEFT, mild NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No MiTcHrYoRsOcIoDpiGcLAANbDnormality Observed --_ - `Company Sanitized. Doss not contain TSCACBI 9H0-.2D46a7y8O;naSubGeahvraogneiSctTuodxiyicintRyats --_ DuPont6554 Showing anIinmdailvidduaatla AfnoirpailndLiivsidtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648204 ADucrcaitdieonntalolfydoKsiilnlge-ddays: 38 AEnxipmoaslureisGrsoigunped: o9f0fdafyr.om necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUMA,, BPRAANICNR,EASS,PICNHACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJEIJCUNLUYMM,OH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIWTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYINXD/LGALRAYNNDX,, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNEVEESIJCOLIENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, Histopathology + LIVERTNFLAVMATION, SUBACUTE/CHRONIC, minimal. No wiKIcDrNoEsYcSo,picLUNAGbSn,ormHaEAlRiTt,y SOKbEsLeErTvAeLd M:USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLONC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLGYHM,PH INLOEDUEM,, GSLAALNIDVSA,RYSGCLIAANTDISC, NEMRAVNED,IBUPLIATRUITLAYRHYPHGLNAONDDE,, TTHHYYMRUOSI,D GALDARNEDN,AL EPYAER(AST)HYWRIOTIHD GOLPATNIDCS,NERTVREA,CHESAK,IN,ESOPPRHOSATGAUTSE,, PSHAERMYIVNNAKL/LVAERSVINKC,LES, SUTREIRNNAURYY, BLBAODNDEERM,ARRTOEWS,TESN,OSEEPIDIDYMIDES, FEMUR/KNEE JOINT, -- J `Company SanDoiestnoiiconztaineTSCdA C.BI 9H0--2D46s7y8O;raSluGbcahvraogneicSTtouxdiyciintyRats --~ DuPont6554 Showing anIinrdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day T Sex: Males Animal Ref Microscopic & Macroscopic Findings 648297 TKeirlmliendalonSDaacyrif: ic1e83 EAnxipmoaslureisGrsoiugpne:d o3ffMonftrhomrneeccorveorpysy Gross Pathology No MaLIcVrEoRs,coKpIiDcNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLGYHMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, TSPHEHYMARIRONYIANXDL/LGVALERASYNIDNC,KL,ESP,ASYREAU(TRSIH)NYARRWOYIITDHBLGALODAPDNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIENEP,SIODPIPHDRAVOGNSUITSDA,ETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology + rm THYROAILDTEGRLAATNIDON, COLLOID, mild No MiLcIrVoEsRcopic Abnormality Observed : --~ TTTe Company Sanitized. Does not contain TSCA CBI 9H02-4D6s7y8O;raSlubGcahvraogneicSTtouxdiyciintyRats DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648298 TKeirlmliendalonSaDcaryif: ic1e83 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrneeccorvoeprsyy Gross Pathology : T2sTSSDISCOLORATION, OPAQUE, LEFT. No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,IC MNAENRDVIEB,ULAPRITLUYIWTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALARNYDN,X, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, --_~ SJOEIMNITN,ALSVTEERSNIUCML,ES,NOUSERINARY BLADDER, EPIDIDYMIDES, FEMUR/XNEE Histopathology + LIVERFATTY CHANGE, MEDIAN CLEFT, minimal. THYROTADLTEGRLAATNIDON:, COLLOID, minimal --~ i CompanySanitized.DoosnotcontTSaCAiCanf F90--2D4a6y78O:naSubGcahvraogneicSTotxiiucintdRyayts --_~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Rot Microscopic & Macroscopic Findings 648307 TKeirlmliendalonSDaacyri:fic9e2 AEnxiproaslureisGrsoiugpned: o9f0fdafyr.om necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,X, PABYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEEMMUIRN/AKLNVEEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDYNIDES, -- Histopathology LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. THYROAILDTEGRLAATNIDON:, COLLOID, minimal. `PHARYIINNFK/LLAAMRMYANTKION, SUBACUTE/CHRONIC, minimal 648307 Continued on the next page --~ Tr ---- CompanySanitized, ossnotcontainTscaca) 9204D6a7y8O:nlSuGbocvhreonicStudyToxiciintRyats -- Duoncess Showing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males nial Ref Nicroscopic & Macroscopic Findings 548307 Continued from previous page Histopathology No MLiUcNrGoSs,copHiEAcRTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL MCCOOALRNODDN,I,SUSLRTEOACMRTAUCLMHY,,UPHMDEUNSOODEDENENT,UEMR,ITHCYJWELUJYSUW,NPGHNA,DNORDEIENL,AEULMS,GALLAIPNVADNASCR,RYEAGSSLC,AINADCTSEI,CCUM, NEESROVPEH,AGUPSI,TUIETYAE(RSY)GLWAINTDH, OPPTAIRCATNHEYRRVOEI,D GSLKAINN,DS,PROTSRTAACTHEE,A, SEMINAL VJOEISNITC,LESS,TEURRINN,ARYBONBLEADMDAERRR,OW,TESNTOESSE, EPIDIDYMIDES, FEMUR/KNES ~~ --- CompanySenftized. DossnotcontainTSCA Ca 29H00-D-24aD6ay7yO8O:unlSauGbGecahvragogneiSeSutTuodxdyiciiintnyRRatass --_ DDuuePomnts6s5s54t Showing anIinmdailviddautala AfnoirmailndLiivsidtuianlg animals Dose Group: I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648311 KTeirlmliendalonSaDcayrif: ic12e2 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoeprsyy Gross Pathology : No MAaLOIcRVrTEoARs,,coBpKRiIAcDINNEA,YbSn,SoPrImLNUaNAlGLiSt,CyOROHDEb,AsReTSr,TvOeMSdAKCE:HL,ETADLUODMEUNSUCML,E,JESJPULNEUEMN,, NAIODLDREEUE,MN,AL`SPAGALLNIACVNRADERSAY,S,GLSACCNEICDAUSTN,IM,CMACNEONRLDVOIENB,,ULARPREICTTLUUYIMMT,PAHRYMNEOGSDLEEAN,NTDE,RTHIYCMULSY,MPH TPHHYARROYNIXD/LGALRAYNND,X, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMUIRN/AKLNVEEESIJCOLIENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDVMIDES, Histopathology r LIVER THYROIIDNFGLALMAMNADTION, SUBACUTE/CHRONIC, minimal. ALTERATION, COLLOID, minimal. No MiKcIrDoNsEcYSopic Abnormality Observed : --_ _--mm oe ------- `Company Saniized. Doesnotcontain TSCA CBI 9H0--2D4a6y78O:raSullGbacvhraogneiSctTuodxiyciintRyats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ret Microscopic & Macroscopic Findings 648315 TKeirlmliendalonSDaacyrif: ic92e AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology No MLaIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIXD/LGALRAYNDN,X, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNEVEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDVMIDES, --_~ Histopathology + LIVER:INFLAMMATION, SUBACUTS/CHRONIC, minimal. PANCREARTRSOPHY, minimal. THYROAILDTEGRLAATNIDON:, COLLOID, minimal EYE(S)FOLWDI/TRHOSOEPTTTIEC, NERRETVIEN:AL, minimal NOSE O: DONTODYSPLASTA, minimal. 648315 Continued on the next page .. --_ EE + -- `CompanySanitized.DoesnotcontainTSCA CBI --~ 20 H9-002-4DD6a7y8OO;ruSalulGbaGcvahavrgaogeneiSctSTutoduxydiyicinitnRyaRattss DDuuoPomnt66s5s54d Showing anIinmdailviddautaal AfnoirmailndLiivsidtuianlg animals Dose Group : I - 0 mg/kg/day Treatment: 0 mg/kg/day I Sex: Males Animal Ref Microscopic & Macroscopic Findings 648315. Continued from previous page Histopathology No MiKcIDrNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y OSbKsEeLErTvAeLd M:USCLE, SPLEEN, AORTA, BCREACIUNM,, CSOPLIONNA,L CROERCDT,UM,STOMMEASCEHN,TERDUIOCDELNYUMMP,H NJOEDJEU,NUMS,ALIILVEAURMY, GSLCAINNDTSI,C NMEARNVDEI,BULPAIRTULIYTMAPRHY GNLOADNED,, THPYAMRUAST,HYARDORIEDNGALLANGDLSA,NDS, TVJOREIASNCITHC,ELAE,SS,TEERUSNROUPIMHN,AAGRUYBSO,BNLEAPDMHDAAERRRYR,NOXW/TLEASRTYESN,X, EPSIKIDNI,DYNPIRDOESST,ATEF,ENUSRE/MKINNEAEL --_ - `Company Sanitized. DoesnotcontTSaCAiCBnI 9B02.4D6a7y8O:raSluGbasvoangiecSTtodiiintyRas Ps Duroncsst Showing anItnedsi)vidGuaatla AfnoirmailndLiivsidtuianlg anivals Dose Group : ITI - 60 ro/ka/day (Iso) Treatment: 60 mo/ko/day TTI Sex: Males Raima net Microscopic & Nacroscopic Findings Sawn TKeirlmliendalonSaacyrif: ic5e AEnxipnoaslureisGrsoiugpn.e:d o3f0fdafyron necropsy Gross Pathology : No MAaLOIcRVrTEoARs.,coBpKRiIAcDINNEA,YbSn,oSrPLmIUaNNlAGiLSt,CyORHODEb,AsReESr,TvOeMdSAKCE:HL,ETADULODWEUNSUCML.E, JSSPTLOENEMN,, ANIOOLDEREGE,HA,LSAPGLALINAVCNRADERSAY,S,GLSACCNRIDCFSUI,N,CANONEDLRINVBES,,LARRP.EICTTLUUYIMHT,PAHRMYENOSGDELENA,TDE.RTIHCRss:pi TBSHEHYNARTRONYIANDL/LGVALERASYNINDCK,L,ESB,AEYRUEA(RTSIA)NYARRWOYIIDTBHLGALODAPDNTEDIRSC,, NETTRERVSAETC,EHSE.AS.KISNPE.8IbDPPIHRDAOGAGUIPSAN.GI,SE,. FERUR/KE Some, STERN, HOE Histopathology ~ HLaHvReOnISDNPGLAASDNTION, SUBMCUTE/CHAOHTC, minimal. AUTSRATION, COLLOTD, severe. No Mipcrrosecopic Abnormality Observed --_-- Company Sanitized.Dossnotcontain TScA cat F9-02-4D6a7y8O;raSlubGcahvraogneiSctTuodxiyicintRyats DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : III - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day III Sex: Males Animal Ref Microscopic & Macroscopic Findings 648232 TKeirlmliendalonSDaacyrif: ic92e AEnxipmoaslureisGrsoiugpne:d 90 day off from necropsy Gross Pathology POPLIMTAESASL, LYLEWFeTH, NO6DXEeX3 CM DIA. No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLOaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUND,UODMEENSUEMN,TERJIECJUNLUYYM,PH ANODDREE,NA'LSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNGOLDEA,ND,THYMUS, PTHHAYRRYOIINDX/GLLAARNYDN,X, PAEYREA(TSH)YRWOIIDTHGOLAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, --_ SFEEMMIUNRA/LKNEVEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDVITDES, Histopathology : LiverINFLAMMATION, SUBACUTE/CHRONIC, minimal POPLITHEEAMLANLGyIMOPSHARNCOODMEA:(x) No miKIcDrNoEsYcSo,picTHAYbRnOIoDrmaGlLiAtNyD Observed : (BI<BENIGN, [M) MALIGNANT -- --_--m CompanySaniizsd,`DossnotcontainTsca cay 9H02-4D6a7y8O:raSluGbachvraogneiSctTuoxdiyciintRyats -- DuPont6554 Showing anTinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : III - 60 mg/ky/day (Iso) Treatment: 60 mo/kg/day III Sex: Males Animal Ret Microscopic & Macroscopic Findings 648252 TKeirlmliendalonSaDcaryif: ic9e2 AEnxipmoaslureisGrsoiugpne:d o9f0fdafyr.om necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDASP,IC MNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNNDX,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEEMMUIRN/AKLNEVEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYNIDES, Histopathology : --~ LIVER INFLAMMATION, SUBACUTE/CHRONIC, minimal. No MiKcIDrNoEsYcSo,picTHYARbOnIorDmGaLliAtNyD Observed : --~ - ww `Company Sanitized. Doss not contain TSCA CBI H90--2D4s6y78O;raSluGbacvhraogneiScuTdoxyiicintRyats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group: III - 60 ma/kg/day (Iso) Treatment: 60 mg/kg/day IIT Sex: Males animal Ret Microscopic & Macroscopic Findings 648258 KTeirlmliendalonSDaacyrif: ic5e2 AEnxipmoaslureisGrsoigunped: o9f0fdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,ONARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMW,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNTDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `SPTEHHMAYIRRNYONAIXLD/LVGAELRSAYINNDC,XL,ESP,EAVREUA(RTSIH)NYARWROIYITDHBGLLAODAPDNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIENPE,ISDOIPPDHRYAONGSIUTDSAE,TSE,, FEMUR/KNES. JOINT, STERNUM, NOSE -- Histopathology : LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROIADLTEGRLAATNIDON, COLLOTD, minimal. No MiKcIDrNoEsYcSopic Abnormality Observed : --~ i-- CompenySanitized.Doesnotcontain TSCA CBI 9H-02-4D6a7y8O:raSluGbachvraogneieSTtouxdiyciintyRats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : III - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day III Sex: Males Animal Ref Microscopic & Macroscopic Findings 648269 TKeirlmliendalonSaDcaryif: ic9e2 AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NASLAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNNDX,, PBAYREA(TSH)YRWOIIDTHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, F`SEEMMUIRN/AKLNVEEESIJCOLIENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, --_~ Histopathology LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYFSATTY CHANGE, MEDIAN CLEFT, minimal. THYROINDEPHGRLOAPNADTH:Y, CHRONIC PROGRESSIVE, minimal. ALTERATION, COLLOID, minimal. --~ --- ww CompenySaniized. DossnotcontainTSCACal 9H-02-4D6a7y8O;raSlubGcahvvaogneicStTuodxiyciintyRats --_ DuPont6554 Showing anIinrdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : III - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IIT Sex: Males Animal Ret Microscopic & Macroscopic Findings 648274 TKeirlmliendalonSaDcaryif: ic9e2 AEnxipmoaslureisGrsoigunpe:d o90ffdafyr.om necropsy Gross Pathology : No MaLcIVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULIYTMAPRHYNGODLEA,ND,THYMUS, `PTHHAYRRYONIKD/LGALRAYNND,K, PAEVREA(TSH)YRWOIXTDHGOLAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNEVEESIJCOLIENST,, SUTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, -- Histopathology LIVER:TNFLAMMMTION, SUBACUTE/CHRONIC, minimal. THYROIADLTEGRLAATNIDON:, COLLOID, minimal No uiKcIrDoNsEcYSopic Abnormality Observed --_ = --- CompanySanitized. DoesnotcontainTSCACBI H-24678; Subchronic Toxicity 90-DayOral GavageStudyinRats DuPont6554 Showing anIinrdailviddautaal AfnoirmailndiLviisdtuianlg animals Dose Group : III - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day III Sex: Males Animal Ref Microscopic & Macroscopic Findings 648290 TKeirlmliendalonSDaacyrif: ic92e AEnxipmoaslureisGrsoiugpne:d 9o0ffdafyr.om necropsy Gross Pathology : No MaLIcVrEoRs,coKpIiDcNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODWEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,ND,THYMUS. `PTHHAYRRYONIXD/LGALRAYNND,X, PAEYREA(TSH)YRWOIITDHGOLAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEEMMUIRN/AKLNVEEESIJCOLIENST,, USRTIERNNAURMY, BLNAODSDEER, TESTES, EPIDIDYHIDES, Histopathology + LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal THYROIFDATGTYLACNHDAN:GE, MEDIAN CLEFT, mild. ALTERATION, COLLOID, minimal. No MiKcIrDoNsEcYSopic Abnormality Observed : EE J -- Company Sanftized. Dose not contain TSCA CBI 9H02-4D6a7y8O:raSlubGcahvraogneicStTuoxdiyciintyRats DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : IIT - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IIT Sex: Males Animal Ref Microscopic & Macroscopic Findings 648299 TKeirlmliendalonSaDcayrif: ic9e2 AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKIiDcNEAYbSn,orLmUaNlGiSt,y Observed HEART, SKELETAL MUSCLE, SPLEEN, ATOLREUTMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND.THYMUS, TPHHYARROYNIXD/LGALRAYNND,X, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, F`SEEMMUIRN/AKLNVEEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology : --~ LIVER THYROIIDNFGLALGAINADTI:ON, SUBACUTE/CHRONIC, minimal. `ALTERATION, COLLOID, minimal No MiKcIrDoNsEcYoSpic Abnormality Observed : -- -- w= CompanySanilized. Doesnotcontain TSCA Caf 9H0--2D4s6y75O:raSulbGcahvraogneiScTtoxyiicintRyats DuPont6554 -- Showing anIinmdailviddautaal AfnoirmailndLiivsidtuianlg animals Dose Group : IIT - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IIT Sex: Males Animal Ref Microscopic & Macroscopic Findings 648302 TKeirlmliendalonSDaacyr:ific9e2 AEnxipmoaslureisGrsoiugpned: 9o0ffdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHbEsAReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,X, PEAVREA(TSH)YRWOIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEENMUIRN/AKLNEVEESIJCOLINETS,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology --~ LIVER: FIANTFLTAYMMCAHTAINOGNE,, MSEUDBIAACNUTEC/LCEFHTR,ONImCi,nimmailniral. KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. THYROIADLTEGRLAATWIDON:, COLLOTD, miniral. --_ BR Company Sanitized. Does not containTSCAGBI 9H-02.4D6a7y8O:nSaubGcahvraogneicStTuoxdiyciintyRats ~~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : III - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IIT Sex: Males Animal Ref Microscopic & Macroscopic Findings 648303 TKeirlmliendalonSDaacyrif: ic9e2 AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, AILRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,NA'LSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULYIMTSAHRYNOGDLEA,ND,THYMUS, TPHHYARROYIIKD/LGALRAYNNDK,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMTUNRA/LKNEVEESIJCOLTENST,, USTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDVMIDES, Histopathology : --_ Laver THYROIIDNFGLLAMAMNADTI:ON, SUBACUTE/CHRONIC, minimal. `ALTERATION, COLLOID, mild. No MiKcIrDoNsEYcSopic Abnormality Observed : -- --- ws `Company Sanitzed. Does notcontain TacA oat 9H0--2D4a67y8O:raSluGbacvhargoenSitTuodxyiicintRyats ~~ DuPont6554 Showing anIinmdailviddautaal AfnoirmailndLiivsitdiunagl animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ret Microscopic & Macroscopic Findings 648221 TKeirlmliendalonSaDacyrif: ic92e AEnxipmoaslureisGrsoiugpne:d o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYIGD/LGALRAYNNDK,, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNEVEESIJCOLTENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology : --~ LIVER NIENCFRLOASMIMSA,TIOFNO,CALS,UBmAiCnUiTmEa/lC.HRONIC, minimal. KIDNE'YHSY:DRONEPHROSTS, UNILATERAL, mild. No MiTcHrYoRsOcIoDpiGcLAADbnormality Observed : --- ww `Company Sanitized.DoesnotcontainTSCAC1 9H0-2-4D6a7y8:OrSaulbGcahvroangiecSTtouxdiyciitnyRats --~ DuPont.6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648220 TKeirlmliendalonSaDcayrif: ic92e AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross pathology : No MAaLOIcRVrTEoARs,,coKBpRIiADcINNEA,YbSn,oSPrILmUNaNAlGLiSt,CyOROHDEb,AsReTrS,TvOeMSdAKCE:HL,ETDAULODMEUNSGCYL,E, JESJPULNEUEMN,, NAIODLDEREUE,MN,ALSAPGLALNIACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMACNOENLRDOVINEB,,ULARPERICTTLUUIYMTM,APRHYWENGOSLDEEAN,NTDE,RTHIYCMULSY,MPH TPSHHEYAMRRIYONNIAXDL/LVGAELRSAYINNCDKL,,ESP,EAYREUA(RTSIH)NYARRWOYIITDHBGLLAODAPDNTEDIRSC,, NTTEERRVSAETC,EHSE,AS,KIENPE,ISDOIPDDHRYAOMGSIUTDSA,ETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : r LIVER THYROIIDNFGLALMAMNADTI:ON, SUBACUTE/CHRONIC, minimal. ALTERATION, COLLOTD, minimal No MKiIcDrNoEsYcSopic Abnormality Observed --~ - `Company Sanitzed. Doesnotcontain Tacar | 0HL-2D4a67y8O:raSuGbachvraogneiSctTuodxyiicintRyats ~~ DuPont6554 Showing anIinndailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Growp : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ret Microscopic & Macroscopic Findings 648205 KTeirlmliendalonSaDcaryif: ic9e2 ASnxipmoaslureisGrsoiugpne:d o9f0fdafyr.om necropsy Gross Pathology : No MaALOIcRVrTEoARs,,copKBiRIAcDINNEA,YbSn,oSrPmILaNUNlAGiLSt,yCORHODEb,AsReTrS,vTOeMdSAKCE:HL,ETADLUODMEUNSUCML,E,JESJPULNEUEMN,, ANIDOLDREEUE,MN,AL'SPAGALLNTACVNRAEDRASYS,,GLSACCNIEDCASUT,MI,CMANCEONRLDVOIENB,,ULAPRREICTTLUUYIMMT,APRHYMENGOSLDEEAN,NTDE,RTHIYCMULSY,MPH `SPTHEHAMYRIRYNONAIXLD/LVGAELRSAYINNCDKL,,ESP,BAYREUA(RTSIH)NYARRWOYIITDHBLGALODAPDNTEDIRSC,, NTETERRSVATEC,EHSE,AS,KIENPE,ISDOIPPDHRYAOMGSIUTDSA,ETSE,, FEWUR/KNEE JOINT, STERNUM, NOSE Histopathology : ~~ LIVER THYROIIDNFLGALMAMNADTI:ON, SUBACUTE/CHRONIC, minimal. ALTERATION, COLLOID, minimal No MiKcIrDoNsEcYSopic Abnormality Observed -- TT Te ------ Company Sanitized. Doss notcontain TSCA CBI | 9H0L-2D4a67y8O:raSluGbachvraogneiSctTuodxyiicintRyats --~ Dupont6554 Showing anIinmdailvidduaatla AfnorimailndiLviisdtuianlg animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ret Microscopic & Macroscopic Findings 648253 TKeirlmliendalonSDaacyrif: ic1e83 AEnxipnoaslureisGrsoiugpne:d o3ffMonftrhomrneeccorvoeprysy Gross Pathology No MaALOIcRVrTEoARs,,copBKRIiADcINNEA,YbSn,oSPrILmUNaNAlGLiSt,CyORHODEb,AsReTSr,TvOeMdSAKCE:HL,ETDAULODMEUNSUCML,E,JESJPULNEUEMN,, ANIDOLDREEEU,N,ALSAPGLALNIACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMNACEONRLDVOIENB,,ULAPRREICTTULUIYMTM,APRHYMENGOSLDEEAN,NTDE,RTHIYCMULSY,MPH S`PTEHHMAYIRRYNONAIXLD/LVGAELRSAYINNDCX,L,ESP,EAYREUA(RTSIH)NYARRWOYIIDTBHLGALODAPDNTEDIRSC,, NTETRERVSAETC,EHSE,AS,KIENPE,YSDOIPPDHRYAOMGSIUTDSA,ETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology ~ LIVER: THYROIIDNFGLALMAMNADTI:ON, SUBACUTE/CHRONIC, minimal. `ALTERATION, COLLOID, minimal. --_ _--m------_-------- Company Santized. Does not contain TSCA CBI F9-02-4D6a7y8:OrSaulbGcahvraogneicSTtouxdiyciintyRats --~ DuPon-6554 Showing anIinmdailvidduaatla AfnoirmailndLiivisdtuianlg animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648250 KTeirlmliendalon SDaacyr:ific18e3 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrneeccorvoeprsyy Gross Pathology : No waLcIVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUMP,H ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPRHYNGOLDEA,ND,THOMUS, `PTHHAYRRYONIKD/LGALRAYNND,X, `PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEEMMUIRN/AKLNVEEESIJCOLIENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYVIIDES, ~~ Histopathology : LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROHIYDPEGRLPALNADSI:A, BILE DUCT, minimal. ALTERATION, COLLOID, minimal. --~ -_-- Compeny Sanitized. Doesnotcontain TSCA CB H9-02-4D6a7y8O;raSulbGcahvraogneicSTtouxdiyciintyRats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 6a8265 TKeirlmliendalonSaDacyrif: ic18e3 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrneeccorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLaUNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC MANENRDVIEB,ULAPRITULIYTMPAHRYNGOLDEA,ND,THYMUS, TPHHAYRRYONIKD/LGALRAYNDN,K, PABYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEEMMUIRN/AKLNVEEESIJCOLIENST,, USRTIERNNAURMY, BLNAODSDEER, TESTES, EPIDIDVIIDES, Histopathology + --~ LIVER THYROIIDNFGLLAMAMNADTION, SUBACUTE/CHRONIC, minimal. ALTERATION, COLLOID, minimal. --_ _--_---------------------- CompanySanitized.Does notcontain TSCAC81 9F0--2D46a7y8O:naSubGcahvraogneiSctTuodxiyciintRyats ~~ DuPont-6554 . Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : V - 10 mg/kg/day Treatment: 10 mo/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648273 TKeirlmliendalonSDaacyrif: ic9e2 AEnxipmoaslureisGrsoiugpned: o9f0fdafyr.om necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNGODLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNNDK,, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNVEEESIJCOLTENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPLDIDYMIDES, Histopathology ~~ LIVER: FIANTFTLYAUCAHTAINOGNE,, CSEUNBTARCIULTOEB/UCLHARRO,NICm,inimmianli.mal. KIDNEYNSECR:OSIS, FOCAL, minimal. THYROINDEPHGRLOAPNADTH:Y, CHRONIC PROGRESSIVE, minimal. ALTERATION, COLLOID, minimal. --_ ---- -- ---- ee ------ Company Sanitized. Does not contaln TSCA CBI H-24678; SubchronicToxicity 90.DayOral GavageStudyinRats --_ DuPont6554 Showing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648263 TKeirlmliendalonSaDcaryi:fic1e83 AEnxipmoaslureisGrsoiugpne:d o3ffMonftrhomrenceocvreorpysy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, IAOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSYT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIKD/LGALRAYNNDK,, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNEVEESIJCOLIENST,, SUTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDYNIDES, Histopathology : PS LIVER: THYROITDNPGLLAMAMNADTI:ON, SUBACUTE/CHRONIC, minimal ALTERATION, COLLOID, minimal. --~ EE -- Company Sanitized. Does not contain TSCA CBI 9H0--2D46a7y8O;raSlubGcahvraogneicSTtouxdiyciitnyRats -- DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animale Dose Group : V - 10 mg/kg/day Treatment: 10 ma/k/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 548286 TKeirlmliendalonSaDcaryi:fic92e AEnxipmoaslureisGrsoiugpned: o9f0fdafyr.om necropsy Gross Pathology No MaLcIVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LSTAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYOIINDE/GLLAARNYDN,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMUIRN/AKLNVEEESIJCOLINETS,, SUTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, --~ Histopathology : LaverINFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROIFDATGTLYACNHDAN:GE, CENTRILOBULAR, minimal ALTERATION, COLLOID, minimal. No MiKcIrDoNsEcYoSpic Abnormality Observed : -- I -- `Company Sanftized. Does not contain TSCA CBI 9F-02-4D6a7y8O:raSluGbcahvraogneicStTuoxdiyciintyRats --_ DuPont6554 Showing anIinmdailvidduaatla AfnoirrailndLiivsidtuianlg aninals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 6an288 TKeirlmliendalonSDaacyrif: ic9e2 EAnxipmoaslureisGrsoiugpne:d o9f0fdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAVbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEYN,TERJIECJULNYUM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUIYTMAPRHYNOGDLEA,ND,THYMUS, TPHHYARROYNIKD/LGALRAYNND,K, PAEVREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRAVEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEENMUIRN/AKLNVGEESIJCOLIENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYVIIDES, Histopathology + LiverIN:FLAMMATION, SUBACUTS/CHRONIC, minimal. KIDNEYHYSPE:RPLASIA, BILE DUCT, minimal. THYROINDEPHGRLOAPNADTH:Y, CHRONIC PROGRESSIVE, minimal `ALTERATION, COLLOID, minimal. -- gerer errmmre CompanySanitizad.Dossnotcontain TSCACAL 501..2D4a6y75O:nSluGbeahrvoneicSTtourdyiicn Rats -- Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dupant6ss4 Dose Group + V - 10 mo/kg/day Treatment: 10 mu/kg/day V Animal Ret Microscopic & Macroscopic Findings Sensor TKeirlmliendalonSaDcaryif: ic32e EAnxipmoaslureisGrsoiugpned o9f0fdafyrom necropsy Gross pathology : Sex: Males No MAaLOIcRVrTEoARs,,coKBpRIiADcINNEA,YbSn,oSrPmILaUNNlAGiLSt,yCOROHDEb,AsReTrS,TvOeMSdAKCE:HL,ETDAULODMEUNSUCML,E, JESJPULNEUEMN., NAIODLDEREUE,NN,ALSAPGALLNIACVNRAEDRASYS,,GSLACCNIEDCASUTN,I,CMNCAEONRLDVOIENB,,ULARPARICTTLUUYIMVT,PAHRWYENOSGDLEEAN,NFDE,RTIHCISL,P: TSPHHEYAWRRIOYNNIAEDL/LVGAELRSAYINNDC,XL,ESP,EAYREAU(TRSHI)YNRAWORIIYDTHBGLLAOADPNDTDEISRC,, NETTRERVSAETC,EHSE,AS,KIENPS,ESDOIPDDHRYAOMGSIUTDSA,ETSE,, PEMUR/KNER JOINT, STERNOM, NOSE --_ iistopathology + Laver xaoNEYNIESNCFRL:OASMIMSA,TIOFNO,CALS,UBmAiCnUiTnEa/lC.HRONIC, mininal. NEPHROPATHY, CHRONIC SROGRESSIVE, minimal. No MiTcHrYoRsOcIDopiGcLANADbnormality Observed -- --_-- ww CompanySanioszs aeotcdon.an TSCACBI H-24678; SubchronicToxicity 90.Day Ona GavStuadyignRaets --_ DuPont6554 Showing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Aninal Ret Microscopic & Macroscopic Findings 648309 TKeirlmliendalonSDaacyrif: ic92e AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIKD/LGALRAYNND,K, PAEVREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, F`SEEMMUIRN/AKLNEVEESIJCOLIENST,, SUTREIRNNAURMY, BLNAODSDEER, TESTES, EPYDIDYNIDES, --_ Histopathology : LIVERIN:FLAMMATION, SUBACUTE/CHRONIC, minimal. THYRONIEDCRGOLSAINSD, FOCAL, minimal. `ALTERATION, COLLOID, minimal. No MiKcIrDoNsEcYSopic Abnormality Observed : --_ = --- Company Sanilized. Doss notcontain TSCACBI 0H--2D4a67y8O;raSluGbacvhraogneiSc tToyxiicintRyats DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Animal Ref Microscopic & Macroscopic Findings 648310 TKeirlmliendalonSDaacyrif: ic1e83 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrneeccorvoeprsyy Gross Pathology KIDNEYDSISC:OLORATION, MOTTLED, BILATERAL. No MaLIcVrEoRs,copLiUNcGSA,bnoHrEmARaTl,itySKOEbLsEeTrAvLeMdUS:CLE, SPLEEN, AORTA, BRAIN, CSEPCIUNMA,L CCOORLDO,N, STROEMCATCUHM,, DMUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVANACRRYEAS. GSLCAINADTSI,C NMEARNVDEI,BULPAIRTULIYTMAPRHY NODE, GLAND, THYMUS, ADRENAL THYROID GLAND, GLANDS, EPYAER(AST)HYWRIOTIHD OGLPATNIDCS,NERTVREA,CHESAK,IN,ESOPPRHOASGTUASTE,, PSHEAMRIYNNAXL/LVAERSYIEC,LES, --~ SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, Histopathology THYRO`IADLTGELRAANTIDON, COLLOID, minimal. No MLiIcVroEsRcopic Abnormality Observed : --~ -- Company Sanitized. Does not contain TSCA CBI 9F0--24D6a7y8O:raSlubGcahvraogneiSctTourdiyciintRyats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : V - 10 mg/kg/day Treatwent: 10 mg/kg/day V Sex: Males Anival Ref Microscopic & Macroscopic Findings sa8312 TKeirlmliendalonSaDcaryi:fic9e2 EAnxipmoaslureisGrsoiugpne:d o9f0fdafyr.om necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, IALOERUTMA,, PBRAANICNR,EASS,PINCEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDRSE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTAPRHYNGOLDEA,ND,THYMUS, TPHHYARROYNIKD/LGALRAYNND,X, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEVMIUNRA/LKNVEEESIJCOLIENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, --~ Histopathology : LaverINFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNENYESPH+ROPATHY, CHRONIC PROGRESSIVE, minimal. THYRO`IADLTGELRAANTIDON:, COLLOID, minimal. -- --- CompanySanitizsd. Loss noiGuna TSCACBI 9F0--2D4a67y8O:raSluGbacvharogneiSctTuodiyciintRyats --_~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : V - 10 mg/kg/day Treatment: 10 mg/kg/day V Sex: Males Anival Ref Microscopic & Macroscopic Findings 6ag313 TKeirlmliendalonSDaacyrif: ic9e2 EAnxipmoaslureisGrsoiugpned: 9o0ffdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYKM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYOWIED/LGALRAYNNDE,, `PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNEVEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDVMIDES, Histopathology + --_ LIVER: FIANTFTLYAMMCAHTAINOGNE,, CSEUNBTARCIULTOEB/UCLHARRO,NICm,inimmianliral THYROIADLTEGRLAATNIDON:, COLLOID, minimal. No wiKcIrDoNsEcYSopic Abnormality Observed : --_ -- ww Company Senitized. Does not contain TSCA CB H902-4D6a7y8:OraSlubGcahvraogneicStTuordiyciintyRats DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648223 TKeirlmliendalonSDaacyrif: ic9e2 EAnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJULNYUM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,ND,THYMUS, TPHHYARROYNIXD/LGALRAYNND,X, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNVEEESIJCOLTENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYWIDES, ~~ Histopathology + LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYFSATT: Y CHANGE, CENTRILOBULAR, mild. vst, minimal. No miTcHrYoRsOcIDopiGcLAANbDnormality Observed --~ - CompanySanitized. Doss notcontaln TSCACBI F9-02-4D6a7y8O:rSaulbGcahvraogneicSTtourdiyciintyRats --_ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648237 TKeirlmliendalonSaDcaryif: ic9e2 EAnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL VUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NA'LSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMASRHYNOGDLEA,ND.THYMUS, PTHHAYRRYONIKD/LGALRAYNND,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNVEEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDVMIDES, Histopathology --_ Liver IFNAFTLTAYMMCAHTAINOGNE,, SCEUNBTARCIULTOEB/UCLHARRO,NICm,ilmdinimal. FATTY CHANGE, MEDIAN CLEFT, mild. No MiKIcDrNoEsYcSo,picTHYARbOnIoDrmGaLlAiNtDy Observed : I `Company Sanitzed. Dossnotcontain TSCACBI 9H0--24D6a7y5O;raSluGbachvraogneiSctTuodxiyicintRyats --_ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings sas243 TKeirlmliendalonSDaacyrif: ic9e2 AEnxipmoaslureisGrsoiugpned: o9f0fdafyr.om necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNAELCC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYINKD/LGALRAYNDN,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, F`SEEMMUIRN/AKLNEVEESIJCOLTENST,, USTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, Histopathology : --~ LiveR : INFLATION, SUBACUTE/CHRONIC, minimal. No MiKIcDrNoEsYcSo,picTHAYbRnOIoDrmaGlLiAtNyD Observed : --_ --- ss `Company Sanitized. Doesnotcontain TSCA CBI 9F-02-4D6a7y8O:raSluGbcahvraogneicStTuodriyciintyRats --~ DuPont6554 Showing aInnidailviddautaal AfnoirmailndLiivsitdiunagl animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648244 TKeirlmliendalonSaDcaryi:fic9e2 AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJULNYUM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYNIKD/LGALRAYNND,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEVMIUNRA/LKNEVEESIJCOLIENST,, SUTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDVNIDES, --_ Histopathology LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYNSECR:OSIS, FOCAL, minimal THYROINEDPHGRLOAPNADTH:Y, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, FOLLICULAR, minimal. --~ --- Company Sanitizsd. Doos not contain TSCA CBI 9H02.4D6a7y8O;raSlubGcahvraogneieStudyToxiicintRyats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivisdtuianlg animals Dose Group : VIT - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Rot Microscopic & Macroscopic Findings sa8259 TKeirlmliendalonSDaacyrif: ic92e EAnxipnoaslureisGrsoigunpe:d o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NA'LSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYNIXD/LGALRAYNND,K, `PEAVREA(TSH)YRWOIITDHGOLAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNEVEESIJCOLIENST,, USRTIERNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, Histopathology LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYNSECROSIS, FOCAL, minimal NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No MTiHcYrRoOsIcDopiGcLANADbnormality Observed : --_ I -- Company Santized. Dossnotcontain TSCA CBI 9H0--24D6a7y5O;raSluGbachvraogneiSctTuodxiyciintRyats DuPont6554 Showing andiimvaildduaatla AfnoirmailndLiivsidtuianlg animals Dose Group: VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648266 TKeirlmliendalonSDaacyrif: ic9e2 AEnxipmoaslureisGrsoiugpned: 9o0ffdafyrom necropsy Gross Pathology : No maLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,ONARCEHC,TUND,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNGOLDEA,ND,THYMUS, TPHHAYRRYOIINDK/GLLAARNYDN,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMVIUNRA/LKNEVEESIJCOLIENST,, SUTREIRNNAURMY, BLNAODSDEER, TESTES, EPLDIDYMIDSS, Histopathology + -- LIVER : HIYNPFELRATMRMOAPTIHOYN,, `HSEUPBAATCOUCTYET/E,CHRCOENNITCR,ILOmBiUnLiAmRa,l.minimal. FNEACTRTOYSICSH,ANGFEO,CALC,ENmTiRnIiLOmBaUlL.AR, minimal. THYRO`IADLTGELRAANTIDON:, COLLOID, minimal. No MiKcIrDoNsEcYSopic Abnormality Observed : = --- `CompanySantized.Doss actcontainTSCACBF 9H0--2D4a67y8O;raSluGbacvhraogneiSc TtoxiuicindtRyayts --~ DuPont6554 Showing anIinmdailviddautaal AfnoirmailndLiivsidtuianlg animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648268 TKeirlmliendalonSaDcayrif: ic16e3 EAnxipmoaslureisGrsoiugpne:d o3ffMonftrhomrneeccorvoeprsyy Gross Pathology No MLaIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSALGLIAVNADRSY, GLSACNIDAST,IC MNAENRDVIEB,ULAPRITLUYIMTAPRHYNGOLDEA,ND,THYMUS, TPHHYARROYNIXD/LGALRAYNND,X, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, F`SEEMNUINRA/LK,NVEEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, --_~ Histopathology + LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal THYROIADLTEGRLAATNIDON, COLLOID, minimal -- I ww `Company Sanitized. Does not contain TSCA CBI F-24678: Subchronic Toxicity 90-DayOralGavageStudyinRats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Anival Ref Microscopic & Macroscopic Findings 648270 TKeirlmliendalonSDaacyrif: ic9e2 AEnxipmoaslureisGrsoiugpned: 9o0ffdafyr.om necropsy Gross Pathology No MaLIcVrEoRs,copKIiDcNEAVbSn,orLmUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUMA,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEKC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC MNAENRDVIEB,ULAPRITLUYIMTAPRHYNOGDLEA,ND,THYMUS, TPHHYARROYNIXD/LGALRANYDN,X, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMUIRN/AKLNVEEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDVMIDES, --_ Histopathology : LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYNSEPH+ROPATHY, CHRONIC PROGRESSIVE, minimal. THYROIADLTEGRLAATNIDON:, COLLOID, minimal. ~~ --- ws CompanySanitized.Doesnotcontain TSCA CBE 9H.02:4D6a7y8O:raSlubGcahvraogneicStTuordiyciintyRats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : VII - 60 mg/k/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648279 TKeirlmliendalonSaDcayr:ific1e83 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrneeccorvoerpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, `PTHHAYRRYOIINDK/GLLAARNYDN,X, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEWMIUNRA/LKNEVEESIJCOLIENST,, USTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDYNIDES, --_ Histopathology : LIVERINFLAMYATION, SUBACUTE/CHRONIC, minimal. HNEYCPREORSPILSA,SIAF,OCABLI,LEmiDnUiCTm,al.minimal. THYROAILDTEGRLAATNIDON+, COLLOID, minimal. -- -- ws Company Senftized.DassnotcontTSaCAlCnBI 9H0--2D46a7y8O:raSluGbaehvraogneiSctTuodxiyicintRyats ~~ DuPont-6554 Showing anItnrdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : VIT - 60 mg/kg/day Treatment: 60 ma/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648260 TKeirlmliendalonSaDcayrif: ic92e AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NASLAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYNUS, PTHHAYRRYONIED/LGALRAYNNDK,, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, F`SEEMNUIRN/AKLNVEEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology : ' Laver: THYROIIDNFLGALMAMNADTION, SUBACUTE/CHRONIC, minimal. H`AYLPTEERRTARTOIPOHNY,, COFLOLLOLIIDC,ULAmRi,nimmailn.imal No MiKcIrDoNsEcYoSpic Abnormality Observed : --_ --_--mm CorapanySanitized.Lossnotcontain YSGAGBI 9H0--2D4a67y8O;raSluGbacvhraogneiSctTuodxyiicintRyats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648285 TKeirlmliendalonSDaacyrif: ic1e83 EAnxipmoaslureisGrsoigunped: o3ffMonftrhomrneeccorvoerpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDRES,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUIYTMAPRHYNGOLDEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,X, PAEVREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRAVEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEENMUIRN/AKLNVBEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, --~ Histopathology : LIVER:INFLATION, SUBACUTE/CHRONIC, minimal. THYROIFDATGTLYANCDHAN:GE, CENTRILOBULAR, minimal. `ALTERATION, COLLOID, minimal. -- --- `CompanySanitzed. DossnotcontainTSCA CBI 9H0--2D4a6y78O;raSluGbachvraogneiSctTuodxiyciintRyats ~~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648296 TKeirlmliendalonSDaacyrif: ic1e83 EAnxipmoaslureisGrsoiugpne:d 