Document 3JvM8z8qozY7E1GVe0rJ8RzO0

AR AR6- 3233 405 _-- - TRADE SECRET Study Title H9-02-47D6a8y:GaSvuabgcehrSotnuidcyTionxRiactisty with One-Generation Reproduction Evaluations Volume 5 of 5 Laboratory Project ID: DuPont-5990 HRaze - 2225 oDwupoe5s590 TEST GUIDELINES: OU.PS.PTESP8A70He.a3l1t0h0E(f1f9e9c8t)s Test Guidelines AUTHOR: Susan A. MacKenzie, V.M.D., Ph.D., DAB.T. = STUDY COMPLETED ON: January 18, 2002 PERFORMING LABORATORY: EH.LaskedlulPLoanbtodraetNoerymofourrHseaanltdhCaonmdpEannvyironmental Sciences NEelkwtaornk,RoDaedl,awP.a0r.e B1o9x71540-0050 --_-- REI Company Saniized. Does not contain TSCA CBI H24768: Subchronic Toxicity 90-Day Gavage Study in Rats with OneGeneration Reproductive Evaluations DuPont5990 APPENDIX MM INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fy ADULTS -- TTioe- - Company Sanitized. 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Does not contain TSCA C81 9H0--2D47a6y8G:avSaugbeehSrtoundiyc iTnoxRiactistywithOneGeneration Reproducive Evalustions DuPon-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS EXPLANATORY NOTES abbreviations SD = Sacrificed by design LESION GRADING: Hchiasrtaocptaetrh,olodgiisctarlibucthiaonngesanadresevdeersictryi.bedThaeccodridsitnrgibuttoiotnhei(rexmtoernpthoolfogtiicssue miunlvtoilfvoecmaeln,t) diisf.fuisned,icautneidl,atewrhaelr,e abiplpartoeprraila,te,etcb.y moAdisfeiveerrsitysucshcoraes, foicfal, appropriate, is also assigned as follows: MINIMAL: mrp: MODERATE: SEVERE: Tchoensaimdoeurnetd otfo bcehawngiethipnrensoernmtalbarleilmiytse.xceeds that which is sIenvegreinteyr.al, Thtehelelseisoinonpriosbaebalsyildyoeisdennottifiperdodubcuet aofnylifumnictteidonal impairment. Tihnecrelaesseidonseivserpirtoym.inenLtimbiutted thteirsesueisorsiogrngiafnicadnytsfpuontcetnitoinalis for possible. Tohregrdeeagtreeenoofughchainngeintiesnseiittyherorasextceonmtplettoeeaxspecctonssiigdneirfeidcapnotssible tissue or organ dysfunction comeen: Garacdoenstinmuinuinmawliththmrionuigmhalsevleerseionrseprbeesienngt tpheroglreeasstsivseeveirnevoalnvdemseenvte/rseevelreistiyonsalong cbheairnagcttehreismotsitcsseovferlee.sionWsh,ilethetyhealgsroadeisndirceafteer ttoheithreremloartpihvoelogbiicoallogical significance. Glreotstsersobs(eir.vc.a,tioA,nsb,lics.tind,g meutel.t)iple masses for a tissue are distinguished with his: CompanySanitized.Doesnot containTSCAC81 H0--2D4a76y8:GaSvuabgcehrSotruidcyTionxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - B ADULTS MALE RATS Grove: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646328 DAYS ON TEST: 105 MODE OF DEATH: SD GMIRCORSOSSCOOBPSEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEPHIEDIFDOVLWLIODWEISN,G TPRIOSSSTUAETSE,WERSEEMUINNARLEMVAERSKIACBLLEES,NICROSCOPICALLY: COAGULATING GLANDS, TESTES TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, SEXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC --_ SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN Tee Company Sanitized. Does not contain TSCA C81 H24768: Subchroric Toxicity 90-DayGavageStudyinRatswithOneGeneration ReproductiveEvaluations DuPon-5990 P= INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- P; ADULTS MALE RATS Grove: 1-0 DOSE: 0 mg/kg/day ANIMAL : 646352 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) `SEMINAL VESICLES - SWALL, RIGHT MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSTS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE -= `Company Sanitized. Does not contain TSCA C8l H9-02D47a6y8:GavSaugbeehSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: 1-0 DOSE: 0 mg/kg/day ANIMAL B: 646357 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGAFNOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTNIIONONANETSIOONF;TOHREGAFNOLNLOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC - a Company Sanitzed.DoesnotconTtSaCAiCani 'H9-02-4D7a6y8:GaSvubaegherSotnuidcy TinoxRiactistywith OneGeneration Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: 1-0 DOSE: 0 mg/kg/day ANIMAL 8: 646358 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. -= Company Sanitized. Doesnotcontain TSCA CBI 9H.02-4D76a8y;:GavSaugbeehrSotnuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: 1-0 DOSE: 0 mg/kg/day ANDOAL b: 646383 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVCATOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;THOERGAFNOLNLOOTWINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE me Company Sanitized. Doesnot conTtSaCAiCBnI H-24768: Subchronic Toxicity '90-Day Gavage Study in Rats withOne-GenerationReproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS MALE RATS GROUP: 1-0 DOSE: 0 ma/ka/day ANIMAL 8: 646392 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL.ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE | MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA.UTOLYZED; WICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTNIIONONANETSIOONF;TOHREGAFONLNLOOWTINCGOUTNTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -ws Company Sanitized. Doesnot containTSCA Cal H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPon-5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- P; ADULTS MALE RATS GROVER: 1-0 DOSE: 0 mg/kg/day ANDHAL 8: 646395 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDESNECVEERTEABLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE --- Ts CompanySanitized. DoesnotcontTSaCAiCanl 9H0--24D7a6y8G:avSaubgcehSrtoundiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 pe INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Group: 1-0 DOSE: 0 mg/ka/day ANIMAL 0: 646402 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE ESXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE: HE Company Sanitized. Does not contain TSCA CBI H9-02-4D7a6y8:GavSaugbeehSrtonuidcy iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS Grove: 1-0 DOSE: 0 mo/ka/day ANIMAL : 646408 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE SEXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC `NONE -_-- =m Company Sanitized.Doesnotcontain TSCA CBI H9-02-4D7a6y8G:avSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont. 5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: 1-0 DOSE: 0 mg/kg/day ANDOL 8: 646409 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF: TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE. Ee CompanySanilized.Doesnot conTtSaCAiC8n1 H9-02-4D7a6y8G:avSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont5990 --- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS MALE RATS Grove: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 64642 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MIC`REOPSICDOIPDIYCMIDOEBSSERVATIONS: - ONE OF A PAIR PRESENT Testes ~ ONE OF A PAIR PRESENT | TPHROESTFAOTLEL,OWISNEGMITNIASLSVUEESSICWLEERSE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGAFNONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF:THNEOFNOELLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC _ ESXEACMTIINOANTSIOONF;TOHREGAFONLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - ws `Company Sanitized. Doesnot contain TSCA CBI 9H02-4D7a6y8G:aSvuabgcehSrtoundiyciTnoxRiactistwyithOneGeneration ReproductiveEvaluations DuPon-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS Grove: 1-0 DOSE: 0 mg/kg/day ANIMAL 8: 646425 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF:THNEONFOELLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. CAUSE OF DEATH/NORTBUND CONDITION: SACRIFICED BY DESIGN - --m-____________________ Company Sanitized. Doesnotcontain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/ka/day ANIMAL #: 646440 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGAFNONLOLOTWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `Nowe: SEXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE: Tis -- Company Sanitized. Donotecontsain TSCA CBI 'H9-02-4D7a6y8G:avSaubgeehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 ~~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS MALE RATS Grove: 1-0 DOSE: 0 mg/kg/day ANIMAL 8: 646445 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOYLMLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNARLEMVAERSKIACBLLEES,MICROSCOPICALLY:e COAGULATING GLANDS, TESTES MTHIECROFSOCLOLPOIWCINEGXATMIISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC --_ SEXEACMTIINOANTSIOONF: THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. "im: Company Sanitized.Does notcontTSaCAiCnBI H-24768: SubchronicToxicity 90-Day Gavage Study in Rats withOneGeneration Reproductive Evaluations DuPon-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: 1-0 DOSE: 0 mg/kg/day ANIMAL : 646461 DAYS ON TEST: 105 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFONLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE: - ws `Company Sanitized. Does not contain TSCA CBI F-24768: Subchronic Toxicity 0-Day Gavage Study in Rats withOneGeneration Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646470 DAYS ON TEST: 105 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. Tis Company Sanitized.DoesnotcontTSaCAiCBnI H-24768: Subchronic Toxicity 0-Day Gavage Study in Rats withOne.Generation Reproductive Evaluations DuPont. 5990 -- INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS WALE RATS GROVE: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646473 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE: mse CompanySanitized. Doesnotcontain TSCACBI F9-02-4D7a6y8:GaSvuabgcehvSotruidcyTionxRiactistywith OneGeneration Reproductive Evaluations DuPont5990 _ INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS MALE RATS Group: I-0 DOSE: 0 mg/kg/day ANIMAL #: 646479 DAYS ON TEST: 105 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `Nowe SEEXACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE: EE Company Sanitized. Does not contain TSCA C81 F9-02-4D7a6y8G:aSvuabgcehrSotnuidcy TionxRiactistywith One-Generation Reproductive Evaluations DuPont 5990 = INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/ka/day ANIMAL 4: 646480 DAYS ON TEST: 105 MODE OF DEATH: SD GMIRCORSOSSCOOBSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDESNCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. - we Company Sanitized. DossnotcontainTSCA CBI H9-02-4D7a6y8:GaSvuabgcehrSotnudiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont.5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Group: 1-0 DOSE: 0 ma/ka/day ANIMAL #: 646490 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIERCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFONLOLTOWCIONUGNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. Tie CompanySanitized.DoesnotconTtSaCAiC8n1 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproductive Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GROUP: 111-0 DOSE: 25 mg/kg/day ANIMAL 0: 646326 DAYS ON TEST: 105 MODE OF DEATH: SD GMIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOYLMLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNARLEMVAERSKIACBLLEES,MICROSCOPICALLY: COAGULATING GLANDS, `TESTES MTIHCEROFSOCLOLPOIWCINEGXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGAFNOLNLOOTWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC - ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN Tim: Company Sanitized.Doesnot conTtSaCAiCBnI H902-4D7a6y8:GaSvuabgeehrSotnuidcy TinoxRiacistywithOneGeneration Reproductive Evaluations DuPont-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: TII-0 DOSE: 25 mg/kg/day ANIMAL 8: 646333 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNBSL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOYLMLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNARLEMVAERSKIACBLLEES,MICROSCOPICALLY: COAGULATING GLANDS, `TESTES MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGAFNONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF:THNEONFOELLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC - ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. CAUSE OF DEATH/NORTBUND CONDITION: SACRIFICED BY DESIGN me `Company Sanitized. DoesnotcontainTSCA CBI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont 5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS MALE RATS Grove: IT1-0 DOSE: 25 mg/kg/day ANIMAL #: 646334 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGAFNOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE Ta Company Sanitized. Does notcontainTSCA CBI H9-02-4D7a6y8:GaSvuabgcehvSotnuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS MALE RATS GROUP: TII-0 DOSE: 25 mg/kg/day ANIMAL #: 646340 DAYS ON TEST: 104 MODE OF DEATH: SD MGRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THNEONFEOLLONING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLLNOOWTINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE 7 CompanySanitized. Does not conTtSaCAiCnBI H9-02-4D7a6y8G:avSaugbcehSrtoundiyc TinoxRiactistywith OneGeneration Reproductive