Northwest Bioanalytical a Study No.

Toxicological Summary PFOS Dietary Chronic Pilot Reproductive Study: Mallard Test Substance: Perfluorooctanesulfonate (PFOS) Structure: 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoropotassium salt, CAS# 2795-39-3 Test Remarks: The test substance is a white powder (3M Lot #217).

Pe orheLLmee Si 12 ~ id feo Hes i be f ie TwDappTNoOrretpo|rt = nay STUDY OFTHEEFFECT OF PERFLUOROBUTANESULFONATE, 5 PEPRERFFLLUUOORROOHOEXCATNAESNUELSFOUNLAFTOEONNASNAODTME | ASPECTS OFCHOLESTEROLMETABOLISH INVITRO, b() 5 h SEe F Pine s - omy = o 3 EE NO_epor_of sFtudyiSWEOn T alverson TNCreport 16042008 | || | PERFSLTUUODRYOBOUFTTAHNEEESFUFLEFCOTNOAFTE, || PERFLUOROHEXANESULFONATE AND | PERFLUOROOCTANESULFONATE ON SOME ASPECTS OF CHOLESTEROL METABOLISM IN VITRO.

AR226-1991 DON'T SAY IT-WRITE IT r.

AR226-2042 lO:^^ ( WASHINGTON WORKS C-8 INDUSTRIAL HYGIENE A.

AR226-2338 Fluoropolymers Monitoring Technical Group September 18, 2003 Agenda Program Overview - EPA Suggested Priority Change Discussion Landfills Soil Sampling Biota Sampling ssy ^E^y-^sl Possible Sources of Exposure PFO Impuri POSF R Mate Trans formation to PFOA APFO Manufacture w '< Fluoropolymer Summary Processing Fluoropolymer Manufacture Dry Resin Processing Non Fluoropolymer Products Aqueous Resin Processing APFO Manufacture 99% Reduction in emissions as compared to prior manufacture Air dispersion modeling Water monitoring - Prior Manufacturer - New technology baseline Program Plant Design LOI LOI/other LOI Timi In pl Com Ongo Ongo >99% Emissions Reduction APFO Manufacture Air Dispersion Modeling Water Monitoring LOI ECA Fluoropolymer Summary Processing Fluoropolymer Manufacture Non Fluoropolymer Products Dry Resin Processing Aqueous Resin Processing Non-Fluoropolymer Products Program Tim Commitment to not sell APFO outside fluoropolymer industry LOI Ong I 3s O, hrMi -- ID M m H 0 W M I-' 01 >99% Emissions Reduction APFO Manufacture Air Dispersion Modeling Water Monitoring Fluoropolymer Summary Processing Fluoropolymer Manufacture Dry Resin Processing Aqueous Resin Processing LOI ECA Fluoropolymer Manufacture Global Material Balance 50% Emissions Reduction Commitment 2002 Status - 48% reduction from the baseline Monitoring/Modeling Commitments - Air dispersion modeling - Groundwater - Soil - Landfill Program pre-LOl pre-LOl LOI LOI/other Other Other Timi Com 20 12/31 Ongo (Toda (Toda >99% Emissions Reduction APFO Manufacture Air Dispersion Modeling Water Monitoring LOI ECA Fluoropolymer Summary >50% Emissions Reduction Fluoropolymer Manufacture j-^ Dispersiola tVtodeling ^vVater Sampliing/ ^vionitormg ^/-<^n^--S^\ ------------------11 T31,,-N^/.1n^<' Processmg -> Dry Resin Processing Aqueous -> Resin -> Processing ------------------------k- W 0 I.J M H CT 0 w C.I 10 ^ aSu M CO I-' 0 W M It Processing/Articles of Commerce Program Tim Articles of commerce testing - "New" Articles of Commerce - "Aged" Articles of Commerce Dispersion processors material balance Incineration testing LOI ECA LOI ECA 12/3 200 12/3 6/30 >99% Emissions Reduction APFO Manufacture Air Dispersion Modeling Water Monitoring LOI ECA Fluoropolymer Summary >50% Emissions Reduction ^ Fluoropolymer Manufacture ^\ir Disperstoii ^viodeling \ Water Samplung/ 3v\ ionitoring ^C^S ^ ^Ton 1 k Processing ~> Dry Resin Processing Aqueous -+ Resin -^ Processing Articles of Commerce Tes Dispersion Processors Mat Aged Articles of Commer Incineration Testing sl a s s ro o ^ EPA Proposal Delay "Articles of Commerce" testing and goal date and accelerate "Air dispersion modeling" at Fluoropolym manufacturing sites in order to expedite the process to determine if additional monitoring (and ECA) is need these facilities.

AR226-2439 INTEROFFICE MEMORANDUM TO: Roger J.

AR226-2760 FOR OU POUT USE ONLY cc; I.

AR226-2784 FOR DU POUT USE ONLY Copies to Haskell E.

AR226-2799 Study Title Repeated Dose Oral Toxicity: 14-Day Feeding Study vith H-19683 and B-19704 in Hale Rats Author John V.

\ J - Copl;es to AR226-2857 Material Tested ------3 HaskelI HASKELL [ E.

FOR DU FONT USE ONLY AR226-2887 Copies Co E.

B105EARCH INCORPORATED P.O.

FOR DU PONT USE ONLY AR226-2937 Du Pont HLR 784-88 Study Title Eye Irritation Test in Rabbits of Author William J.

AR226-3137 CONFIDENTIAL SPONSOR ElfAtochemS.A.