Document 6wL06eL69yLz0r1xyjVYNmaG3

FOR DU FONT USE ONLY AR226-2887 Copies Co E. I. du Pone de Nenours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 CD&P Dept. Jackson Laboratory EYE IRRITATION TEST IN BABBITS Procedure; One-tenth milliliter of undiluted test material was placed into the right conjunctlval sac of each of 2 male albino rabbits.** After 20 seconds, 1 treated eye was washed with tap water for 1 minute. The treated eye of the other rabbit was not washed. Observations of the cornea, iris and conjunctiva were made with a hand-slit laap at 1 and 4 hours, and at 1, 2, and 3 days, Fluor-i-strip stain and a biomlcroscope were used at examinations after the day of treatment. Results: Dose Treatment 0.1 ml Not Washed undiluted test material 0.1 ml Washed undiluted test material Ocular Effects Cornea Iris Localized slight cloudiness at 1 hr. None None None Conjunctiva Redness: Mild - 4 hrs. StfelliagsSliebt 1-4 hrs. Discharge:Coptoun - 1 hr, Moderate - 4 hrs (Hemastix* +). Redness; Mild 1 hr.-l day. Swelling:Slight - 1 hr. Discharge:Mild - 1 hr. Company Sanitized. Does not contain TSCA CB1 Summary :BB^BBbused transient slight corneal cloudiness, mild to slight conjunctiv^is^nth copious discharge and no iritis when tested in the eye of a rabbit. This eye returned to normal within 1 day. An eye dosed with the compound and promptly washed had mild to slight conjunctivitis and no corneal or iritic effects. This eye was normal within 2 days' This material is a mild ocular irritant. copiously with water. In the event of contact, flush eyes Approved by: P^.JtJ ^ ^------.J_______ Gerald L. Kenno'Oy Chief, Acute Investigations Section PA:jrg Study Director: 0. L. Dashiell .Date Issued: July 30^J.980 2 - Company Sanitized. Doss no! certain TSCA CE