;and 1 Work pidemioiogic Norway, n. 074. e of primary 1:6-16. udy of vinyl American Journal of Industrial Medicine 34:251-256 (1993) LETTER TO THE EDITOR Diagnostic Bias in Occupational Epidemiologic Studies: An Example Based on the Vinyl Chloride Literature Key words: vinyl chloride, brain cancer, emphysema, chronic obstructive pulmonary disease, diagnostic bias INTRODUCTION Dr.

ENSR ENSF1 Consulting and Engineering Commercial Terms TIME AND MATERIALS CONTRACT AGREEMENT Effective January 1,1991 SCOPE OF SERVICES - ENSR Corporation, referred to herein as "ENSR," will perform the services described in its proposal, or, in the absence of a proposal, as defined in writing and approved by ENSR and Client, referred to herein as "Services" in accordance with the following "Commercial Terms," These services shall be performed on a Time and Materials basis.

PATTON BOGGS, L.L.P. 2550 M STREET, N.W.

1803 BUILDING January 5,1995 Tht' Dow Chemical Company Midland, Michigan 48674 Hasmukh C.

| Mg The Vinyl TM m Institute A Division of The Society of The Plastics Industry, Inc.

1995 ANNUAL REPORT R&S 041444 bail V ..

OxyChem Vinyl Chloride (Monomer) ox-yCUtM VJCM *AST>5 W. iq - 1990 DANGER!

FEB-04-97 TUE 01:19 PM ?.

Chemical Manufacturers Association March 31,1997 Raymond E.

BORDEN SERVICES COMPANY "QUALITY BUSINESS SOLUTIONS" MARK A.

:f: v>*. 1995 CMA 121471 P 04\034\023\0001\000001 ii.iv, 0f Loulv\Propot*l-Brin Cancer Study sO