Evaluations DuPont5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS MALE RATS GROVE: 111-0 DOSE: 25 mg/ka/day ANIMAL 646342 DAYS ON TEST: 105 MODE OF DEATH: SD GMIRCORSOSSCOOBSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEPHIEDIFDOVLNLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNARLEMAVRESKIACBLLEES,MICROSCOPICALLY: COAGULATING GLANDS, `TESTES MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSTS DID NOT PRECLUDE TOHREGAFNONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC -~ SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN -es Company Sanitized. Does not contain TSCA CBI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with OneGeneration Reproductive Evaluations DuPont5990 -~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GROVR: TII-0 DOSE: 25 mg/kg/day ANIMAL 4: 646350 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNBSL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE . ETPHIEDIFDOYLMLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNARLEMVAERSKIACBLLEES,MICROSCOPICALLY: COAGULATING GLANDS, TESTES MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `Nowe ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC - SEXEACMTIINOANTSIOONF; THOERGFAONLLNOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. CAUSE OF DEATH/MORTBUND CONDITION: SACRIFICED BY DESIGN - wea `CompanySanitized.Doesnot conTtSaCAiCBnI H-24768: Subehronic Toxicity 0-Day Gavage Study in Rats with One-Generaion Reproductive Evaluations DuPont:5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: III-0 DOSE: 25 mg/kg/day ANIMAL : 646354 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE ESXEACMTIINOANTSIOONF:THNEONFOELLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGFAONLLNOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE - es `Company Sanitized.Doosnotcontain TSCA CBI H-24768: SubchronicToxicity 90-Day Gavage Study in Rats withOGneeneration Reproductive Evaluations DuPon-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: TII-0 DOSE: 25 mg/kg/day ANIMAL #646363 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE ETPHIEDIFDOVLMLIODWEISN,G PTRIOSSSTUAETSE,WERSEEMUINNARLEWVAERSKIACBLLEES,NICROSCOPICALLY: COAGULATING GLANDS, TESTES MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC - SEXEACMTIINOANTSIOONF;THOREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. CAUSE OF DEATH/MORTBUND CONDITION: SACRIFICED BY DESIGN - Company Sanitized. Does not contain TSCA CBI 'H9-02-4D7a6y8:GavSaubgeehSrotnuidcy TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont:5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS Group: II1-0 DOSE: 25 mg/kg/day ANDOL #646377 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE , MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF:TOHREGAFNOLNLOOWTICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE. ee Company Sanitzed.DoesnotconTtSaCAiCBnI H-24768: Subchronic Toxicity 90-Day Gavage Study in Ras with OneGeneration Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS WALE RATS GROUP: TTI-0 DOSE: 25 mg/kg/day ANIMAL : 646378 DAYS ON TEST: 103 NODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINEGXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE . SEEXCATMIIONANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE Tas Company Sanitized.DoesnotcontTSaCAiC8n1 H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: ITI-0 DOSE: 25 ma/kg/day ANIMAL 0: 646381 DAYS ON TEST: 105 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE . THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE . MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDESNECVEERTEALBYLESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;THOERGAFNOLNLOOTWICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE. Tie Company Sanitized. Doesnotcontain TSCA CBI F9-02-4D7a6y8G:aSvuabgcehSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - , ADULTS ALE RATS GROVE: TII-0 DOSE: 25 mg/kg/day ANIMAL #: 646404 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSQOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. 1250Company Sanitized. Does notcontainTSCA CBI H9-02-4D7a6y8:GaSvuabgcehrSotnuidcyTionxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS MALE RATS Grove: TTI-0 DOSE: 25 mg/kg/day ANDOAL #: 646410 DAYS ON TEST: 108 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MIC`REOPSICDIODPYIMCIDOEBSSERVATIONS: TeSTES ~- OONNEE OOFF AA PPAAIIRR PPRREESSEENNTT TPHROESTFAOTLEL,OWISNEGMINTAILSSVUEESSICWLEERSE UNREMARKABLE NICROSCOPICALLY: COAGULATING GLANDS, MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, SEXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC --_ SEXEACMTIINOANTSIOONF;THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN me Company Sanitized. Does not contain TSCA C81 H-24768: Subchroric Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Exalustions DuPont5990 _ INDIVIDUAL ANTMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS MALE RATS GROUP: III-0 DOSE: 25 mg/kg/day ANIMAL #: 646415 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIERCVACTOIRORNESLATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEEXCATMIINOANTSIOONF; TOHREGAFNOLNLOOWTICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE Tem CompanySanitized.DoesnotcontTSaCAiCBnI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont 5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: TII-0 DOSE: 25 mg/kg/day ANIMAL #: 646450 DAYS ON TEST: 105 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. "1s -- Company Sanitized.DoesnotcontainTSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study inRaswithOneGenerationReproductiveEvaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS MALE RATS Group: TII-0 DOSE: 25 mg/kg/day ANIMAL #646467 DAYS ON TEST: 105 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE . THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE . TMHIECROFSOCLOLPOWIICNGEXTAIMSISNUATEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE ESXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;THOERGAFNOLNLOOTWICNOGUNTITSESDUEISN WIENRCIEDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE --_-- me Company Sanitized.Doesnot conTtSaCAiC8n1 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 --- INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS- P, ADULTS MALE RATS Group: 111-0 DOSE: 25 mg/kg/day ANIMAL : 646478 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPJCALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;THOERGAFNOLNLOOTWICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. - ws CompanySanitized. DossnotconTtSaCAiCBnI H0--2D47a6y8:GavSaugbeehSrtoundiyc iTnoxRiactistywith One Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS Grove: TII-0 Dose: 25 ma/ka/day ANDMAL : 646483 DAYS ON TEST: 103 MODE OF DEATH: SD GMIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREWARKABLE WICROSCOPICALLY: NONE MTHIECROFSOCLOLPOWIICNGEXTAIMSISNUATEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE T`OHREGAFNONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE me CompanySanitized. Doesnot containTSCA C81 9H0-2:4D7a6y8:GavSaubgeehSrotnuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS MALE RATS Group: III-0 DOSE: 25 mg/kg/day ANIMAL 8: 646486 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE . TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `Nowe, SEXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. - wes `Company Sanitized. Doesnot conTtSaCAiCBnI H0--2D47a6y8:GSauvbacgherSotnuidcyTionxRiactistywithOneGeneration Reproductive Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS ALE RATS GROVE: TTI-0 DOSE: 25 mg/kg/day ANDHAL 8: 646493 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MIC`REOpSTCDOIPDIYCMIODBESSERVATIONS: TesTES ~- OONNEE.OOFF AA PPAAIIRR PPRREESSEENNTT TPHROESTFAOTLEL,OWISNEGMINTAILSSVUEESSICWLEERSE UNREMARKABLE NICROSCOPICALLY: COAGULATING GLANDS, MTIHCEROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOAUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC - ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN iss Company Sanitized. Does not contain TSCA CBI 9H0--24D7a6y8G:avSaugbcehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- P, ADULTS MALE RATS Grove: v-0 DOSE: 100 ng/ka/day ANIMAL: 646330 DAYS ON TEST: 103 MODE OF DEATH: SD GMIRCORSOSSCOOBSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE * THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE . MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDESNECVEERTEABLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEEXCATMIIONANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEEXCATMIIONANTSIOONF;TOHREGAFNOLLNOOWTICNOGUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. Ti%9`Company Sanitized. Does not contain TSCA CBI 9H0--24D7a6y8G:avSaubgeehSrtoundiye TinoxRiactistywithOneGeneration Reproductive Evaluations DuPon-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: v-0 DOSE: 100 mg/kg/day. ANIMAL : 646336 DAYS ON TEST: 105 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) `TESTES = SoFT, BILATERAL MICREOPTSDCIODPYIMCIDOEBSSERVATIONS: MODE`RTAESTTEE.S BILATERAL, MODERATE - OLIGOSPERNIA/GERM CELL? DEBRIS, BILATERAL, - DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, TPRHOESTFAOTLEL,OWISNEGMINTAILSSUVEESSIWCLEERSE UNREWARKABLE WICROSCOPICALLY: COAGULATING GLANDS, MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE - SEEXCATMIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOTWICNOGUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE CAUSE OF DEATH/MORTBUND CONDITION: SACRIFICED BY DESIGN T1260`Company Sanitized. Donotecontsain TSCA CBI 9H0--2D47a6y8G:aSvuabgeehSrtoundiyciTnoRxaitcistwyith OneGenerationReproduciveEvaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: v-0 DOSE: 100 mg/kg/day. ANIMAL B: 646338 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `None ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOWTICNOGUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. -ee CompanySanitized. DoesnotcontainTSCA CBI H9-02-4D7a6y8:GavSaugbeehSrtonuidcy iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont:5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS Grove: v-0 DOSE: 100 mg/kg/day. ANIMAL : 646341 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICREOPSICDIODPYIMCIDOEBSSERVATIONS: - ONE OF A PAIR PRESENT TESTES. - ONE OF A PAIR PRESENT . TPHREOSTFAOTLEL,OWSINEGMITNIASLSUVEESSICWLEERSE UNREVARKABLE WICROSCOPICALLY: COAGULATING GLANDS, MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THNEONFOELLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC --_ ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE. CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN 7 `Company Sanitized. Does not contain TSCA CBI H9-02-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GROVE: V-0 DOSE: 100 mg/kg/day ANIMAL 9: 646348 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOYLMLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNRAELMAVRESKIACBLLEES,MICROSCOPICALLY: COAGULATING GLANDS, `TESTES MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `owe: SEXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC - SEEXCATMIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN ee `CompanySanilized. DoesnotconTtSaCAiC8n1 F9-02-4D7a6y8:GaSvuabgeehSotnuidcy TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS MALE RATS Grove: V-0 DOSE: 100 mg/kg/day. ANIMAL #: 646353 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECRFOOSLCLOOPWIICNGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGAFNOLNOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOREGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE Ee Company Sanitized.DoesnotcontTSaCAiCBnI H-24768:Subchronic Toxicity 90-Day Gavage Study in Rais withOneGeneration Reproduive Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS MALE RATS GROVE: V-0 DOSE: 100 mg/kg/day. ANIMAL B: 646356 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF: THENONFEOLLONING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE ES `CompanySanitized. DoesnotconTtSaCAiCBnI H-24768:SubchroricToxicity 90-Day Gavage Study in Rat withOneGeneration Reproductive Evaluations DuPont5990 --- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS MALE RATS Grove: V-0 DOSE: 100 mg/kg/day ANIMAL N: 646366 DAYS ON TEST: 105 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF:THOERGAFNOLNLOOWTICNOGUNTITSESDUEISN WIENRCIEDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE T1266 Company Sanitized. Does not contain TSCA C81 F-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPon-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS MALE RATS Group: V-0 DOSE: 100 mg/kg/day ANIMAL #646375 DAYS ON TEST: 105 MODE OF DEATH: SD GMIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICRPORSOCSOTPAITCE OBSERVATIONS: - INFLAYMATION, SUBACUTE/CHRONIC, MINIMAL