Differentiation therapy of acute myeloid leukemia: past, present and future Kevin Petriea, Arthur Zelenta and Samuel Waxmanb aSection of Haemato-Oncology, Institute of Cancer Research, Sutton, UK and bDepartment of Medicine, Mount Sinai School of Medicine, New York, USA Correspondence to Samuel Waxman, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA Tel: +1 212 241 6771; fax: +1 212 996 5787; e-mail: samuel.waxman@mssm.edu Current Opinion in Hematology 2009, 16:8491 Purpose of review Since the 1970s, the concept of differentiation therapy has been viewed as a promising and revolutionary approach for the treatment of acute myeloid leukemia (AML) and other cancers.

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UNITED STATES OF AMERICA Securities and Eaohanc.e Commission PLAINTIFF'S EXHIBIT ATT EC fA I k j{ I I HEREBY ATTEST that: Attached is a copy of, current report on Form 8-K, dated December 15, 2000, received in this Commission December 19, 2000, under the name Crown Cork & Seal Company, Inc., File No. 1-2227, pursuant to the provisions of the Securities Exchange Act of 19347 i file in this Commission July 26, 2001 (Date) Larry Mills Records Officer It is hereby certified that the Associate Executive Director, Office of Filings and Information Services, IJ S Securities and Exchange Commission, Washington, D.C., which Commission was created by the Securities Ex change Act of 1934 (15 U.S C 78a et s-;g. i is official custodian of the records and files of said Commission, and dll records and tiles created or established by the Federal Trade Commission pursuant to ihe provisions of the Securities Act of 1933 and transferred to this Oommis non m accordance with Section 210 of the Securities Exchange Act of 1934 and was such official custodian at the time of executing the above attestation and that he/she, and persons holding the positions of Deputy Director, Associate Directors, Special Assistant to the Director Reconls uificer and the Branch Chief of Records Management, or any one ot them, me authorized to execute the above attestation.

NO. 96-333 IRMA BUSTAMANTE, INDIVIDU3LLY AND AS PERSONAL REPRESENTATIVE OF THE HEIRS'ANDTSTATE OF JOSE PERALTA, DECEASED ZZ VS. .

Dana Corporation Page 59 of 176 Table of Contents An analysis of our 2003 and 2002 gross and operating margins and selling, general and administrative expense is presented in the following table.