Dow Chemical, Louisiana Division Control Chart T53EDC Date of Report 22-APR-1998 ''`art Date 1-JAN-1996 1 Date 22-APR-1998 Sampling Point S-T53 Analysis S-PER Component EDC 06:59 Date Group Name Value 1 19-FEB-1996 08:29 1277 2 20-FEB-1996 22:57 1379 3 23-FEB-1996 15:39 1527 4 8-MAR-1996 20:02 2534 5 10-MAR-1996 09:39 2649 6 11-MAR-1996 20:35 2756 7 20-MAR-1996 13:20 3328 0.000 0.000 0.000 0.000 0.000 0.000 0.000 8 22-MAR-1996 09 : 06 3435 0.000 9 23-MAR-1996 22:56 3521 0.000 10 25-MAR-1996 09:40 3605 0.000 11 27-MAR-1996 08:37 3783 0.000 12 l-APR-1996 15:21 4208 0.000 13 3-APR-1996 13:57 4383 0.000 14 5-APR-1996 10:36 4544 0.000 15 19-APR-1996 01:06 5900 0.000 16 20-APR-1996 10:07 6018 0.000 17 21-APR-1996 17:48 6119 0.000 18 23-APR-1996 05:58 6288 0.000 19 25-APR-1996 02:41 6445 0.000 20 26-APR-1996 10:32 6576 0.000 21 28-APR-1996 01: 54 6720 0.000 22 30-APR-1996 12:41 6937 0.000 23 ll-MAY-1996 16:21 7944 0.000 24 13-MAY-1996 11:56 8116 0.000 25 14-MAY-1996 16:56 8219 0.000 26 15-MAY-1996 20:35 8340 0.000 27 17-MAY-1996 03:00 8444 0.000 28 18-MAY-1996 21:36 8606 0.000 Sample ID rep Comment 1277 1 1379 1 1527 1 2534 1 2649 1 2756 1 3328 1 Product Name:PERDG 3435 1 Product Name:PERDG 3521 1 Product Name:PERDG 3605 1 Product Name:PERDG 3783 1 Product Name:PERDG 4208 1 Product Name:PERDG 4383 1 Product Name:PERDG 4544 1 Product Name:PERDG 5900 1 Product Name:PERDG 6018 1 Product Name:PERDG 6119 1 Product Name:PERDG 6288 1 Product Name:PERDG 6445 1 Product Name:PERDG 6576 1 Product Name:PERDG 6720 1 Product Name:PERDG 6937 1 Product Name:PERDG 7944 1 Product Name:PERDG 8116 1 Product Name:PERDG 8219 1 Product Name:PERDG 8340 1 Product Name:PERDG 8444 1 Product Name:PERDG 8606 1 Product Name:PERDG ^0 065543 cNFrDETNTrAt Date Group Name Value 29 20-MAY-1996 01:52 8714 30 21-MAY-1996 12 : 24 8849 31 2 3 -MAY-19 9 6 00:52 8978 32 2 4 -MAY-19 9 6 15:15 9111 33 26-MAY-1996 15:14 9287 34 28-MAY-1996 23:20 9500 35 31-MAY-1996 11: 07 9744 36 25-JUN-1996 04:09 11425 37 26-JUN-1996 20:02 11594 38 28 -JUN-1996 04:52 11721 39 29-JUN-1996 10 rl3 11838 40 3 0 -JUN-19 9 6 14:29 11940 41 1-JUL-19 9 6 19:42 12069 42 4 -JUL-19 9 6 00:31 12315 43 5 -JUL-19 9 6 14:29 12471 44 6-JUL-1996 18:12 12579 45 8 -JUL-19 9 6 03:29 12703 46 9-JUL-1996 13:54 12854 47 10-JUL-19 9 6 15:43 12961 48 11-JUL-1996 21:25 13086 49 12 -JUL-19 9 6 18:18 13168 50 13-JUL-1996 22:20 13262 51 15 -JUL-19 9 6 00:38 13378 52 16 -JUL-19 9 6 06:33 13498 53 17-JUL-19 9 6 14:25 13615 54 18 -JUL-19 9 6 11:44 13693 55 19-JUL-19 9 6 14 :4 0 13797 56 2 0 -JUL-19 9 6 15:19 13891 57 21-JUL-19 9 6 14:03 13978 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 8.000 0.000 0.000 0.000 1.000 0.000 2.000 0.000 0.000 0.000 0.000 0.000 0.000 11.000 3.000 0.000 Sample ID rep Comment 8714 1 Product Name :PERDG 8849 1 Product Name PERDG 8978 1 Product Name PERDG 9111 1 Product Name PERDG 9287 1 Product Name PERDG 9500 1 Product Name PERDG 9744 1 Product Name PERDG 11425 1 Product Name PERDG 11594 1 Product Name PERDG 11721 1 Product Name PERDG 11838 1 Product Name PERDG 11940 1 Product Name PERDG 12069 1 Product Name PERDG 12315 1 Product Name PERDG 12471 1 Product Name PERDG 12579 1 Product Name PERDG 12703 1 Product Name PERDG 12854 1 Product Name PERDG 12961 1 Product Name PERDG 13086 1 Product Name PERDG 13168 