f THE UPJOHN COMPANY K A LA M A ZO O , M IC HIG A N 49001 TELEPHONE (616) 382-4000 M EDICAL SERVICES Office of KENNETH B HAAS D V M July 13, 1976 Hearing Clerk Food and Drug Administration Room h-SS 5600 Fishers Lane Rockville, Maryland 20852 Dear Sir: In compliance with the Federal Register Notice, Volume 40, Number 51, March lA, 1975, page 11865, titled "Asbestos-form Particles in Drugs for Parenteral Injection", we are supplying the attached memo as an updated report for replacement of asbestos filters.

ON T3 vO vOsf <r II I Ftp-r. r v . tv .

DETECTION OF ASBESTIFORM AMPHIBOLE IN TALC FOR COSMETIC USE The method for the detection of asbestiform ' amphibole in talc for cosmetic use consists of initial analysis for amphibole minerals above the 0.5% (w/w) level, followed by characterization of the amphibole m ineral present, if any, as asbestiform or nonasbestiform by dispersion staining/optical m icroscopy.

*-------- -------- ------ 1 FY: 1974 DATE: 9/6/73 "-ogram: COSMETICS PPE USE ONLY 00679 # Subprogram: Aerosols & Hair Preparations rroject litle: Asbestos and Other Contaminants in Talc Project Manager 6 Mailing Symbol : John Stuart (BF-446) Statement of Obi active: Develop one or several methods of sufficient sensitivity and reliability which will permit the determination of asbestos and other contaminants in talc-containing products with the necessary degree of accuracy and at concen trations at which such contaminants present a potential health hazard. -- ------- * The inhalation of certain asbestiform minerals is a known health hazard.

*UlUUUt-t-IU1T T U C + "Sic Mo.

TALC A N D CHLORITE D E P O S IT S IN MONTASIA by Richard B.

ENGINEERING DEPARTMENT - EL PASO, TEXAS SPECIFICATION NO.

PLAINTIFF'S EXHIBIT me- Memorandum Engineering Department Materials Laboratory Richmond, California November 23, 1976 4/e WEATHER JACKET OVER EXISTINC CaSlO/, INSULATION - REFINERY PIPING Materials Laboratory File: M-283.00 MR.

Amoler A/C Pipe Plant industrial Hygiene Survey December 3-12, 1979 TABLE 1 Oust/Fiber Exposures PAGE 23.

17.

VICTOR G&SKffT OfV PROFIT AND LOSS STATEMENT FOR MONTH ENDED31,1970 G&C5S SHIPMENTS Direct Ships. -- OEM Service Direct Skips. -- After-market Direct Ships. -- OEM Production Platka Interplant -- Parts Co.

/ UF.RF.UY cr.nan' THAT 'lhA foregoing is a true rind cm record uns e stabiisl.cd and fUrdin my office j n accordance .

:= \:_.s-=:al fela-cns DIVISION OF OCCUPATIONAL SAFETY AND HEAlTfH CITATION 1 30* CHEMICAL U.S.A.

Respiratory Health in Workers Exposed to Man-made Vitreous Fibers1'1 ,{(t /t*"* FST00Q60H HANS WEILL, JANET M.

PLAINTIFF'S EXHIBIT THE DOW CHEMICAL COMPANY restricted FOR USE OF DOW EMPLOYEES ONLY t-O -=r OMrion cr TEXAS i AllttlOfS V.