Fluoroc Sample CentreAnal icalLaboratoriesI,nc. 3048ResearcDhrive Phone: (814)231-8032 StateCollege,PA 16801 Fax: (814)231-1253or (814)231-1580 An -aI-W-(AL;Mal Report Fluorochemical Characterization of Drinking Water Samples Pensacola,Fl (W2176) Centre AnalyticalLaboratoryReport No. 023-007D TestingLaboratory CentreAnalyticLaalboratoryI,nc. 3048 Research Drive StateCollege,PA 16801 3M Environmental Laboratory Contact Kent R.

CENTRE FOR XENOBIOTIC RESEARCH UniversityofDundee, BiomedicalResearch Centre,Level5,NinewellsHospitaland Medical School,Dundee, DD1 9SY Study Report Determinationof cyanideinsensitivPeaimitoyi-CoA oxidationinsamples from 3M Environmental Laboratory - Covance Studies6329-183 and 6329-212 Study Number XR0108 Author: Approved: t.M.Elcom,be C.R.EL .e- XR0108 PaLyeI of 3 Date: I Introduction The purposeofthisstudywas toinvestigattehelevelsof PCOA oxidationinthefrozen liversamplesprovidedby 3M EnvironmentalLaboratoryfrom Covance studie6s329-183 and 6329-212. 2 TestSubstance 6329-183:PFOS, 20ppm, administeredby Covance untilweek 4. 6329-212:ETFOSE-OK 100 and 300ppm, administerebdy Covance untilweek 4. 3 TestingFacility CentreforXenobioticResearch,UniversityofDundee, BiomedicalResearchCentre, Level5,NinewelisHospitaland MedicalSchool,Dundee,DDI 9SY, UK. 4 Homogenste Preparation 4.1 Reagents SET buffer0:.25M Sucrose,5mM EDTA and 20mM Tris-HCI,pH 7.4 4.2 Instruments Potter-Elvehjehmomogeniser 4.3 Method Frozen liversampleswere thawed on ice,blottedand weighed.A 25% homogenate was preparedinicecoldSET usinga Potter-Elvehjehmomogeniser(6passes). 5 Determinationof Cyanide-in.sensitPiavlemitoyi-CoOxidation The 25% homogenate liversampleswere dilutedI partin 10 partswithicecoldSET.

July30,1998 Faxto:Dr.JackMoore Dr.Joe Rodricks Fax # 202-289-8530 Fax # 703.516.2393 Frorm John L.Butenhoff Fax # 651.733-1773 Tel # 651.733-1962 I have attachedourrationalfeordose settingon thesixmonth chronicoralstudyof PFOS inCynomolgus Monkeys.

CorporateHealthPhvsies Corporate IndustriaHlygiene& Erounumics CorporateoccupationalNledicine Corporate Toxicolo@3NI 'viedical Depar@nment 3M Center,Buildin2g20-2E-02 PO Box 332'-70 St.Pau',"@IN5@1 6 @@1 1 10 Nia,,,I -@

Oral Teratology Study of FM-3422 in Rats Experiment No.: Conducted At: Inclusive Dosing Period: Study Director: 0680TROO10 Safety Evaluation Laboratory Riker Laboratories, Inc.

-@ l@@ 1@4 -I----m cov ArgoooCoomE@m THE DEVELOPMENT SERVICES COMPANY DraftReport 13-Week DietaryToxicityStudy withN-Methyl PerfluorooctanesulfonamiEdtohanol(N-MeFOSE, T-6314) inRats PREPARED FOR: 3M St.Paul,Minnesota COVANCE STUDY NUMBER: 6329-225 COVAW-C'E'."'

ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity:[2-(N-Ethylperfluorooctanesulfonamiedtoh)ylacrylate;may also be referredtoas B1228, D-1, ETFOSEA, or FX-13.(2-Propenoicacid,2[ethyl[heptadecafluorooctyl)sulfonyl]aminoe]settehry,ClAS # 423-82- 5) Remarks:MateriiaslanambersolidS.amplepuritaynd notrecorded3.M lot number 13.

3M Environmental Laboratory ( Final Report- Analytical Study Single-dose DermalAbsorption/Toxicity Study of T-6049 in Rabbits In-Vivo Study Reference Number: HWI#6329-130 Study Number: AMDT-020895.1 Test Substance: FC-95 (T-6049) Name and Address of Sponsor: 3M SCD Division 367 Grove Street St.

M2E5E0-12= MICROBICS MICROTOX TOXICITY TEST TEST SUBSTANCE Identity: PFeCr-f9l5uoorrooacstapnaerstuolfftohneatme;ixmeadypraoldsoucbteFrMe-f3er6r2e0d t(oseaes RPeFmaOrSkso)r.

3M MEDICAL DEPARTMANT CORPORATE TOXICOLOGY To: John Butenhoff Andrew Seacat From: Marvin Case Date: 5 April 2000 Subject: Liver Slide Review conclusons re 1 have completed the PFOS chronic mstyudmyi.crMosycofpiincdirnegvsiaerweofltishteed,lbivyergrsoeucpt,ioonns of the 14-week attached pages.

: AR226-0184 ATTACHMENT TO LETTER TO C.

* Sf { | A International Research and Development Corporation 249% 1 sPoNSOR: conpouND: susJECT: 3M Company R-3022 TNoixnteeclyeyDayStuSduyb.acute Rhesus Monkey hn SVidcweinPrI.esiGdoblndcancahnadl, Ph.D Director df Research Collaborators: i D.DiC.reJcetsosrupo,f PRhe.sDe.a,rchAssociate - } R.anGd.

ADVANCED Mm BIOANALYTICAL SERVICES, INC.

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