1 Product Name PERDG 13262 1 Product Name PERDG 13378 1 Product Name PERDG 13498 1 Product Name PERDG 13615 1 Product Name PERDG 13693 1 Product Name PERDG 13797 1 Product Name PERDG 13891 1 Product Name PERDG 13978 1 Product Name PERDG DO 065544 CONFIDENTIAL Date Group Name Value 58 22-JUL-1996 13:56 14066 59 2 3 -JUL-19 9 6 13:08 14157 60 24-JUL-1996 13:57 14270 61 2 5-JUL-19 9 6 13:57 14412 62 26-JUL-1996 16 :52 14516 63 27-JUL-1996 14:11 14611 64 28-JUL-1996 09:54 14685 65 2 9 -JUL-19 9 6 09 :31 14786 66 3 0 -JUL-19 9 6 07:21 14874 67 31-JUL-1996 09:34 14976 68 4-AUG-1996 16:17 15371 69 8-AUG-1996 04:16 15703 70 9-AUG-1996 02 : 00 15792 71 10-AUG-1996 10:09 15914 72 12-AUG-1996 07:24 16103 73 13-AUG-1996 19:42 16259 74 21-AUG-1996 09:35 16951 75 22-AUG-1996 23:02 17086 76 23-AUG-1996 23:49 17219 77 25-AUG-1996 10:50 17392 78 26-AUG-1996 13:20 17493 79 21-SEP-1996 21:39 19922 80 23-SEP-1996 13:26 20064 81 25-SEP-1996 07:37 20247 82 27-SEP-1996 01:31 20397 83 28-SEP-1996 14:46 20529 84 30-SEP-1996 03:42 20662 85 2-OCT-1996 00:32 20844 86 3-OCT-1996 13:53 20992 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 2.000 1.000 0.000 0.000 0.000 0.000 Sample ID rep Comment 14066 1 Product Name:PERDG 14157 1 Product Name:PERDG 14270 1 Product Name:PERDG 14412 1 Product Name:PERDG 14516 1 Product Name:PERDG 14611 1 Product Name:PERDG 14685 1 Product Name:PERDG 14786 1 Product Name:PERDG 14874 1 Product Name:PERDG 14976 1 Product Name:PERDG 15371 1 Product Name:PERDG 15703 1 Product Name:PERDG 15792 1 Product Name:PERDG 15914 1 Product Name:PERDG 16103 1 Product Name:PERDG 16259 1 Product Name:PERDG 16951 1 Product Name:PERDG 17086 1 Product Name:PERDG 17219 1 Product Name:PERDG 17392 1 Product Name:PERDG 17493 1 Product Name:PERDG 19922 1 Product Name:PERDG 20064 1 Product Name:PERDG 20247 1 Product Name:PERDG 20397 1 Product Name:PERDG 20529 1 Product Name:PERDG 20662 1 Product Name.- PERDG 20844 1 Product Name:PERDG 20992 1 Product Name:PERDG DO 065545 CONFIDENTIAL Date Group Name Value 87 5-OCT-1996 13 :37 21165 88 6-OCT-1996 17:25 21251 89 7-OCT-1996 14:06 21365 90 8-OCT-1996 07:57 21432 91 9-OCT-1996 10:32 21528 92 10-OCT-1996 17:56 21657 93 11-OCT-1996 14:19 21721 94 5-NOV-1996 21:45 24140 95 7-NOV-1996 14:11 24290 96 8-NOV-1996 21:12 24405 97 9-NOV-1996 21:06 24503 98 ll-NOV-1996 00:26 24599 99 12-NOV-1996 08:39 24728 too 13-NOV-1996 21:09 24884 101 15-NOV-1996 04:58 24987 102 20-NOV-1996 22:57 25561 103 22-NOV-1996 00:43 25663 104 23-NOV-1996 03:41 25758 105 24-NOV-1996 10 : 09 25882 106 25-NOV-1996 19:11 26017 107 27-NOV-1996 02:07 26122 108 28-NOV-1996 12:46 26263 109 29-NOV-1996 16:39 26362 110 30-NOV-1996 14:18 26457 111 4-DEC-1996 15:56 26837 112 12-DEC-1996 00:55 27531 113 29-DEC-1996 08:44 29121 114 30-DEC-1996 16:27 29246 115 1-JAN-1997 08:59 29404 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 Sample ID rep Comment 21165 1 Product Name:PERDG 21251 1 Product Name:PERDG 21365 1 Product Name:PERDG 21432 1 Product Name:PERDG 21528 1 Product Name:PERDG 21657 1 Product Name:PERDG 21721 1 Product Name:PERDG 24140 1 Product Name:PERDG 24290 1 Product Name:PERDG 24405 1 Product Name:PERDG 24503 1 Product Name:PERDG 24599 1 Product Name:PERDG 24728 1 Product Name:PERDG 24884 1 Product Name:PERDG 24987 1 Product Name:PERDG 25561 1 