AR226-3360 ATMOSPHERIC LIFETIMES AND DEGRAD MECHANISMS OF FLUOROTELOMER ALCOHOLS C^F^C^CR^Ofi Valerie Bossoutrot*, Tanya Kelly^ Isabelle Magneron*, Wahid Howard Sidebottom#, Klaus Wirtz and Georges Le Br * Laboratoire de Combustion et Systemes Reactifs, CNRS Orle # Chemistry Department, University College, Dublin (IRL Centro de Estudios Ambientales del Mediterraneo, Valencia SETAC Prague 18-22 April 2004 .ontext: 1 A .i -^Sis^ Long chain perfluorinated carboxylic acids (PFCAs, Cj^C(0)OH observed in fish and mammals PFCAs : not generally used directly in consumer or industrial materials - presumably degradation products of precursor chemicals : potentially FTOHs Fluorotelomer alcohols (FTOHs, C^F^CH^CH^OH): -Uses: intermediates in manufacture of diverse products - Production: 5x106 kg yr1 (80% polymeric applications) (20% non polymeric ) - Observed in the atmosphere (up to 135 pg m"3) - Atmospheric sources : degradation o^ polymer and non polymeric that incorporate FTOHs (?)

CorporatHeealthPWsics 3M Center2,20-2E-02 CorporatOeccupationMaeldicine PO Box33220 CorporatPeroductResponsibffity St.PaulM,N 55133-3220 CorporatTeoxicology 6517331110 3M MedicalDepartment MortalitSytudyofEmployeesat3M PlantinDecaturA,labama A retrospectciovheormtortalisttyudyofemployeewsh,o workedatleasotneyear (beginninginMarch, 1961)atthe3M chemicaland filmplantsinDecaturAlabama, was conductedby UniversityofMinnesota epidemiologisttso determinewhetherthe mortalityexperienceoftheseemployeeswas significantdliyfferenftrom thatwhich would be expected.

Toxicit 3820( TOXICITY TO AQUATIC PLANTS (E.G.

Study Plan aerobicac soil/sedim fluorochert m --. -- StudyDesigns- 3M MicrobiaMletabolismProgram Goal:To optimizeconditiontshatpermitenrichmentofmicrobial populationcsapableofmetabolizinfgluorochemicals.

Protocol.PFOS: A 96 Marine Diatom (Skele -0--- PROTOCOL PFOS: A 96-HOURT03aCITY TEST WITH THE MARINE DIATOM (S7celetonecmoastatum) US.

F-xperiment No.: Conducted At: Dates Conducted: Conducted By: Reviewed By: Acute Oral Toxicity Screen with T-3421 in Albino Rats 0883A.RO287 Safety Evaluation Laboratory Riker Laboratories, Inc.

3M ModbW Departfnent L%cNdno Huft Physics IndustW Hygiene ToxkmiM 3M CerterBldg.220-2E-02 SL PaulM,N 55144-1000 612f7331110 Analyticaanld ResearcPhroperti-e3sM IndustriHsydgienelabomtory January1993 Scope Thisisa methodforthedeterminatoifoNn-EthyPlerfluorooctanesulfonamide in air.

I MICROBIAL INHIBITION (DEHYDROGENASE ACTIVITY TEST) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonawthei,ch may alsobe referretdoas PFOS, FC-95,oras a component ofFC-203.

BIODEGRADATION (BOD/COD) TEST SUBSTANCE Identity:Mixturecontainingperfluorooctanesulfonawtheich may alsobe referredtoas PFOS, FC-95, or as a component of FC-3003. (1Octanesulfoniaccid)(CAS # 2795-39-3).

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Lo eff ~~ 8 | ~ AR2R-6 3433 37 000370 did il | ' r---- ---- --.Ak% 2% d croc procsanes m sioon swerss = - ma A-- Polymerization -- ---- So ---y .

--_-- AR 226 _ 3566 IMENVIRONMREENRTOARLTLNAG.BOER9A8T5O6R6Y% Amended Final Report Analysisof PFBS, PFHS, PFOS and PFOA in Water Samples Collected at 3M Guin Laboratory Request Number: E05-0662 Method Requirement: 3M Method ETS-8-154.1 (modified) Testing Laboratory 3M EHS Operations. 3M Environmental Laboratory Building 2-36-09 935 Bush Avenue St Paul, MN 55108 Requester Gary Hohenstein 3M Building 42-02-E-27 PO Box 3331 `Saint Paul, MN 55133-3331 Phone: (651) 778-5150 Fax (651) 778-7203 `SMCONFIDENTIAL 2 Pago 101 13 34 ENVIRONMHEENRTARLLHAOB.OREAosTOouRsY SaHw EETniemiocnimLeenmaaaoaabnReerinspttoAaynanlge,rValk. rRes.genP,H0. , EoRnCoraayrCCaotosanr, nspepc ea Prsoofessorc LoSbaOvposn Parse!

ARAa 6 p 136a 8 Federal Register/ Vol . 71, No . 19/Monday, January 30, 2006/Notices 4913 SUMMARY : The EPA Science Advisory several Federal Register notices 69 FR ENVIRONMENTAL PROTECTIO N Board (SAB) Staff Office announces a 16249-16250 (March 29 2004) ; 70 FR AGENCY public teleconference meeting of the 2157-2158 (January 12, 2005) ; 70 FR chartered SAB to discuss a draft SAB 32771-32772 (June 6, 2005) .

Name: Chine Sakr, MD MPH ' Robin Leonard, PhD 2 Mark Cullen, MD 1 Program Affiliation: Address: Phone: Fax: Email: `-Yale Occupational and Environmental Medicine Program 2Epidemiology Program at DuPont Haskell Laboratory for Health and Environmental Sciences 135 College Street, 3rd floor New Haven, CT 06510 856-816-1539 203-785-7391 carine.sakr@ yale.edu TITLE Twenty-five year longitudinal study of serum total cholesterol related to a serum biomarker of exposure (serum perfluorooctanoate or PFOA) in a polymer production plant.