3offMonftrhomrneeccorvoerpysy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNNDX,, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNVEEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology + r LIVER: THYROIIDNFGLALMAMNADTION, SUBACUTE/CHRONIC, minimal `ALTERATION, COLLOID, mild. -- --- `CompanySanitized. Does notcontainTSCA CBI 910.2-4D6a7y8:OrSaulbGeahvraognei STtouxdiyciintyRats -- Dupont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : VII - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Aniral Ref Microscopic & Macroscopic Findings 648300 TKeirlmliendalonSaDcary:ific92e EAnxipnoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAN,, BPRAANICNR,EASS,PICNBACLUNC,ORDC,OLOSNT,OMARCEHC,TUND,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYWUS, TPHHYARROYNIKD/LGALRAYNND,K, PAEYREA(TSH)YRWOIITDHGOLAPNTDISC, NTERRVAEC,KERS,KINE,SOPPHRAOGSUTSA,TE, FSERNNIUNRA/LKNVEEESIJCOLIENST,, SUTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, Histopathology : r LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. KIoNEYNESPH+ROPATHY, CHRONIC PROGRESSIVE, minimal. Yo Mi"TcHrYoRsOcIoDpiGcLANADbnormality Observed : EE CompanySaniized.Doss notcontainTsca cay 9F-02-4D6a7y8O:raSluGbcahvraogneicStTuoxdiyciintyRats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : VIT - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 648305 TKeirlmliendalonSDaacyrif: ic9e2 AEnxiproaslureisGrsoiugpne:d 9o0ffdafyr.om necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS. TPHHAYRRYOIINDX/GLLAARNYDN,X, PAEVREA(TSH)YRWOIIDTHGOLAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNEVEESIJCOLIENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, Histopathology + --~ LIVER + IFNAFTLTAYMMCAHTAINOGNE,, SMUEBDAICAUNTEC/LCEHFRTO,NImCi,nimmailn.imal. THYROIADLTEGRLAATNIDON, COLLOID, minimal. No MiKcIrDoNsEcYSopic Abnormality Observed : T TT ------ ee `Company Sanitized. Does not cantain TSCA CBI H902.4D6a7y8;OrSalubGcahvraogneicSTtouxdiyciintyRats --~ DuPont6554 Showing anIinmdailvidduaatla AfnorimailndLiivsitdiunagl animals Dose Group : VIT - 60 mg/kg/day Treatment: 60 mg/kg/day VII Sex: Males Animal Rot Microscopic & Macroscopic Findings 6ag314 TKeirlmliendalonSaDcaryif: ic1e83 EAnxipmoaslureisGrsoiugpned: o3ffMonftrhomrneeccorvoeprysy Gross Pathology LIVERDISCOLORATION, PALE. KIDNEYCSHRO:NIC PROGRESSIVE NEPHROPATHY, BILATERAL. No MaLOcNrGoSs,copHiEAcRTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL CCOORLDO,N, SRTEOCMTAUCMH,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPAVNACRRYEAGSL,ANDCSE,CUM, MNEARNVDEI,BULPAIRTULIYTWAPRHY GNLOADNE,D, TTHYHMYURSO,IDADGLRAENNDA,L GPLAARNADTSH,YRSOCIIDAGTLIACNDS, -- TERYAE(CSH)EA,WITEHSOPOHPATGIUCS,NERBVHEA,RYNSKK/INL,ARYPNRKO,STATE, SEMINAL VESICLES, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, FEMUR/KNSE JOINT, Histopathology + LIVERFIBROSIS, BILE DUCT, moderate. EICNTFALSAIMAM,ATIBOINL,E DSUUCBTA,CUTsEe/vCeHrReO.NIC, minimal. THYROIADLTEGRLAATNIDON:, COLLOID, miniral. EE `Company Sanitized. Doss not contaia TSCA CBI H9-02-4D6a7y8O:rSaulbGcahvraogneicSTotxuiyciintyRats -- DuPont6554 Showing anIinmdailviddautaal AfnoirmailndLiivsidtuianlg animals Dose Group : TX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648217 TKeirlmliendalonSDaacyrif: ic92e AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,K, PAEVREA(TSH)YRWOIITDHGOLAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, F`SEENMUIRN/AKLNEVEESIJCOLIENST,, SUTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, --_ Histopathology : LIVERHYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYHSYPERTROPHY, TUBULAR, minival. THYRONIEDPHGRLOAPNADTH:Y, CHRONIC PROGRESSIVE, minimal. HALYTPEERRATTRIOOPNH,Y, COFLOLLOLIIDC,ULAmRi,nimmailn.imal. PROSTAITNEFLAMMATION, SUBACUTE/CHRONIC, minimal 648217 Continued on the next page .... -- --- ww `Company Sanitzed. DonoscontsainTscoy 9H0--2D46s7y8O:raSlubGcahvraogneicSTtouxdiyciitnyRats --_ DuPont6554 Showing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648217 Continued from previous page Histopathology No MiLUcNrGoSs,copHEiAcRTA,bnoSrKmEaLElTiAtLy OMUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL CCOOLRODN,, SRTEOCMTAUCMH,, MDUEOSDEENNTUEMR,ICJLEJYUWNPUHM,NODIEL,EUMS,ALIPAVNACRRYEAGSL,ANDCSE,CUM, MNEARNVDEI,BULPAIRTUILTYAMRPYH NGLOADNED,, THPYAMRUAST,HYARDORIEDNAGLLANGDLSA,NDST,RACSHCEIAA,TIC ESSEOMPIHNAAGLUSV,ESIPCHLAERSY,NN/ULRAIRNYANRKY, BLEAYDED(SE)R,WITETSHTEOSP,TICEPINEDRIVDEV,MIDSEKSI,N, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE --~ --~ --- `Company Sanftzed. boes notcontain TSCA cat 910..2D4a67y8O:nSluGbacvhraogneicStTuodxiyciintyRats. --~ Duoncsst Showing anIinndailvidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IX = 300 mg/kg/day Treatment: 300 ma/kg/day TX Aninal Ref Microscopic & Macroscopic Findings pre TKeirlmliendalonSaDcayrif: ic92e AEnxipmoaslureisGrsoiugpned+ o9f0fdafyrom necropsy Gross patholony : Sex: Males No MaLAIOcRVrTEoARs,,copBKiRIAcDINNEA,YbSn,oSrPmLIUaNNAlGLiSt,CyOROHDEb,AsReTrS,TvOeMSdAKCE:HL,ETDAULODMEUNSUCML,E,JESIPULNEUEMN,, NAIODLDREEEU,N,ALSAPGLALNIACVNRADERSAY,S,GLSACCNIEDNCSTU,I,CMCNAOENLRDOVINEB,,ULARPERICTFULUIYNTW,APRHYMEOSGDELEAN,NTDE,RTHIYCMULSY,MPH TPSHHEYAMRROYININXD/LVGAELRSAYINNDC,KL,ESP,AEYREUA(RTSIH)NYARRWOYIITDHBGLLOAAPDNTEDIRSC,, NETTRERVSAETC,EHSE,RS,KIENPE,ESDOIPPDHRWAOMGSIUTDSA,ETSE,, FEWUR/ANEE JOINT, STERNUM, NOSE Histopathology : - LaveINFLANTION, SUBACUTE/CHRONIC, mininal. KoonHsYP:ERTROPHY, HEPKTOCYTE, CENTRILOBULAR, mild. wearHYPERTROPHY, TUBULAR, minimal. THYROICDARDGILOANDYORATRY, minimal. PARNTAHHYLYPTREEORRITADRTOIGPOLHNAY,N,DSCOFLOLLOLIIDC,ULAmRi,ld.mininal. 548218 Continued onNOthTePRnEeSxEtNTp.age .... - GompanySanDiossinokzconeta dTS,CA! 9F0--2D4a67y8O;raSlubGcahvraogneiStTuodxiyciintRyats ~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 ma/kg/day TX Animal Ref Microscopic & Macroscopic Findings sa8218 Continued from previous page Sex: Males Histopathology Nos I: NFLAMMATION, SUBACUTE/CHRONIC, minimal No MiLUcNrGoSs,copSiKcELAEbTnAoLrmMUaSlCiLtEy, ObSPsLeErEvNe,d A:ORTA, BRAIN, SPINAL CORD, SRETCOTMUAMC,H,`MDEUSOEDNETNEURMI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAANRCYREGALSA,NDSC,ECUMMA,NDICOBLUOLNA,R LPIYTMUPIHTNAORDYE,GLATNHDY,MUST,RACAHDERAE,NALESOGPLAHNADGSU,S, SPCHIAARTYINCK/NLEARRVEY,NX, EUYREI(NSA)RYWIBLTAHDDOEPRT,ICTENSETREVSE,, SEKPIIND,IDYPMRIODSETSA,TE,FEMSUERM/IKNANLEEVEJSOIINCTL,ES, STERNUM, BONE MARROW --~ - Company Sanitized. Does not contain TSCA CBI 9H-02-4D6a7y8O;raSluGbcahvraogneicStTuoxdiyciintyRats --~ DuPont6554 Showing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IK Sex: Males Aninal Ret Microscopic & Macroscopic Findings 548230 TKeirlmliendalonSDaacyrif: ic12e2 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoerpysy Gross Pathology : No MaLcIVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIID/LGALRAYNNDK,, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSREMMUIRN/AKLNEVEESIJCOLTENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, --~ Histopathology : LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYHSYPE:RTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. THYROIHDYDGRLOAENPDHR:OSTS, UNILATERAL, minimal. AHYLPTEERRTARTOIPOHNY,, COFLOLLOLIIDC,ULAmRo,dermaitnei.mal --_ emg `Company Sanitized. Donotecons tain TSCACBI 9H-02-4D6a7y8O;raSluGbcahvraogneicStTuoxdiyciintyRats DuPont6554 Showing anIinmdailviddautala AfnoirmailndiLviisdtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648231 DFuoruantdioDneaodf dosing-days: 57 AEnxipnoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology LunesFLUID, CLEAR, DIFFUSE. No MaLIcVrEoRs,copKiIcDNEAYbSn,orHmEaAlRiTt,y SOKbEsLeErTvAeLd M:USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PHINLOEDUEM,, SGLAALNIDVSA,RYSGCLIAANTDISC, NEMRAVNED,IBUPLIATRUILTYAMRPYHGLNAONDDE,, TTHHYYMRUOST,D GALDARNEDN,AL PEYAER(AST)HYWRIOTIHD GOLPATNIDCS,NERTVREA,CHESAK,IN,ESOPPRHOASGTUAST,E, PHSAERMYINNKA/LLAVREYSNIKC,LES, ~~. UsRtINeArRY, BNLAoDsDeER, TESTSS, EPIDIDYMIDES, PEMUR/KNEE JOINT, Histopathology + LIVER:HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYNESPH:ROPATHY, CHRONIC PROGRESSIVE, minimal LowesHY+ PERTROPHY, TUBULAR, minimal. . `FEODREEMAI,GNmMiAnTiEmRaIl.AL, mild. HEARTCARDIOYOPATHY, minimal. 648231 Continued on the next page .... --~ eT ------ Company Senitized. Does not contain TSCA Ca 24678: Subchronic Toicity -- 20DayOnlGuvageSudyinRats 0 Dubomessd Showing anIinndailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Aninal Ret Wicroscopic & Macroscopic Findings sez31 Continued from previous page tistopathology THYROAIUDTOGLLYASNIDS: NECROPSY AND HISTOLOGY PERFORMED, minimal. SARATNHOYTROIPDRESGELNATN.DS woe F OREIGN MATERIAL, mild. Yo MiSScTKOrENoLAsECcTHoA,pLicMDUUSOACDbLEnENo,OrMm,aSPlJLiEEtEJyNU,NOUbMAs,OeRrTvIAeL,EdUMB:,RAIPNA,NCRSEPAISN,ALCECCOURMD,, COLON, RLEPCTRUM,NODMEE,SENTTHYEMRUISC, LAYDMRPEHNNAOLDEG,LANSDASL,IVASRCYIAGTLIACNDNSE,RVEM,ANDIBULAR PPHIATRUYINTXA/RLYARGYLNANN,D, ETYEH(YSR)OIWDIGTLHANODP,FICTRANCEHREVAE,, ESKSIONP,HAGPURSO,STATE, PN SFEEMNIUNRA/LKNEVESSIJCOLIENST,, USRTIENRARNY, BLBAODNDEERM,ARTREOSWTES, EPIDIDYMIDES, -- 2 -- `Company Senitized. Doss not contain TSCA CBI 910.-2D4a6y78O:raSlubGcahvraogneicStTuodsyicitnyRats --~ Dupont6554 Showing anniansavlidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Animal Ref Microscopic & Macroscopic Findings se23 TKeirlmliendalonSaDacyrif: ic18e3 nExipnoaslureisGrsoiugpned: o3ffMonftrhomrneeccorvoeprsyy Gross Pathology: Sex: Males No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRTEA,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,KOMD,UODMEENSGEMNN,TERJEIJCUNLUYMM,PH ANDODREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICVANENRDVIEB,ULAPRITLUYIMTPAHRYNGODLEA,D,THOS, TPSHHEYAMRRIOYNNIAKDL/LGVAELRSAYIDNC,KL,ESP,EAYREUA(RTSIH)NYARRWOYIITDHBLGAOLDAPDNTEDIRSC,, NETTRERVSAETC,EHSE,RS,KIENPE,ISDOIPPDHRYAOMGSIUTDSA,ETSE,, FENUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIverIN: FLAMMATION, SUBACUTE/CHFONIC, minimal. THYROIFDATTGYLANCHDAN+GE, MEDIAN CLEFT, mild. ALTERATION, COLLOID, mininal. -- _----m-_ Company Saniizec. Doss not contain TSCA cai H90--2D4a6y78O:raSluGbacvhraogneicStTuodxyicnitRyats -- DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Animal Ref Microscopic & Macroscopic Findings 648235 TKeirlmliendalonSaDcayri:fic92e AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology + Sex: Males No MAaLOIcRVrTEoARs,,copKBiRIcADINNEA,YbSn,oSrPmLIUaNNAlGLiSt,CyOROHDbE,AsReTrS,vTeOMdSAKCE:HL,ETADULOMDEUNSUCML,E,JESJPULNEUEMN,, NIOLDEEU,M, SAPLANICVRAERAYS,GLACNEDCSUM,, MACONLDOINB,ULARRECTLUYMM,PHMENOSDEEN,TERTHIYCMULSY,MPH ATDHRYREONIADL GGLLAANNDD,S, PASRCIAATTHIYCROINEDRVGEL,ANDPSI,TUTIRTAACRHYEAG,LANEDS,OPHAGUS, SFPEEHMMAIURNRYAN/XLK/NLEVAEERSYIJNCOXLI,ENST,,EYEUS(TRSEI)RNNAUWRMIY,THBNLAOODSPDTEEIRC, NETRZVSET,ES,SKIENP,IDIPDRYOVSNTIADTEES,, --~ Histopathology + LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal KIDNEYHSYPE:RTROPHY, HEPATOCYTE, CENTRILOBULAR, mild NHEYPPHERROTPRAOTPHHYY,, CTUHBRUOLNAIRC, PmRiOnGiRmEaSlS.IVE, minimal HEARTCA+ RDIOMYOPATHY, minimal. THYROAILDTEGRLAATNIDON:, COLLOID, minimal. . TESTEDSE:GENERATION/ATROPHY, SEMINIFEROUS TUBULES, BILATERAL, 648235 Continued onmitnhieranle.xt page .... --- Company Saaitized. Dossnotconta scacay 9H0L-24D6a7y5O:rSaulbGcahvraogneieSTtouxdiyciintyRats --_ DuPont6554 Showing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648235 Continued from previous page Histopathology No MiLUcNrGoSs,copSiKcELEATbAnLorMmUaSlCiLtEy, ObSsPLeErEvNe,d : AORTA, BRAIN, SPINAL CORD, SRETCOTMUAMC,H,`MDEUSOEDNETNEURMI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAARNYCREGALSA,NDSC,ECUMNA,NDICOBLUOLNA,R LPYIMTPUHITNAORDYS,GLATNHDY,MUSP,ARAADTRHEYNRAOLIDGLGALNADNSD,S, STCRIAACTHIECA,NEREVSEO,PHAGUS. SPEHMAIRNYNAXL/LVAERSYINCXL,ES,'EYUER(IS)NAWRIYTHBLAODPDTEIRC, NEERPVIED,IDYSMKIIDNE,S,PROFSETMAUTRE/,KNES JOINT, STERNUM, BONE WARROM, NOSE TT ------ Company Sanitizac. Doss not contain Tea cay H-24678; Subchroni Toxicity 90-DayOral GavageStudyinRats ~~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IX - 300 mg/kg/day Treatment: 300 ma/kg/dsy IX Animal Ref Microscopic & Macroscopic Findings sa8236 TKeirlmliendalonSaDcaryif: ic92e EAnxipnoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology Sex: Males No MaLIcVrEoRs,coKpIiDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLREUTMA,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIKD/LGALRAYNNDX,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNEVEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDVMIDES, Histopathology : LIVERIN: FLAMMATION, SUBACUTS/CHRONIC, miniral. KIDNEYHYSPE:RTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. NHEYPPHERROTPRAOTPHHYY,, CTUHBRUOLNAIRC, PmRiOnGiRmEaSlS.IVE, minimal. THYROAILDTEGRLAATNIDON:, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. 648236 Continued on the next page ... -- --- ws `CompanySanitized.Dossnotcontain TSCACBI 09H0LD2-4D6a7y8O:OnSrluaCbGcoahvvraaogngeiecSSTutoudxdyiyciiintnyRRaatss --~ 00 DDuuPeomn6t6s5s5s4 Showing anIinmdailviddauatla AfnoirmailndLiivsidtuianlg animals Dose Group: IX - 300 mg/kg/day Treatment: 300 mg/kg/day TX Sex: Males Animal Ret Microscopic & Macroscopic Findings 648236 Continued from previous page Histopathology No MiLUcNrGoSs,copHEiAcRTA,bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL CCOOLRODN,,' SRTEOCNTAUCME,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANCRRYEAGSL,ANDCSE,CUM, NMEARNVDEI,BULPIATRULIYTMAPRHY GNOLDAEN,D, THPYAWRUAST,HYARDORIEDNAGLLANGDLSA,NDST,RACSHCEIAA,TIC PERSOOSPTHAATGEU,S, 'SPEHMAIRNYANLKV/ELSAIRCYLNEXS,, EUYER(ISN)ARWYITBHLADODPETRI,C NTEERSVTEE,S, SKIN, EPIDIDYNIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE --_ eT em---- Company Sanitized.Does notcontainTSCACBI F9-02-4D6a7y8:OrSaulbGcahvraogneicSTtouxdiyciintyRats DuPont6554 Showing anIinmdailvidduaatal AfnoirmailndLiivisdtuianlg animals Dose Group: IX - 300 mg/kg/day Treatment: 300 ma/kg/day IK Sex: Males Anival Ref Microscopic & Macroscopic Findings 548239 TKeirlmliendalonSDaacyrif:ic9e2 AEnxipmoaslureisGrsoiugpned: o9f0fdafyr.om necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSOEMN,TERJEIJCUNLUYMW,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTAPRHYNGOLDEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,K, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNEVEESIJCOLIENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, Histopathology : -- LIVER : FIANTFTLYAMMCAHTAINOGNE,, CSEUNBTARCIULTOEB/UCLHARRO,NICm,odemriantiem.al. KIDNENYESP:HROPATHY, CHRONIC PROGRESSIVE, minimal PANCREHAYSPER:TROPHY, TUBULAR, minimal. AITNRFOLPAHMYM,ATImOiNn,imaSlU.BACUTE/CHRONIC, minimal. THYROAILDTEGRLAATNIDON, COLLOID, moderate. 648239 Continued onHYtPhEeRTnReOxPtHYp,ageFOL.L.I..CULAR, mild. --_ --- w= Company Sanitized. Doss not containTSCACB H9-02.4D6a7y8O:rSaulbGcahvraogneicSTtouxdiyciintyRats - DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day TX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648239 Continued from previous page Histopathology : ESOPHNAOGTUSP:RESENT. Nose I+ NFLAMMATION, SUBACUTE/CHRONIC, minimal. No MiLUcNrGoSs,copHiEAcRTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edSP: LEEN, AORTA, BRAIN, SPINAL CROERCDT,UM,"STMOEMSAECNH,TERDIUCODELNYUMMP,H JNOEDJEU,NUMS,ALIIVLEAURMY, GCLEACNUDMS,, CMOALNODNI,BULAR LPIYTMUPIHTANRODYE,GLATNHDY,MUSP,ARAADTRHEYRNOAILDGLGALNADNDSS,, STCRIAACTHIECA,NERVE, PSHEAMRIYNNAKL/LVAERSYINCXL,ES,'EYUER(SI)NARWYITHBLAODPDTEIRC, NTEREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, BONE MARROW -- --~ - ww `Company Sanitized. Doosnotcontain TSCA CBI 9H02-4D6a7y8:OrSaulbGcahvroangiecStTuoxdiycintyRats ~~ DuPont6554 Showing anIinrdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ret Microscopic & Macroscopic Findings 648200 TKeirlmliendalonSaDcayrif: ic1e83 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrneeccorvoerpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE:LETAL WUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PINCAELCC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULIYTMAPRHYNGOLDEA,ND,THYMUS, TPHHYARROYNIKD/LGALRAYNND,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNEVEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology + --~ LIVER NIENCFRLOASMIMSA,TIOFNO,CALS,UBmAiCnUiTmEa/lC.HRONIC, minimal. THYROIADLTEGRLAATNIDON, COLLOID, severe. --_~ eg Company Sanitized.Dossnotcontain TSCACBI H-24678; SubchroncToxicity --_ 0-DayOralGavageStudyinRats Dubom6ssd Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : IX - 300 ma/ka/day Treatment: 300 mg/kg/day TX Sex: Males Animal Ref Microscopic & Macroscopic Findings sa8201 TKeirlmliendalonSDaacyrif: ic1e22 AEnxipmoaslureisGrsoiugpne:d o1ffMonftrhomrenceocvreorpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaONlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIKD/LGALRAYNND,K, PAEVREA(TSH)YRWOIITDHGOLAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEEMMUIRN/AKLNEVEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDYNIDES, --_ Histopathology LIVERIN:FLAVMATION, SUBACUTE/CHRONIC, minimal. THYROIHDYPEGRLTARNODPH:Y, HEPATOCYTE, CENTRILOBULAR, minimal ALTERATION, COLLOID, severe. No MiKcIDrNoEsYcSopic Abnormality Observed : -- es Company Sanitized. Does not containTSCACBU 9H0--2D4a67y8O:raSuGbachvraogneiSctTuodxiyciintRyats --_~ DuPont6554 Showing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg animals Dose Group : Ix - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648208 TKeirlmliendalonSDaacyr:ific92e AEnxipmoaslureisGrsoiugpne:d o9f0fdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUNMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULIYTMAPRHYNGOLDEA,ND,THYMUS, `PTHHAYRRYONIAD/LGALRAYNND,X, `PEAVREA(TS)HYRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNEVEESIJCOLIENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology + r LIVER HIYNPFELRATMRMOAPTHIYO,N, HESPUABTAOCCUYTTEE/,CHRCOENNITCR,ILOmBiUnLiAmRa,l.mild. KIDNEYHSYPE:RTROPHY, TUBULAR, minimal. PANCREIRNSFLA:MMATION, SUBACUTE/CHRONIC, minimal. THYROIHDYPEGRLPALNADSIA, FOCAL, ACINAR CELL, minimal. AHLYTPEERRATTRIOOPNH,Y, COFLOLLOLIIDC,ULAsRe,vermei.nimal. 