DRAFT Shanghai Health Study Update from the Benzene Health Research Consortium (BHRC) to API General Committee for Special Programs February 14, 2008 Presenter: Patsy Clegg, Chair BHRC Oversight Committee Talking Points: Study protocols Case accrual goals achieved by PIs based on YE07 report NHL case accrual completed Jan 08 - one month extension AML concluded end of June 07 Financials Sponsors have met obligations for financial support API reports that progress in being made on getting appropriate documentation for Cinpathogen expenses CinPathogen has requested additional funding for IT expenses in support of databases to meet QA expectations Contracts .Gi!

From: Sent: To: Cc: Subject: Attach: myron. c.harrison@exxonmobil.com Tuesday, September 25,20077:00 PM (GMT) Clegg, Patsy M SCC-DCSI22 <patsy.c1egg@shell.com> alex.yelland@chevron.com; anita.balaraman@chevrontexaco.com; brian.e.doll@exxonmobi1.com; burnetdm@bp.com; Williams, Elizabeth J SCAI-DCSI22 <elizabeth.williams@shell.com>; feldman@api.org; hargettb@api.org; heroldra@bp.com; hughm7@bp.com;jarnotb@api.org; jennifer.b.galvin@conocophillips.com; mfitzsimmons@steptoe.com; michae1.g.bird@exxonmobil.com; michae1.j .roman@exxonmobil.com; Mike.dJohnston@conocophillips.com; Sykes, Paul B SCC-DCSI23 <Pau1.Sykes@shell.com>; Snyder, Phil J SDIUS-DXX/9 <phi1.snyder@shell.com>; Colmer, Robert W SC-DCSI18 <Rob.Colmer@shell.com>; Tsai, Shan P SHLOIL-SHS <Shan.Tsai@shell.com>; stephen.m.bowes@exxonmobi1.com; Cagen, Stuart Z SHLOIL-SHOIL-SHS <stuart. cagen@shell.com>; wagner@api.org; whiter@api.org; ZachW ong@chevrontexaco.com Re: Shanghai Health Study - Update to Special Programs Committee - Review and Comments Requested Shanghai Health Study Update - Sept 27 07 with mch comments. doc Patsy, mostly good news, but a few comments ...... .

From: Sent: To: Subject: Matt Todd <ToddM@api.org> Tuesday, June 3, 2003 7:02 PM (GMT) BHRC Communications Committee (E-mail) <benzconsort-cc@listserve.api.org>; BHRC Oversight Committee (E-mail) <benzconsort-oc@listserve.api.org>; BHRC Technical Committee (E-mail) <benzconsort-tc@listserve.api.org> Shanghai Health Study: NEW Conference Call Info Dear BHRC Member: Print this email!

From: Sent: To: Subject: Matt Todd <ToddM@api.org> Friday, October 15, 2004 7: 12 PM (GMT) BHRC Oversight Committee (E-mail) <benzconsort-oc@listserve.api.org>; BHRC Technical Committee (E-mail) <benzconsort-tc@listserve.api.org>; BHRC Communications Committee (E-mail) <benzconsort-cc@listserve.api.org> Shanghai Health Study Update: October 15,2004 Shanghai Health Study Update Announcements: The next Oversight Committee Meeting is scheduled for the afternoon of November 3rd and morning of the 4th in Houston, Texas.

From: Sent: To: Cc: Subject: Attach: Fu Hua <hfu@shmu.edu.cn> Tuesday, May 17,2005 4:00 AM (GMT) 'Bruce Jarnot' <jarnotb@api.org> Tsai, Shan P SHLOIL-SHS <shan.tsai@shell.com>; 'shanghaihealthstudy' <info@shanghaihealthstudy.org> ??

