AR AR6- 3233 405 _-- - TRADE SECRET Study Title H9-02-47D6a8y:GaSvuabgcehrSotnuidcyTionxRiactisty with One-Generation Reproduction Evaluations Volume 5 of 5 Laboratory Project ID: DuPont-5990 HRaze - 2225 oDwupoe5s590 TEST GUIDELINES: OU.PS.PTESP8A70He.a3l1t0h0E(f1f9e9c8t)s Test Guidelines AUTHOR: Susan A.

, p ~2 ~a6_ 33 9~6 gE,y~ _ r 204 - ~ sg g ~ 2550 PATTON B000S N LIP AIIORNEYS Al lAW M Street, N W ~z oz S1760o0DC20037-1350 DEC 0 O {('~ P~ ~' : 3 Facsimile202-457-6315 U www.pattonboggs .com December 10, 2004 I'cter D.

FinalReport Unscheduled DNA SynthesisinRat LiverPrimary CellCultures With PFOS PREPARED FOR: 3M CorporateToxicology COVANCE STUDY NUMBER: 20784-0-447 C 0 V A- -C'-E-.'@-' THEDENU UNSCHEDULED FINAL REPORT DNA SYNTHESIS IN RAT LIVER PRDAARY CELL CULTURES WITH PFOS AUTHOR Maria A.

IVI/,-\ y u MEDICAL LABORATORIES ENT NAME N,iosw EFERRING PHYSICIAN TWMD COLLECTION RECEIVED ()2/02/99 DATE TIME DATE 10:21114 TIME -FATIENT NUMBER 200 FirstStreetSouthwest Rochester,Minnesota 65905 AGE PURCHASE NUMBER REPORT PRINTED 02/27/99 DATE 002 8:32* TIME SPECIMEN INFORMATION BOD-533-171 0 SEX LAS.

InternCaolrrespondence dc: M.

Pathology Associates International A Company of ScienceApplicationsInternationaClorporation AnErobrmk)wmdCoMmy Sponsor: 3M St.Paul,Minnesota PROTOCOL Study Title: CellProliferatiSotnudy withN-EthylPerfluorooctanesulfonamEitdhoanol(N-EtFOSE; 3M T-6316.11), PerfluorooctanSeulfonicAcid PotassiumSalt(PFOS; 3M T-6295.16)a,nd N-EthylPerfluoroctanesulfonamid (PFOSA 3M T-7091.1)inRats Date: January12, 1999 Performing Laboratory R.O.W.

/0 Submitted to: BIOSE^RCH, INC.

AOVANCEO BIOANALYTICAL SERVICES, INC

3M EnvironmentalLaboratory FinalReport-AnalyticaSltudy Single-DosIentravenouPsharmacokinetiSctudyofT-6067inRabbits In-VivoStudyReferencNeumber: HWI#6329-151 StudyNumber: AMDT-120694.1 TestSubstanceL:-13492(T-6067) Name and AddressofSponsor: 3M SCD Division 367 Grove Street St.Paul,NfN 55106 Name and Address of TestingFacility: 3M EnvirorunentaTlechnology & Services 935 Bush Avenue St.Paul,MN 55106 Method Numbers AMDT-M-1-0, AMDT-M-2-0, AMDT-M-4-0, AMDT-M-5-0, AMDT-M-8-0, AMDT-M-14-0, and Revisions: Thermal Extractionof Fluorideby Means of a Modified Dohnnann DX2000 OrganicHalideAnalyzer-Liver FluorideMeasurement by.Means of an Orion EA940 Expandable Ion Analyzer Extractionof Fluorochemicalsfrom RabbitLiver Analysisof RabbitLiverExtractforFluorochemicalsUsing ElectrosprayMass Spectrometry Analysisof FluorideUsing theSkalarSegmented Flow Analyzer with Ion SelectiveElectrode Thermal Extractionof Fluorideby Means of a Modified Dohnnann DX2000 OrganicHalideAnalyzer-Serum InitiatioDnate: See attachedprotocol Author:James D.

-2- Absorption of FC-143-14 C In Rats After a Single Or&) 0060 December 28* 1979 WC#\ JAN I Pi1'980 Conducted at: During: Conducted by; Report by: Reviewed by: Riker Laboratorl*s,Inc.

TOXICITY TO AQUATIC PLANTS TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95 or as a component of FC-201AF. (1Octanesulfonicacid)(GAS # 2795-39-3).

ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUB TANCE Identity:A mixturecontainingperfluorooctanesulfonawthei,ch may also be referredtoas PFOS, FC-95, or as a component of FC-600. (1-Octanesulfoniaccid,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadegafluoro-p,otassium saltC,AS # 2795-39-3) Remarks: The 3M productionlotnumber was notnoted.

CentreAnalyticaLlaboratoriesI,nc. 3048ResearchDrive Phone: (814)231-8032 StateCollege,PA 16801 Fax:(814)231-1253 or (814)231-1580 Ana calReport Fluorochemical Characterization of Surface Water Samples Pensacola, Fi (W2176) Centre AnalyticalLaboratory Report No. 023-014C Testing Laboratory Centre AnalyticaLlaboratory,Inc. 3048 Research Drive State College,PA 16801 3M Environmental Laboratory Contact Kent R.

AR226-3633 3NORTH E NUT ESTRO TiE r E pHs ne i in ne aT i pe ot RSatL a f 0 IR ye fg jit] ll2l a, Si Seer = | ed : ee gp Ail] | | ;{ 2 Disposal Faclity Lo 1 a Ceram gp | i Ger g BowEerY OER ELSl)Eat cSkE El ey " oo iha Sebes ed4 cE, => opt EN la, SNEEg SE Na ey TEr BA NERbot 2f a2 Pe lThrad EBolEaFRcESs & ron eTA E0p" le LEGEND pO hes Es Hi BD totvomum | pWat Ei Rulieg UaR r; LDaRee sidBausa euwemll EF MNIES XAM evTd Sr "FB @ OpD saorewersnmveswnoae "Aerial Viewoftheformer3MOakdaledisposalarea showing the losationsof the newl|y he ---- Figur2e 000004

or AARR22262_6- -33636]41 suewROwaET:eAsORATORY Final Report Analysis of PFOA, PFOS, PFHS, and PFBS From Newly Constructed Wells at the Oakdale, Minnesota Disposal Site Laboratory Request Number: E06-0151 Method Requirement: 3M Method ETS-8-154.1 (modified) Testing Laboratory 3M EHS Operations 3M Environmental Laboratory Building 2-3E-09 935 Bush Avenue St.