648248 Continued on the next page .... ~ --- Company Sanitized. Doss not containTSCACB 9H02-4D6a7y8O:rSaulbGcahvraogneicSTtoxuiyciintyRats --_ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day If Sex: Males Animal Ret Microscopic & Macroscopic Findings sa8208 Continued from previous page Histopathology + No MiLUcNrGoSs,copHEiAcRTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edSP: LEEN, AORTA, BRAIN, SPINAL CROERCDT.UM,STOMMEASCEHN,TERDIUCODELNYUMMP,H NJOEDJEU,NUMS,ALIILVEAURMY,GLCAENCDUSM,, MCAOLNODNI,AULAR LPYINTPUHITNAORDYE,GLATNHDY,WUSP,ARAATDRHEYNRAOLIDGLGALNADNSD,S, STCRIAACTHIECA,NEREVSEO,PHAGUS, SPHEAMRIYNIANLI/VLEASRIYCNYL,ES,EYEU(RSI)NAWRIYTHBLAODPDTEIRC, NTEERSVTE,ES,SKIENP,EDIPDRVONSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -- -- T --- w Company Sanitzed. Does not contain TSCA CBI 9H0--2D4a67y8O:raSluGbcahvraogneicStTuoxdiyciintyRats -- DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IX - 300 ma/kg/day Treatment: 300 mo/kg/day TX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648249 TKeirlmliendalonSaDcaryi:fic1e22 AEnxiproaslureisGrsoiugpned: 1offMonftrhomrneeccorvoeprsyy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, PTHHAYRRYONIAD/LGALRAYNNDK,, PEAYREA(TSH)YRWOIITDHGOLAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNEVEESIJCOLIENST,, USRTIERNNAURMY, BNLOASDDEER, TESTES, EPIDIDYMIDES, --~ Histopathology LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal. NFEACTRTOYSICSH,ANGFEO,CALM,EDImiAnNimCaLlE.FT, minimal. KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROIADLTEGRLAATNIDON:, COLLOID, mild. AHUYTPOELRYTSRIOSP:HY,NECFORLOLPISCYULAANRD, HmIiSnTiOmLaOlG.Y PERFORMED, minimal --_ I -- Company Sanitized.Dossnotcontain TSCACBI H0--2D46a7y8O:rSaulbGcahvraogneicSTortiicuintdRyayts --~ DuPont6554 Showing anTinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Aninal Ref Microscopic & Macroscopic Findings 648261 TKeirlmliendalonSaDcaryif: ic1e22 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrenceocrvoeprsyy Gross Pathology : No Macroscopic Abnormality Observed : ALIOILRVETEUARM,,, KBPRIAADNINCNER,YESA,SS,PLICUNNEAGCLSU,MC,ORHDCE,AORLTOS,NT,OMSAKRCEEHCL,TEUTMAD,LUODMMEEUNSSUCEMLN,ET,ERJIESCJPULNELUEYMNM,,PH NAODDREE,NA'LSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYWUS, `PTHHAYRRYONIXD/LGALRAYNND,X, `PEAVREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMUIRN/AKLNEVEESIJCOLIENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYNIDES, Histopathology r LIVER:INFLAGONTION, SUBACUTE/CHRONIC, minimal. THYRO`IADLTGELRAANTIDON, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. No MiKcIrDoNsEcYoSpic Abnormality Observed --_ a a Company Sanitized. Dossnotcontain TSCA Cai H90--2D4a6y78O:raSlubGchraoniSvctTuoadxyiicgintRyaets --_~ DuPont6554 Showing anIinmdailvidduataal AfnoirmailndiLviisdtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Aninal Ref Microscopic & Macroscopic Findings sa8262 TKeirlmliendalonSDaacyri:fic1e22 AEnxiproaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoerpysy Gross pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEEN,TERJIECJUNLUYNM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICWANENRDVIEB,ULAPRITLUIYTMAPRHYNOGDLEA,ND.THYMUS, TPHHAYRRYONIXD/LGALRAYNND,X, PAEYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNVEEESIJCOLIENST,, USRTIERNNAURMY, BLNAODSDEER, TESTES, EPIDIDYNIDES, Histopathology : LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYHYSPE:RTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal THYROINDEPGHRLOAPNADTH:Y, CHRONIC PROGRESSIVE, minimal. `ALTERATION, COLLOID, severe. -- - Company Sanftized.possnotcontainTc cay 9H0--2D4a6y78O;raSlubGcahvraogneiSctTuodxyiicintRyats DuPont 6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 6a8272 TKeirlmliendalonSDaacyrif: ic1e83 AEnxipmoaslureisGrsoiugpned: 3offMonftrhomrneeccorvoeprysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PINCAECLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNNDX,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEEMMUINRA/LKNVEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology + --~ LIVER: NIENCFRLOASMIMSA,TIOFNO,CALS,UBmAiCnUiTmEa/lC.HRONIC, minimal. THYRO`IADLTGELRAANTIDON, COLLOTD, mild. _--_--m-- Company Sanitized. Doss notcontain TSCA CBI H0--2D4a67y8O:raSluGbacvhraogneiSctTuodxyiicintRyats --_ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : Ix - 300 mg/kg/day Treatment: 300 mg/kg/day Ii Sex: Males Animal Ref Microscopic & Macroscopic Findings 648275 TKeirlmliendalonSDaacyrif: ic9e2 EAnxipmoaslureisGrsoiugpned: o90ffdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC MNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYOITNDK/GLLAARNYDN,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEWMIUNRA/LKNEVEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, --_ Histopathology + LIVER:HYPERPLASIA, BILE DUCT, minimal. HIYNPFELRATMRMOAPTHIYO,N, HESPUABTAOCCUYTTEE/,CHRCOENNITCR,ILOmBiUnLiAmRa,l.mild. KIDNEYHSYPE:RTROPHY, TUBULAR, minimal. PANCRAELATSERATION, BASOPHILIC, FOCAL, minimal. THYROIIDNFGLALMAMNADTI:ON, SUBACUTE/CHRONIC, minimal. PROSTAALTTEER:ATION, COLLOID, minimal. 648275 Continued onItNhFeLAMnMeAxTtIOpNa,geSU-B..A.CUTE/CHRONIC, mild. -- -- ww Company Seniitizzed. poees notcontain TA ogy 90H.-2D4a6y78O;raSlubGcahvraogneiSetTuodxyiicintyRats -- DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648275 Continued from previous page Histopathology + No MiLUcNrGoSs,coHpEiAcRTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL CROERCDT.UM,STOMMEASCEHN,TERDIUCODELNYUMMP,H JNOEDGEU,NUMS,ALIIVLEAURMY, GLCAENCDUSM,, MCAOLNODNI,BULAR LPYIMTPUHITNAORDYE,GLATNHDY,VUSP,ARAADTRHEYNRAOLIDGLGALNADNSD,S, STCRIAACTHIECA,NEREVSEO,PHAGUS, VPEHSAIRCYLNEXS/,LARUYRNIXN,ARY'EYBEL(AS)DDEWRI,THTEOSPTTEISC, NEERPVIED,IDYSMKIIDNE,S,SEFMEINMAULR/KNEE JOINT, STERNUM, BONE MARROW, NOSE --_ - ws `Company Sanitized. Does not contain TSCA GBI 9F-02-4D6a7y8O:raSlubGcahvraogneicSTtouxdiycintRyats --_ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : IX - 300 mg/ka/day Treatment: 300 mg/kg/day TX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648277 TKeirlnliendalonSaDcaryif: ic1e22 EAnxipmoaslureisGrsoiugpne:d o1ffMonftrhomrneeccorvoeprysy Gross Pathology No wacroscopic Abnormality Observed : ALOIRVTEAR,, KBRIADINNE,YS,SPLIUNNAGLS,CORHDE,ARTS,TOMSAKCEHL,ETDAULODMEUNSUCML,E, JESJPULNEUEMN,, NTOLDEEU,M, `SPAALNICVRAERAYS,GLACNEDCSUM,, MACONLDOINB,ULARERCTLUYMM,PHMENOSDEEN,TERTIHYCMULSY,MPH A`TDHRYERNOAILD GGLLAANNDD,S, PASRCAITAHTYICROINEDRVGEL,ANDPSI,TUTIRTAACRHYEAG,LANEDS,OPHAGUS, SPHEAMRIYNNAXL/LVAERSYINCKL,ES,EYEU(RSI)NARWYITHBLAODPDTEIRC, NTEERVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology --_ LIVER HIYNPFELRATMRMOAPTIHOYN,, HESPUABTAOCCUYTTEE/,CHRCOENNITCR,ILOmBiUnLiAmRa,l.minimal. THYRO`IADLTGELRAANTDION:, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal No MKiIcDrNoEsYcSopic Abnormality Observed : --_ ww CompanySanitiz 2.DoesnotcontTsacaiongy 90H.-2D4a6y78O;raSluGbachvraogneicSTotxiciuintdRyayts DuPont6554 Showing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg animals Dose Group : If - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings sa8282 TKeirlmliendalonSDaacyrif: ic1e22 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoerpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLREUTMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,ND,THYMUS, TPHHAYRRYONIID/LGALRAYNNDK,, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNEVEESIJCOLIENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology + LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. THYRO`TADLTGELRAANTIDON:, COLLOID, minimal. --~ --_-- ompany Senilized. DoesnotcontainTSCA Cay 5204-6D7ay8:OraSlubGcalvraogneicStTuoxdiyciintyRats Dupont6554 --_ Showing anIinndailvidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group IX - 300 ng/ko/day Treatment: 300 ma/kg/day TK Sex: Males Animal Ret Microscopic & Macroscopic Findings Ginzee TKeirlmliendalonSDaacyrif: ic1e72 AEnxipmoaslureisGrsoiugpned o1ffHonftrhomrenceocrvoeprsyy Gross patholosy + No MaLAIOcVRrEToRAs,,copKGiRIAcDINNEA,YbSn,oSrPmLIUaNNlAGiLSt,CyOROHDEb,AsReTrS,TvOeMSdAKCEHL,ETDAULODMEUNSUCML,E, JESIPULENRONM,, NIOLDEEU,K, SAPLANICVRAERAYS,GLACNEDCSU,N, ACNODLIOSNU,LARRECTLUYMP,HMENOSDEEN,FERTHIYCMULS,ib ATPHDHYRARERONYIAYDL/LGGALLRAAYNNYDDX,S,, PESAYCREIM(NHSTY)IRCOWIINDTERHVGEOL,APNTDIPSCI,TNUTEIRRTVAAECR,HYEASG,KLIANNS,DS,OPBHRAOGSUTSA,TE, FSEEHUIRNA/LKIVEESIJCOLIENST,, USRTIENRARNY, BNLOADSDEER, TESTES, EPLDIDWIDSS, -- tscopatholony Laver IHYNPFELRTARTOIPHOYN,, HESPUABTMOCCUYTTEE/,CHRCOENNITCR,ILOmBiUnLiAmRa,l.minisal. KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. THYROAIHLDPTEEGRRLTAARTNOIDPORN:Y,, COFLOLLOLIIDC,ULAmRi,nnmailn.ial. --_ --_-- w= Company Sanlized. Dossnotconten sca cay 9H0--2D4a67y8O;raSulbGcahvraogreiSctTuodxiyciintRyats -- DuPont6554 Showing anIinmdailviddautaal AfnoirmailndLiivsidtuianlg animals Dose Group: IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648287 TKeirlmliendalonSDaacyrif: ic1e83 AEnxipmoaslureisGrsoiugpne:d o3ffMonftrhomrneeccorveorpysy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,X, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNEVEESIJCOLIENST,, SUTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDVMIDES, --_ Histopathology + LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal THYRO`IADLTGELRAANTIDON:, COLLOID, mild. --_ eet `Company Sanitized. Doesnotcontain TSCA CBI 9H0--24D6a7y8O;rSaubGcahvargoeiSctTuodxyiicintRyats --_~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : IX - 300 mo/ka/day Treatment: 300 mg/kg/day TX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648289 TKeirlmliendalonSDaacyrif: ic9e2 AEnxipnoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology : No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC MNAENRDVIEB,ULAPRITLUYIWTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYNIXD/LGALRAYNND,K, PAEVREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, F`SEEMMUIRN/AKLNVEEESIJCOLIENST,, SUTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, Histopathology : -- LIVER IHYNPFELRATMRMONPTHIYO,N, HESPUABTAOCCUYTTEE/,CHRCOENNITCR,ILOmBiUnLiAmRa,l. moderate. KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. PANCRHEYRPSER:TROPHY, TUBULAR, minimal. THYROIADTROGPLHAYN,D m: inimal. AHYLPTEERRTARTOIPOHNY,, COFLOLLOLIIDC,ULAsRe,vermei.nimal 648289 Continued on the next page .... -- --- Company Sanhized.Doss notcontain TSCA CBI 9H0--2D4s6y78O:rSaulbGcahvraogneiSctTuodxiyciintRyats ~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648289 Continued from previous page Histopathology : No miLUcNrGoSs,copHiEAcRTA,bnoSrKmEaLElTiAtLy MOUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL `RCEOCRTDU,M|,STOMMEASCEHN,TERDIUCODELNYUMMP,H JNOEDJEU,NUMS,ALIIVLEAURMY,GLCAENCDUSM,, CMOALNODNI,AULAR LPYIMTPUHITANRODYE,GLATNHDY,WUSP,ARAADTRHEYRNOAILDGGLLAANNDDSS,, STCRIAACTHIECA,NEREVSEO,PHAGUS, `PSHEAMRIYNNAXL/LVAERSYINCXL,ES,'BYUER(IS)NARWYITHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FENUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE --_ ee ---- `Company Sanitized. Doos not containTSCACBI H90--2D4s6y78O:raSluGbchraonivSctTuoadxiyicgintRyaets ~ DuPont6554 Showing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg aninals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Aninal Ref Microscopic & Macroscopic Findings sa8292 TKeirlmliendalonSDaacyrif: ic1e83 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrneeccorvoerpysy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUMA,, BPRAANICNR,EASS,PICNEACLOMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, TPHHYARROYINXD/LGALRAYNDN,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEEMNUIRN/AKLNEVEESIJCOLTENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDVNIDES, Histopathology r LIVER NIENCFRLOASMIMSA,TIOFNO,CALS,UBAmCoUdTeEra/tCeH.RONIC, minimal. THYRO`IADLTGELRAANTDION, COLLOID, minimal. -- T Company Sanuw lizes. Lo fotGsousain dsa TSCAGaBIr H90--2D4s6y75O:raSluGbcharonivSetTuoadxyiicgintRyaets --~ Dupont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Animal Ref Microscopic & Macroscopic Findings 648203 TKeirlmliendalonSDaacyrif: ic9e2 AEnxipmoaslureisGrsoiugpned: 9o0ffdafyrom necropsy Gross Pathology : Sex: Males No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUVM,F NAODDRSE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC MNAENRDVIEB,ULAPRITLUYISTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIKD/LGALRAYNNDX,, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMUIRN/AKLNVEEESIJCOLINETS,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, --_ Histopathology : LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. HFYAPTETRYTRCOHPAHNGYE,, HECPEANTTORCIYLTOEB,ULACRE,NTRmIiLlOd.BULAR. mild. KIDNEYNESPH+ROPATHY, CHRONIC PROGRESSIVE, minimal. | `THYROHIYDPEGRLTARNODPH:Y, TUBULAR, mininal NOSE `:ALTERATION, COLLOID, severe. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 648293 Continued on the next page .... -- - Gompeny Sanltized. Does notcontain Tscacal 9H0--24D6s7y5O:rSaubGcahvraogneicSTtouxdiyciintyRats -- DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndLiivsidtuianlg animals Dose Group: TX - 300 mg/kg/day Treatment: 300 mg/kg/day TX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648293 Continued from previous page Histopathology No miLUcNrGoSs,copHiEAcRTA,bnoSrKmEaLElTiAtLy MOUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL CCOORLDO,N, SRTEOCMTAUCMH,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPAVNACRRYEAGSL,ANDCSE,CUM, MNEARNVDEI,BULPAIRTULIYTWAPRHY GNLOADNE,D,THPYAWRUAST,HYARDORIEDNGALLANGDLSA,NDST,RACSHCEIAA,TIC PESROOPSHTAAGTUES,, SPEHMAIRNYANLX/VLEASRIVCNLEKS,, EUYER(ISN)ARYWITBHLADODPETRI,C NERVE, TESTES, SKIN, EPIDIDYMIDES, PEMUR/KNEE JOINT, STERNUM, BONE MARROW --~ --_ -- ww Company Sanitized. Dass not contain TSCA CBI 9H0--24D6a7y8O;raSlulGbacvharogneicSTtouxdiyciintyRats DuPont6554 ~~ Showing anIinmdailviddautaal AfnoirmailndLiivsidtuianlg animals Dose Group : TX - 300 mg/kg/day Treatment: 300 mg/kg/day TX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648306 TKeirlmliendalonSaDcaryif: ic1e22 EAnxipmoaslureisGrsoiugpned: 1offMonftrhomrenceocvreorpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NASLAGLLIAVNADRSY, GLSACNIDNST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYOIINDK/GLLAARNYDN,K, PEAVREA(TSH)YRWOIIDTHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LK,NEVEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDVMIDES, Histopathology : ~~ LIVER: IHYNPFELRATMRMOAPTHIYO,N, HESPUABTAOCCUYTTES/,CHRCOENNITCR,ILOmBiUnLiAmRa,l minimal. THYROAILDTEGRLAATNIDON:, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. No uiKcIrDoNsEcYSopic Abnormality Observed : --~ --- Company Sanitized. Doas not contain TSCA CBI 9H0--2D4a67y8O:raSluGbachvraogneiSctTuodvyiicintRyats --_ DuPont6554 Showing anIinmdailviddautaal AfnoirmailndLiivisdtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648308 TKeirlmliendalonSDaacyrif: ic9e2 AEnxipmoaslureisGrsoiugpned: o9f0fdafyr.om necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,ND,THYMUS, PTHHAYRRYOIINDK/GLLAARNYDN,K, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEVMIUNRA/LKNEVEESIJCOLTENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYNIDES, Histopathology : --_ LIVER IHYNPFELRATMRMOAPTHIYO,N, HESPUABTAOCCUYTTSE/,CHRCOENNITCR,ILOmBiUnLiAmRa,l. mild. KIDNEY`NSEP:HROPATHY, CHRONIC PROGRESSIVE, minimal. HEARTHY PERTROPHY, TUBULAR, minimal. THYROI(CDARGDLIAONMDYOP: ATHY, minimal. AHLYTPEERRATTRIOOPNH,Y, COFLOLLOLIIDC,ULAmRo,dermaitnei.mal. 548308 Continued on the next page .... ~~ --- Company Senilized. DossaoconTtSaCAiCBnI H9-02-4D6a7y8O:raSlubGcahvraogneicSTotxuiycintyRats --~ DuPont6554 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group : IX - 300 mg/kg/day Treatment: 300 mg/kg/day IX Sex: Males Animal Ref Microscopic & Macroscopic Findings 648308 Continued from previous page Histopathology + No MiLUcNrGoSs,copSiKcELAEbTnAoLrmMUaSlCiLtEy, ObSsPLeErEvNe,d A:ORTA, BRAIN, SPINAL CORD, R`SETCOTMUAMC,H, MEDSUOEDNETNEURNI,C LJEYJMUPNHUMN,ODEI,LEUSMA,LIVPAANRCYREGALSA,NDSC,ECUMMA,NDICOBLUOLNA,R PLIYTMUPIHTANRODYS,GLATNHDY,MUSP,ARAADTRHEYNRAOLIDGLGALNADNDSS,, STCRIAACTHIECA,NEREVSEO,PHAGUS, `PSHEAMRIYNIAXL/LVAERSYINCXL,ES,'EYUER(SI)NARWYITHBLAODPDTEIRC, NTEERSVTE,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -- --~ --- ww Company Sanitized. Doss not contain TSCA Cai 9H0-.2D4a6y75O:raSluGbcahvraogneiSctTuodxyiicintRyats -- DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : II - 0 mg/kg/day Treatment: O mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648306 TKeirlmliendalonSaDcayri:fic12e2 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoeprsyy Gross Pathology No MaLIcVrEoRs,coKpIiDcNEAYbSn,orLmUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TEJREIJCUNLUYMM,PH NAODDREE,NALSALGLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYINTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIKD/LGALRAYNNDX,, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIESRSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology -- No Microscopic Abnormality Observed : THYROID GLAND --_ N.S `Company Sanitized. Does not contain TSCA CBE H90--2D4a6y78O;raSluGbchraonivSctTuoaxyiicgintRyaets DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Aninal Ref Microscopic & Macroscopic Findings 648351 TKeirlmliendalonSDaacyrif: ic9e3 EAnxipmoaslureisGrsoigunped: o90ffdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIOCUNLUYEM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAERYNGOLDEA,ND,THYWUS, `PTHHAYRRYONIKD/LGALRAYNNDX,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAGGAURS,Y GFLEAWNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology LIVERFATTY CHANGE, MEDIAN CLEFT, minimal. THYROATLDTEGRLAATNIDON, COLLOID, minimal. PHARYNINXF/LLAAMRMYANTXION, SUBACUTE/CHRONIC, minimal. MARIANROYTGLPARNESDEN(TF.EMALE) : 648351 Continued on the next page .... --~ --- ww Company Sanitized. Doss not containTSCACat 9H0--2D4a67y8O;raSluGbachvraogneiSctTuodxyiicintRyats --~ DuPont 6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648351 Continued from previous page Histopathology No MiKIcDrNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y OSbKsEeLrEvTeAdL : MUSCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEISCUNLUYYM,PH INLOEDUEM,, GSLAALNIDVSA,RYSGCLIAANTDISC, NMERAVNED,IBUPLIATRUITLAYRMYPHGLNAONDDE,, TPHAYRMKUTSH,YRAODLRDEGNLAALNDS, TUTREARCUHSE,A, UREISONPAHRAYGUBSL,ADDEEVRE,(S)FEWMIUTRH/KNOEPSTIJCOINNETR,VE,STESRKNIUN,M, OVBAORNIEES, MARROW, NOSE --_~ --- ww Company Sanitized. Doss notcontain TSCA CBI 0F--2D4a67y8O:naSuGbacvhraogneiSctTuodxyiicintRyats --~ DuPont6554 Shouing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648353 TKeirlmliendalonSDaacyrif: ic9e3 AEnxipmoaslureisGrsoiugpned: 9o0ffdafyr.om necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH . NAODDREE,NAL`SAGLLIAVNADRSY,GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,KD,THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,X, `PEAYREA(TSH)YRWOIITDHGOLAPNTDISC,NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, --~ Histopathology LIVER:INFLAMMATION, SUBACUTE/CHRONIC, minimal. PARATNHOYTROIPDRESGELNATN.DS No MiKIcDrNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y OSbKsEeLrEvTeAdL M:USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMP,HINLOEDUEM,, GSLAALNIDVSA,RYSGCLIAANTDISC, NMERAVNED,IBUPLIATRUILTYAMRPYHGLNAONDDE,, TTHHYYMRUOSI,D GALDARNEDN,AL 648353 Continued on the next page .... _-- Company Sanitized. Does not contain TSCA CBI 9F0--2D4a6y78O:ralSuGbachvraogneicStTuordiyciintRyats --_ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex; Females Animal Ref Microscopic & Macroscopic Findings 648353 Continued fron previous page Bistopatholooy No MiTRcArCoHsEcAo,picESAObPHnAoGrUmSa,litPyHAORbYNsKe/rLvAeRdYN:X, EOYVEA(RSI)ES,WITUHTEROUPST,ICURNEIRNVAER,Y SBKLIAND,DERM,AYVFAERMYURG/LKANNEDE J(OFIENMTA,LE), STERNUM, BONS MARROW, NOSE PN --_ - ww Company Sanitized. boas notcontain TSCA CB) H90--2D4s6y78O;raSluGbachvraogneiSctTuodxiyicintRyats -- DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group: II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648356 TKeirlnliendalonSaDcaryif: ic1e83 AEnxipmoaslureisGrsoiugpne:d o3ffMonftrhomrneeccorvoerpysy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, IALOERUTMA,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULIYTMPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,K, `PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFELMAUNRD/K(NFBEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology r THYRO`IADLTGELRAANTDION, COLLOID, minimal. - `Company Sanitized. Doesnotcontain TSCACBI 9H:02-4D6a7y8O:raSluGbcahvraogneicSTtoxyiciintyRats --_~ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/kg/day Treatment: 0 my/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648357 TKeirlmliendalonSDaacyrif: ic1e83 AEnxipmoaslureisGrsoigunped: o3ffMonftrhomrneeccorvoerpysy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PINCBAOLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NA' LSAGLLIAVNADRSY, GLSACNIDAST,IC MNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THOUS, TPHHAYRRYONIXD/LGALRAYNNDK,, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology + ls THYROIADLTEGRLAATNIDON:, COLLOID, miniral. ~~ _-- `CompanySanitized.Doesnotcontain TSCACBI H902-4D6a7y8O;nlSuGbcahvraogneicSTtouxdiyciintyRats --_ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648370 TKeirlmliendalonSaDcaryi:fic9e3 AEnxipnoaslureisGrsoiugpne:d o9f0fdafyrom necropsy Gross 2athology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNAELCUC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NASLAGLLIAVNADRSY, GLSACNIDAST,IC MANENRDVIEB,ULAPRITLUIYTMAPRHYNOGDLEA,ND,THYMUS, TPHHAYRRYOIINDX/GLLAARNYDN,X, PEAYREA(TSH)YRWOIITDHGOLAPNTDISC,NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,OM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : -- LIVER UTERUSINF LAMMATION, SUBACUTS/CHRONIC, miniral. DILATATION, GLAND/LUMEN, mild. No MiKIcDrNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y OSbKsEeLrEvTeAdL M: USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH INLOEDUEM,, GSLAALNIDVSA,RYSGCLTAANTDISC, NEMRAVNED,IBUPLIATRUILTYAMRPYHGLNAONDDE,, TTHHYYMRUOSI,D GALDARNEDN,AL 648370 Continued on the next page .... ~ - ws CompanySanitized.Does not contain TSCA CBI 9H0--2D4a67y8O:raSluGbaevhargoenSctTuodxiyciintRyats --_~ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group: IT - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ret Microscopic & Macroscopic Findings 648370 Continued from previous page Histopathology : No MiPcArRoAsTcHoYpRiOcIDAGbLnAoNrDmSa,liTtRyACOHbEsAe,rveEdSOP:HAGUS, PHARYNX/LARYNX, OEVYAER(IS)ES,WITUHRIONPATRIYCBLNAEDRVDEE,R, SKFIENM,URM/KANMEMEARJYOIGNLTA,NDST(EFRENMUAML,E),BONE MARROW, NOSE --_~ ~~ - H9-02.4D6a7y8O;nlSubGcahvraogneicSTtouxdiyciintyRats --_ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Anival Ref Microscopic & Macroscopic Findings 648372 TKeirlmliendalonSDaacyrif: ic9e3 AEnxipvoaslureisGrsoigunped: o9f0fdafyr.om necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIWTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNNDX,, PEAYREA(TSH)YRWOIITDHGOLAPNTDISC, NTERRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology LaverINFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. THYROAILDTEGRLAATNIDO:N, COLLOTD, miniral. rERUSDIL+ATATION, GLAND/LUMEN, mild. 648372 Continued on the next page .... --_ - Company Sanilized. Loss nos contain TSCA CBI 9H0--24D6a7y5O:rSaulbGcahvraogneiSctTuodxiyicintRyats DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648372 Continued from previous page Histopathology : No MiLUcNrGoSs,copHiEAcRTA,bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL CCOOLRODN,, STROEMCATCUHM,, DMUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANRCRYEAGSL,ANDCSE,CUM, MNEARNVDEI,BULPIATRULIYTHAPRHY NGLOADNED,, THPYAMRUAST,HYARDORIEDNGALLANGDLSA,NDST,RACSHCEIAA,TIC MESAOMPMHAARGYUSG,LANPDHAR(YFNEKM/ALLEA)R,YNXO,VAREIYEES(,S) URWIINTAHRYOPBTLIACDDNEERR,VE, SKIN, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE ~~ -_-- `CompanySanitized.Does nolcontain TSCACBI 124678: Subshronic Tosicity --~ NDoyOulGrvogeStudyioDReems s Showing aInnidniavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Aninal Ref Microscopic & Macroscopic Findings 648369 TKeirlmliendalonSDaacyrif: ic1e22 nExipnoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoerpysy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANTCNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEYN,TERJEIJCUNLUYMM,PH NAODDREE,NASLAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIKD/LGALRAYNDN,K, PEAYREA(TSH)YRWOIITDHGOLAPNTDISC, NTERRVAEC,HEAS,KINE.SOPMHAANGAURS,Y GPLEAMNUDR/K(NFEEEMAJLEO)T,T,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology No MTiHcYrRosOcIoDpiGcLANADbnormality Observed : --~ = --- `Company Sanitized. Doss not contain TSCA CBI 9H-02.4D6a7y5O;raSlubGcahvraogneicStTuoxdiyciintyRats DuPont6554 ~~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day TI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648393 TKeirlmliendalonSaDcaryif: ic9e3 AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE:LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,ND,THOUS, TPHHYARROYNIKD/LGALRAYNNDK,, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology + -- LIVER : THYROIIDNFGLLAMAMNADTION, SUBACUTE/CHRONIC, minimal. "PARATAHLYTREORIADTIGOLNA,NDSCOL:LOID, minimal. VAMUARNYOTGPLRAESDENT(.FEMALE) : UTERUSNDIOLT:ATPARTEISOENN,T.GLAND/LUMEN, minimal. 648393 Continued on the next page .... --~ -- ww `Company Sanitized. Does notcontain TSCA CBI 9H0--2D46a7y5O;raSlubGcahvraogneiSctTuodxiyicintRyats Dupont.6554 --_~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/ka/day Treatment: O mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648393 Continued rom previous page Histopathology + No miKcIDrNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y OSbKsEeLrEvTeAdL M: USCLE, SPLEEN, AORTA, BPARNACNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PHINLOEDUEM,, SGLAALNIDVSA,RYSGCLIAANTDISC, NMERAVNED,IBUPLIATRUITLAYRMYPHGLNAONDDE,, TTRHAYCMHUESA,, ADESROEPNHAALGUS, UPRHIANRAYRNYX/LBALRAYDNDXER,, EYFEE(MSU)R/WKINTEHE OJOPITNITC, NESRTVEER,NUMS,KINB,ONOEVAMRAIRERSOW,, Nose. --~ --_ = --- Company Samiizes. Lows act contain TSCA Cal 9H0L.2D4a6y7O:ralSuGbcahviaogneicStTuodxiyciintyRats Dupont6554 ~~ Showing aInnidniavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : II - 0 mg/kg/day Treatment: O mg/kg/day IT Sex: Females nial Ref Microscopic & Macroscopic Findings 61839 TKeirlmliendalonSaDcaryif:ic1e22 AEnxipmoaslureisGrsoiugpned: o1ffNonftrhomrneeccorvoerpysy Gross Pathology No MLaIcVrEoRs,coKpIiDcNEAYbSn,ormLUaNlGiSt,y OHbEAsReTr,vedSKE LETAL MUSCLE, SPLEEN, AIOLREUTYA,, BPRAANLCNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUIYTPAHRYNOGDLEA,ND,THYNUS, TPHHYARROVIIXD/LGALRAYNND,K, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)T,NT,OVASRTIEESR,N,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : ~ THYROIADLTEGRLAATNIDON, COLLOID, minipal. --~ --- `CompanySanitizad.Dossnotcontain TSCA Cal F9-02-4D6a7y8O:raSlubGcahvraogneicStTuoxdiyciintyRats DuPont6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ret Microscopic & Macroscopic Findings 648395 TKeirlmliendalonSDaacyrif: ic9e3 AEnxipnoaslureisGrsoiugpned: o90ffdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYNIXD/LGALRAYNNDX,, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : --~ LIVER KIDNEYISNFL+AMMATION, SUBACUTE/CHRONIC, minimal PANCRENAESPHROPATHY, CHRONIC PROGRESSIVE, minimal. `ATROPHY, minimal. 548395 Continued on the next page .... -- --- CompanySaniized.Dossnot conan TSCACBI 9H-02.4D6a7y8O:raSlubGcahvraogneieStTuoxdiyciintyRats DuPont6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648395 Continued trom previous page Histopathology No MiLcONrGoSs,copHiEAcRTA,bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL RCOERCDT,UM,STMOEMASCEHN,TERDIUCODELNYUMMP,H NJOEDJEU,NUYS,ALIIVLEAURMY,GLCAENCDUSM,, MCOALNODNI,BULAR LPYIMTPUHITNAORDYE,GLATNHDY,MUST,HYRAODIRDENGALLANGDL,ANDPSA,RATSCHIYARTOIICD NGLEARNVDES,, STYREA(CSH)EA,WITEHSOPOHPATGIUCS,NERPVHEA,RYNSXK/INL,ARYMNAXM,MARY GLAND (FEWALE), SOTVEARRNIUEMS,, BUTOENREUSM,ARRUORWI,NARNYOSEBLADDER, FEMUR/KNEE JOINT, --~ --_ = --- `Company Sanitized. Doss not contain TSCA CBI 9H0--2D46a7y8O;rSaubGcahvraogneiSctTuodxiyciintRyats --~ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/kg/day Treatment: 0 mg/kg/day IT Sex: Females Animal Ref Microscopic & Macroscopic Findings 648400 TKeirlnliendalonSaDcaryif: ic1e22 EAnxipmoaslureisGrsoigunped: o1ffMonftrhomrneeccorvoerpysy Gross Pathology : No MaLcIVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYWUS, TPHHYARROYNIXD/LGALRAYNND,X, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HERS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEVALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed : --- `Company Samtized. oes okcontainTECACB 9H0-.2D4a67y8O;raSluGbachvraogneiSctTuodxiyicintRyats ~~ Showing aInnidniavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPont6554 Dose Group : II - 0 mg/kg/day Treatment: O mg/kg/day II Sex: Females Aniral Ref Microscopic & Macroscopic Findings 648405 TKeirlmliendalonSDaacyrif: ic1e83 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrneeccorvoeprsyy Gross Pathology : No MaLcIVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUND,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC MNAENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYOIINDX/GLLAARNYDN,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEZRSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : --~ THYROID GLAND : `ALTERATION, COLLOID, minimal. -- -------------------------------------------------- Company Sanitized. Doesnotcontain TSCA Cal 9H0--2D4a6y75O;rSaulbGcahvraogneiSctTuodxiyicintRyats --_ DuPont-6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/kg/day Treatment: O mg/kg/day II Sex: Females Animal Ret Microscopic & Macroscopic Findings 648421 TKeirlmliendalonSaDcayri:fic93e AEnxipmoaslureisGrsoiugpne:d o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHbEAsReTr,vedSKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NALSALGLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTAPRHY NGODLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,X, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology + --~ LIVER FINAFTLTAYMMCAHATNIGOEN,, MSUEBDAICAUNTEC/LCEHFRTO,NImCi,nimmailn.imal. KIDNEY`NSEP:HROPATHY, CHRONIC PROGRESSIVE, minimal. LovesINFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCR'EDRESGE+NERATION/NECROSTS, ACTNAR CELL, minimal. . HYPERPLASIA, FOCAL, ACINAR CELL, minimal. 648421 Continued on the next page .... --_ --- Company. `SaDnoeisnottcointazinTascdac.a 9H02.4D6a7y8:OraSlubGcahvraogneicSTtouxdiyciintyRats --_ Showing aInnidmiavlidduaatla AfnoirrailndLiivsitdiunagl animals Dupont6554 Dose Group : IT - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Hicroscopic & Nacroscopic Findings sesaal Continued fron previous page Histopathology : No MiHcEArRoTs,copSiKcELAEbTnAoLrmMaUlSCiLtEy, ObSPsLeErEvNe,d A:ORTA, BRAIN, SPINAL CORD, MSETSOMEANCTHE,RICDUOLDYEWNPUHM,NODJEE,JUNSUAML,IVAIRLEYUMG,LANCDESC,UM,MACNODLIOBNU,LARR ELCYWTP,'S GNOLDAEN,D,THTYHNYURSO,IDADGRLEANNADL,' GPLAARNADTSH,YROSICDINGTLIACNDNSE,RVST,RACPHIETAU.ITARY MEASMOPMRAARGYUSG,LANPDHAR(FYENN/ALLAER)Y,NKO,VAREIYEES(,S) UWTEIRTUHS,OPTUIRCINNAERRYVEB,LADSDKEIRN,, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE --~ -- -- ww `Company Sanfizec. Dossnotcontain TSCA cai 9H0--2D46a7y8O;raSluGbaehvraogneiStTuodxiyciintRyats DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl anirals Dose Group : IT - 0 mg/kg/day Treatment: O mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings sa8a22 TKeirlmliendalonSDaacyrif: ic1e83 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrneeccorvoerpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PINCAECLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,ND,THWMUS, TPHHYARROYNIXD/LGALRAYNND,X, PAEVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : --~ `THYROID GLAND : ALTERATION, COLLOID, minimal. -- --_---- `CompanySanitized. Does notcontTSaCAiCnBI 9H0L-2D46a7y5O:nlSubGcahvraogneicSTtouxdiyciitnyRats Dupont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/kg/day Treatment: 0 mg/kg/day TI Sex: Females Aniral Ref Microscopic & Macroscopic Findings siai23 TKeirlmliendalonSDaacyrif: ic9e3 AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSo,maLUlNiGtS,y OHEbAsReTr,vedSKE LETAL MUSCLE, SPLEEN, AIOLRETUAN,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYEb,H ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,IC MANENRDVIEB,ULAPRITULYIMTPAHRYNGODLEA,ND,THYMUS, TPHHYARROYINGD/LGALRAYNDN,K, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FEGLMAUNRD/K(NFEEEMALJEO)T,HT,OVASRTIEERSN,UE,UTENROUSSE, VAGINA, URINARY BLADDER, --~ Histopathology LiverFATTY CHANGE, MEDIAN CLEFT, minival. THYROIIDNFGLLAMAMNADTION, SUBACUTE/CHRONIC, mininal. EVE(S)ALTWEIRTAHTIOOPNT,ICCNOLELROVIED, miniral. uresusOPTIC NERVE NOT PRESENT. DILATATION, GLAND/LUMEN, mild. 648423 Continued on the next page .... ~~ -- ww `Company Sanitized. Doss not contain TSCA Cal 9H0--2D4a6y78O:raSluGbachvraogneicSToxtiicintRyyats --~ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648423 Continued from previous page Histopathology No MiKcIrDNoEsYcSo,picLUNAGbSn,ormWEaAlRiTt,y OSbKsEeLrEvTeAdL M: USCLE, SPLEEN, AORTA, BPRAANTCNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PHINLOEDOEM,, GSLAALNTDVSA,RYSGCLIAANTDISC, NMERAVNED,IBUPLIATRUITLAYRMYPHGLNAONDDE,, TPHAYRMAUTSH,YRAODIRDENGLAALNDS, ETYREA(CSH)EA,WITEHSOPOHPATGIUCS,NERPVHEA,RYNSKK/INL,ARYMNAXM,UARY GLAND (FEVALE), OMAVRARROIWE,S,NOUSREINARY BLADDER, FEMUR/XNEE JOINT, STERNUM, ONE --_ --~ = --- `Company Sanitized. Doss not contain TSCA CBI 9H0--24D6a7y8O;raSluGbachvraogneiSctTuodxiyciintRyats DuPont-6554 Showing aInnidriavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648425. TKeirlmliendalonSDaacyrif: ic1e22 EAnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJULNYYM,PH NADORDEEN,ALS,AGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, PTHHAYRRYONIED/LGALRAYNNDX,, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : No MiTcHrYoRsOcIDopiGcLAANbDnormality Observed ew `Company Sanitized. Doss not contain TSCA CBI 9H-02-4D6a7y8O:raSluGbcahvraogneicStTuoxdiyciintyRats DuPont6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group: IT - 0 mg/kg/day Treatment: O mg/kg/day IT Sex: Females Animal Ref Microscopic & Macroscopic Findings 648426 TKeirlmliendalonSaDcaryif: ic1e22 AEnxiproaslureisGrsoigunped: o1ffMonftrhomrneeccorvoeprysy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NA'LSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULYIWTPAHRYNGODLEA,ND,THYMUS, TPHHYARRYOIIUD/LGALRAYNDN,K, `PEAYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology ~~ THYROID GLAND : ALTERATION, COLLOTD, minimal. --~ = --- `Company Senitized. Does not contain TSCA GBI 9H02-4D6a7y5:OrSauGbcahvraogneicSTuodxyiicntRyas DuPont6554 --~ Showing aInnidniavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Aninal Ref Microscopic & Macroscopic Findings 648427 TKeirlnliendalon SaDcaryif: ic1e22 AEnxipnoaslureisGrsoiugpned: o1ffMonftrhomrencecorvoeprsyy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETGAN,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OWARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIES,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYINDX/GLLAARNYDN,, PAEVREA(TSH)YRWOIIDTHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHRAOGGURS,Y GFLEANNUDR/K(NFEESMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology r No M"iTcHrYoRsOcIoDpiGcLAANbDnormality Observed --_ --- Company Sanitizec. Does not contain TSCA CBI 9H-02-4D6a7y8O:raSlubGcalvraogneicStTuoxdiyciintyRats DuPont6554 -- Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 548430 TKeirlmliendalonSaDcaryif: ic9e3 AEnxipmoaslureisGrsoigunped: o9f0fdafyrom necropsy Gross Pathology : - No MLaIcVrEoRs,copKiIcDNEAYbSn,orrLaUNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULIYTMAPRHYNGODLEA,ND,THYMUS, TPHHYARRYONIGD/LGALRAYNND,K, 'EPYAREM(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEESMALJEO)T,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal KIDNE`YNSEP:HROPATHY, CHRONIC PROGRESSIVE, minimal. INFARCT, minimal. No MiLUcNrGoSs,copHiEcARTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL CCOOLRODN,, SRTEOCMTAUCMH,, MDUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODTEL,EUMS,ALIPAVNACRRYEAGSL,ANDCSE,COM, NMEARNVDEI,BULPAIRTULIYTMAPRHY GNOLDAEN,D, TTHYHWYURSO,IDADGLRAENNDA,L GPLAARNADTSH,YROSICIDAGTLIACNDS, 648430 Continued on the next page ... -- -- ww Company Sanitized. Doss not contain TSCA CBI 9H0--2D46a7y8O;rSaulbGcahvraogneiSctTouxdiyciintRyats DuPont.6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648430 Continued from previous page Histopathology : No Mi`TcRrAoCsHcEAo,picESAObPHnAoGrUmSa,litPyHAROYbNsXe/rLvAeRdYN:X, OEVYAER(SI)ES,WITUHTEROUPST,ICUNREIRNVAER,Y SBKLIAND,DERM,AMMFAERMYUR/GKLNAENED J(OFIENMTA,LE), STERNUM, BONE NARROW, NOSE --_ --_ -- ww Company Sanitized. Doesnotcontain TSCA CBI 9B02-4D6a7y8:OnSaubGcalvraogneicStTouxdiyciintyRats ~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dupont6554 Dose Group : II - 0 ma/kg/day Treatment: O me/kg/day II Sex: Females Animal Ref Microncopic & Macroscopic Findings Ere TKeirlmliendalonSDaacyrif: ic1e83 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrenceocvreorpysy Gross pathology Yo MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y GHEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OWARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYHUS, TPHHYARRYONIXD/LGALRAYNNDX,, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEANNUDR/(NFEEEMALJEO)I,NT,OVASRTIEERSN,M,UTENROUSSE, URINARY BLADDER, istopathology : mhyRO"IADLTGELRAANTIDON, COLLOID, minimal. eee CompanySanitized. Doss notcontain TSCAC8! H9-02-4D6a7y8:OrSaulbGcahvraogneicSTtouxdiyciitnyRats --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPont-6554 Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Anival Ref Microscopic & Macroscopic Findings 648438 TKeirlmliendalonSDaacyrif: ic1e22 EAnxipmoaslureisGrsoigunped: 1 Month recovery off from necropsy Gross pathology : No MaLIcVrEoRs,copKiIcDNGAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedS:KELETAL MUSCLE, SPLEEN, ATOLRETOAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNND,X, PAEVREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEWAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology -- No Microscopic Abnormality Observed: THYROID GLAND --_ = --- Company Sanitized. Does not contain TSCA CB 9H-02-4D6a7y8O:raSlubGcalvraogneicStTuoxdiyciintyRats DuPont6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648436 TKeirlmliendalonSDaacyrif: ic93e AEnxipmoaslureisGrsoiugpned: O90ffdafyrom necropsy Gross Pathology + No MaLIcVrEoRs,copKiIcDNEAVbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAY,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPRHYNGOLDEA,ND,THIWUS, TPHHAYRRYONIXD/LGALRAYNND,K, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : --_ LIVER IN: FLAMMATION, SUBACUTE/CHRONIC, minimal HEARTCARDIOMYOPATHY, minimal PANCRERS : ADRENAALTROGPLHAYN,DSmi:nimal. `THYRONIODTGLPARNESDEN:T, MEDULLA. ESOPHAALGTUESRA:TION, COLLOID, minimal. 