From: Sent: To: Cc: Subject: Attach: Lorraine Twerdok <Twerdokl@api.org> Tuesday, February 25, 2003 10:48 PM (GMT) Benzene consort comm (E-mail) <benzconsort-cc@api.org>; Benzene consort tech (Email) <benzconsort-tc@api.org>; Benzene OC listserve (E-mail) <BenzConsortOC@api.org> 'myron. c. harrison@exxonmobil. com' (E-mail)<myron.c.harrison@exxonmobil.com> SHS exec brief - 2125 revision China Benzene Paper API Exec Comm 2-25-03 Draft.doc SH ELL-MCCLU RG-054876 Draftfor March 18,2003 Meeting Fourth revision 2125103 Attachment For Action API Executive Committee Issue: The Benzene Health Research Consortium is seeking guidance on options to address a shortfall in funding the industry-sponsored Shanghai Health Study (SHS), A five-year project designed to investigate the potential health effects of benzene, the study sponsors have secured $16,5 million of the $22,8 million required to carry it to fruition, Although preparations for the research have begun, this $6,3 million funding gap - - if not closed - - will either compromise the study or lead to its demise, Background: Continued concern about the potential health effects of benzene is reflected by two recent studies that suggest a link between benzene exposure and certain cancers not previously associated with the chemical, The Consortium is thus sponsoring a five-year study in Shanghai, China, which could significantly decrease the uncertainty surrounding the issue, A joint investigation primarily managed by the University of Colorado and Fudan University, the SHS includes protocols developed with the assistance of a 12-member international scientific review panel and Chinese, European and American bio-ethics specialists, It also has strong support and active participation from Chinese universities, hospitals and regulatory agencies, The United States EPA has expressed interest in participation, The quality of Shanghai's occupational benzene exposure records offers an unprecedented opportunity, and perhaps the last of its kind, to conduct this type of study on the relationship between benzene exposure and the risk of certain blood diseases, The SHS will enhance industry's product stewardship, while providing the scientific, regulatory and business communities with better information on benzene, Project Status: Three inter-related studies are underway: (1) a Case-Control Epidemiology study; (2) a Disease Progression Study; and (3) a Molecular Epidemiology Study, Laboratory construction, technical training and exposure assessments are nearing completion and individual case acceptance will begin in spring, 2003, Legal and public affairs expertise has been retained to facilitate Consortium activities, Funding Status: Current funding for the program is projected to run out during the first quarter of 2004, Five companies (BP, ChevronTexaco, ConocoPhillips, ExxonMobil and Shell Chemical Company) have contributed $16,5 million, While the study was initiated with a modest shortfall, subsequent protocol enhancements recommended by independent scientific and ethics review panels led to the final budget of $22,8 million, The Consortium has made presentations to ACC, ARPEL, CONCAWE, IPIECA, and NPRA; held focused discussions with Dow Chemical Company, Marathon Ashland, and Sunoco, and approached AGIP-ENI, ARPEL, BASF, Citgo, Dupont, Lyondell-Equistar, Petronas, Statoil, and TotalFinaElf To date, none of these entities has agreed to join the Consortium and contribute funds, Implications of funding shortfall: The Consortium Technical Committee studied the impacts of a funding shortfall and determined that, at best, only one of the three studies could be completed with current funds, The reality, however, is that an unclosed gap would result in loss of Chinese collaboration, in which case none of the studies could be completed, In addition to the lost scientific and product stewardship opportunities, this situation could have public, regulatory and legal ramifications for the entire industry, At this point, Consortium members are not optimistic that additional companies will commit Given that the study would benefit the entire industry, the Consortium is requesting that API leadership consider whether API can provide support to eliminate the shortfall, Possible options include API (1) providing direct funding for the study; (2) underwriting the shortfall that is not met by ongoing recruitment efforts; or (3) leave the gap unfunded, SH ELL-MCCLU RG-OS4877 Draftfor March 18,2003 Meeting Fourth revision 2125103 For Action: The Executive Committee is requested to advise the Consortium of its' decision on SHS funding, SH ELL-MCCLU RG-054878

To: Howard Feldman <Feldman@api.org>; Benzene OC listserve (E-mail) <BenzConsort- OC@listserve.api.org> From: Clegg, Patsy M SCC-CHSE-PC </O=SHE LUOU=MSXSCC/CN=RE CI PI ENTS/CN=PH197432> Cc: Bcc: Received Date: 2003-10-09 17:39:01 GMT Subject: RE: Oversight Committee response I guess that I am okay with it.

To: 'carol.a.fairbrother@exxonmobil.com' <carol.a.fairbrother@exxonmobil.com>; 'Broddle, William' <bill.d.broddle@usa.conoco.com>; 'burnetdm@bp.com' <burnetdm@bp.com>; 'sptsai @shell.com' <sptsai @shell.com>; 'szcagen@ Shell.

From: Sullivan, Nancy E SCC-CBAR Sent: Friday, October 17, 2003 8:28 AM To: Tholstrup, Susan C SCC-HSE; Clegg, Patsy M SCC-CHSE-PC Subject: FW: Progress Report on Benzene Health Research Consortium Fyi- a reminder when pressure is exerted people can find a way to do it with less money!

From: Lorraine Twerdok [Twerdokl@api.org] Sent: Wednesday, March 13, 2002 2:02 PM To: Benzene OC listserve Cc: George Woodall Subject: BZ OC - 3/14 Conf.

DRAFT 3122/02 Update on the Benzene Health Effects Consortium Shanghai Health Study March, 2002 The protocols for the Shanghai Health Study are currently undergoing approval by the appropriate Institutional Review Boards in the US and China.

5/2/02 Draft Benzene Health Research Consortium Summary - Oversight Committee Conference Call 5/2/02 Present: Don Burnett, BP Carol Fairbrother, ExxonMobil Paula Podhasky, API Matt Todd, API George Woodall, API Lorraine Twerdok, API Absent: Patrick Beatty, ChevronTexaco Bill Broddle, Conoco Patsy Clegg, Shell Review ofAction Items from 3114102 Call: Planning for First Annual Research Review Meeting: 3114 Action item and status:_Availability of PIs, SRP members and Ethics Committee members for first Annual Research Review Meeting in January, 2003 (George Woodall) In progress - see attached list of responses Second half of January (3fd week?)

To: benzene-erp@ listserve. api. org <benzene-erp@ listserve. api. org>; benzene- srp@listserve.api.org <benzene-srp@listserve.api.org> From: Bruce Jarnot <jarnotb@api.org> Cc: Bcc: Received Date: 2005-04-0821 :28:53 GMT Subject: Shanghai SRP / ERP...

ELSEVIER Available online at www.sciencedirect.com SCIENCE@OIRECT Leukemia Research xxx (2005) xxx-xxx LeukemIa Research www.elsevier.com/locate/leukres Chronic exposure to benzene results in a unique form of dysplasia Richard D.

To: BenzConsort-OC@listserve.api.org <BenzConsort-OC@listserve.api.org>; BenzConsort-TC@listserve.api.org <BenzConsort-TC@listserve.api.org>; BHRC Communications Committee <benzconsort-cc@ listserve. api. org> From: Russell White <whiter@api.org> Cc: Howard Feldman <Feldman@api.org> Bcc: Received Date: 2006-11-0820:27:50 GMT Subject: Shanghai Health Study conference call - Thursday, November 9, 12 noon EST Draft agenda * Establish quorum and note taker - Patsy * Review antitrust guidelines - Mark * Update on Dr.