JIM WEAVER 4 th District.

-i R E P 0 R T .

DIOXINS IN ENVIRONMENT, Chapter 20, Panel Discussion, Plaintiffs' Exhibit 1802: McConnell, page 271: "We have shown in animals that chronic low-level exposures in several species of animals appear to be more potent than a single equivalent dose.

fa ' -* PJSSS QUERY COMPANY (OpUnit or Corporate): MIC SUBJECT: TRACE LEVELS OF TCDD IN ORTIIOCHLOROPHENOL REPORTER &.MEDIA: TIME & DATE: F e b r u J(o3h1n4 ary ) 1 F 6 4r a4n2k- 3, , 197 1 9 6C1o l -- u m bia 3:40 M issourian p.m QUESTION & RESPONSE: TCtateiCfonDstmuDet imirnnweggntahts:eqopuuTsrreehpseOstiieClonnPl nat wirtnueiangsrsee raitvhsnoeef ut hOstnhaCacmePto pnMralseencodpinouosntnarhanttabetiolltre' knos nnoaeecctwot n m. o n th ___-_______X_XX_XXXX_____ _X_ _ XXXXXX T; WJNMWJMNMEJJJBJTGMSKMD..N...e..er.....AI.PC.TTEuFwwCPTJRRRIPCs....issLHLS..CcWRRPMNYPIeMPPPkBhMRB.l.R...oRo.RoPascRicuislrrKRuu'sCarPdskMhMHlGFeEsnee((ha-uoaheGWyPrJoabuoapav-ueIcl..eIWinissrblctPlhsbsllceahieYaSRrhcisaisygnhepoilRogliel-afunatelnotngnilinatopogot.ni))snosD.n.CsD..C.

TOXICITY AND HAZARDS Safety of operations in the Aroclor Plant depends on the individual operator* Materials being handled and operations must be observed closely to guard against the following: (1) Chlorine Qas CAUSE AND ACTION TO PREVENT Chlorine gas is a very toxic corrosive gas.

Monsanto e o o A - 307( a ) Cw^-'W] MONSANTO INDUSTRIAL CH EM ICALS CO. 800 N Llndbicol' 8oulvid S i lo a n .

JUL-19-93 HON 10:29 WILLIAMS & OTNOLLY / Ir-T RO BERT J.

SULFURIC ACID General- Information Synonyms: Oil of vitriol; dipping acid Description: Colorless, oily liquid.

L [f 1 p It 1 ]1 i1 1 1 [ a1 1 [L[L:3i]hl January 10, 10^9 Dr.

TCDD; PCDF-- AS CONTAMINANT Acute Symptoms Headache Nausea, Vomiting Respiratory Skin Irritation Eye Chlorinated Naphthalenes Acute Yellow Atrophy of Liver C07496

I; s f T ' /Q Tcv-H-bc. ><-. .

ZACK-GAFFEY REPORT DEATHS IN EXCESS OF EXPECTED CAUSE * Lung cancer Genitourinary cancer Bladder cancer ** Lymphatic cancer *** Other sites **** All cancers Heart disease NUMBER 10 2 2 3 2 18 27 PERCENTAGE OF DEATHS HIGHER THAN EXPECTED 143% higher 108% higher /V 809%,/higher' 92% 'TTigher 26% higher 43% higher 37% higher * Four deaths omitted from Zack-Gaffey Report -- ** Completely omitted from Zack-Gaffey Report *** One death omitted from Zack-Gaffey Report **** Nine deaths omitted from Zack-Gaffey Report

ATTACHMENT F '-- c-% 1" *

Notes from a chart paper too large to reduce/copy ISSUES Surrogate exposures Confounding factors Case-control vs. cohort Power Site concordance & human experience (Rail) Di agnosi s "Human experience" Scientific limitations in general CONCLUSIONS Some strong + Some (not confirming) Limitations B2 BULLET-ESE No single study In toto > inadequate ""TTuman experience" (Intuitively troubling but scientifically inconclusive)

V IK THE UNITED STATES DISTRICT COURT SOUTHERN DISTRICT OP WEST VIRGINIA CHARLESTON, WEST VIRGINIA JAMES M, ADKINS, Administrator of the Betate of Ralph E.