CorporatHeealthPWsics 3M Center2,20-2E-02 CorporatOeccupationMaeldicine PO Box33220 CorporatPeroductResponsibffity St.PaulM,N 55133-3220 CorporatTeoxicology 6517331110 3M MedicalDepartment MortalitSytudyofEmployeesat3M PlantinDecaturA,labama A retrospectciovheormtortalisttyudyofemployeewsh,o workedatleasotneyear (beginninginMarch, 1961)atthe3M chemicaland filmplantsinDecaturAlabama, was conductedby UniversityofMinnesota epidemiologisttso determinewhetherthe mortalityexperienceoftheseemployeeswas significantdliyfferenftrom thatwhich would be expected.

FinalMult and Pens FINAL MULTI-CITY STUDY FIELD REPORT FOR MOBILE ALABAMA AND -PENSACOLA FLORIDA - BATTELLE DUXBURY ACTIVITEES for ProjectNumber N100672-01 Submitted to C onf*idential September 29, 1999 Prepared by ChristopherGagnon Battelle 397 Washington Street Duxbury, MA 02332 (781)934-0571 TableofContents Page:I TABLE OF CONTENTS page 1. introduction I 1.

THE EFFECT OF PERFLUORINATED ARYLALKYLSULFONAMIDES ON BIOENERGETICS OF RAT LI[VER MITOCHONDRIA KendallB.

BIOCONCENTRATION TEST SUBSTANCE Identity:N-ethylperfluorooctasnuelfonamidoethanolm;ay alsobe referredto as N-ETFOSE Alcoholor FM-3422. (1-OctanesulfonamideN,-ethyl1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-N-(2-hydroxyethyl)-, CAS # 1691-99-2) Remarks: Materialisan off-whitwea,xy solidofuncharacterizepdurity.

-- --.r I I I 1-co i(,-Pi COVAA'Cio,rEm.o"@ THE DEVELOPMENT SERVICES COMPANY Summary Report 104-Week DietaryCarcinogenicitSytudy with Narrow Range (98.1%) N-Ethyl Perfluorooctanesulfonamido Ethanol in Rats PREPARED FOR: 3M COVANCE STUDY NUMBERS: 6329-212 and -228 SUMMARY REPORT -WEEK 53 104-Week DietaryCarcinogenicitSytudywithNarrow Range (98.1%) N-Ethyl PerfluorooctanesulfonamiEdtohanolinRats Ilmelines Covance 6329-212: In-hfestartdate:January26, 1998 Week 53 completed:January31, 1999 Covance 6329-228: In-lifsetartdate:April6, 1998 Week 53 completed:April11,1999 Introduction The purposeof thesestudieswas to assessthecarcinogeniciotfythetestmaterialT,-6316 (Narrow Range N-EthylPerfluooctanesulfonamiEdtohanoLNETFOSE), when administereidnthediettoratsforatleast104 weeks.

N OTOX Sof ty a Environm*ntal Restarch LV.

BIODEGRADATION (301E) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredto as PFOS, FC-95, or as a component ofFC-203.

TOXICITY TO AQUATIC PLANTS TEST SUBSTANCE Identity:A mixturecontainingperfluorooetanesulfonamtaey; alsobe referretdo as PFOS, FC-95,or as a component ofFC-203C and L-5440.(1-Octanesulfoniaccid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecpaoftlausosriou-m, saltC,AS # 2795-39-3) Remarks: The 3M productionlotnumber was notnoted.The test sample isFC-203C and isreferretdo by thetestinglaboratoryas "81-1/8".

MICROBICS MICROTOXS TOXICITY TEST TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredto as PFOS, FC-95, or as a component of FC-603F. (1Octanesulfonicacid)(CAS # 2795-39-3).

BIODEGRADATION (BOD/COD) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh;i,chmay alsobe referredtoas PFOS, FC-95, or as a component ofFX-3106. (1Octanesulfoniaccid)(CAS # 2795-39-3).

c 0 V A-N--C--E@ THE DEVELOPMENT SERVICES COMPANY Covance LaboratoriesInc.

AR226-3573 PERFLUOROOCTANESULFONYL FLUORIDE (POSF; T-7661.4) TOXICITY STUDY BY INHALATION ADMINISTRATION TO CD RATS FOR 13 WEEKS FOLLOWED BY A 4 WEEK RECOVERY PERIOD Volume 1 MIN 313/023622 PERFLUOROOCTANESULFONYL FLUORIDE (POSF; T-7661.4) TOXICITY STUDY BY INHALATION ADMINISTRATION TO CD RATS FOR 13 WEEKS FOLLOWED BY A 4 WEEK RECOVERY PERIOD Volume 1 Sponsor 3M Center, 3M Corporate Toxicology, Building 220-2E-02, St Paul, MN 55133-3220, USA.

3M Katherine E .

T_ c"21o 0 3 oola.

CASE REPORT p. 1 ~70 9 Acute Pulmonary Toxicity Linked to Use of a Leather Protecto r s From the Centre Anti-Poison du trlaFtu tatie.n:,, MD, FRCP(C) Leather protectors are used extensively for waterproofing leather Quekc' S'"&-Foy, Q"&", Ca"d .