648436 Continued onTNtFhLeAMnYeAxTtIOpNa,geSUB-.A.C.UTE/CHRONIC, minimal. --- ww Company Sanitized. Does not contain TSCACBI 9H-02-4D6a7y8O:raSlubGeahvraogneicStTuoxdiyciintyRats DuPont6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648436 Continued fron previous page Histopathology + No MiKcIrDoNEsYcSo,picLUNAGbSn,ormSaKlEiLtEyTAOLbsMeUSrCvLeEd, :SPLEEN, AORTA, BRAIN, CSOPLIONNA,L RCOERCDT,UM,STOMMEASCEHN,TERDIUCODELNYUMMP,H JNOEDJEU,NUMS,ALIIVLEAURMY, GLCAENCDUSM,, NMEARNVDEI,BULPAIRTUILTYAVRPYH GNLOADNED,, THPYAMRUAST,HYARDORIEDNGALLANGDLSA,NDST,RACSHCEIAA,TIC GPLHAARNYDIV(XF/ELMAARLYEN)K,, OEVYAER(ISE)S,WITUHTEROUPST,ICURNEIRNVAER,Y SBKLIAND,DERM,AMMARY FRMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE PN --- wm Company Sanitized. Dossnotcontain TSCA GB 9F-02-4D6a7y8O:raSluGbeahvraogneicStTouxdiyciintyRats DuPont6554 ~~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648439 ADcucriadteinotnalolfydoKsiilnlge-ddays: 122 AEnxipmoaslureisGrsoigunped: o1ffMonftrhomrneeccorvoeprysy Gross pathology : EYE(S)DIWSICTOHLOROAPTTIIOCN,NEWRHVIETE:, LEFT. No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANNERDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, PTHHAYRRYONIKD/LGALRAYNDN,K, PASKRIANT,HYMRAOMIMDARGLYANGDLSA,NDTR(AFCEHMEAAL,E),ESOOPVHAARGIUESS,, --_ rUoTsERsUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, Histopathology + LIVERFA: TTY CHANGE, MEDIAN CLEFT, mild. BgAUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, moderate TuewAU:TOLYSTS: NECROPSY AND HISTOLOGY PERFORMED, mild. PARATNHOYTROIPDRESGELNATN.DS : 648439 Continued on the next page .... -- --- ww Company Senitized. Does not contain TSCA CBI 9H0--2D4a67y8O:raSluGbacvhraogneiSctTuodxyiicintRyats DuPon-6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : II - 0 mg/kg/day Treatment: 0 mg/kg/day II Sex: Females Animal Ref Microscopic & Macroscopic Findings 648439 Continued xom previous page Histopathology + No MiKcIrDNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y OSbKsEeLrEvTeAdL M: USCLE, SPLEEN, AORTA, PBRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PHINLOEDOEM,, GSLAALNIDVSA,RYSGCLIAANTDISC, NEMRAVNED,IBUPLIATRUITLAYRMYPHGLNAONDDS,, TTHHYYMRUOSI,D GALDARNEDN,AL TERVAEC(SH)EA,WITEHSOPOHPATGIUCS,NERPVHEA,RYNSXK/INL,ARYMNAXM,AARY GLAND (FEMALE), OSVTAERRINEUSM,, BUTOENREUSM,ARRUORWI,NANROYSEBLADDER, FEMUR/KNEE JOINT, --- ww CompanynySanitSaniized. Does not contain TSCA Gal 9H-02-4D6a7y5O:raSlubGcahvraogneicStTuodxiyciintyRats DuPont6554 ~~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IT - 0 mg/kg/day Treatment: 0 mg/kg/day IT Sex: Females Animal Ref Microscopic & Macroscopic Findings 648002 TKeirlmliendalonSDaacyri:fic1e22 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoerpysy Gross Pathology No MaLIcVrEoRs,copKIiDcNEAVbSn,ormLUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OWARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIKD/LGALRAYNNDK,, `EPYAREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGELMAUNRD/K(NFEESMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology --_~ No uicroscopic Abnormality Observed : `THYROID GLAND --~ --- ws Company Sanitized. Doss not contain TSCA CBI 9H0--2D4a6y78O:raSluGbachvraogneicStTuodxyiicintRyats DuPont6554 --_ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group: IV - 60 mg/kg(Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648368 TKeirlmliendalon SaDacyrif: ic93e EAnxiproaslureisGrsoiugpned: 9o0ffdafyrom necropsy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYOIINDK/GLLAARNYDN,K, PAEYREA(TSH)YRWOIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y FGELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed : -- -- = `Company Sanitized. Dos not contain TSCA cal 9F0--2D46a7y8O:raSlubGcahvraogneicSTtourdiyciintRyats --_ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPont6554 Dose Group : IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648369 TKeirlmliendalonSaDcaryif: ic9e3 EAnxipmoaslureisGrsoiugpned: o9f0fdafyr.om necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NA`LSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNDN,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAGGGUASR,Y GFELMAUNRD/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : r No Mi`TcHrYoRsOcIoDpiGcLANADbnormality Observed : --_ -- ww Company Sanitized. Doss not contain TSCA CBI H9-02-4D6a7y8O:raSluGbeahvraogneicStTuoxdiyciintyRats --_ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648390 TKeirlmliendalonSDaacyrif: ic9e3 EAnxipmoaslureisGrsoigunped: o9f0fdayxom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIWTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIED/LGALRAYNND,K, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPWHAAMGYUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : --~ No Microscopic Abnormality Observed `THYROID GLAND -= -- `Company Sanitizad. Doss not contain TSCA CBI 9F0--24D6a7y8O:ralSuGbachvraogneicStTuodxyiicintRyats --_ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ret Microscopic & Macroscopic Findings 648396 TKeirlmliendalon SDaacryif: ic9e3 AEnxipmoaslureisGrsoiugpned: 9o0ffdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLvUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYWUS, TPHHYARRYONIXD/LGALRAYNND,X, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFSEEWALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, --~ Histopathology : THYROIADLTEGRLAATNIDON:, COLLOID, minimal --_ EE -- CompanySenitized. Doss not contain TSCA CBI 9H0--2D4a67y8O:nSaubGealvraogneicStTuodxyiicnitRyats --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPont.6554 Dose Group : IV - 60 mg/kg/day (iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ret Microscopic & Macroscopic Findings 648397 TKeirlmliendalonSDaacyri:fic9e3 AEnxipmoaslureisGrsoiugpne:d O9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDNST,ICMANENRDVIEB,ULAPRITLUIYTWAPRHYNOGDLEA,ND,THYMUS, TPHHAYRRYONIXD/LGALRAYNND,K, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, -- Histopathology + No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed : = --- `Company Sanitized. Does not contain TSCA CBI H9-02-4D6a7y8:OrSaulbcGharvoangiecStTuodxyiciintyRats --_ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl aninals Dose Group : IV - 60 mg/kg/day (iso) Treatment: 60 mg/kg/day IV Sex: Femsles Animal Ref microscopic & Macroscopic Findings 648402 TKeirlmliendalonSDaacryif: ic9e3 AEnxipmoaslureisGrsoiugpne:d 9o0ffdafyr.om necropsy Gross Pathology : No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICWANENRDVIEB,ULAPRITULIYTMAPHRYNOGDLEA,D,THYMUS, TPHHYARROYNIKD/LGALRAYNNDK,, `EPYAER(AST)HYRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, --_ Histopathology : No miTcHrYoRsOcToDpGiLcANADbnormality Observed : -- EE -- `Company Sanitized. Does not contain TSCA CBI 9H02-4D6a7y8O:raSlubGcahvraogneicStTuoxdiyciintyRats --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPont6554 Dose Group : IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648408. TKeirlmliendalonSDaacyrif: ic9e3 AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICWNWEDRIVBEU,LAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYNIXD/LGALRAYNNDX,, `EPAVREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFELMAUNRD/K(NFEESMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology + -- `THYROID GLAND : ALTERATION, COLLOID, minimal. --_ EE -- `Company Sanitized. Does not contain TSCA CBI 9F-02-4D6a7y8O:raSluGbcahvraogneicStTuoxdiyciintyRats -- DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648409 TKeirlmliendalonSDaacyrif: ic93e AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology KIDNEYcSsr:, RIGHT, 24 DIA. No MaLIcVrEoRs,copLUiNcGSA,bnoHrEAmRaTl,itySKOEbLEsTeArLveMdUS:CLE, SPLEEN. AORTA, BRAIN, SCEPCIUNMA,L CCOORLDO,N, 'SRTEOCMTAUCMH,, MDEUSODEENNTUEMR,ICJELVYUMNPUHM,NODIEL,EUMS,ALIPVANACRRYEAS, GSLCAINADTSI,C MNEARNVDEI,BULPAIRTULIYTNAPRHY GNOLDAEN,D, TTHYHMYURSO,IDADGLRAENNDA,L GLANDS, PEYAER(AST)HYWRIOTIHD GOLPATNIDCS,NERTVREA,CHESAK,IN,ESOMPAHMAMGAURSY, GLPHAANRDYN(XF/ELMAARLYEN),X, --~ OSVTAERRINEUSM,, NUTOESREUS, VAGINA, URINARY BLADDER, FENUR/KNEE JOINT, Histopathology + No MiTcHrYoRsOcIoDpiGcLAANbDnormality Observed : --- Company Sanitized. Does not contain TSCA CBI 0F--2D4a67y8O:raSluGbacvhraogneicStTuodxyiicintRyats DuPont6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 6a8a10 TKeirlmliendalonSDaacyrif: ic9e3 AEnxipmoaslureisGrsoigunped: o9f0fdafyrom necropsy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDNST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIKD/LGALRAYNIDK,, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPAHAKGHUASR,Y FGELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : --~ No Microscopic Abnormality Observed : `THYROID GLAND TTT Company Sanitized.oDeoes001oicomamTSOATEL 9H0--2D4a67y8O:raSluGbacvharogneiSctTuodxyiicintRyats DuPont-6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : IV - 60 mg/kg/day (Iso) Treatment: 60 mg/kg/day IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 648420 TKeirlmliendalonSDaacyr:ific9e3 AEnxipmoaslureisGrsoigunped: o90ffdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y OHbEAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM., BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJEIJCUNLUYMM,PH NAODDREE,NA'LSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, P`THHAYRRYONIXD/LGALRAYNNDK,, `EPAYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEANNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : No MiTcHrYoRsOcIoDpiGcLAANbDnormality Observed : ww `CompanySanitized. Doss fotcontainTSCACBI H9-02-4D6a7y8O:raSlubGeahvraogneicStTuoxdiyicintRyats DuPon-6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648345 `KTielrlmeidnalonSDaacyrif: ic9e3 AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC MANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, PTHHAYRRVONIXD/LGALRAYNND,X, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y FGELMAUNRD/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology r No Mi`TcHrYoRsOcIoDpiGcLANADbnorrality Observed : --~ wm Company SanitDioezsneodt .taincorialsn TSaCAcCBI 9H0--2D4a67y8O:raSluGbcahvraogneiSctTuodxyiicintRyats DuPont-6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648352 DUunrsacthieodnuleofd dSoascirnigf-idcaeys: 161 AEnxipmoaslureisGrsoiugpned: 3 Month recovery off from necropsy Gross Pathology : sky:MASS, PINK, FIRM, INGUEN, RIGHT, 8CM DIA. No MaLcIrVEoRs,copKiIcDNEAVbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, BTOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEYN,TERJIECJUNLUYYM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONTED/LGALRAYNNDK,, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAM,AMMEASROPYHAGGLUASN,D -- J(OFIENMTA,LE)S,TERONVUAYR,IESN,OSUETERUS, URINARY BLADDER, FEMUR/KNEE Histopathology THYROAILDTEGRLAATNIDON:, COLLOID, minimal MAMMARFYIBGRLOAANDDENO(MFAEMA(L5E).) : (BJ=BENIGN, [i] MALIGNANT --~ ww `Gompeny Sanitized. Dogs notcontatinal TSCA CBI 90H.-2D4a6y75O:raSluGbachvraogneiSctTourdiyciintRyats DuPont.6554 ~~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Aninal Ref Microscopic & Macroscopic Findings 648365 TKeirlmliendalonSaDcaryif: ic1e83 AEnxipmoaslureisGrsoigunped: o3ffMonftrhomrneeccorvoeprysy Gross Pathology No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, PTHHAYRRYONIXD/LGALRAYNND,X, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAKAGGIUASR,Y GFELMAUNRD/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, --~ Histopathology : THYROIADLTEGRLAATNIDON:, COLLOID, minimal --~ --- ww `Company Sanitized. Does not containTSCACBI 9H0--24D6a7y8O:rSaulbGcahvraogneicStTuondiyicintRyais DuPont.6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group: VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648366 TKeirlmliendalonSDaacyrif: ic93e AEnxiproaslureisGrsoigunped: o9f0fdafyr.om necropsy Gross Pathology : No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIAD/LGALRAYNDN,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology --_~ No Microscopic Abnormality Observed : `THYROID GLAND --~ = -_-- Company Sanitizad. Does not contain TSCA CBI 9H0-.2D46a7y8O;raSlubGcahvraogneiSctTuodxyiicintRyats DuPont6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648374 TkeirlmliendalonSaDcaryif: ic9e3 AEnxipmoaslureisGrsoiugpned: 9o0ffdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLaUlNiGSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAY,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYYM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYWUS, TPHHYARROYNIXD/LGALRAYNND,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGLEANNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : No Mi`TcHrYoRsOcToDpiGcLANADbnormality Observed : --~ 5 Company Senilized. Doss notcontain TSCA CBI H9-02-4D6a7y8;OrSaulbcGhaevoangiecSTtouxdiyciitnyRats DuPoni-6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648382 TKeirlmliendalonSDaacyrif: ic9e3 AEnxipmoaslureisGrsoigunped: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYNIXD/LGALRANYDN,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAANGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : --~ No Microscopic Abnormality Observed `THYROID GLAND ~~ --- ws `CompanySanitized.Doesnotcontain TSCACBI 9H-02-4D6a7y8O:raSluGbacvharogneicStTuodxyiicintRyats DuPont6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648380 TKeirlmliendalonSDaacyrif: ic1e83 AEnxipmoaslureisGrsoiugpned: o3fMfonftrhomrneeccorvoeprysy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJEIJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIID/LGALRAYNND,K, `BPAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNURD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : THYRO`IADLTGELRAANTIDON:, `COLLOID, mild. --~ a `Company Sanitized. Doss notcontain TSCA CBI 9H-02-4D6a7y8O:raSlubGcalvraogneicStTuondiyciintyRats DuPont6554 -- Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648385 TKeirlmliendalonSaDcaryif: ic1e83 AEnxipmoaslureisGrsoigunpe:d o3ffMonftrhomrenceocvreorpysy Gross Pathology : No MLaIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLOMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDNST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIID/LGALRAYNNDK,, `EPYAREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/(KFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : THYRO`IADLTGELRAANTIDON:, COLLOTD, minimal. ~~ EE Company Saniized. Does notcontain TSCA CBI 9H0--2D06a7y8O:rSaulbGcahvraogneiSctTuodxyiicintRyats DuPont-6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648403 TKeirlmliendalonSDaacyri:fic93e AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYYM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUIYTMAPRHYNOGDLEA,ND,THYWUS, `PTHHAYRRYOIIVDK/GLLAARNYDN,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFELNAUNRD/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, --_~ Histopathology : No MiTcHrYoRsOcIoDpiGcLAANbDnormality Observed : -- ww Company Sznitized. Dos not contain TSCACBI 90H--2D4a67y8O:rSaulbGcharvoangiecSTtouxdiyciitnyRats DuPont6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 648406 TKeirlmliendalonSaDcaryi:fic93e AEnxipmoaslureisGrsoiugpned: 9o0ffdafyrom necropsy Gross Pathology : No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNAELCC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIKD/LGALRAYNDN,K, 'PEAYREM(NST)HYRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : --~ THYROID GLAND : ALTERATION, COLLOID, minimal. --- ww Company Sanitized. Doss not contain TSCA CBI 9H0--2D4a67y8O:rSaulbGcahvraogneicStTuodxyiicintRyats DuPont6554 --_ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl anirals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 548413 TKeirlmliendalonSaDcaryif: ic1e83 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrneeccorvoeprsyy Gross Pathology : KIDNEYDSILATATION, LEFT. URINA`RCYALBCLUALDUDSE\RCA:LCULI No MaLIcVrEoRs,copLiUNcGSA,bnoHrEAmRaTl,itySKOEbLsETeArLveMdUS:CLE, SPLEEN, AORTA, BRAIN, CSEPCIONMA,L CCOOLRDO,N, SRTEOCMTAUCMH,, DMUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANCRRYEAS, GSLCAINADTSI,C MNEARNVDEI,BULPAIRTUILTYAMRPYH GNOLDAEN,D, THTYHMYURSO,IDADGLRAENNDA,L GLANDS, ~ EPYAER(AST)HYWRIOTIHD GOLPATNIDCS,NERTVREA,CHESAK,IN,ESOMPAHMAMGAURSY, GLPAHNADRYN(XF/ELMAARLYEN),K, OVARIES, UTERUS, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : `THYROAILDTEGRLAATNIDON:, COLLOID, minimal --_~ ET -- CompanySanitized. Does not contain TSCA CBI 9H0--2D46a7y5O:nSaubGcahvraogniecSuTodsyiciintyRats -- Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dupont6554 Dose Group : VI = 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Aninal Ref Microscopic & Macroscopic Findings sisa1 TKeirlnliendalon SaDcaryif: ic9e3 AEnxipmoaslureisGrsoiugpned: 