ISnudpeexrv2isory Information anual october 26, 1992 To: ALL EMPLOYEES MORTALITY AND CANCER INCIDENCE SURVEILLANCE UPDATES epmrpoldouyceeessIntuaotreWsvapisodhnesioentgattpooenseWmtophrliksosy,Jeeutrhi.entesrioetxseit'csoalEndmopgliyon,yqeueEirpRiieedssempiaoobnlosouintbyl,teheCaanrdheetaeTlteehananofd t"oCacnchearckCoonucterfnrsomatnhdeMTeraiarneingavDaitviiasbiloen.for safety meetings and for individuals dascribinTghethveidTeaottaapsesofrGeafretrhtaondincfaonrmcaetrioinncfirdoenmceaa1m9o8n9g WaesphidienmgiotloongyWroerpkosrt ceommpplaoryeedes.to aTlh)e DruepoPorntt.idncolmuedsetdicdeatmaplotyhereosughin1a98n7.attOeumrptstepolofydeeenstiwfeyreany haaith probleas nesding attention. report IVnecluhdaevse arlelcednetaltyhsrectehirvoeudghan19u9p1daitnetohfe mthoarttal1i98t9y sretpuodryt,.butThecannceewr Ccaosaepsanoynlsyitetsh.rough 1989, due To a delay In the reporting of dita from several of a partIincutlhaersekisntduditehsa,n w1ofulwde bhaeveexpeexcpteerdi,enc1e%d1msorseaiddeWatehshavoeF caannceexrcescsa.sesIf Ceateagroeryf,ortthuennatweeehnaovugehatodefhiacviet.fewKerescpaisnegsitnhmanindextpheactteddefiinciatsceratreaignood and sexicgensisfeiscanatr:s Bad, here are the results that areconsidersdpossibly 1. oIfn 3t7heca1t9e8g9ormioerst,alintaymelsyt:udy,"ovweerahlal,d cdeerfeibcriotvsasfcourlamra,leseumicpildoey,eesandinot4heorut maocrctidaelnittsy.exFceemsaslees fsomrploreeisthemrorgteandleirt.y results were forsal. fare wre no 2. dIenfitchiets199f2n omvoerrtaalllitdyeastthusd,y duepadtahtse,'dumealteoecmaplrosybereosvasstciulllarhdaidsesxisgen,ifaincdant cHsouawitecavigdeoerrs,i.es`w;eThssepheodcweieffdiiccnaieltwlymi,anltethotedaelfsiocctiahtnascreroasfc,cdidereaentsthpssircfaarttooerngyotrchayrnecdeeirsc,aapnpuceneadrreddi.gestive Rwcahonirccteharl.iitnycFleuemdxaeplseerideeenamctpehlsoyoefdeuseourthoawdmoimasemcnoerlwltoarankleeiortusysveacxsacuenssesosr.mianl.Otthheerrweissied,ualthecategory, g RE = 22 ER =2 : i - | Asp010008 Esa ze 3.

ATtotxaiccohlmoegnytsSttuodLieetstearntdoOCt.heArueIrnfdoartmeadtiMoanyon25P,F2O00A0 A Teratology 1) Teratology Studyof T-2998CoC in Rats 2) Oral Rangefinder Studyof T-2998CoC in Pregnant Rats, Riker Laboratories, Inc, Study No. 0680RR0018, February 25, 1981 b) IFnicn.alSRteupdoyrtN,oO.r0a6l8T1eTrRatOoLl1o0g,yDSetucdeymobfeTr-1259,91898C1o,CwiitnhRAatmse,nRdimkeerntLatboorFaitnoarlies, Report, December 22, 1981 and Protocol 2) Teratology Studyof T-3141CoC in Rabbits 2) OIrnacl, RSatnugdeyfNion.de0r6S8t1uRdBy0o3f31T-,3N1o4v1eCmobCerin18P,re1g9n8a1nt Rabbits, Riker Laboratories, b) Final Report, Laboratories, Oral Inc., TSetruadtyoNloog.y0S6t8u1dTyBo0f3T98-,31F4e1bCruoaCryin2R3a,bb1i9t8s2, Riker ) 3WiMntIenrtetomaDlRCoRrircekserp,onddaetnecdeFreebraunaalryyti5c,al19a8n2alyses of T-3141CoC, from LD 3) Letter re `Franklin fDu.rtGhreifrftietsht,idnagtferdoNmoEv. eMmabresrha1l9l, Johnson, 1982 Jefferson Medical College to Dr. 4) M3aMyM2e6,mo199re8,FeCn9c5laonsdian1n4g3aTnearlaytsoisloofgty,hefreoymeMlaenrsvdCeafescetto Georjean Adams, dated . 7 02025 oral rangefinder Study of T-2996CoC in Pregnant Rats Experiment No.: Conducted at: Dosing Period: Study Director: ossorso018 RSitk.ePrauLla,borMaitnonreiseost,a Inc.

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ARR_2 066 64 FOSA or PFOSA Ongoing - | wl 3M MEDICAL DEPARTMENT, CORPORATE TOXICOLOGY Protocol for Study No.

Lo AR226 _ 0775 ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-203S. (1Octanesulfonic acid) (CAS # 2795-39-3).

AR 226 - 0869 ACUTE TOXICITY TO FISH (MUMMICHOG) TEST SUBSTANCE Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a componentof FC-780. (1Octanesulfonic acid) (CAS # 2795-393).

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BACK TO MAIN SOIL ADSORPTION (METHOD DEVELOPMENT / PILOT STUDIES) TEST SUBSTANCE Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: Sample was radiolabeled (isotope and labeling position not specified).

BACK TO MAIN WATER SOLUBILITY IN NATURAL SEAWATER AND 3.5% SODIUM CHLORIDE SOLUTION - SHAKE FLASK METHOD TEST SUBSTANCE Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: The test substance is a white powder.

BACK TO MAIN TOXICITY TO AQUATIC INVERTABRATES (Daphnia magna) TEST SUBSTANCE Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: The test substance is a white powder of uncharacterized purity.

BACK TO MAIN ACCUMULATION OF PERFLUOROOCTANESULFONATE AND RELATED FLUOROCHEMICALS IN MINK AND RIVER OTTERS John P.

BACK TO MAIN DESIGN AND STRUCTURE OF MULTI-CITY STUDY submitted to 3M Environmental Laboratory 935 Bush Avenue St.

Sponsor: 3M St.