Document ZZQ3jkNE7Gzd23x12061YnrO

AR226-2042 lO:^^ ( WASHINGTON WORKS C-8 INDUSTRIAL HYGIENE A. J. Piaytis, 6/30/99 PJB003934 EID613626 C-8 IN BLOOD HISTORICAL 1978 Informed by 3H tha-t C-8 is fount) in the blood of exposed workers and persists for a long tiBe. 1979 1880 C-8 found in blood of DuPorrt workers. Workers with blood C-8 found to have normal liver function. (. ?. ''" 19B1 Birth defects scare - additional sampling. - r/' 1982 Blood program continues on voluntary basis - no trends noted. .... . ' a?/i-/-(H to , 1980 Formal re view of blood data. - .-;.--{ ."', .'U 1993 Journal Of Occupational Medicine study of 3M workers, '" '' :.-.: :-' 1993 No connaction found betHeen W cancer cases and C-8 exposure. ,' . 1995 First S-year "snapshot". 1&B6 No excess disease incidence found in 51 MM employees with highest 0-8 blood levels. . '"' ).. 1996-7 Follow-up from 1895 blood study. "yb'> i^'<'f-i Q.'^-f'.k^{''^ f .-: L ... ^Xi--v.^ i ,{ '' (? -^ 4- . .,.,) - ' ^i '- -^ '' p V u..'-'-M.- 6(?tw ..-''.: ^.^ .. ..7-^. 4 ^-.' r^i/ . PJB003935 EID613627 C-8 DOCUMENT LIST Liver function Study Of Washington Morka Employees Exposed To 0-8. W. E. FayerMeather, 1/28/61 Review Of Washington Works 0-6 Data. Blood Data. H. A, Smith, 3/19/90 Per-sonal Air Monitoring Ann Work Histories Of specific Cancer Cases. A. U. Playtis, 11/15/93 Suinnary Of 1995 C-8 Blood Testing. A. <J. Playtis, 5/7/96 C-8 Study. Y. L. PoM@r, 8/5/96 Washington Works Response to Ramirez/Reinhardt O.H. Review. A. J. Playtia, 12/12/96 C-8 Industrial Hygiene Follow-up. A. J. Playtis, 12/18/9S 8uin>ary Of Special C-B Sampling Pro]'ect. J. Niohole, 8/16/97 PJB003936 EID613628 1990 C-8 INDUSTRIAL HY6IEHE DATA REVIEW (HA Smith, JE Loschiavo, RD Lanyon, WE Crawley) CONCLUSIONS (Recognizing the data limitations) There 1s confused Exposure of about a correlation between blood and air by dermal exposure. .c1- at the AEL of 0.56 mpb would result 3 ppm. C-B levels In a blood that Is level Background blood level for the Teflon* area 1s between 0.1 and 0.5 ppm. Dermal exposure Is the cause for higher blood levels. Half life for C-8 in blood is about 4 to 5 years. Annual blood testing is not useful and should be replaced by "snapshots" at longer Intervals. PJB003937 EID61362& 1995 C-8 IN BLOOD "SNAPSHOT1' PURPOSES Monitor the overall effectiveness of our C-8 'industrial hygiene programs. Create and maintain a continuous data base for epidenriologic surveillance of our exposed population. Provide closure for Issues raised by the 1990 data review. Honor employee requests for voluntary testing. TEST POPULATIONS Employees in C-8 jobs (82 of 140) Employees not in C-8 jobs with a previous result >3 ppm (9 of 12) Pensioners with a high previous result (9 of 19) Volunteers (18) PJB003938 EID613630 1&95 C-8 BLOOD STUDY