9o0ffdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULPAIRTULYIMTPAHRYNGOLDEA,ND,THYMUS, TPHHYARROYINGD/LGALRAYNDN,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGOUASR,Y GFLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology. No MiTcHrYoRsOcIoDpiGcLAANbDnormality Observed --_ EE `Company Sanitized.Does notcantain TSCA Gl 9H0--2D4a6y78O:naSuGbacvharogneiSctTuodryiicintRyats DuPont6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ret Microscopic & Macroscopic Findings 548429 TKeirlmliendalonSDaacyrif: ic9e3 AEnxipmoaslureisGrsoiugpned: 90 day off from necropsy Gross pathology No MaLIcVrEoRs,copKIiDcNEAVbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEGCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, PTHHAYRRYOIINDI/GLLAARNYDN,X, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, --_ Histopathology : THYRO'IADUTGSLRAANTDION:, COLLOID, minimal. --~ -- ww Gompany Senitized. DoesnotcontainTSCACBI '9H0--2D4a6y78O:nSluGbcahvraogneicSTuodxyiciintyRats : Dupont6554 -- Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl anipals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings saan TKeirlmliendalon SaDcaryif: ic9e3 EAnxfproaslureisGrsoigunped: o9f0fdafyrom necropsy Gross pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIUTPAHRYNGODLEA,ND,Trnus, TPHHYARROYINXD/LGALRAYNDN,K, PAEVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGGUASR,Y GPLEANNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : -- mHEROID GLAND 'AUTERATION, COLLOID, minimal. -- -- Company Senitized. Doesnotcontain TSCA CBI 9H0--2D46a7y8O:rSaulbGcahvraogneicSTtourdiyciintyRats DuPont6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VI - 10 mg/kg/day Treatment: 10 mg/kg/day VI Sex: Females Animal Ref Microscopic & Macroscopic Findings sa8aa1 TKeirlmliendalonSDaacyrif: ic93e EAnxipmoaslureisGrsoiugpned: 9o0ffdafyrom necropsy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYNIXD/LGALRAYNNDK,, PEAVREA(TSH)YRWOIIDTHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAANGMUASR,Y FGELNAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : --~ No Microscopic Abnormality Observed : `THYROID GLAND --~ -- = Company Sanitzed. Doss not contaln TSCA CBI 9H-02-4D6a7y8O:raSluGbacvharogneiSctTuodxyiicintRyats DuPont6554 --~ Showing aInnidmiavlidduaatla AfnoirrailndLiivsitdiunagl animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings sa83ae TKeirlmliendalon SaDcaryif: ic93e AEnxipmoaslureisGrsoiugpne:d 9o0ffdafyrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNGODLEA,ND,THYMUS, TPHHYARROYNIXD/LGALRAYNND,K, PEAYREA(TSH)YRWOIIDTHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOMPHAAMGAURS,Y FGLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : No Mi`TcHrYoRsOcIoDpiGcLAANbDnormality Observed - = Company Senitizsd, Doss nol contain TSCACBU 9H0--2D4a67y8O:rSaulbGcahvraogneiSctToundiyciintRyats -- Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPont-6554 Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648329 TKeirlmliendalonSDaacyrif: ic18e3 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrneeccorvoerpysy Gross Pathology : No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIID/LGALRAYNNDK,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIESRSN,IM,UTENROUSSE, URINARY BLADDER, Histopathology : ~ THYROIADLTEGRLAATNIDON:, COLLOID, minimal. --- Company Sanitized. Doesfol contain TSCA CBI | H.24675: Subloni Toxicity 50.DayOrsGavage Study in Rats --~ Showing aInnidniavlidduaatla AfnoirmailndLiivsitdiunagl animals Dupont554 Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females | animal Re Hicroscopic & Macroscopic Findings sen3sa TKeirlmliendalonSaDcaryif ic9e AEnxipmoaslureisGrsoiugpned: 9o0ffdafyom necropsy Gross vathology No MaLAIOcVRrEToRAs,,copKBiRIcADINNEA,YbSn,SoPrImLNOaNAlGLiSt,CyORHODEb,AsReTSr,TvOeKSdAKCEHL,ETADLUOMDUESNCIL,E,JESPOLNEUSMN., NAIODLDEREUE,MR,ALSAPGLALINACVNRADERSAY,S,GLSACCNEIDCNSUT,MI,CMANCEONRLDVOIENB,,ULAPRREICTTULUXPMT,AHRYMNEOGSDLEEAN,NPDE.RTIHCVGLS,ib TGPLHHAYANRRYDONIKD(/FLGEALMRAAYNLNDEK,),. PEOAYVREAA(RTSIH)EYSR,WOIITUDHTEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HERUS,RKIINNE,ASROYPMHAASAGLUARSDY,DSR, FENUR/KNEE JOINT, STERN, NOSE Histopathology : r TrROTADLTEGRLAATNIDON, COLLOID, minimal. ~ er e st----7s-- emes-- is ----y CompanySanitzed. Dossnot ortTSaCiACnBI H-24678: SubchronicTovicity 90-Day Oral Gavage Study in Rats --_~ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VIII - 60 mg/kg/day Treatment: G60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648360 TKeirlmliendalonSaDcaryif: ic1e83 AEnxipmoaslureisGrsoigunped: 3 Nonth recovery off from necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, IAOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIED/LGALRAYNND,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAADGIUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, --~ Histopathology THYROATLDTEGRLAATNIDON, COLLOID, mild. ~ --- ww Company Sanitized. Doss not contain TSCA CBI 9H-02-4D6a7y8O:raSlubGcahvraogneicStTuodxiyciintyRats -- Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPont.6554 Dose Group : VIII - 60 mg/kg/day Treatment: 60 me/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings sa8362 TKeirlmliendalonSDaacyrif: ic93e AEnxipmoaslureisGrsoigunped: o9f0fdafyrom necropsy Gross Pathology : LIVERHERNIA, INVOLVINS DIAPHRAGH. No MaKIcDrNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y Observed SKELETAL : MUSCLE, SPLEEN, AORTA, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PHINLOEDUEM,, SGLAALNIDVSA,RYSGCLIAANTDISC,NEMRAVNED,IBUPLIATRUILTYAMRYPHGLNAONDDE,, TTHHYYMRUOSI,D GALDARNEDN,AL PBYAER(AST)HYWRIOTIHD GOLPATNIDCS,NERTVREA,CHESAK,IN,ESMOPAHMAMGAURSY, GLPHAANRDYN(KF/ELMAARLYEN),K, ~ OsVAeRmIE,S, NUToEsREUS, VAGINA, URINARY BLADDER, FEMUR/KNEZ JOINT, Histopathology THYROAILDTEGRLAATNIDON:, COLLOID, minimal ~~ --- CompanySanhtized. Doss notcontainTSCA CBI 9H0-.2D46a7y8O;rSaulbGcharvoangiecStTuodxyicitnyRats ~~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPont-6554 Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648368 TKeirlmliendalonSDaacyri:fic93e AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEYN,TERJIEJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICWNAEDRIVSEU,LAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, PTEHAYRRYONIXD/LGALRAYNND,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPAHAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, --~ Histopathology No M`iTcHrYoRsOcToDpiGcLAANbDnormality Observed : --_ --- ww CompanySanitized.DoesnotcontainTSCA CBI 9H0--2D4a67y8O:rSaulbGcahvraogneiSctTuodxyiciintRyais --~ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ret Microscopic & Macroscopic Findings 648379 KTeirlmliendalonSDaacyrif: ic18e3 AEnxipmoaslureisGrsoigunped: o3ffMonftrhomrneeccorvoerpysy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIID/LGALRAYNND,K, `SPAYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, --_ Histopathology No M`iTcHrYoRsOcIoDpiGcLANADbnormality Observed : ~ --- Company Sanitized. Does nocontain TSCA CBI 9H0--2D4a67y8O:raSlubGcahvraogneiSctTuodxiyicintRyats --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPont:6554 Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648380 TKeirlmliendalon SaDcaryif: ic9e3 AEnxipmoaslureisGrsoiugpned: 9o0ffdafyr.om necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,IC MNAENRDVIEB,ULAPRITLUYIMTPAHRY NGOLDEA,ND,THYMUS, `PTHHAYRRYONICD/LGALRAYNDN,E, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPNHAANGWUASR,Y GFELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : --_~ No Microscopic Abnormality Observed `THYROID GLAND - `Company Sanitized. Does not contain TSCA CBI 9F-02-4D6a7y8O:raSlubGcahvraogneicStTuoxdiyciintyRats --~ DuPont.6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Nacroscopic Findings 648381 TKeirlmliendalonSaDcaryi:fic9e3 EAnxipmoaslureisGrsoiugpne:d 90 day. off from necropsy Gross Pathology : No MLaIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICWNAEDRIVBEU,LAPRITLUYIMTPAHRYNOGDLEA,ND,THYUS, TPHHYARROYINKD/LGALRAYNDN,K, `PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFELMAUNRD/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : --~ No microscopic Abnormality Observed : `THYROID GLAND --~ EE -- Company Sanitized. Does not contain TSCA CBI 9H0--2D46a7y8O;raSlubGcahvraogneicSTtourdiyciintyRats DuPont6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648386 TKeirlmliendalonSDaacyrif: ic1e83 AEnxipmoaslureisGrsoigunped: o3ffMonftrhomrneeccorvoerpysy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIKD/LGALRAYNNDX,, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : THYROAILDTEGRLAATNIDON:, COLLOID, minimal. --- w= Company Sanilized. Does not contain TSCA CBI F9-02-4D6a7y8O:raSluGbcahvraogneicStTuoxdiyciintyRats --_~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPont6554 Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648401 TKeirlmliendalon SaDcaryif: ic9e3 AEnxipmoaslureisGrsoiugpne:d o90ffdafyr.om necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEYN,TERJIECJUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNDN,Y, 'EPAYREN(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFELMAUNRD/K(NFEESMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, --_ Histopathology : No MTiHcYrRoOsIcoDpiGcLAANbDnormality Observed : ~~ - ws Company Sanitized. Doss not contain TSCA CBI 9H0--2D4a67y8O:raSluGbacvharogneicStTuodxyiicintRyats -- Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPont6554 Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings saga1s TKeirlmliendalonSDaacyrif: ic1e83 AEnxiproaslureisGrsoigunped: o3ffMonftrhomrenceocvreorpysy Gross Pathology : No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC.TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,IC MNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIXD/LGALRAYNNDK,, `EPYAREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPYHAAMGMUASR,Y GFLEAMNURD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, ~~ Histopathology + THYROAILDTEGRLAATNIDON:, COLLOID, mild. --_ CompanySaniDtosisnzotecodnta.inTea car 09H0-D2-4D6a7y8O;OurSlaulGbaGcavhvraaoggneeiScSTutodunydiyciinitnRyRaartss -- DuDubPoonwt.s6s55s4 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648417 TKeirlmliendalonSDaacyrif: ic93e EAnxipmoaslureisGrsoiounped: o9f0fdafyr.om necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUMM,P NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIXD/LGALRAYNNDX,, `EPYAER(AST)HYRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NPEEEWALJSO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology r THYROID GLAND : ALTERATION, COLLOID, minimal --~ - ws Company Sanitized. Does not contain TSCA Cal 9H0-.24D6a7y8O:rSaulbGcahveaogneicSTtourdiyciitnyRats --~ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648432 TKeirlmliendalonSDaacryif: ic9e3 AEnxipmoaslureisGrsoigunped: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM., BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULIYTMAPHRYNOGDLEA,ND.THYMUS, `PTHHAYRRYONIXD/LGALRAYNDN,X, `PSAYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPAHAMGMUASR,Y GFLEANNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology -- No Microscopic Abnormality Observed : `THYROID GLAND _-- `Company Sanitized. DossnotcontainTSCA Cai F9-02-4D6a7y8:OrSaulbGsaovangiecSTtouxdiyciitnyRats --~ DuPon-6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : VIII - 60 mg/kg/day Treatment: 60 mg/kg/day VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 648440 TKeirlmliendalonSDaacyrif: ic93e AEnxipmoaslureisGrsoigunped: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y WOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM., BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NA'LSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPHRYNOGDLEA,ND,THOUS, `PTHHAYRRYONIKD/LGALRAYNNDX,, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,OM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology THYROAILDTEGRLAATNIDON, COLLOID, minimal. i `CompanySaniDtoois znotecodnta.in TSCACBI 9H0--2D4a6y78O:naSuGbcahvraogneicStTuoxdiyciintyRats --_ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648347 TKeirlmliendalonSDaacyrif: ic93e AEnxipmoaslureisGrsoigunped: o9f0fdafyrom necropsy Gross Pathology : No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYNIXD/LGALRANYDN,X, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGLEAMNUDR/K(NFEEENAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, --~ Histopathology + PANCRAETARSOPHY, minimal. PITUIHTYAPREYRPGLLAASNIDA,: FOCAL, ACTNAR CELL, mild CYST, minimal No wiLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, CBERCAUIMN,, CSOPLIONNA,L CROERCDT,UM,STOMMEASCEHN,TERDIUCODELNYUMNP,H NJOEDJEU,NUN, GSLAALNIDVSA,RYSGCLIAANTDISC, NEMRAVNED,IBTUHLYARROILDYMPGLHANNDO,DE,PATRHAYTMHUYSR,OIADDRGLEANNADLS, 648347 Continued on the next page ... J -- Company Sanitized. Doesnotcontain TSCACBI H9-02.4D6a7y8:OnSlubGcahvraogneicSTtouxdiyciintyRats --_ DuPont-6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ret Microscopic & Macroscopic Findings 648347 Continued from previous page Histopathology : No Mi`TcRrAoCsHcEAo,picESOAPbHnAoGrUmSa,litPyHAORbYsNXe/rLvAeRdYN:X, OEVYAER(IS)ES,WITUHTEROUPST,ICURNEIRNVAER,Y SBKLIAND,DERM,AMMFAERMYURG/LKANNEDE J(OFIENMTA,LE), STERNUM, BONE MARROW, NOSE --~ --~ --- Company Sanitized. Doss notcontainTSCA CBI H90--2D4a6y78O:raSlubGcalvraogneiSctTourdiyciintRyats DuPont.6554 Showing aTnnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Animal Ref Microscopic & Macroscopic Findings 648350 TKeirlmliendalonSDaacyrif: ic12e2 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoeprsyy Sex: Females Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYWUS, `PTHHAYRRYONIXD/LGALRAYNND,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMAHIAQGGUASR,Y GFLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : THYROAILDTEGRLAATNIDON:, COLLOID, minimal. - Company Sanitized. DossnotcontainTSCA CBI 9H0--2D46a7y8O;raSlubGcahvraogneicSTtouxdiyciitnyRats --_~ DuPont-6554 Showing aTnnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648355 TKeirlmliendalonSDaacyri:fic1e22 EAnxipmoaslureisGrsoigunped: o1ffMonftrhomrneeccorvoeprysy Gross Pathology No waLcIVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJULNYUM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYINTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNND,X, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPJHAAMGVUASR,Y GFLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEZRSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : --~ `THYROID GLAND : ALTERATION, COLLOTD, minimal - es Company Sanilized. Doss nol contain TSCA CBI H24678: SubchroicTosiciy S0DuyOns GavageSudyinRas Duos Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Aninal Ref Microscopic & Macroscopic Findings sas358 TKoirlnliendalonSDaacyri:fic1e83 nExipaoslureisGrsoigunped o3ffMonftrhomrneeccorvoeprysy Gross Pathology : No MAaLOIcRVrTEoARs,,copKBRIiADcINNEA,YbSn,oSrPmLIUaNNlAGiLSt,yCORHODEb,AsReTrS,vTeOMdSAKCE:HL,ETADLUODMEUNSUCML,E,JESJPULNEUEMN,, NIOLDEEU,M,|SAPALNICVRAERAYS,GLACNEDCSU,M, `MCAONLDOINB,ULRAERCTLUYMW,PHMENOSDEEN,TERTIHCOULSY,MPH TAPHADYARRREYONNIAEDL/LGGALLRAAYNNNDD,XS,, PSEAYCREIA(ATSTH)IYCRWOINIETDRHVGEOL,APNTDIPSCI,TNUETIRRTVAAECR,HYEAGS,LKAINNE,DS,OPMHAAMGMUASR,Y GFLEANNUDR/K(NFEEEMAJLOEI),NT,OVASRTIEERSN,ON,UTENROUSSE, URINARY BLADDER, ~~ Histopatholoay No MiTcHrYoRsOcIoDpiGcLAANbDnormality Observed : --_ - Company Sanilizec. Dos not contain TSCA Cat 2904.6D7ay8:OrSaulbGsavoangiecSTuodxiyciitnyRats Dupont 554 -- Showing aInnidmiavlidduaacla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mu/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ret Microscopic & Macroscopic Findings sans T%eirlmliendalon SDaacyrif: ic1e22 AEnxipmoaslureisGrsoigunped: o1ffMonftrhomrneeccorvoerpysy Gross Pathology Yo MAaLOIcRVrTEoARs,,copBKRIiADcINNEA,YbSn,oSrPLmIUaNNAlGLiSt,CyOROHDbE,AsReTrS,vTeOMdSAKCE:HL,ETDAULODWEDNSUCML,E, JESJPULNEURMY,, NATODLDREEEU,N,AL`SPAGALLNIACVNRADERSAY,S,GLSACCNEIDCASUT,NI,C MNACEONRLDVOIENB,,ULAPRREICTTLUUYIMMT,PAHRMYENOSGDLEEAN,NPDE,RnIiC sL,YMPH GPTLHHAAYNRRYDOVIID(KF/GELLNAAARNLYDEK,),, POASVYRAENR(TISH)EYSR,WOIITUDHTEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HEASU,KRIINNB,ASROVPYHAABMGLAUARSD,DYER, FENOR/KNEE JOINT, STERN, NOSE -- istopatholony TROT CLD AUTERATION, COLLOID, minimal Es `Company Sanitzed. Does,not eontain Tscg, car H90:-2D4a6y78O:rSaulbGcahvraogneicSTotxiiucintdRyatys DuPont.6554 Showing aInnidniavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648363 TKeirlmliendalonSDaacyr:ific93e AEnxipmoaslureisGrsoigunped: o9f0fdafyrom necropsy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIID/LGALRAYNDN,K, PBAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, --~ Histopathology LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. - THYROATLDTEGRLAATNIDON:, COLLOID, minimal. No MKiIcDrNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y OSbKsEeLrEvTeAdL M:USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMN,PHINLOEDUEM,, GSLAALNIDVSA,RYSGCLIAANTDISC,NEMRAVNED,IBUPLIATRUITLAYRMYPHGLNAONDDE,, TPHAYRMAUTSH,YROAIDDRENGLAALNDS, 648363 Continued on the next page .... EE -- `Company Santized.DoesnotcontainTSCACBI 9BL02-4D6a7y8O:ralSuGbachvraogneicStTuodxyiciintRyats -- Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dupont 6554 Dose Group: X = 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Aninal Ref Microscopic & Macroscopic Findings su8353 Continued from previous page Histopathology No MiTRcArCoHsEcRo,picESOAPbHnAoGrUmSa,litPyHAORbYNsKe/rLvAeRdYN:X, EOYUEA(RSI)ZS,VITUHTEROUPST,ICUNREIRNVAER,Y BSKLIAND,DERM,AMMFAERMYURG/LKANNEED J(OFIENMTA,LE), STERNUM, BONE MARROW, NOSE --_ -- - ww co pany Sanittiized. Doss not contain Tscacal 9H0--2D4a6y78O:raSluGbacvhraogneiSctTuovyiicintRyats --~ DuPont 6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group: X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ret Microscopic & Macroscopic Findings 648367 K"Tielrlmeidnaoln SaDcaryif: ic1e83 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrneeccorvoeprysy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,veSdKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR.EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODNEENSUEMN,TERJIECCUNLUYMM,PH NAODDREE,NA'LSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, PTHHAYRRYOITODU/GLLAARNYDN,K, `EPAYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFBEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology r THYROID GLAND : ALTERATION, COLLOID, minimal. -- - Company Sanitized. Does not contain TSCA