Medical science has long been cog nizant that exposure to airborne as bestos fibers of high enough intensity and long enough duration will lead to a diffuse inorganic-dust pneumoconiosis known as asbestosis.

In a recent study, NIOSH considered chemicals with the greatest carcinogenic hazard to be, among others, formaldehyde, benzene, lead, kerosine. nickel, chromium and carbon tetrachloride.

CITATION and NOTIFICATION OF PENALTY ISSUANCE DATE 1 OSHANU riBER 05/05/78 R5407]p027 .

ATTACHMENT 3 BACKGROUND STATEMENT BY ENVIRONMENTAL PROTECTION AGENCY ADMINISTRATOR, RUSSELLE.

/t*J=2*72.

Without exception, this has been leading.

Reprinted from CANCER.

March 29, 1971 Former Third Mate Leads Adventuresome Life As MSC Diver John W.

August 8,1975 ASBESTOS ASBESTOS EXPOSURE DURING SERVICING OF MOTOR VEHICLE BRAKE AND CLUTCH ASSEMBLIES 105481 001682 Ml PRODUCED BY FORD (36) DEPARTMENT OF HEALTH.

It was questioned if our Tinners, Leadburners, and others who worked with lead at times should be given appropriate clinical testing.

SC-1003 (Rv. 1-60) r^&HBili.cCHEMrCAL COMPANY m&. ft DtSiHIB.

The Mount Sinai group encountered "high" levels of lead in a study on subway car brake shoe repair w ork.

Thus even limited expo sures to high levels leads to continuing presence of inhaled asbestos perticles or - over - CfiNl 0SS2 B ullat i t Ko. 4 - 2 - 8/22/63 fibers within the luag.

c at doses that are 'orders of magnitude smaller than the activity levels of other simple organic molecules, implying relatively unusual mechanisms of pharma cological action; (b) the non-carcinogenic toxic effects exhibited by the PCDF's and PCDD are identical in all species of animals examined to date, implying that the mechanisms of non-carcinogenlc pharmaco logical action are the same for both agents; (c) the reported carcino genicity of PCDD at ppt levels implies a very unusual mechanism of pharmacological action; (d) it would be most implausible to assume that PCDD was capable of two different mechanisms of unusually potent pharmacological activity, one leading to carcinogenesis and the other to characteristic syndromes of non-carcinogenicj effects (including^ teratagenesis); (e) accordingly, one must presume that PCDF, which' mimics PCDD in its other toxic effects, will also be found to dupli cate its carcinogenicity.

Y/ o) C CONTAMINANTS IN GREAT STAFF REPORT LAKES FISH ' JUNE 1975 by John L.