TEHPEIDIFDOYLMLIODWEISN,G STIESWSIUNEASL VWEESRIECLUENSR,EMATREKSATBESLE NICROSCOPICALLY: COAGULATING GLANDS, MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC - ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - CompanySanitized. DoesnotconTtSaCAiCBnI 9H0-:2D47a6y8G:avSaubgcehSrtoundiyc iTnoxRiactistywithOne.Generation Reproductive Evaluations DuPon-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/ka/day ANIMAL 0: 646387 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESLATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE: SEEXCATMIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEEXCATMIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. T1268 `CompanySanitized. DoesnotconTtSaCAiCBnI H-24768: Subchroric Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproductive Evaluations DuPont 5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: v-0 DOSE: 100 mg/kg/day ANIMAL 8: 646390 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE. SEXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. EE Company Sanitized. Does not contain TSCA C81 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPon-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: v-0 DOSE: 100 mg/kg/day ANIMAL #: 646394 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACOTRIROENLSATE (selected lesions): NO ABNORMALITIES DETECTED MIC`REOPSICDOIPDIVCNIODBESSERVATIONS: - ONE OF A PAIR PRESENT TESTES. - ONE OF A PAIR PRESENT . TPHROESTFAOTLEL,OWISNEGMITNIASLSUVEESSICWLEERSE UNREMARKABLE MICROSCOPICALLY: CORGULATING GLANDS, TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC - SEXEACMTIINOANTSIOONF; THOREGAFNOLNLOOTWICNOGUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE: CAUSE OF DENTH/MORIBUND CONDITION: SACRIFICED BY DESIGN - we CompanySanilized.Doesnotcontain TSCA CBI 9H02-4D7a6y8:GavSaugbeehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont 5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646400 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNBSL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUESWEREUNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE: EE `Company Sanitized. Does not contain TSCA CBI F0--2D4a7y68G:avSaubgcehSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: v-0 DOSE: 100 mg/kg/day. ANIMAL #: 646417 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE . THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE . MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE T`OHREGAFNOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE - m= Company Sanitized.Doesnot contain TSCA Cal H902.4D7a6y8:GavSaubgeehSrtoundiyc iTnoxRiactistywith One-Generaton Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS ALE RATS Grove: v-0 DOSE: 100 mg/kg/day ANIMAL 8: 646429 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEPHIEDIFDOVLMLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNARLEMVAERSKIACBLLEES,WICROSCOPICALLY: COAGULATING GLANDS, TESTES MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC po ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN -- C173 Company Sanitized. Doesnotcontain TSCA CBI H-24768: Subchronic Toxicity 90-DayGavageStudyinRatswithOne-GenerationReproductive Evaluations DuPon-5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROVE: V-0 DOSE: 100 mg/kg/day. ANIMAL : 646447 DAYS ON TEST: 105 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SEEXACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEEXCATMIINOANTSIOONF; THOERGAFNOLNLOOWTICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC owe pvr `Company Sanitized. Does not contain TSCA CBI H9-02-4D7a6y8G:avSaugbecShrtoundiycTionxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GroP: V-0 DOSE: 100 mg/kg/day. ANIMAL 0: 646465 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL.ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE T`OHREGAFNOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE Tse CompanySanitized. Doesnot containTSCA CBI H24768: Subchroric Toxicity 90-Day Gavage Study in Rats withOne Generation Reproductive Evaluations DuPont 5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROVE: V-0 DOSE: 100 mg/kg/day. ANIMAL : 646476 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDESNECVEETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC `NONE - ws Company Sanitized. Does not contain TSCA CBI F0--2D4a76y8:GaSvuabgcehrSotruidcyTionxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS Grove: v-0 DOSE: 100 mg/kg/day ANDHAL : 646496 DAYS ON TEST: 105 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE `THEEPIDIFDOYLNLIODWEISN,G TPIRSOSSTUAETSE,WERSEEIUNNARLEMVAERSKIACBLLEES,MICROSCOPICALLY: COAGULATING GLANDS, . Testes MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC - SEXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE CAUSE OF DEATH/MORTBUND CONDITION: SACRIFICED BY DESIGN Te `CompanySanitized. Doesnot conTtSaCAiCBnI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GrovR: V-0 DOSE: 100 ma/ka/day ANIMAL #: 646499 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGAFNOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOTWICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC Nowe, - ws Company Sanitized. Does not contain TSCA C81 'H9-02-4D7a6y8;GavSaugbeehSrtounidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Group: VIT-0 DOSE: 500 mg/kg/day ANDGL 8: 646332 DAYS ON TEST: 105 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;TOHREGFAONLLNOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. -ww CompanySanitized.Doesnot conTtSaCAiCn81 H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont:5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS MALE RATS GROVR: VII-0 DOSE: 500 mg/kg/day. ANDOAL 8: 646351 DAYS ON TEST: 103 MODE OF DEATH: SD GMIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE SEEXCATMIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. - w= Company Sanitized.DossnotconTtSaCAiCBnI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generaton Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: VII-0 DOSE: 500 mg/kg/day ANIL #: 646359 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREWARKABLE NICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTNIIONONANETSIOONF;TOHREGAFONLNLOOWTICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC Tw Company Sanitized. Doesnotcontain TSCA CBI H-24768: Subchvoic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont:5990 --_ INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GROUP: VIT-0 DOSE: 500 mg/kg/day ANIMAL #: 646362 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE * THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE . TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE - ww Company Sanitized. Does not contain TSCA C81 H24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont. 5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS MALE RATS Grove: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646365 DAYS ON TEST: 105 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEPHIEDIFDOYLNLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNRAELMVAERSKIACBLLEES,WICTRESOTSECSO,PICALLY: COAGULATING GLANDS, TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC Ps NONE. CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - ws Company Sanitized. Does not contain TSCA CBI F9-02-4D7a6y8:GavSaugbeehSrtoundiyc iTnoxRiactistywithOne.Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: VIT-0 DOSE: 500 mg/kg/day ANIMAL : 646382 DAYS ON TEST: 103 MODE OF DEATH: SD `MGIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE SEXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. - ms `Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646386 DAYS ON TEST: 105 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE . TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, SEXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE -es `CompanySanitized. Does notcontain TSCACBI H902-4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Exaluations DuPont5990 pe INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day. ANIMAL : 646393 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINEGXATMIISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTIESDSUIENSTWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUTNTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. we `Company Sanitized. Doesnotcontain TSCA C81 H9-02-4D7a6y8:GaSvuabgcehvSotnuidcy iTnoxRiacittywithOneGeneration Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS ALE RATS GROVE: VII-0 DOSE: 500 mg/kg/day. ANIMAL 8: 646401 DAYS ON TEST: 104 MODE OF DEATH: SD `MGIRCORSOSSCOOBPSEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THEFOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINEGXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. -ws `CompinySanitized. Does not conTtSaCAiC8n1 H9L02-4D7a6y8G:avSaubgcehSrtoundiyc TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont 5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646405 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY:: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGFAONLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE - ws Company Sanitized.Does notcontTSaCAiCnBI H9-02-4D7a6y8:GavSaugbcehSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont5990 --- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: VII-0 DOSE: 500 ma/kg/day. ANIMAL #: 646406 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES! WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE me `Company Sanitized. Does not contain TSCA CBI F9-02.0D7a6y8:GaSvuabgcehrSotnuidcy iTnoxRiaciistywithOneGeneration Reproductive Evaluations DuPon-5950 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day. ANIMAL #646418 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREWARKABLE MICROSCOPICALLY: NONE . MTHIECROFSOCLOLPOWIICNGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. me CompanySanitized. Doesnot contain TSCA CBI H9-02-4D7a6y8:GaSvuabgeehrSotnuidcy TinoxRiactistywith One-Geneation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS MALE RATS GROUP: VII-0 DOSE: 500 ma/ka/day. ANIMAL 4: 646441 DAYS ON TEST: 105 MODE OF DEATH: SD MGRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMSISNUATEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE. OTHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOWTICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC NONE. --- ws Company Sanitized. Doosnotcontain TSCA CBI F9-02-4D7a6y8:GaSvuabgcehrSotruidcy iTnoxRiacistywithOneGeneration Reproductive Evaluations DuPon-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646451 DAYS ON TEST: 106 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE -> `Company Sanitized. Does not contain TSCA C81 H9-02-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiacittywith OneGeneration Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2; ADULTS MALE RATS Grou: VII-0 DOSE: 500 ma/ka/day ANIMAL #: 646452 DAYS ON TEST: 105 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUETOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `Nowe ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTICNOGUNTTIESDSUETSN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC NONE. - ms `Company Sanitized. Does not contain TSCA CBI H9-02-4D7a6y8:GSauvbacgherSotruidcyTionxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: VII-0 DOSE: 500 ma/ka/day ANIMAL #: 646491 DAYS ON TEST: 103 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: SEXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE: - ws `Company Sanitized. Does not contain TSCA CBI H9-02-4D7a6y8G:aSvuabgeehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646497 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE . TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE Tis -- Company Sanitized. Doesnotcontain TSCA C81 H9.02-4D7a6y8G:avSaugbcehSrtourdiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Group: VIT-0 DOSE: 500 ma/kg/day ANIMAL 8: 646498 DAYS ON TEST: 104 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE ICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF: THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN IWENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE. - ws Company Sanitized.Does notcontain TSCA C81 H9-02-4D7a6y8:GaSvuabgcehrSotruidcy TionxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS fe DOSE: 0 mg/kg/day ANIMAL : 646503 DAYS ON TEST: 118 MODE OF DEATH: SD MGIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) SALIVARY GLANDS - DISoCuOLbOIRAATION, TAN, FIRM, RIGHT; 1.0 MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGAFNONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC - NONE. Ter CompanySanitized. Does not contain TSCACBI H-24768: Subehronic Toxicity 90.Day Gavage Study in Rats with One GenerationReproductive Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Grove: TI-0 DOSE: 0 mg/kg/day ANIMAL 8: 646520 DAYS ON TEST: 126 MODE OF DEATH: SD GMIRCORSOSSCOOBPSIECRVACTOIRORNBSL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTHAEGIFNOALLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDESNCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE. ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF:TOHREGAFONLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC --_ NONE. CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN 19 Company Sanitized. Does not contain TSCA CBI H.24768: Subchroic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULAS FEMALE RATS GROUP: 11-0 DOSE: 0 mg/kg/day ANIMAL: 646526 DAYS ON TEST: 118 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, SEEXCATMIIONANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;THOREGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC one i: -- Company Sanitized. Does not contain TSCA CBI F0--2D4a7y68G:avSaubgcehSvtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: 11-0 DOSE: 0 mg/kg/day ANIMAL 646544 DAYS ON TEST: 118 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE : THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE . TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA.UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE SEXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE CompanySanitized. DoesnotconTtSaCAiCanl H-24768:Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPoni-5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Grove: TI-0 DOSE: 0 ma/ka/day ANIMAL #: 646550 DAYS ON TEST: 127 MODE OF DEATH: SD `MGIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESAUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. - wa Company Sanitized. Does notcontain TSCA C81 HL24768: Subchronic Toxicity 90-DayGavageStudy in Rats withOne-Generation Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS Grove: TI-0 DOSE: 0 mg/kg/day ANIMAL #: 646552 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGAFNONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC - NONE. CAUSE OF DENTH/MORIBUND CONDITION: SACRIFICED BY DESIGN T1302- ~ Company Sanitized. Does not contain TSCA Cal H902-4D7a6y8:GavSaugbcehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - By ADULTS FEMALE RATS GROUP: TI-0 DOSE: 0 mg/kg/day ANDIAL 8: 646557 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE WICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINEGXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT ERECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. --- ee `Company Sanitized. Does not contain TSCA C81 'H9-02-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywith OneGenerationReproductive Evaluations DuPont:5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Grove: TI-0 DOSE: 0 mg/kg/day ANIMAL #: 646569 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRROENLSA:TES (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SEEXACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEEXCATMIIONANTSIOONF;THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. ET Company Sanitized. Does not contain TSCA C81 H24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPon-5950 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS FEMALE RATS Group: 11-0 DOSE: 0 mg/kg/day ANIMAL #: 646575 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE `THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE ` TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE T`OHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFONLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE. 10s -- `Company Sanitized. Doesnot contTSaCAiCnBI H9-02-4D7a6y8:GavSuabgcehSrotnuidcy iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont.5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS FEMALE RATS GROUP: 11-0 DOSE: 0 mg/kg/day ANIMAL 8: 646585 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ONE, ESXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF: THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE CAUSE OF DEATH/MORTBUND CONDITION: SACRIFICED BY DESIGN TT306- -- Compiny Sanitized. Doosnotcontain TSCA CBI H9-02.4D7a6y8G:avSaubgeehSrotnuidcy iTnoxRiactistywith One.Generation Reproductive Evaluations DuPont5990 ~ INDIVIDUAL ANTMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: 11-0 DOSE: 0 mg/kg/day ANIMAL 8: 646591 DAYS ON TEST: 120 MODE OF DEATH: SD GMIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED: MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. 07 Company Sanitized. Does not contain TSCA C81 9H0--2D47a6y8G:avSaugbeehSrtoundiyc iTnoxRiactistywithOne-Generation Reproductive Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: TI-0 DOSE: 0 ma/ka/day ANIMAL #: 646604 DAYS ON TEST: 122 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE . MTIHCEROFSOCLOLPOIWCINEGXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, SEXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE: T308`CompanySanitized. Does not contain TSCA CBI F9-02-4D7a6y8:GaSvuabgcehrSotruidcy iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ; ADULTS FEMALE RATS Grove: TI-0 DOSE: 0 mg/kg/day ANTHAL 8: 646606 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE -- me. `Company Sanitized. Does not contain TSCA CBI H9-02-4D7a6y8:GaSvuabgcehrSotnuidcyTionxRiactistywith OneGeneration Reproductive Evaluations DuPon5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS FEMALE RATS GROUP: 11-0 DOSE: 0 mg/kg/day ANIMAL #: 646622 DAYS ON TEST: 125 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE "HE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE . TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. _---- "Bios Company Sanitized. Doosnotcontain TSCA Cai F9-02.4D7a6y8:GaSvuabgcehvSotnuidcy TinoxRiacistywith One-GenertionReproductive Evaluations DuPont5990 ~ INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: TI-0 DOSE: 0 mg/kg/day ANIMAL : 646644 DAYS ON TEST: 117 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE stounc (selecte"dDIlSeCOsLiOoRnAsT:)ION, BLACK, FEW, GLANDULAR; <5MM LINEAR MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISON:WERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEEXCATMIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC --_ NONE, Thin: `Company Sanitized. Doesnot contain TSCA CBI 0H--2D4a7y68G:avSaugbechSrtoundiyc iTnoRxiactistwyith One-Gencrstion Reproductive Evaluations DuPon:5990 ~ INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS Group: TI-0 DOSE: 0 ma/ka/day ANIMAL : 646646 DAYS ON TEST: 118 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;TOHREGFAONLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. Thi: `CompanySanitized.Doesnot conTtSaCAiCBnI 9H0--2D4a76y8G:avSaugbeeShrtoundiyciTnoRxaictistwyithOne-GenerationReproductive valuations DuPont:5990 --_ INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Grou: TI-0 DOSE: 0 mg/kg/day ANIMAL 8: 646651 DAYS ON TEST: 118 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE WICROSCOPICALLY: NONE . TMIHCEROFSOCLOLPOIWCINGEXTAIMSINSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGAFNOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE. ESXEACMTIINOANTSIOONF: THENOFNOELLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTNIIONONANETSIOONF;THOERGAFNOLNLOOTWICNOGUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC "Bi. Company Sanitized. Doas not contain TSCA CBI H9-02-4D7a6y8G:avSaugbecShrtoundiyciTnoRxaictistwyithOne-Generation ReproductiveEvaluations DuPont-5950 -~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Grove: 1-0 DOSE: 0 mg/kg/day ANIMAL : 646653 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, SEXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC `owe hia: `Company Sanitized. Does not contain TSCA CBI 'H9-02-4D7a6y8:GavSaubgcehrSotnuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPon:-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: TI-0 DOSE: 0 ma/kg/day ANDIAL 8: 646654 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGAFNONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEEXACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;TOHREGFAONLNLOOWTINCGOUTNITESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. his`Company Sanitized. Doesnot contTSaCAiCnBI H9-02-4D7a6y8:GSauvbacgherSotnuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPoni-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS FEMALE RATS Group: TI-0 DOSE: mg/kg/day ANIMAL #: 646668 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: . NONE TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEEXACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;TOHREGFAONLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE EET `Company Sanitized. Doos not contain TSCA CBI 9H02.4D7a6y8:GavSaugbcehSrtourdiyc iTnoxRiactistywith One GencrtionReproductive Evaluations DuPont5990 -- INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Grou: 1V-0 Dose: 25 mg/kg/day ANIMAL #: 646504 DAYS ON TEST: 118 MODE OF DEATH: SD MGRIOCSRNSOOSCAOOBBPSNIEOCRRVMAACTLOIIROTRNIESEL:SATEDET(EsCeTlEeDcted lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMHIECRFOOSLCLOOPWIICNGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE. ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGFAONLLNOOWTINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE hi `Company Sanitized. Does not containTSCA CBI 9H0-.2D47a6y8G;avSaubgcehSrtoundiyc TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont:5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROVE: TV-0 DOSE: 25 mg/kg/day. ANIMAL 8: 646529 DAYS ON TEST: 118 MODE OF DEATH: SD MGRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE . MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEXEACMTIINOANTSIOONF: THENOFNOELLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTNIIONONANETSIOONF;THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC Bis. Company Sanitized.DoesnotcontTSaCAiCBnI 9H-02.4D7a6y8G:avSaugbesSotnuidcy TinoxRiactistywith OnGeeneration Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: 1V-0 DOSE: 25 mg/kg/day ANIMAL 8: 646543 DAYS ON TEST: 118 MODE OF DEATH: SD MGRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;THOERGAFONLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. Th `Company Sanitized.Doesnotcontain TSCA C81 F9-02-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont:5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS FEMALE RATS Grove: TV-0 DOSE: 25 mg/kg/day ANIMAL : 646553 DAYS ON TEST: 122 MODE OF DEATH: SD GMIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMSISNUATEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, SEXEACMTIINOANTSIOONF:THNEONFOELLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE, Tm Company Sanitized. Does not contain TSCA C81 'H9-02-4D7a6y8G:avSaubgeehSrtoundiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPon5990 _ INDIVIDUAL, ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ; ADULTS FEMALE RATS Grove: TV-0 DOSE: 25 mg/kg/day ANIMAL 0: 646554 DAYS ON TEST: 126 MODE OF DEATH: SD MGRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, MTIHCEROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID-NOT PRECLUDE TOHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDESNECVEERTEABLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEEXACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC - NONE, CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN oe `Company Sanitized. Does not contain TSCA C8I H9.02-4D7a6y8:GaSvuebgcehrSotnuidcy TionxRiacittywithOne:Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: TV-0 DOSE: 25 mg/kg/day ANIMAL 8: 646558 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID-NOT PRECLUDE TOHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, Nowe SEXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC _ SEXEACMTNIIONONANETSIOONF;TOHREGAFNOLNLOOWTICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN Tas Company Sanitized. Doesnotcontain TSCA CBI 9H0-2D4a7y68G:avSaugbeehSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPon:5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GRovE: TV-0 DOSE: 25 mg/kg/day ANIMAL #: 646559 DAYS ON TEST: 118 MODE OF DEATH: SD MGRIOCSRNSOOSCAOOBBPSNIEOCRRVMACATOLIRIORTNEISLE:SATDEET(EsCeTlEeDcted lesions:) MICROSCOPIC OBSERVATIONS: NONE : THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE . MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGAFNOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE ms `Company Sanitized. Does not contain TSCA CBI 9F0--2D47a6y8G:aSvuabgcehSrtourdiyciTnoRxaictistwyithOne Generation Reproductive Evaluations DuPont:5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS FEMALE RATS GROUP: TV-0 DOSE: 25 mg/kg/day ANIMAL #: 646561 DAYS ON TEST: 118 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) : NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREWARKABLE WICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID~NOT PRECLUDE TOHREGANFOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `Nowe, SEXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTNIIONONANETSIOONF;THOERGAFNOLNLOOWTICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC Tia Company Sanitzed. Donotecontsain TSCA CBI H9-02D4a76y8:GavSaugbcehSrtoundiyc TinoxRiacittywith One-Genersion Reproductive Evaluations DuPon-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Group: TV-0 Dose: 25 mg/kg/day ANIMAL #: 646564 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTAHGEINFAOLLOWENG TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID~NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;TOHREGAFONLLNOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC - NoxE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN ss `CompanySanitized. Doesnot conTtSaCAiCBnI F9-02-4D7a6y8G:avSaugbeeShrtoundiyc TinoxRiactistywith One-Generaton Reproductive Evaluations DuPon:5990 ~ INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUR: 1-0 DOSE: 25 mg/kg/day ANIMAL 4: 646573 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSROSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTHAEGIFNOALLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID=NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN Tie `Company Saniized. Does not contain TSCA CBI H9-02-4D7a6y8G:avSaubgeehSrtoundiyc iTnoxRiactistywithOne-Generation Reproductive Evaluations DuPont:5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: 1-0 DOSE: 25 mg/kg/day ANIMAL 8: 646579 DAYS ON TEST: 117 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE STOMACH (selected"DlIeSsCiOoLOnRsA:)TION, BLACK, FEW, GLANDULAR; <5MM LINEAR MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID4NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE SEXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;TOHREGFAONLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC ~ NONE "17 Company Sanitized. Dossnotcontain TSCA C81 H9-02-4D7a6y8:GaSvuabgcehrSotruidcyTionxRiactistywithOne-Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Group: TV-0 Doss: 25 mg/kg/day ANIMAL #: 646584 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTHAEGIFNOALLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, . TMHIECROFSOCLOLPOIWCINGEXTAIMSISNUATEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DIDbiNOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE: ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC - Nowe: CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN 28Company Sanitized. Does not contain TSCA C81 H9-02-4D7i6y8G:avSaubgcehSrtoundiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS FEMALE RATS Group: 1V-0 DOSE: 25 mg/kg/day ANIMAL 3: 646587 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSROSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCORICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOWIICNGEXTAIMSISNUATEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID~NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: SEXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC = NONE CAUSE OF DEATH/MORTBUND CONDITION: SACRIFICED BY DESIGN Tie Company Sanitized. DoesnotcontTSaCAiC8n1 H9-02-4D7a6y8:GavSaubgeehSrtoundiyc iTnoxRiactistywithOne-Generation Reproductive Evaluations DuPon:5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS FEMALE RATS Grove: TV-0 DOSE: 25 mg/kg/day ANIMAL #646596 DAYS ON TEST: 118 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREVARKABLE NICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID.NOT PRECLUDE TOHREGAFNOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: SEEXCATMIINOANTSIOONF: THENOFNOELLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. T3%0CompanySanitized.Doesnot conTtSaCAiCBnI 9H-02.4D7a6y8G:avSaubgeehSrtoundiyc iTnoxRiactistywithOGneeneration Reproductive Exaluatons DuPont5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROVE: TV-0 DOSE: 25 mg/kg/day ANIMAL 8: 646598 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, MTHIECROFSOCLOLPOWIICNGEXTAIMSISNUATEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID-NOT PRECLUDE TOHREGAFNOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTEALBLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `Nowe, ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC ~ `NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN Time CompanySanitized. DossnotcontTSaCAiCnBI F9-02.4D7a6y8:GavSaugbeehSrtoundiyc iTnoxRiactistywith OneGeneration Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Grove: TV-0 DOSE: 25 mg/kg/day ANIMAL #: 646603 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID |NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF:THNEONFOELLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC NONE. Ts Company Sanitized. Doesnotcontain TSCA CBI H9L02-4D7a6y8:GaSvuabgcehrSotruidcy TionxRiactistywithOne.Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: TV-0 DOSE: 25 mg/kg/day ANIMAL : 646631 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE PITUITARY GLAND (selecte"dLAlReGsEi,onMsO:)DERATE. MICROSCOPIC OBSERVATIONS: NONE TVHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, . TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DIDNOT PRECLUDE T`OHREGAFNONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SEXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEEXCATMIIONNATSIOONF;THOERGAFNOLNLOOWTICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC --_ owe CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN TEC CompanySanitized. Doesnot containTSCA CBI F9-02-4D7a6y8G:avSaubgcehrSotnuidcy TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Pi ADULTS FEMALE RATS Grove: TV-0 DOSE: 25 mg/ka/day ANIMAL : 646638 DAYS ON TEST: 118 MODE OF DEATH: SD MGRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE T`OHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE SEEXCATMIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE JE Tas `Company Sanitized. Doesnotcontain TSCA CBI H902.4D7a6y8:GaSvuabgcehrSotruidcy TinoxRiactistywith One.Generation Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS Group: 1V-0 DOSE: 25 mg/ka/day ANTWAL #: 646670 DAYS ON TEST: 126 MODE OF DEATH: SD GMIRCORSOSSCOOBSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TVAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID-NOT PRECLUDE OTRHGEANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOWTICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC ~~ NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN EE-- `Company Sanitized. Does not contain TSCA CBI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPoni-5990 -- INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Group: 1V-0 DOSE: 25 ma/ka/day ANIMAL #646672 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) MAMMARY GLANDS - MASDSI,A TAN, FIRM, VENTRAL, NECK; 2H MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE . TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DIDbiNOT ERECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNITESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE EE CompanySanitzed. DoesnotconTtSaCAiCBnI H9-02-4D7a6y8G:avSaugbeehSrtoundiyc TinoxRiactistywith One-Generaton Reproductive Evaluations DuPont-5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Group: VI-0 DOSE: 100 mg/kg/day ANIMAL 8: 646521 DAYS ON TEST: 121 MODE OF DEATH: SD GMIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) `STONACH ~ ULCLEIRN/EEARROSION, FEW, GLANDULAR: < 314 skmy - ALOLPIEMCBI;A,ABDBOIMLAETNERAL, FRONT, REAR, MICROSCOPIC OBSERVATIONS: NONE : THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDESNCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC - ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. 17s `CompanySanitized.DoesnotconTtSaCAiCani H-24768: Subchronic Toxicity 90-DayGavage Study in Rats with One.Generation Reproductive Evaluations DuPont-5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL B: 646524 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTAHGEIFNOALLOWING TISSUES WERE UNREWARKABLE NICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID -NOT PRECLUDE TOHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED: MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THNEOFNOELLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC --- NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN EC Company Sanitized.Doesnot conTtSaCAiC8n H0L-2D4a76y8:GaSvuabgcehrSotruidcy iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont:5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646527 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DIDNOT PRECLUDE TOHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC - NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN TC -- Company Saniized. Does not contain TSCA CBI 9H0-2-4D7a6y8:GavSaugbcehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont5990 --- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Grove: VI-0 DOSE: 100 mg/kg/day ANIMAL 4: 646546 DAYS ON TEST: 118 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) ska ALOPECIA, ; HINDQUARTERS MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID|NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE --- Company Sanitized.Doesnotcontain TSCA C81 24768: Subehronic Toxicity 90-Day Gavage Study in Rats with OneGeneration Reproductive Evaluations DuPont5990 --_ INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE FATS GROUP: VI-0 DOSE: 100 mg/kg/day. ANIMAL : 646547 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE WICROSCOPICALLY: NONE . MTHIECROFSOCLOLPOIWCINGEXTAIMSISNUATEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID|NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEES:NT FOR MICROSCOPIC NONE - me Company Sanitized. Does not contain TSCA CBI H902-4D7a6y8:GavSaugbeehSroundiyc TinoxRiactistwyith One Generation Reproductive Evaluations DuPon-5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS Grove: VI-0 DOSE: 100 mg/kg/day ANIMAL : 646555 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MI`CURTOESCROUPSIC OBSERVATIONS: ~- IHYNPFELRAPMLMAASTIIAO,N,CYSSUTBIACCUTEEN/DCOHMREOTNRIICA,L, MIMNIINMIAMLAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID'NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SEEXCATMIIONANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC -_ SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN we CompanySanitized. DoesnotconTtSaCAiCanl H-24768:Subehronic Toxicity 90.Day Gavage Study in Rats with OneGeneration Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 ma/ka/day ANIMAL 8: 646589 DAYS ON TEST: 126 MODE OF DEATH: SD `MGIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TVAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DIDNOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SEEXCATMIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEEXCATMIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC - NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN --- ms CompanySanitized. Doesnot conTtSaCAiC8n1 HL24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPon-5990 --_ INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Grove: VI-0 DOSE: 100 mg/kg/day. ANIMAL: 646590 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) PITUITARY GLAND ~ LARGE, MILD MICROSCOPIC OBSERVATIONS: NONE TVHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID-NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT BRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC - NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN Tas Company Sanitized. Does not contain TSCA CBI H9-02-4D7a6y8:GavSaubgcehSrtoundiyc iTnoxRiactistywith One Generation Reproductive Evaluations DuPoni-5990 -- TNDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANTHAL 8: 646594 DAYS ON TEST: 118 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUETOLYZED; DEGREE OF AUTOLYSIS DID.NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SEEXCATMIIONNATSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE: ms Company Sanitized. Doesnot contain TSCA Cal 1H902-4D7a6y8G:avSaugbecShtroundiyciTnoRxaitcistwyithOne-Generation Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROVE: VI-0 DOSE: 100 mg/kg/day. ANIMAL #: 646600 DAYS ON TEST: 118 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE . THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DIDANOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDESNCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `Nowe ESXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. `Company Sanitized. Does notconTtSaCAiCnBI H9-02-4D7a6y8:GaSvuabgcehrSotnuidcy iTnoxRiactistywithOne-Generation Reproductive Exaluations DuPont5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS FEMALE RATS Grove: VI-0 DOSE: 100 mg/kg/day ANIVAL 4: 646605 