Cal 9H-02-4D6a7y8O:raSluGbacvharogneicStTuodvyiciintRyats DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648373 TKeirlmliendalonSaDcaryif: ic1e83 EAnxipmoaslureisGrsoigunped: o3ffMonftrhomrneeccorvoeprysy Grose Pathology No MLaIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICWANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYOIINDG/GLLAARNYDN,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology + THYROAILDTEGRLAATNIDON, COLLOID, minimal. -- Company Sanitized. Does notcontain TSCA CBI H9-02-4D6a7y8O:SraulbcGkarvoangeicSTtouxdiyciintyRats DuPont6554 --~ Showing aInnidriavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648375 FDouurnadtioDneaodf dosing-days: 5 EAnxipmoaslureisGrsoiugpned: o9f0fdafyr.om necropsy Gross Pathology LIVERDISCOLORATION, DARK, RAISED, LEFT, MIDDLE, FEW, < IMM DIA EACH. No MaKIcDrNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y OSbKsEeLrEvTeAdL M: USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TEJREIJCUNLUYMW,PHINLOEDUEM,, GSLAALNIDVSA,RYSGCLIAANTDISC, NEMRAVNED,IBUPLIATRUILTYAMRPYHGLNAONDDE,, TTHHYYMRUOSI,D GALDARNEDN,AL PARATHYROID EYE(S) WITH GOLPATNIDCS,NERTVREA,CHESAK,IN,ESOWPAHMAMGAURSY, GLPAHNARDYN(KF/ELMAARLYEN),X, -- OSVTAERRINEUSM,, NUTOESREUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, Histopathology : LIVERAUTOLYSTS: NECROPSY AND HISTOLOGY PERFORMED, minimal. KIDNEYASUTO:LYSIS: NECROPSY AND HISTOLOGY PERFORMED, mild. DUODEANUUTMOL:YSTS: NECROPSY AND HISTOLOGY PERFORMED, mild. aBIONAMUTO:LYSIS: NECROPSY AND HISTOLOGY PERFORMED, mild 648375 Continued on the next page .... = Company Sanilized. Doss not contain TSCA CBI 9H-02-4D6a7y8O:raSlubGcahvraogneicSTtouxdiyciintyRats DuPont6554 -- Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648375 Continued from previous page Histopathology : preAUTOLYSIS: NECROPSY AND HISTOLOGY PERFORVED, moderate. THYROIADUTOGLLYASNTDS:: NECROPSY AND HISTOLOGY PERFORVED, moderate. PARATNHOYTROIPDREGSELNATN.DS : ESOPHAIGNUFSLAM:MATION, SUBACUTE/CHRONIC, mild. "PHARYNNKO/TLAPRRYENSXE.NT:. BYE(S)AUWTOILTYHSTOSP:TINCECNREORPVESY :AND HISTOLOGY PERFORMED, severe. BONE MAUATRORLOYWSI:S: NECROPSY AND HISTOLOGY PERFORVED, mild. -- Nos : AUTOLYSTS: NECROPSY AND HISTOLOGY PERFORMED, mild. No MiLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,EH ANDODREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPRHY NGOLDEA,ND,THIWUS, MTAHMYMRAORIYD GGLLAANNDD, (TFREAMCAHLEEA),, OEVYAER(IS)ES,WITUHTEROUPST,ICUNREIRNVAER,Y SBKLIAND,DER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE --_ EE Company Sanitized. Doss not contain TSCA CBI 9H-02-4D6a7y8O:raSluGbcahveaogneicStTuodriyciintyRats DuPont-6554 --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X ~ 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Pindings 648376 TKeirlmliendalonSDaacyrif: ic9e3 AEnxipmoaslureisGrsoiugpne:d 90 day off from necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUlNGiSt,y OHbEAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNGODLEA,ND,THYNUS, TPHHYARROYINXD/LGALRAYNDN,K, 'PEAYREM(TSH)YRWOITTDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFELMAUNRD/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : --~ KIDNEYS: HEARTNE: PHROPATHY, CHRONIC PROGRESSIVE, minimal. `THYROCIADRDGILOAMNYDOP:ATHY, minimal. ALTERATION, COLLOID, minimal. No MiLIcVrEoRs,copLUiNcGSA,bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL CCOORLDO,N, STROEMCATCUHM,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPAVNACRRYEAGSL,ANDCSE,CUM, MNEARNVDEI,BULPAIRTUILTYAMRPYH GNLOADNE,D, THPYAMRUAST,HYARDORIEDNGALLANGDLSA,NDST,RACSHCEIAA,TIC 648376 Continued on the next page .... ww `CompanySanitized. Donotecontsain TSCA Cal 9H0--2D4a67y8O;raSlubGcahvraogneiSctTouxdiyciintRyats -- Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPon6554 Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648376 Continued from previous page Histopathology : No MiEcSOrPoHsAcGoUpSi,c APbHnAoRrYmNKa/lLiAtRyYNOXb,serEvYEe(dS): WITH OPTIC NERVE, SKIN, MFEAMMUMRA/RKYNEGELAJNODIN(TF,EMASLTEE)R,NUMO,VARBIOENSE, MAURTREORWU,S,NOUSREINARY BLADDER, --~ --~ -- wer Company Senitized. Dossnotcontain TSCA GBI 9H0--2D4a67y8O:ralSuGbaevhraogneicStTuodxyiicintRyats -- Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPont6554 Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648378 Terminal Sacrifice EKixlploesdureonGrDoayup: : 1212Month recovery Animal is signed off from necropsy Gross Pathology : No MLaIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NA'LSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIWTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIXD/LGALRAYNND,X, `PEAYREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGLEAMNUDR/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology ~~ THYROAILDTEGRLAATNIDON:, COLLOID, minimal --~ - ww `CompanySanitized.Doosnot contain TSCA CBI 9H-02-4D6a7y8O:raSlubGcahvraogneicStTuodriyciintyRats DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648383 TKeirlmliendalonSDaacyrif: ic12e2 AEnxipmoaslureisGrsoigunped: o1ffMonftrhomrneeccorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIKD/LGALRAYNNDX,, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, -- Histopathology THYROAILDTSGRLAATNIDON:, COLLOID, minimal. - TwCompany Sanitiized,zed.DDoossssnnootlcontain TSCA CBI 9H0--2D46a7y8O:rSaulbGcahvraogneiScTtourdiyciintyRats -- Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl aninals DuPon-6554 Dose Group: X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648387 TKeirlmliendalonSDaacyrif: ic1e22 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLrUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICWANENRDVIEB,ULAPRITLUYIMTPAHRYNGODLEA,ND,THYMUS, TPHHYARROYNIKD/LGALRAYNNDK,, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRAVEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology THYROIADLTEGRLAATNIDON:, COLLOID, mild. -- --- Company Senltized. Doss not contain TSCA CBI 9H0-.2D4a6y75O:rSaulbGcahvraogneicSTtouvdiyciitnyRats DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648368 TKeirlmliendalonSDaacyrif: ic9e3 AEnxipmoaslureisGrsoiugpned: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PI NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIKD/LGALRAYNNDK,, `EPYAREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAQGOUWSR,Y GFLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, -- Histopathology : LIVERFA: TTY CHANGE, MEDIAN CLEFT, mild. HEARTIN FLAMMATION, SUBACUTE/CHRONIC, minimal. PARATCHAYRRDOIIODWYGOLPAANTDHSY,| minimal. NOSE N:OT PRESENT. REGENERATION, OLFACTORY, EPITHELIUM, minimal. 648388 Continued on the next page .... EL Company Sanitized. Doss not contain TSCA CBI 9H0--2D4a67y8O;rSaubGcahvraogneicSTtouxdiyciitnyRats --_~ DuPont6554 Showing aInnidriavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648388 Continued trom previous page Histopathology : No MiKIcDrNoEsYcSo,picLUNAGbSn,ormSaKlEiLEtTyALObMsUeSrCvLeEd, : SPLEEN, AORTA, BRAIN, CSEPCIUNMA,L CCOOLRODN,, SRTEOCMTAUCMH,, DMUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANCRRYEAS, `SGCLIAANTDSI,C MNEARNVDEI,BULPAIRTUILTYAMRPYH NGLOADNED,, THTYHMYURSO,IDAGDLRAENNDA,L GTLRAANCDHSE,A, MEASMOPMHAARGYUSG,LANPDHAR(YPNEXM/ALLSA)R,YNXO,VAREIVEES(,S) UWTIERTUHS,OPTUIRCINNAERRYVEB,LADSDKEIRN,, FEMUR/KNEE JOINT, STERNUM, BONE MARRON - w= Compeny Sanitized. Does not contain TSCA F9-02-4D6a7y8:OrSaulbGcahvraogniecSTtouxdiyciitnyRats --~ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPont6554 Dose Group: X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648301 TKeirlmliendalonSDaacyrif: ic1e83 AEnxipmoaslureisGrsoiugpned: o3ffMonftrhomrenceocvreorpysy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLREUTMA,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUIYTMAPRHYNGODLEA,ND.THYMUS, `PTHHAYRRYONIID/LGALRAYNND,K, `EPYAREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, --~ Histopathology : THYROIADLTEGRLAATNIDON:, COLLOID, minimal. --_-- Company Sanitized. Does notconTtSaCAiCBnI 9H0.2-4D6a7y8;OrSaulbGcahvraogneicSTtouxdiyciitnyRats --_ Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals DuPon6554 Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648352 TKeirlmliendalonSDaacyrif: ic9e3 AEnxipmoaslureisGrsoiugpned: o90ffdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y Observed HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,ND,THYMUS, TPHHYARROYINXD/LGALRAYNDN,K, 'SPYAER(AST)HYWRIOTDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFELMAUNRD/K(NFEESMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology --~ LIver UTERUSINFLAMMATION, SUBACUTE/CHRONIC, minimal. DILATATION, GLAND/LUMEN, minimal. No MiKIcDrNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y Observed: SKELETAL MUSCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH INLOEDUEM,, SGLAALNIDVSA,RYSGCLIAANTDISC,NEMRAVNED,IBUPLIATRUILTYAMRPYHGLNAONDDE,, TTHHYYMRUOSI,D AGDLARNEDN,AL 648392 Continued on the next page .... -- EE -- `CompanySanitized.DoesnotcontainTSCA CBI 'H9-02-4D6a7y8O:ralSuGbacvhraogneicStTuodxiyciintyRats DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group: X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 6a8302 Continued from previous page Histopathology : No MiPcArRoAsTcHoYpRiOcTDAbGLnAoNrDmSa,liTtRyACOHbEsAe,rveEdSOP:HAGUS, PHARYNX/LARYNK, OEYVEA(RSI)ES,WITUHRIONPATRIYCBLNAEDRDVEER,, SKFIENM,URM/AKMNMEAERJYOIGNLTA,NDST(EFRENMUAML,E),BONE MARROW, `NOSE --_ --- ww Company Sanitized.Doesnolconiain TSCA CBI 9H0--2D4a6y78O;raSluGbcahvraogneicStTuodxiyciintyRats -- DuPont:6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648308 TKeirlmliendalonSaDcayrif: ic1e22 AEnxipmoaslureisGrsoiugpned: o1ffMonftrhomrneeccorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,orLmUaNlGiSt,y OHbEAsReTr,veSdKE:LETAL MUSCLE, SPLEEN, AIOLRETUMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, `PTHHAYRRYOIIVDG/GLLAARNYDN,X, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : THYROIADLTEGRLAATNIDON:, COLLOID, minimal. - Tw Company Saniiized. Doesnotcontain TSCA C 90H0D--2oD4ya67y8O:ralSuGbacvharaoggneeiScStTuodnyiyicinintRRyaattss --_ 00 DuPoonmts6s5s5s4 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648399 TKeirlmliendalonSaDcaryif: ic1e22 AEnxipmoaslureisGrsoiugpne:d o1ffMonftrhomrneeccorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIGD/LGALRAYNDN,X, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : THYROIADLTEGRLAATNIDON:, COLLOID, minimal. --_ _-- Tor Company Sanitized. Doos notcontainTSCACB H9-02-4D6a7y8O:raSlubGcahvraogneicStTuodxiyciintyRats --~ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648400 TKeirlmliendalonSDaacyrif: ic9e3 AEnxipmoaslureisGrsoiugpned: 90 day off from necropsy Gross Pathology : No aLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIID/LGALRAYNND,K, PAEYREA(TSH)YRWOIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPAHAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLOEI),NT,OVASRTIEERSN,GM,UTENROUSSE, VAGINA, URINARY BLADDER, --_ Histopathology + LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCRDEEAGSEN:ERATION/NECROSTS, ACINAR CELL, minimal. THYROIHDYPEGRLPALNADSI:A, FOCAL, ACINAR CELL, minimal. AHLYTPEERRATTRIOOPNH,Y, COFLOLLOLIIDC,ULAmRi,nimmailn.imal. 648400 Continued on the next page .... -- - wm Company Sanitized. Does not contain-- TSC-- A CBI 9H0--2D46a7y8O:rSaulbGcahvraogneicSTtouvdiyciintRyats --_ Dupont-6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648400 Continued from previous page Histopathology + No MiKIcDrNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y SOKbEsLeErTvAeLd M:USCLE, SPLEEN, AORTA, CBERCAUIMN,, CSOPLIONNA,L CROERCDT,UM,STOMMEASCEHN,TERDIUCODELNYUMMP,I NJOEDJEU,NUMS,ALIIVLEAURMY, GTSRLCAAICNAHDTESIA,C, NMEEARSNVODEPI,HBAUGLPUAISRT,ULIYTPMAHPRAHYRYNNGOXLDA/ENL,DA,RYTNHPKYA,MRUAST,HYARODIRDENGALLANGDLSA,NDS, BOYVSA(RSI)ES,WITUHTEROUPST,ICUNREIRNVAER,Y SBKLIAND,DERM,AMMFAERMUYR/GKLNAENED STERNUM, BONE MARROW, NOSE J(OFIENMTA,LE), --~ --~ - ww Company Santized. Does not contain TSCA CBI 9H0--2D4a67y8O;naSubGcahvargoenSctTouxdiyciintRyats -- DuPont 6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648407 TKeirlmliendalon SaDcaryif: ic9e3 EAnxipmoaslureisGrsoiugpned: o90ffdafyr.om necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYNIXD/LGALRAYNND,X, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINB,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : LIVERINFLAMMATION, SUBACUTE/CHRONIC, miniral. KIDNENYESPH+ROPATHY, CHRONIC PROGRESSIVE, minimal. PARATNHOYTROIPDRESGELNATN.DS : No MiLUcNrGoSs,copHEiAcRTA.bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL `CCOORLDO,N,' SRTEOCMTAUCMH,, DMUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPAVNACRRYEAGSL,ANDCSE,CUM, 648407 Continued MNEARNVDEI,BULPAIRTUILTYAMRPYH GNOLDAEN,D, TTHYHWYURSO,IDADGLRAENNDA,L on the next page .... GTLRAANCDHSE,A, SCEISOAPTHIACGUS, --_ EEEd CompanySanitized. Dossnotcontain TSCACBI S09H-0D2-u4D6ay7y8OO:rnaSlluGbcahvraaogngeiecSStTtuoudxiydcyiinityRnaRtass --~ DDuubPonmte6s5s5t4 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648407 Continued from previous page Histopathology : No MiPcHrAoRsYNcXo/pLiAcRYANbKn,ormEYaEl(iSt)y WOIbTsHervOePTdIC: NERVE, SKIN, MAMMARY GFLEANNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTEBROUNSE, MAURRRIONWA,RYNOBLSAEDDER, -- - Tw Company Sanilized. Does not contain TSCACBI 9H-02-4D6a7y8;OrSaulbGeahvraogneicStTuoxdiyciitnyRats --_ DuPont-6554 Showing aInnidviavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 6asatt KTeirlnliendalonSDaacyr:ific18e3 AEnxipmoaslureisGrsoiugpned: o3fMfonftrhomrenceocvreorpysy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND.THYMUS, TPHHYARROVINID/LGALRAYNDN,X, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HERS,KINE,SOPMHAAMGMUASR,Y GFELMAUNRD/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : r THYROAILDTEGRLAATNIDON, COLLOID, mild. --~ - we `Company Sanitized. Donotecontsain TSCA CBI H-24678; SubchronicTovicity 90-DayOral Gavage Study inRats DuPont6554 Showing aInnidmiavlidduaatla AfnoirrailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings sasa12 TKeirlmliendalon SDaacyrif: ic93e AEnxipmoaslureisGrsoiugpned: 90 day off from necropsy Gross Pathology : No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIXD/LGALRAYNND,X, 'PEAYREN(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y FGELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, --_ Histopathology ESOPHAIGNUFSLAW:MATION, SUBACUTE/CHRONIC, minimal UTERUSDILATATION, GLAND/LUMEN, mild. No MiLcIVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC MNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, 648412 Continued on the next page .... --_ -- ww Company Sanitized. Does not contain TSCA CBI 2904-6D7ay8:OrSaubGcahvvaogneieSTtouxdiyciitnyRats ~ Dupont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl snimals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Nacroscopic Findings sasuiz Continued Exon previous page Histopathology : No MiTEcHYrEY(oRSsO)cIoDpWiIGcLTAHNADOb,PnToIrPCmAaRNlAEiTRtHVyYER,OOTbDsSKeIrGNLv,AeNdDNSA:,WMTRRYACHGELAA,NDPH(AFREYMNAKL/E)L,ARYNK, OHAVRARROIWE,S, NOUSREINARY BLADDER, PEMUR/KNEE JOINT, STERWM, BONE PS --_ E`L Company Sanitized, Does notconlain TSCA CBI F0--2D46a7y8:OrSaulbGcahvraogneicStTuoxdiyciintyRats DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648410 TKeirlmliendalonSDaacyrif: ic12e2 AEnxipmoaslureisGrsoigunped: o1ffMonftrhomrneeccorvoeprsyy Gross Pathology No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYIM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTNAPHRYNOGDLEA,ND,THYMUS, TPHHYARROYNIKD/LGALRAYNNDK,, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGYUASR,Y GFELVAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, -- Histopathology THYROAILDTEGRLAATNIDON:, COLLOTD, minimal. - Tw `Company Sanitized. Does notcontain TSCA CBI H0O--D2D4aa6y7y8OO:rraalSluGbcahvraaogngeiecSStTtuoudxiydcyiinityRnaRtass DuuPpoonmt66s5s5s4 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648435. TKeirlmliendalonSDaacyrif: ic93e AEnxipmoaslureisGrsoigunped: o9f0fdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETDAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NA'LSAGLLIAVNADRSY, GSLACNIDAST,ICWNAEIRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THOUS, TPHHYARROYNIKD/LGALRAYNNDX,, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFELNAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, ~ Histopathology LIVERINFLAMMATION, SUBACUTE/CHRONIC, minimal KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. PARATNHOYTROIPDRESGELNATN.DS : No MiLUcNrGoSs,copHiEAcRTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edSP: LEEN, AORTA, BRAIN, SPINAL CCOORLDO,N, "SRTEOCMTAUCMH,, MDEUSODEENNTUEMR,ICJLEJYUMNPUHM,NODIEL,EUMS,ALIPVAANCRRYEAGSL,ANDCSE,CUM, 648435 Continued MNEARNVDEI,BULPAITRULIYTMAPRHY NGOLDAEN,D, on the next page ... THTYHMYURSO,IDAGDLRAENNDA,L GTLRAANCDHSE,A, SCSISOAPTHIACGUS, --_ a-- Company Sanftizac. Does not contain TSCA CBI 9H0--2D4a6y78O;raSulbGcahvraogneicSTtouxdiyciitnyRats --_~ DuPont6554 Showing aInnidmiavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 648435 Continued from previous page Histopathology : No MiPHcArRoYsVcNoIp/iLcARYANbKn,ormBYaEl(iSt)y WOIbTsHervOePTdIC: NERVE, SKIN, MAMMARY GFLEAMNUDR/K(NFEEEMAJLOEI),NT,OVASRTIEERSN,UY,UTEBROUNSE, MAURRRIONWA,RYNOBLSAEDDER, -- --_ - ww Company Sanitized. Doss not contain TSCA CBI H9-02-4D6a7y8O:raSluGbcahvraogneicStTuodnyicitn yRats DuPont6554 Showing aInnidriavlidduaatla AfnoirmailndLiivsitdiunagl animals Dose Group : X - 300 mg/kg/day Treatment: 300 mg/kg/day X Sex: Females Animal Ref Microscopic & Macroscopic Findings 64843 TKeirlmliendalonSaDcaryif: ic9e3 AEnxipmoaslureisGrsoiugpne:d o90ffdafyrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCAECLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJIESCUNLUYYM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIKD/LGALRAYNDN,K, 'EPYAREN(TSH)YRWOITTDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEWAJLEO)I,NT,OVASRTIEERSN,GM,UTENROUSSE, VAGINA, URINARY BLADDER, -- Histopathology : LIVERINFLAMMATION, SUSACUTE/CHRONIC, minimal. No MiKIcDrNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y OSbKsEeLrEvTeALd M: USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMW,PHINLOEDUEM,, GSLAALNIDVSA,RYSGCLIAANTDISC, NMERAVNED,IBUPLIATRUILTYAMRYPHGLNAONDDE,, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, TTHHYYMRUOSI,D AGLDARNEDN,AL PHARYNX/LARYNK, EOYVEA(RSI)ES,WITUHTEROUPST,ICUNREIRNVAER,Y SBKLIAND,DERM,AMMFAERMYURG/LKANNEDE J(OFIENMTA,LE), STERNUM, BONE MARROW. NOSE --~ TTT TTT eee. Company Santized. Doss not contain TSCA CBI