CONCLUSIONS o AVERAGE BLOOD LEVELS FOB DIFFERENT JOBS RANGE FROM 0.5 TO 8.5 PPM 0 MOST JOB AVERAGE BLOOD LEVELS HAVE SOME DOMN FROM 1989 TO 1995, PROBABLY DUE TO REDUCED SKIN CONTACT o NO ONE TESTED HAD A BLOOD LEVEL >5 PPM o TWO PEOPLE IN THE SAME JOB FOR MAW YEARS CAN HAVE VERY DIFFERENT BLOOD LEVELS 0 MECHANICS AVERAGE ABOUT 1 PPM 0 PENSIONER DATA INDICATES A BLOOD HALF-LIFE OP.ROUGHLY 4 YEARS, BUT MITH WIDE INDIVIDUAL VARIATION. 0 THE CORRELATION BETWEEN AIR LEVELS AND BLOOD LEVELS IS MEAK 0 BETTER DATA COULD CHANQE MANY OF THESE CONCLUSIONS PJB00393& EID613631 TABLE 1 RESULTS SUMMARY- OPERATORS JOB 08PE 08PF 08PH 08PI 08PJ 08PM 1BPA 18PB 18PC 18PD 1BPJ 18PK DESCRIPTION autoclave polykettle dispersion FP finishing FP packout C-8 dryer recovery FEP polykettle FEP extruder/oven FEP wet finishing FEP packout PFA/FEP bead FEP safety/disp 1995 AVERAGE (n) 2.5 (6) 2.9 (7) 2.2 (2) 2.2 (5) 0.6 (5) 1.7 (2) 2.3 (4) 1.6 (5) 3.3 (2) O.I [3) 0.7 (2) 2.1 (2) 1989 AVERASE (n) 4.7 (7) 4.0 (4) 3.2 (3) 2.0 (6) 0.5 (3) RESULTS SUMMARY~ MECHANICS 58HC 58MD 58HG 68MA 68HB FP/d1sp/9ran/TA general shift process E&I general shift FEP E&I 1.4 (1) 1.1 (8) 0.8 (7) I.I (5) 0.9 (7) PJB003&40 EID613632 HALF UFE RESULTS FROM PENSIONERS C8 DATE :PPM[ 4/89 5. 7 3/87 1. 2 9/81 6. 5 3/88 2.8 8/84 2. 4 7/84 5.9 3/85 3. 0 9/82 6. 3 3/88 1. 7 KET. DATE 4/91 6/92 4/85 12/92 4/85 12/81 4/85 12/82 12/93 C8 DATE PPM 3/95 4 .3 3/95 1 .1 3/95 1 .1 3/95 2 .2 3/95 . 72 3/95 . 94 3/95 . 14 3/95 . 57 3/95 2 ,4 1/2 LIFE (YEARS) 9.7 22 3.9 6.5 5.7* 4.0* 2.3* 3.5* --- For * results, n= 4 average = 3.9 eigtta ^ 1.4 using log n = -.301 t no tl/2 PJB003941 EID613633 WASHINGTON WORKS AIR SAMPLING RESULTS <10% AEL <501s AEI<100% AEL >100% AEL TOTAL PERSONAL SAMPLES 1994 1995 lgg6 1997 1998 1999* 40 15 4B 60 50 30 14 14 19 31 18 11 3 1 2 10 9 1 S07 030 069 1102 0 77 0 42 ISM 43 AREA SAMPLES 1995 26 1996 29 1987 171 1998 40 199&* 18 "through 6/31 o PERS (DOHMS) system used to determine where personal samples are needed. o S12T used to determine sampling frequencies, usually 90, 160, or 380 days. o Area samples have support role, identifying locations where C-B levels are high. PJB003942 EID613634 m^ PATH FORWARD Finish Data Analysis Employee Communication Site Industrial Hygiene Efforts Toxicology Work (Do we need a BEI?) Continue Annual Voluntary Testing Take Another Snapshot In 2000 PJB003943 BID613635 MASHINOTON HORK8 0-8 INDUSTRIAL HYGIENE LOOKING FORWARD ONGOING SITE PROGRAMS 0 AIB MONITORING o BLOOD MONITORINQ o EPIDEMIOLOGY 0 CONTINUOUS IMPROVEMENT OF CONTROL MEASURES QUESTIONS TO BE ANSWERED o DO HE HAVE SUFFICIENT TOXICOLOQY DATA? o SHOULD HE DO ADDITIONAL WDICAL SURVEILLANCE? o DO ME MEED A BEI? o ARE HE SATISFIED MITH OUR CURRENT AEL? o SHOULD BLOOD TESTING BE MANDATORY? PJB003944 EID613636