Document 3QvNmvbwx3xemjyv9MKVE0qnD
/0 Submitted to:
BIOSE^RCH, INC.
p.o.box 8598 philadelphiap,ennsylvania19101 t e Ie p h o n e : (2 1 5 ) 848-4499
Project Number -78-1161A
3M Company 3M Center St. Paul, Minnesota
55101
Material: Sample ReceivedDate of Report:. Test: Object of Test: Method of Test:
Results:
3M Company - T-2038CoC
1/5/78 Study Initiated:1/9/78Study Completed:1/16/78
2/2/78
Primary Eye IrritationStudy - Rabbits
To determinethe degreeof irritation,if any, which the subject material may produce when instilledintothe eyes of albinorabbits.
The methods employed in the testing, evaluation and in the gradingof the test materialare those described in Section 1500.42 - Hazardous Substances and Articles, Administrationand EnforcementRegulations, FederalRegister,Val. 38. No. 187, P. 27019, 27 September 1973.
The sample was used as supplied.
Six healthy young adult albino rabbitswere used in this study. 0.1 gm of the experimentalmaterial was instilledinto the righteyesof the test animals while the other eyes remained untreated to serve as controls. The test materialwas not washed from the eyes. The treated eyes were examined at 1, 24, 48 72 hrs. 5 & 7 days followinginstillatioonf the test material into the eyes. Interpretatioonf the resultswas made in accordance with the grading system outlined in the "IllustratedGuide for GradingEye Irritation By Hazardous Substances".
See Table 1.
3M Company - T-2038CoC, Primary Eye Irritation Study.
Conclusion:
Based on the accompanying table, the subject
material is not a primary ocular irritant within the definitionof the Act-Reference: Section 1500.42 (b) (1) (2) P. 27019 and requiresno cautionary labelingwith respect to that section.
Karl L. Gabriel, V.M.D., Ph.D. Director
TABLE I Grades for Ocular Lesions
Material: 3M Company - T-2038CoC, as supplied.
Rabbit No.
Cornea Opacity Area
1 2
1 hour
3
4
5 6
1
2
24 hours
3
4
5 6
1
2
48 hours
3
4
5 6
1
2
72 hours
3
4
5 6
1 2
5 days
3
4
5 6
1 2
7 days
3
4
5 6
1
4
1
4
0
0
1
4
0
0
1
4
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
Iris
Conjunctivae
Redness Chemosis
0
1
1
1
1
1
0
1
1
0
1
1
0
1
1
0
1
1
0
1
1
0
1
1
0
1
1
0
1
1
0
0
0
0.
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
Discharge
1 1 1 1
1 1 1
1
0 0 0 0 0 0
0 0 0 0 0 0
0 0 0 0 0 0
0 0 0 0 0 0