Product Name:PERDG 25663 1 Product Name:PERDG 25758 1 Product Name:PERDG 25882 1 Product Name:PERDG 26017 1 Product Name:PERDG 26122 1 Product Name:PERDG 26263 1 Product Name:PERDG 26362 1 Product Name:PERDG 26457 1 Product Name:PERDG 26837 1 Product Name:PERDG 27531 1 Product Name:PERDG 29121 1 Product Name:PERDG 29246 1 Product Name:PERDG 29404 1 Product Name:PERDG 065546 confidential Date Group Name Value 116 3-JAN-1997 00:20 29545 117 5-JAN-1997 21:04 29809 118 8-JAN-1997 22:19 30096 119 11-JAN-1997 20:49 30357 120 14-JAN-1997 16:56 30586 121 16-JAN-1997 15:21 30782 122 26-JAN-1997 01:27 31630 123 28-JAN-1997 22:04 31907 124 30-JAN-1997 19:18 32097 125 1-FEB-1997 14:03 32238 126 3-FEB-1997 12:36 32419 127 9-FEB-1997 08:15 32963 128 11-FEB-1997 08:48 33147 12 9 13-FEB-1997 10:03 33340 130 15-FEB-1997 02:50 33482 131 16-FEB-1997 16:04 33619 132 18-FEB-1997 07:49 33752 133 19-FEB-1997 22:40 33882 134 21-FEB-1997 00:32 33987 135 22-FEB-1997 22:20 34159 136 23-FEB-1997 09:20 34204 137 25-FEB-1997 20:54 34442 138 27-FEB-1997 08:07 34583 139 28-FEB-1997 14:09 34707 140 28-FEB-1997 14:55 34709 141 28-FEB-1997 21:47 34739 j.42 2-MAR-1997 03:54 34843 143 3-MAR-1997 08:49 34971 144 28-MAR-1997 14:39 36673 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 Sample ID rep Comment 29545 1 Product Name:PERDG 29809 1 Product Name:PERDG 30096 1 Product Name:PERDG 30357 1 Product Name:PERDG 30586 1 Product Name:PERDG 30782 1 Product Name:PERDG 31630 1 Product Name:PERDG 31907 1 Product Name:PERDG 32097 1 Product Name:PERDG 32238 1 Product Name:PERDG 32419 1 Product Name:PERDG 32963 1 Product Name:PERDG 33147 1 Product Name:PERDG 33340 1 Product Name:PERDG 33482 1 Product Name:PERDG 33619 1 Product Name:PERDG 33752 1 Product Name:PERDG 33882 1 Product Name:PERDG 33987 1 Product Name:PERDG 34159 1 Product Name:PERDG 34204 1 Product Name:PERDG 34442 1 Product Name:PERDG 34583 1 Product Name:PERDG 34707 1 Product Name:PERDG 34709 1 Product Name:PERDG 34739 1 Product Name:PERDG 34843 1 Product Name:PERDG 34971 1 Product Name:PERDG 36673 1 Product Name:PERDG DO 065547 CONFIDENTIAL Date Group Name Value 145 28-MAR-1997 21:51 36703 146 30-MAR-1997 02:40 36827 147 30-MAR-1997 11:20 36863 148 3 0-MAR-1997 12:03 36867 149 31-MAR-1997 03:26 36928 150 l-APR-1997 04:24 37044 151 2-APR-1997 18 : 58 37222 152 4-APR-1997 00:03 37335 153 5-APR-1997 03:48 37433 154 6-APR-1997 07:43 37559 155 7-APR-1997 14:03 37673 156 8-APR-1997 20:20 37805 157 10-APR-1997 00:54 37930 158 ll-APR-1997 11:03 38055 159 13-APR-1997 00:54 38212 160 23-APR-1997 23:55 39322 161 25-APR-1997 12:46 39573 162 25-APR-1997 14:17 39574 163 27-APR-1997 18:22 39921 164 2 9-APR-1997 10:51 40159 165 3 0-APR-1997 18:01 40361 166 3-MAY-1997 02 : 01 40659 167 4-MAY-1997 08 :19 40851 168 5-MAY-1997 15:17 41012 169 7-MAY-19 9 7 07:26 41261 170 9-MAY-1997 12:51 41533 L71 ll-MAY-1997 00:46 41726 172 12-MAY-1997 06:40 41913 173 21-MAY-1997 22:59 43236 0.000 0.000 0.000 0.000

REACTIVE CHEMICALS PROGRAM GUIDELINE DO 071 SOP CONFIDENTIAL June 1997

CMA 3/30/97 PAGE 1/2 CMA cr Chemical Manufacturers Association Vinyl Chloride Health Committee FAX September 30/1997 TO: COMPANY: Dr.

Risk Science Institute International Life Sciences Institute MEMORANDUM TO: Use ofNon-Tumor Dm in Cancer Risk Assessment Working Group: Dr.