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TVAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSISDIDNOT PRECLUDE TOHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; WICROSCOPIC DIAGNOSES NOT MADE, NONE: ESXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC - SEXEACMTNIIONONANETSIOONF:TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC CAUSE OF DEATH/MORTBUND CONDITION: SACRIFICED BY DESIGN ~ 147s CompanySanitized. DoesnotcontTSaCAiCnBI 'H9-02-4D7a6y8:GavSaugbcehSrtonuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- P, ADULTS FEMALE RATS GROVE: VI-0 DOSE: 100 mg/kg/day. ANIMAL #: 646607 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) KUIRDINNEAYRSY BLADDER -~ CCYASLTC,ULUFSE,W, `SCELVEEARRE, BILATERAL - CALCULUS, SEVERE, BILATERAL, SEVERE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID'NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE, SEXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC - ESXEACMTIINOANTSIOONF; THOREGAFNOLNLOOWTICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. ms Company Sanitized. DoesnotconTtSaCAiCBnI F9-02-4D7a6y8G:avSaubgcehSrtourdiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Group: VI-0 DOSE: 100 mg/kg/day. ANDHAL 8: 646615 DAYS ON TEST: 121 MODE OF DEATH: SD MGRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID.NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;THOERGAFNOLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE: we. CompanySanitized. Doesnotcontain TSCA CBI H0--2D4a76y8:GaSvuabgcehvSotnuidcy iTnoxRiactistywithOne.Generation Reproductive Evalustions DuPont5990 --- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646645 DAYS ON TEST: 118 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID|NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; WICROSCOPIC DIAGNOSES NOT MADE, NONE, SEEXCATMIIONANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE 1350 -- Company Sanitized. Does not contain TSCA Cai H9-02.4D7a6y8G:avSaugbecShrtoundiycTionxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 . INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Group: VI-0 DOSE: 100 mg/ka/day ANIMAL #: 646647 DAYS ON TEST: 124 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE * THE FOLLOWING TISSUES WERE UNREMARKABLE WICROSCOPICALLY: NONE . MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DIDA NOT PRECLUDE OTRHGEAFNOLNLOTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;THOREGAFNOLNLOOWTICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN.T FOR MICROSCOPIC NONE --_-- me CompanySanitized. DossnotconTtSaCAiCanl 'H9-02-4D7a6y8G:avSaubgcehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 _ TNDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS FEMALE RATS GROv: VI-0 DOSE: 100 mg/kg/day. ANIMAL #: 646648 DAYS ON TEST: 117 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINEGXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID.NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: SEXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;THOREGAFNOLNLOOWTICNOGUTNITSESDUEISN WIENRCIEDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE Ts: -- -- `CompanySanitized. DoesnotconTtSaCAiCBnI 9H0-2-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPon-5990 --_ INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROU?: VI-0 DOSE: 100 mg/kg/day. ANIMAL #: 646661 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIERCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSISDIDNOT PRECLUDE `TOHREGAFNONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC -- NONE. CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN -- mm `CompanySanitized. Does notcontainTSCA CBI 'H9-02-4D7a6y8G:avSaugbeehSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont.5990 ~ INDIVIDUAL ANDMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GRP: VI-0 DOSE: 100 mg/kg/day. ANIMAL #: 646666 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): PITUITARY GLAND = LARGE, MILD MICROSCOPIC OBSERVATIONS: NONE VTHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERDS, TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID_NOT PRECLUDE TORHGEANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SEXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ~ ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE CAUSE OF DEATH/MORTBUND CONDITION: SACRIFICED BY DESIGN TEs ---- CompanySanitized. DoesnotconTtSaCAiCBnI 210H9-:02D-4Do7a6yy8G:GaaSvvuaabggeeehSrStotunuddiyyciiTnnoRxRaiatctsistwywiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiivveeBEvvaalluuaattiioonnss __ DDuuPPoonntt:-55999900. _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day. ANIMAL #: 646671 DAYS ON TEST: 121 MODE OF DEATH: 5D MGRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDESNCEEVERTAEBLLYESA.UTOLYZED; MICROSCOPIC DIAGNOSES NOT WADE, `NONE ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOREGAFNOLNLOOWTICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE -_-- iss Company Sanitized. Does not contain TSCA CBI H902-4D7a6y8:GavSaugbcehSrtoundiycTionxRicaistywithOne-Generation Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - , ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646675 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL.ATE (selected NO ABNORMALITIES DETECTED lesions:) MICROSCOPIC OBSERVATIONS: NONE VTHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSISDID NOT PRECLUDE OTHREGAFNONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC --- SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN NONE WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN -_-- T356- CompanySanitized. Doesnot conTtSaCAiC8n1 'H9-02-4D7a6y8G:avSaubgeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VITI-0 DOSE: 500 mg/ka/day ANIMAL : 646512 DAYS ON TEST: 117 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): LIVER = LARGE, MODERATE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREWARKABLE WICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID .NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, SEEXCATMIIONANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC NONE = Company Sanitized. Does not contain TSCA CBI 9H0--2D4a7y6G8:avSaugbechSrtoundiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS Group: VIII-0 DOSE: 500 mg/kg/day. ANIMAL #: 646532 DAYS ON TEST: 122 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): LsIovyeR "~ LAALROGPEE,CIAM,ODVEERNATTREAL BODY; HINDQUARTERS MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSTSDIDNOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTEIDSSUIENSTWNECRIEDESNCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEEXCATMIIONANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;THOERGAFNOLNLOOWTICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC - NONE we Company Sanitized. Does not contain TSCA CBI F-24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOne Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROVE: VIII-0 DOSE: 500 mg/kg/day ANIMAL 8: 646539 DAYS ON TEST: 118 MODE OF DEATH: SD GMIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE . MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID.NOT PRECLUDE T`OHREGAFNONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;THOERGAFNOLNLOOWTICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. EE CompanySanitized. Doesnot contain TSCACBI H9-02.6D7a6y8:GavSaugbeehSrtoundiyc Toxicity in Ras with OneGeneration Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: VITI-D DOSE: 500 mg/kg/day ANDHAL 8: 646563 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) SKIN STAIN, BROWN: SURROUNDING MOUTH MICROSCOPIC OBSERVATIONS: NONE TVAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSTS DID_NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDESNCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUTNTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC - NONE. CAUSE OF DEATH/NORTBUND CONDITION: SACRIFICED BY DESIGN - we Company Sanitized.Doesnotcontain TSCA C81 9H0-2-4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiacsitywith One:Generation Reproductive Evaluations DuPont 5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: VITI- DOSE: 500 mg/kg/day ANIMAL : 646566 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID.NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOTWICNOGUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE me `Company Sanitized. Does not contain TSCA CBI H9-02.4D7a6y8:GaSvuabgcehrSotruidcy TinoxRiactistywithOGneeneration Reproductive Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Group: VIII-0 DOSE: 500 mg/kg/day. ANIMAL 4: 646570 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): SKIN ALOPECIA, MILD, VENTRAL BODY MICROSCOPIC OBSERVATIONS: NONE VTAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOAUNTEOLYZED: DEGREE OF AUTOLYSTSDIDNOT PRECLUDE OTRHGEANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SEXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC --_ NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN --- ee CompanySanitized. DoesnotcontTSaCAiCBnI 'H9-02-4D7a6y8:GaSvuabgeehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VITI-0 DOSE: 500 mg/kg/day. ANIMAL #: 646572 DAYS ON TEST: 118 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESL:ATE (selected lesions): SKIN ALOPECIA, VENTRAL BODY MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE WICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMSINSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID .NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE SEXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC ONE - -- we Company Sanitized. Doss not containTSCA C8l H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One Generation Reproductive Evaluations DuPont-5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VITI-0 DOSE: 500 mg/kg/day. ANIMAL #: 646574 DAYS ON TEST: 122 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESL.ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE . THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINEGXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DIDaNOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF: THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE He `CompanySanitized. Doesnot containTSCA C81 H9-02-4D7a6y8:GavSaugbeehSrtonuidcy iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 pe INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Grove: VITI-0 DOSE: 500 mg/kg/day ANIMAL #: 646582 DAYS ON TEST: 126 MODE OF DEATH: SD `MGIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) SKI STAIN, YELLOW, PERINEUM MICROSCOPIC OBSERVATIONS: NONE VTAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE WICROSCOPICALLY: OVARIES, UTERUS, MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID-NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `None ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEEXCATMIINOANTSIOONF; THOERGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC --~ owe CAUSE OF DEATH/MORTBUND CONDITION: SACRIFICED BY DESIGN EE CompanySanitized.DoesnotcontainTSCA Cal H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Grove: VIII-0 DOSE: 500 mg/kg/day ANDOAL 8: 646583 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TVHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE. ESXEACMTIINOANTSIOONF: THNEONFOELLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUTNTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC PN `NONE CAUSE OF DEATH/NORTBUND CONDITION: SACRIFICED BY DESIGN -us CompanySanitized.Does notconTtSaCAiCanl 9H0--2D47a6y8G:avSaugbeehSrtoundiyc TinoxRiactistywith One.Generation Reprodicive Evaluations DuPont. 