PERFLUOROOCTANESULFONATE, POTASSIUM SALT (PFOS): A 96-HOUR STATIC ACUTE TOXICITY TEST WITH THE RAINBOW TROUT (<Oncorhynchus mykiss) FINAL REPORT WILDLIFE INTERNATIONAL, LTD.

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Afua- ir / / IN TH E C IR CU IT COURT OF WOOD COUNTY, W EST VIRGINIA JACK w.

AR226-1532 33 PP Screei evel cumul -- \ r \ sment perfluorinated alkyl cids on human health Rich Purdy RECEIVED OPPT NCIC 2003 OCT-9 PM9:30 Guidance on Cumulative Risk Assessment of Pesticide Chemicals That Have a Common Mechanism of Toxicity.

AR226-1734 Toxicological Summary PFOS Dietary Acute Mallard Study Test Substance: Perfluorooctanesulfonate (PFOS) Structure: 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-, potassium salt, CAS# 2795-39-3 Remarks: The test substance is a white powder (3M lot #217).

3M Specialty M ateriali 3M Center S t Paul, MN 55144-1000 651 7331110 January 3,2003 VIA FEDERAL EXPRESS Docum ent C ontrol O ffice (DCO) O ffice o f Pollution Prevention and Toxics (OPPT) US Environm ental Protection Agency EPA East, Room 6428 1201 C onstitution Avenue, NW W ashington, DC 20460 Attention: Docket No.

STUDY TITLE Extraction of Potassium Perfluorooctanesulfonate from Quail Serum and Quail Liver for Analysis Using HPLC-Electrospray/Mass Spectrometry DATA REQUIREMENTS Analytical Method Requirements STUDY DIRECTOR Sean Gallagher STUDY COMPLETED ON September 06, 2001 PERFORMING LABORATORY / TESTING FACILITY Centre Analytical Laboratories, Inc.

0100-/37% 37i l l UNITED STATES ENVIRONMENTAL PROTECTION AGENCY S WASHINGTON, D.C. 20460 AftSiSU -OG09 July 18, 2000 fa OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES NOTE TO FYI FILE by Terry O'Bryan/RAD/OPPT Reference: FYI-0600-01378 Submission Date: June 14, 2000 The above referenced FYI submission is 3M's response to EPA regarding three reports that appeared to be missing from their 5/4/00 submission (also FYI-01378).

qrr Charles Auer 05/16/2000 11:11 AM RECEIVED O P P T HC1C 2000S E P -6 PH 12: 57 e2G 0 6 2 - 3 To: cc: Subject: Barbara Leczynski/DC/USEPA/US@EPA, Mary Dominiak/DC/USEPA/US@EPA, Frank Kover/DC/USEPA/US@EPA, Ward Penberthy/DC/USEPA/US@EPA, Karen Lannon/DC/USEPA/US@EPA Phaseout of PFOS fyi Forwarded by Charles Auer/DC/USEPA/US on 05/16/2000 11:17 AM Charles Auer 05/16/2000 11:06 AM To: Charles Auer/DC/USEPA/US@EPA, blnetti@iss.it, John.Bucdnl@ec.gc.ca, "IMCEAFAX-3001+5ECHADJICHRISTIDI+2C+20Konstantina-fax+5E3A23+5E3018662968+5E"@oecd.or g, shchung@me.go.kr, theresa.gilgallon@cec.eu.int, addeke@lss.it, karen_florlnl@edf.org, amst@baua.do.shuttle.de, bjorn.hansen@jrc.it, hasa@env.cz, mark.hyman@ea.gov.au, "IMCEAFAX-3001+5EICONOMOU+2C+20Maria+5E3A23+5E3016465123+5E"@oecd.org, geir.jorgensen@sft.telemax.no, Rainer-Kurt.Koch.RK@bayer-ag.de, Thaly.Lakhanisky@iph.fgov.be, ivarl@kemi.se, majka@bware.imp.lodz.pl, matejova.jana@flora.lifeenv.gov.sk, TM-TNG@mhw.go.jp, laurence.musset@environnement.gouv.fr, jrn@mst.dk, esa.nikunen@vyh.fi, caria.piccinni-leopardi@cec.eu.int, raimund.quint@bmu.gv.at, rosenbaum@biac.org, esilber@epi.umaryland.edu, urs.staempfli@buwal.admin.ch, nagata-reiko@miti.go.jp, roger_tregunno@detr.gsi.gov.uk, Hty@mst.dk, ungvary@elender.hu, kees.van.Leeuwen@rivm.nl, vickersc@worksafe.gov.au, jwillis@unep.ch, younesm@who.ch, Dian.TURNHEIM@oecd.org, Naoyuki.YASUDA@oecd.org, Lesley.ONYON@oecd.org, Oscar Hernandez/DC/USEPA/US@EPA cc: robert.visser@oecd.org, robert.donkers@cec.eu.int, Susan Wayland/DC/USEPA/US@EPA, William Sanders/DC/USEPA/US@EPA, Pep Fuller/DC/USEPA/US@EPA, milroy.breck@epamail.epa.gov, ig232001@wp-gate.bmu.de, Priscilla Flattery/DC/USEPA/US@EPA Subject: Phaseout of PFOS I would like to draw your attention to an important development in the US which concerns a persistent, bioaccumulative, and toxic chemical.

Katherine E.

AR226-1838 DuPont/3M Meeting with EPA August 25,2004 1:00 P M -4:00 PM Agenda Background/Obj ectives Received OPPT NCIC 2004 SEP-3 Data Review Linear/Branched Study Worker Exposure Data Biology Review P air Forward v \ < e S i y ^Jc^L 5 H *- 'D .J '^ - V % r / o V !

/)/ea~/g5f STUDY TITLE Extraction of Potassium Perfluorooctanesulfonate from Red Blood Cells and Serum for Analysis Using HPLC-Electrospray/Mass Spectrometry DATA REQUIREMENTS Analytical Method Requirements STUDY DIRECTOR Sean Gallagher ANALYTICAL REPORT DATE June 2, 2003 PERFORMING LABORATORY / TESTING FACILITY Exygen Research 3058 Research Drive State College, PA 16801 Phone: 814-272-1039 STUDY SPONSOR 3M Environmental Technology and Safety Services Building 2-3E-09 PO Box 33331 St.