5990 --~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE FATS GROUP: VITI-0 DOSE: 500 ma/ka/day ANIMAL 8: 646602 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) SKIN "ALOPECIA, VENTRAL BODY MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE, MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID.NOT PRECLUDE OTHREGAFNOLNOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SEXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOREGAFNOLNLOOWTICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC NONE "1367- -- `Company Sanitized. Does not contain TSCA G81 H9-02-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiacsitywith OneGeneration Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VIII-D DOSE: 500 mg/kg/day ANIMAL #: 646616 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TVHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUETOLYZED; DEGREE OF AUTOLYSISDIDNOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC - ESXEACMTNIIONONANETSIOONF;TOHREGAFNOLNLOOWTICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC CAUSE OF DEATH/MORISUND CONDITION: SACRIFICED BY DESIGN -ss Company Sanitized. Does not contain TSCA CBI HL24768: Subchronic Toxicity 90-Day Gavage Study in Rats with OneGeneration Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANTMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day. ANIMAL 0: 646619 DAYS ON TEST: 118 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE . THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE | TMHIECROFSOCLOLPOWIICNGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID|NOT BRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; TOHREGFAONLLNOOWTINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE Te - -- `Company Sanitized. Does not contain TSCA C81 H24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day. ANIMAL: 646623 DAYS ON TEST: 118 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNBSL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLONING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID|NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `None. SEXEACMTIINOANTSIOONF:THENONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE, Th70- -- Company Sanitized. Does not contain TSCA CBI `H9-02-4D7a6y8:GavSaubgeehrSotnuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPon-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646628 DAYS ON TEST: 126 1ODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TVAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSISDIDNOT PRECLUDE TOHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NONE ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC - SEXEACMTNIIONONANETSIOONF;THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN.T FOR MICROSCOPIC CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN Tie `Company Sanitized. Donotecontsain TSCA CBI H9-02-4D7a6y8G:SauvbacgherSotruidcy iTnoxRiactistywithOneGenerationReproductiveEvaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANTHAL #: 646640 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) sknn ~ STAIN, YELLOW, PERINEUM MICROSCOPIC OBSERVATIONS: NONE VTHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES,,UTERUS, MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSISDIDNOT PRECLUDE TOHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -_ NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN --- `Company Sanitized. Does not contain TSCA C81 9H0--2D47a6y8G:avSaubgeehSrtoundiyc TinoxRiactistywithOne-GenerationReproductive Evaluations DuPont 5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Grove: VIII-0 DOSE: 500 mg/kg/day. ANIMAL #: 646641 DAYS ON TEST: 118 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF:THNEONFEOLLONING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTNIIONONANETSIOONF;THOREGAFNOLNLOOWTICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC BT Company Sanitized.DoesnotconTtSaCAiCanl H9-02-4D7a6y8:GavSaubgcehSrtourdiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont5990 Pe INDIVIDUAL, ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL 4: 646655 DAYS ON TEST: 121 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNBSL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE `THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE . TMIHCEROFSOCLOLPOIWCINEGXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID .NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE ESXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF; THOREGAFNOLNLOOWTICNOGUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE ee CompanySanitized. Doesnot conTtSaCAiCBnI 9H0-2-4D7a6y8:GaSvubacgherSotnuidcy iTnoxRiactistywithOne Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Ps ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646662 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINEGXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DIDaNOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; WICROSCOPIC DIAGNOSES NOT MADE, NONE, ESXEACMTIINOANTSIOONF:THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SEXEACMTIINOANTSIOONF: THOREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. - es Company Sanitized. DoesnotconTtSaCAiCBnI H-24768: Subehronic Toxicity 90-DsyGavage Study in Rats with OneGeneration Reproductive Evalutions DuPont5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day. ANIMAL B: 646663 DAYS ON TEST: 121 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID.NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; WICROSCOPIC DIAGNOSES NOT MADE, NONE. SEXEACMTIINOANTSIOONF: THNEONFEOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. -- 376 `CompanySanitized. Doesnot conTtSaCAiCanl 9H0-2-4D7a6y8:GavSaugbcehSrtoundiyc iTnoxRiactistywith OneGeneration Reproductive Evaluations DuPont5990 APPENDIX 00 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fy PUPS mm -- Company Sanitized. Doesnotcontain TSCA Cal 910.-2D47a6y8G:avSaugbcehSrtoundiyc TinoxRiactistywithOne Generation Reproducive Evaluations Dupont59%0 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS ~ F; PUPS EXPLANATORY NOTES Abbreviations FD = Founddead Tm Company Sanitzed. Doss not contain TSCA Cal F9-02-4D7a6y8G:avSaubgcehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANDMAL GROSS AND MICROSCOPIC OBSERVATIONS- Fy PUPS DAM GROUP: 11-0 DOSE: 0 MG/KG/DAY oANaIMAL PUP ANPIuMpAL DAYS NUMBER SEX NUMBER ON TEST FATE OBSERVATIONS No pups were found dead in this group. -- -- me -- Company Sanitized. Does not contain TSCA C81 9H0--2D47a6y8G:avSaugbeehSrtoundiyc iTnoxRiactistwyith One-Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - F, BUPS DAM GROUP: TV-0 DOSE: 25 MG/KG/DAY oANyIMAL PUP ANsIuMpAL DAYS NUMBER SEX NUMBER ON TEST FATE OBSERVATIONS 646596 F 649651 -21 FD LSUTNOGMSACH- N-OTNOEMXIPLANKDESDPOT 649652 21 FD LUNGS - NOT EXPANDED --e ---- e--------I38-- 0- eeeeE-- CompanySanitized. Does not conTtSaCAiCnBI H-24768: Subchronic Toxicity 90Day Gavage Study in Rats with One-Generaion Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fy PUPS DAM GROUP: VI-0 DOSE: 100 MG/KG/DAY oANaIMAL PUP ANcIuMpAL DAYS NUMBER SEX NUMBER ON TEST FATE OBSERVATIONS 646547 F 649673 17 FD 646671 F 649672 -21 FD 646645 M 649661 -21 FD F 66449966721 271 FFDD SLUTNOGMSACH- N-ONTOEXMPILAKNDESDPOT NO ABNORMALITIES DETECTED LSUTNOGMSACH- N-ONTOEMXIPLAKNDSEPDOT WNHOOALBENOBROMDAYLI-TAIUETSOLDYESTIESC,TESDEVERE - ew Company Sanitized.Doesnot containTSCA Cal H-24768: Subehronic Toxicity '90-Day Gavage Study in Rats withOneGeneration Reproductive Evaluations DuPont5990 pe INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fy PUPS DAM GROUP: VITI-0 DOSE: 500 MG/KG/DAY. ANoIaMAL PUP ANuIpMAL DAYS NUMBER SEX NUMBER ON TEST FATE OBSERVATIONS 646662 F 649697 -14 FD STOMACH - NO MILK SPOT 646641 MF 66449969811 2211 FFDD WSHTOOLMAECHBOD-YNO- MAUITLOKLYSSPIOST, SEVERE LUNGS - NOT EXPANDED 646572 M 649682 21 FD WHOLE BODY - AUTOLYSIS, SEVERE . 646566 M 649683 21 FD SLTUONMGASCH- N-ONTOEXMPILAKNDESDPOT_ 646655 FM 66449965824 2211 FFDD NNOO AABBNNOORRMMAALLIITTIIEESS DDEETTEECCTTEEDD 646663 M 64985 21 FD UF 664499669836 2211 FFDD SLTUONMGASCH- N-ONTOEMXIPLAKNDESDPOT WWHHOOLLEE BBOODDYY -- CAUATNONLIYBSAILSI,ZEDS,EVE; REONLY HEAD REMAINS --_ 646574 FE 649694 21 FD SLTUONMGASCH- N-ONTOEMXIPLAKNDESDPOT 66449969956 2211 FFDD WSHTOOLMAECHBOD-YNO- MCIALNKNIBSAPLOTIZED LUNGS - NOT EXPANDED -= Company Sanitized. Does not contain TSCA CBI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont5990 APPENDIX PP INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fy WEANLINGS ee Company Sanitized. Does not contain TSCA CEI 1902.4D7a6y8:GavSaugbesSontidc TinoxRitcistywith OneGeneration Reproductive Evaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F; WEANLINGS EXPLANATORY NOTES Abbreviations SP = Sacrificed by design; necropsy performed -- Tw Company Saritzed. Doss not contain TSCA CBI H9-02-4D7a6y8:GavSaugbeehSrtoundiyc Toxicity in Rats with One-Generation Reproductive Evaluations DuPont-5990 _ TNDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fy WEANLINGS |{ ANIL DAYS MALE RATS Grove: 1-1 DOSE: 0 MG/KG/DAY NUMBER ON TEST FATE OBSERVATIONS 650094 1 SP NO ABNORMALITIES DETECTED 650095 1 SP NO ABNORMALITIES DETECTED 650096 1 SP NO ABNORMALITIES DETECTED 650097 1 SP NO ABNORMALITIES DETECTED 650098 1 SP NO ABNORMALITIES DETECTED 650099 1 SP NO ABNORMALITIES DETECTED 650100 1 SP NO ABNORMALITIES DETECTED 650101 1 SP NO ABNORMALITIES DETECTED 650102 1 SP NO ABNORMALITIES DETECTED 650103 1 SP NO ABNORMALITIES DETECTED 650100 1 SP NO ABNORMALITIES DETECTED 650105 1 SP NO ABNORMALITIES DETECTED ~ 650106 1 SP NO ABNORMALITIES DETECTED 650107 1 SP NO ABNORMALITIES DETECTED 650108 1 SP NO ABNORMALITIES DETECTED 650109 1 SP NO ABNORMALITIES DETECTED 650110 1 SP NO ABNORMALITIES DETECTED 650111 1 SP NO ABNORMALITIES DETECTED 650122 1 SP NO ABNORMALITIES DETECTED 650113 1 SP NO ABNORMALITIES DETECTED 650114 1 SP NO ABNORMALITIES DETECTED 650115 1 SP NO ABNORMALITIES DETECTED 650116 1 SP NO ABNORMALITIES DETECTED 650117 1S? NO ABNORMALITIES DETECTED 650118 1 SP NO ABNORMALITIES DETECTED - Ts Company Sanitized. DoesnotconTtSaCAiGBnI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One- Generation Reproductive Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fy, WEANLINGS ANIMAL DAYS MALE RATS NUMBER ON TEST FATE GROUP: 1-1 DOSE: 0 MG/KG/DAY OBSERVATIONS 650119 1 SP NO ABNORMALITIES DETECTED 650120 1 SP NO ABNORMALITIES DETECTED 650121 1 SP NO ABNORMALITIES DETECTED 650122 1 SP NO ABNORMALITIES DETECTED 650123 1 SP NO ABNORMALITIES DETECTED en 1 SP NO ABNORMALITIES DETECTED 650125 1 SP NO ABNORMALITIES DETECTED - 650126 1 SP NO ABNORMALITIES DETECTED 650127 1 SP NO ABNORMALITIES DETECTED 650128 1 SP NO ABNORMALITIES DETECTED 650129 1 SP NO ABNORMALITIES DETECTED 650130 1 SP NO ABNORMALITIES DETECTED - 650131 1 SP NO ABNORMALITIES DETECTED 650132 1 SP NO ABNORMALITIES DETECTED 650133 1 SP NO ABNORMALITIES DETECTED 650130 1 SP NO ABNORMALITIES DETECTED 650135 1 SP NO ABNORMALITIES DETECTED 650136 1 SP NO ABNORMALITIES DETECTED 650137 1 SP NO ABNORMALITIES DETECTED 650138 1 SP NO ABNORMALITIES DETECTED 650139 1 SP NO ABNORMALITIES DETECTED 650140 1 SP NO ABNORMALITIES DETECTED 650141 1 SP NO ABNORMALITIES DETECTED EE `CompanySanitized. Doas not contain TSCACBI F9-02-4D7a6y8:GavSaugbcehSrtoundiyc TinoxRiacistywithOGneeneration Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS ANIMAL DAYS MALE RATS NUMBER ON TEST FATE Grove: TII-1 DOSE: 25 MG/KG/DAY OBSERVATIONS 650196 1 SP NO ABNORMALITIES DETECTED 650197 1 SP NO ABNORMALITIES DETECTED 650198 1 SP NO ABNORMALITIES DETECTED 650199 1 SP NO ABNORMALITIES DETECTED : 650200 1 Se NO ABNORMALITIES DETECTED . 650201 1 SP NO ABNORMALITIES DETECTED 650202 1 SP NO ABNORMALITIES DETECTED - 650203 1 SP NO ABNORMALITIES DETECTED 650208 1 SP NO ABNORMALITIES DETECTED 650205 1 SP NO ABNORMALITIES DETECTED 650206 1 SP NO ABNORMALITIES DETECTED 650207 1 SP NO ABNORMALITIES DETECTED - 650208 1 SP NO ABNORMALITIES DETECTED 650209 1 SP NO ABNORMALITIES DETECTED 650210 1 SP NO ABNORMALITIES DETECTED 650211 1 SP NO ABNORMALITIES DETECTED 650212 1 SP NO ABNORMALITIES DETECTED 650213 1 SP NO ABNORMALITIES DETECTED 650214 1 SP NO ABNORMALITIES DETECTED 650215 1 SP NO ABNORMALITIES DETECTED 650216 1 SP NO ABNORMALITIES DETECTED 650217 1 SP NO ABNORMALITIES DETECTED 650218 1 SP NO ABNORMALITIES DETECTED 650219 1 SP NO ABNORMALITIES DETECTED 650220 1 SP NO ABNORMALITIES DETECTED - ee CompanySanitized. DoesnotconTtSaCAiCanl H-24768: Subehronic Toxicity 90.Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont 5990 --_ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fy WEANLINGS ANnoL DAYS MALE RATS NUMBER ON TEST FATE Grove: TTI-1 DOSE: 25 MG/KG/DAY OBSERVATIONS 650221 1 SP NO ABNORMALITIES DETECTED 650222 1 SP NO ABNORMALITIES DETECTED 650223 1 SP NO ABNORMALITIES DETECTED 650224 1 SP NO ABNORMALITIES DETECTED 650225 1 SP NO ABNORMALITIES DEFECTED 650226 1 SP NO ABNORMALITIES DETECTED 650227 1 SP NO ABNORMALITIES DETECTED - 650228 1 SP NO ABNORMALITIES DETECTED 650229 1 SP NO ABNORMALITIES DETECTED Ee `Company Sanitized. Does not contain TSCA CBI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fy WEANLINGS ANIMAL DAYS MALE RATS NUMBER ON TEST FATE GROUP: V-1 DOSE: 100 MG/KG/DAY. OBSERVATIONS 650261 1 SP WHOLE BODY - SMALL 650266 1 SP NO ABNORMALITIES DETECTED 650267 1 SP NO ABNORMALITIES DETECTED 650268 1 SP NO ABNORMALITIES DETECTED 650269 1 SP NO ABNORMALITIES DETECTED 650270 1 SP NO ABNORMALITIES DETECTED 650271 1 SP NO ABNORMALITIES DETECTED - 650272 1 SP NO ABNORMALITIES DETECTED 650273 1 SP NO ABNORMALITIES DETECTED 650270 1 SP NO ABNORMALITIES DETECTED 650275 1 SP NO ABNORMALITIES DETECTED 650276 1 SP NO ABNORMALITIES DETECTED - 650277 1 SP NO ABNORMALITIES DETECTED 650278 1 SP NO ABNORMALITIES DETECTED 650279 1 SP NO ABNORMALITIES DETECTED 650280 1 SP NO ABNORMALITIES DETECTED 650282 1 SP NO ABNORMALITIES DETECTED 650283 1 SP NO ABNORMALITIES DETECTED 650284 1 SP NO ABNORMALITIES DETECTED 650286 1 SP NO ABNORMALITIES DETECTED 650287 1 SP NO ABNORMALITIES DETECTED 650288 1 SP NO ABNORMALITIES DETECTED 650289 1 SP NO ABNORMALITIES DETECTED 650290 1 SP NO ABNORMALITIES DETECTED - ws Company Sanitized. Dos not contain TSCA CBI 'H9-02-4D7a6y8G:avSaugbcehSrtoundiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont5990 ~ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS ANDMAL DAYS uALE RATS NUMBER ON TEST FATE Grove: v-1 DOSE: 100 MG/KG/DAY. OBSERVATIONS 650291 1 SP NO ABNORMALITIES DETECTED 650292 1 SP NO ABNORMALITIES DETECTED 650293 1 SP NO ABNORMALITIES DETECTED - `Company Sanitized. Donotecontsain TSCA Cal H902-4D7a6y8:GavSaugbcehSrtoundiyciTnoRxaictistywith One-GeneratonReproductiveEvaluations DuPon-5990 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS ANIMAL DAYSMALE RATS NUMBER ON TEST FATE GRovp: VII-L DOSE: 500 MG/KG/DAY. OBSERVATIONS 650333 1 SP NO ABNORMALITIES DETECTED 650332 1 SP NO ABNORMALITIES DETECTED ~ "IIs `Company Sanitized.Doesnot conTtSaCAiCBnI 9H0-2-4D7a6y8:GavSaubgcehSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 --_ TNDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS ANIMAL DAYS FEMALE RATS NUMBER ON TEST FATE GROUP: 11-1 DOSE: 0 MG/KG/DAY OBSERVATIONS 650142 1 SP NO ABNORMALITIES DETECTED 650143 1 SP NO ABNORMALITIES DETECTED 650142 1 SP NO ABNORMALITIES DETECTED 650145 1 SP NO ABNORMALITIES DETECTED : 650146 1 SP NO ABNORMALITIES DETECTED 650147 1 SP NO ABNORMALITIES DETECTED 650148 1 SP NO ABNORMALITIES DETECTED : 650109 1 SP NO ABNORMALITIES DETECTED 650150 1 SP NO ABNORMALITIES DETECTED 650151 1 SP NO ABNORMALITIES DETECTED 650152 1 SP NO ABNORMALITIES DETECTED 650153 1 SP NO ABNORMALITIES DETECTED - 650154 1 SP NO ABNORMALITIES DETECTED 650155 1 SP NO ABNORMALITIES DETECTED 650156 1 SP NO ABNORMALITIES DETECTED 650157 1 SP NO ABNORMALITIES DETECTED 650158 1 SP NO ABNORMALITIES DETECTED 650159 1 SP NO ABNORMALITIES DETECTED 650160 1 SP NO ABNORMALITIES DETECTED 650161 1 SP NO ABNORMALITIES DETECTED 650162 1 SP NO ABNORMALITIES DETECTED 650163 1S? NO ABNORMALITIES DETECTED 650164 1 SP NO ABNORMALITIES DETECTED 650165 1 SP NO ABNORMALITIES DETECTED 650166 1 SP NO ABNORMALITIES DETECTED es `Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F WEANLINGS ANIMA:L DAYS FEMALE RATS NUMBER ON TEST FATE Grove: TI-1 DOSE: 0 MG/KG/DAY OBSERVATIONS 650167 1 SP NO ABNORMALITIES DETECTED 650168 1 Se NO ABNORMALITIES DETECTED 650169 1 SP NO ABNORMALITIES DETECTED 650170 1 SP NO ABNORMALITIES DETECTED 650171 1 SP NO ABNORMALITIES DETECTED 650172 1 SP NO ABNORMALITIES DETECTED 650173 1 SP NO ABNORMALITIES DETECTED : 650170 1 SP NO ABNORMALITIES DETECTED 650175 1 SP NO ABNORMALITIES DETECTED 650176 1 SP NO ABNORMALITIES DETECTED 650177 1 SP NO ABNORMALITIES DETECTED 650178 1 SP NO ABNORMALITIES DETECTED - 650179 1 SP NO ABNORMALITIES DETECTED 650180 1 SP NO ABNORMALITIES DETECTED 650181 1 SP NO ABNORMALITIES DETECTED 650182 1 SP NO ABNORMALITIES DETECTED 650163 1 SP NO ABNORMALITIES DETECTED 650184 1 SP NO ABNORMALITIES DETECTED 650185 1 SP NO ABNORMALITIES DETECTED 650186 1 SP NO ABNORMALITIES DETECTED 650187 1 SP NO ABNORMALITIES DETECTED 650188 1 SP NO ABNORMALITIES DETECTED 650189 1 SP NO ABNORMALITIES DETECTED 650190 1 SP NO ABNORMALITIES DETECTED 650191 1 SP NO ABNORMALITIES DETECTED - ws `Company Sanitized. Does not contain TSCA CBI 0HL-2D4a76y8:GaSvuabgcehrSotnuidcy iTnoxRiactistywith One- Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL ANTAL GROSS OBSERVATIONS - F WEANLINGS ANIMAL DAYS FEMALE RATS NUMBER ON TEST FATE Group: TI-1 DOSE: 0 MG/KG/DAY OBSERVATIONS 650192 650193 650190 650195 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED EE CompanySanitized. Dossnot conTtSaCAiCBnI H0--2D4a76y8:GaSvuabgcehrSotnuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPon-5990 - INDIVIDUAL ANTHAL GROSS OBSERVATIONS - F, WEANLINGS ANIMAL DAYSFEMALE RATS NUMBER ON TEST FATE Group: TV-1 DOSE: 25 MG/KG/DAY OBSERVATIONS 650230 1 SP NO ABNORMALITIES DETECTED 650231 1 SP NO ABNORMALITIES DETECTED 650232 1 SP NO ABNORMALITIES DETECTED 650233 1 SP NO ABNORMALITIES DETECTED 650234 1 SP NO ABNORMALITIES DETECTED 650235 1 SP NO ABNORMALITIES DETECTED 650236 1 SP NO ABNORMALITIES DETECTED 650237 1 SP NO ABNORMALITIES DETECTED 650238 1 SP NO ABNORMALITIES DETECTED 650239 1 SP NO ABNORMALITIES DETECTED 650240 1 Se NO ABNORMALITIES DETECTED 650241 1 SP NO ABNORMALITIES DETECTED - 650242 1 SP NO ABNORMALITIES DETECTED 650243 1 SP NO ABNORMALITIES DETECTED 650240 1 SP NO ABNORMALITIES DETECTED 650245 1 SP NO ABNORMALITIES DETECTED 650246 1 SP NO ABNORMALITIES DETECTED 650247 1 SP NO ABNORMALITIES DETECTED 650248 1 SP NO ABNORMALITIES DETECTED 650249 1 SP NO ABNORMALITIES DETECTED 650250 1 SP NO ABNORMALITIES DETECTED 650251 1 SP NO ABNORMALITIES DETECTED 650252 1 SP NO ABNORMALITIES DETECTED 650253 1 SP NO ABNORMALITIES DETECTED 650250 1 SP NO ABNORMALITIES DETECTED . : - ss Company Sanitized. Doesnotcontain TSCA CBI H-24768: Subchroric Toxicity 90.Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont. 5990 PS INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fy WEANLINGS ANIMAL DAYSFEMALE RATS NUMBER ON TEST FATE Grove: TV-1 DOSE: 25 MG/KG/DAY OBSERVATIONS 650255 650256 650257 650258 650259 650260 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Ee `Company Sanitzed. Does not contain TSCA C81 H9.02-4D7a6y8G:avSaubgcehSrtoundiyciTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont 5990 ~ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS ANDHAL DAYSFEMALE RATS NUMBER ON TEST FATE Group: VI-1 DOSE: 100 MG/KG/DAY. OBSERVATIONS 650298 1 SP NO ABNORMALITIES DETECTED 650299 1 SP NO ABNORMALITIES DETECTED a50301 1 SP NO ABNORMALITIES DETECTED 650302 1 SP NO ABNORMALITIES DETECTED 650305 1 SP NO ABNORMALITIES DETECTED . 650306 1 SP NO ABNORMALITIES DETECTED 650307 1 SP NO ABNORMALITIES DETECTED - 650308 1 SP NO ABNORMALITIES DETECTED 650309 1 SP NO ABNORMALITIES DETECTED : 650312 1 SP NO ABNORMALITIES DETECTED 650313 1 SP NO ABNORMALITIES DETECTED 650314 1 SP NO ABNORMALITIES DETECTED - 650315 1 SP NO ABNORMALITIES DETECTED 650316 1 SP NO ABNORMALITIES DETECTED 650317 1 SP NO ABNORMALITIES DETECTED 650318 1 SP NO ABNORMALITIES DETECTED 650319 1 SP NO ABNORMALITIES DETECTED 650320 1 SP NO ABNORMALITIES DETECTED 550321 1 SP NO ABNORMALITIES DETECTED 650322 1 SP NO ABNORMALITIES DETECTED 650323 1 SP NO ABNORMALITIES DETECTED - CompanySanitized. Doesnot conTtSaCAiCani H9-02-4D7a6y8G:aSvuabgcehrSotnuidcy TinoxRiactistywithOne Generation Reproductive Evaluations DuPont5990 --_ INDIVIDUAL ANTAL GROSS OBSERVATIONS - Fy WEANLINGS ANAL DAYFSEMALE RATS NUMBER ON TEST FATE GROUP: VIII-1 DOSE: 500 MG/KG/DAY. OBSERVATIONS 650340 1 SP WHOLE BODY - SMALL 650345 1 SP NO ABNORMALITIES DETECTED Ee Company Sanitized. Does not contain TSCA CBI F0--2D4a76y8:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 APPENDIX QQ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fy ADULTS TTC -- Company Sanitized. Dos not contain TSCA CBI H9-02.4D7a6y8:GavSaugbcehSrtoundiyc iTnoxRiactistywith One-Generaion Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS -- F; ADULTS EXPLANATORY NOTES Abbreviations FD = Founddead SD = Sacrificed by design DuPont5990 - `Company Sanitized. Does not contain TSCA CBI 9H02-4D7a6y8:GaSvuabgcehrSotnudiyc TinoxRiactistywith One-Generaton Reproductive Evaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, ADULTS wALE RATS Grove: 1-1 DOSE: 0 MG/KG/DAY ANNUIMMBAELR ONDAYTSEST MODDEEATOHF OBSERVATIONS 649992 40 SD NO ABNORMALITIES DETECTED 649993 40 SD NO ABNORMALITIES DETECTED 649994 40 SD NO ABNORMALITIES DETECTED 649995 40 SD NO ABNORMALITIES DETECTED 649996 40 SD NO ABNORMALITIES DETECTED 649997 40 SD NO ABNORMALITIES DETECTED - 649998 40 SD NO ABNORMALITIES DETECTED 649999 40 SD NO ABNORMALITIES DETECTED 650000 40 SD NO ABNORMALITIES DETECTED 650001 40 SD NO ABNORMALITIES DETECTED 650002 40 SD NO ABNORMALITIES DETECTED - 650003 40 SD NO ABNORMALITIES DETECTED 650004 40 SD NO ABNORMALITIES DETECTED 650005 40 SD NO ABNORMALITIES DETECTED 650006 40 SD NO ABNORMALITIES DETECTED 650007 40 SD NO ABNORMALITIES DETECTED 650008 40 SD NO ABNORMALITIES DETECTED - we `Company Sanitized. Does not contain TSCA C81 '9H0--24D7a6y8G:avSaugbechSrtoundiyc TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fy ADULTS wALE RATS Grove: TII-1 DOSE: 25 MG/KG/DAY. NAUNMIBMEARL ONDAYTSEST MODDEEATHOF OBSERVATIONS 650009 40 SD NO ABNORMALITIES DETECTED 650010 40 SD NO ABNORMALITIES DETECTED 650011 40 SD NO ABNORMALITIES DETECTED . 650012 40 SD NO ABNORMALITIES DETECTED 650013 40 SD NO ABNORMALITIES DETECTED : 650014 40 SD NO ABNORMALITIES DETECTED . 650015 40 SD NO ABNORMALITIES DETECTED 650016 40 SD KIDNEYS - DILATATION, MODERATE, RIGHT, PELVIS 650017 40 SD NO ABNORMALITIES DETECTED 650018 40 SD NO ABNORMALITIES DETECTED 650019 40 SD NO ABNORMALITIES DETECTED - we `CompanySanitized. DonotecontsainTSCACBI H9-02.4D7a6y8G:SauvbagcehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont5990 oy INDIVIDUAL ANTAL GROSS OBSERVATIONS - Fy ADULTS MALE RATS GRovR: V-1 DOSE: 100 MG/KG/DAY ANNUIMMBAELR ONDATYSEST MDOEDAETHOF OBSERVATIONS 650020 40 SD NO ABNORMALITIES DETECTED 650022 40 SD NO ABNORMALITIES DETECTED 650023 40 SD NO ABNORMALITIES DETECTED 650024 40 SD NO ABNORMALITIES DETECTED 650025 40 SD NO ABNORMALITIES DETECTED 650026 40 SD NO ABNORMALITIES DETECTED . 650027 40 SD NO ABNORMALITIES DETECTED 650028 40 SD NO ABNORMALITIES DETECTED 650029 40 SD NO ABNORMALITIES DETECTED 650030 40 SD NO ABNORMALITIES DETECTED - a. CompanySanitized.Doesnot conTtSaCAiCnBI 9H0-2-4D7a6y8:GavSaubgcehSrotnuidcy TinoxRiactistywithOne-Generation ReproductiveEvaluations DuPont-5990 - INDIVIDUAL ANTAL GROSS OBSERVATIONS - F; ADULTS ALE RATS Grove: VII-1 DOSE: 500 MG/KG/DAY ANNUIMMBAELR ONDATYESST MODDEEATOHF OBSERVATIONS 650032 15 SD NO ABNORMALITIES DETECTED 650035 13 SD NO ABNORMALITIES DETECTED 650036 3 FD WHOLE BODY - SWALL - ue Company Sanitized.Does not conTtSaCAiCBnI H9L02-4D7a6y8G:avSaubgcehSrtoundiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 ---_ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fy ADULTS FEMALE RATS GROUP: 11-1 DOSE: 0 MG/KG/DAY NAUNMIBMEARL ONDATYESST MODDEEATOHF OBSERVATIONS 650043 40 SD NO ABNORMALITIES DETECTED 650044 40 SD NO ABNORMALITIES DETECTED 650045 40 SD NO ABNORMALITIES DETECTED 650046 40 SD NO ABNORMALITIES DETECTED 650047 40 SD NO ABNORMALITIES DETECTED 650048 40 SD NO ABNORMALITIES DETECTED k 650049 40 SD NO ABNORMALITIES DETECTED 650050 40 SD NO ABNORMALITIES DETECTED 650051 40 SD NO ABNORMALITIES DETECTED 650052 40 SD NO ABNORMALITIES DETECTED 650053 40 SD NO ABNORMALITIES DETECTED --_ 650054 40 SD NO ABNORMALITIES DETECTED 650055 40 SD NO ABNORMALITIES DETECTED 650056 40 SD NO ABNORMALITIES DETECTED 650057 40 SD NO ABNORMALITIES DETECTED 650058 40 SD NO ABNORMALITIES DETECTED 650059 40 SD NO ABNORMALITIES DETECTED EE Company Saniized.Doesnotcontain TSCA CBI 'H9204-7D6ay8:GavSuabgcehrSotnuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPon-5990 --_ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, ADULTS FEMALE RATS Grove: TV-1 DOSE: 25 MG/KG/DAY. NAUNMIBMEARL ONDATYESST MODDEEATHOF OBSERVATIONS 650060 40 SD NO ABNORMALITIES DETECTED 650061 40 SD NO ABNORMALITIES DETECTED 650062 40 SD NO ABNORMALITIES DETECTED 650063 40 SD NO ABNORMALITIES DETECTED 650064 40 SD NO ABNORMALITIES DETECTED 650065 40 SD NO ABNORMALITIES DETECTED - 650066 40 SD NO ABNORMALITIES DETECTED 650067 40 SD NO ABNORMALITIES DETECTED 650068 40 SD NO ABNORMALITIES DETECTED 650069 40 SD NO ABNORMALITIES DETECTED 650070 40 SD NO ABNORMALITIES DETECTED - es CompanySanitized. Doesnot contain TSCA CBI 9H0--2D47a6y8G:avSaugbcehSrtoundiyc iTnoxRiacittywithOneGeneration Reproductive Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, ADULTS FEMALE RATS GROVE: vI-1 DOSE: 100 MG/KG/DAY. ANNOIMMBAELR ONDAYTSEST MODDEEATHOF OBSERVATIONS 650073 40 SD NO ABNORMALITIES DETECTED 650074 40 SD NO ABNORMALITIES DETECTED 650075 40 SD NO ABNORMALITIES DETECTED 650076 40 SD NO ABNORMALITIES DETECTED 650077 40 SD NO ABNORMALITIES DETECTED 650078 40 SD NO ABNORMALITIES DETECTED - 650079 40 SD NO ABNORMALITIES DETECTED 650080 40 SD NO ABNORMALITIES DETECTED 650081 40 SD NO ABNORMALITIES DETECTED - Company Sanitized. Does not contain TSCA C1 F9-02-4D7a6y8:GaSvuabgcehrSotnuidcy iTnoxRiacsitywith OneGeneration Reproductive Evaluations DuPont-5990 -~ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, ADULTS FEMALE RATS Group: VITI-1 DOSE: 500 MG/KG/DAY ANUNMIBMEARL ODNAYTSEST MODDEEATHOF OBSERVATIONS 650083 650086 650087 5 FD 13 SD 2 FD WSHKOILNE-BOSTDAYIN-', SHYEALLLLOW, PERINEUM, INGUEN NO ABNORMALITIES DETECTED LSSMATAROLGMLEACHIINNTT-EESSDTTIIISNNTEEEND_-EDDDIISSWTTITEEHNNDDGEEADDSWWIITTHH GGAASS WSHKOILNE-BOSTDAYIN-, SHYAELLLL.OW, PERINEUM, INGUEN Tia0s- ~-- CompanySanitized. DoesnotcontainTSCAGBI